[Optimization of devices for antibiotic phoretic physiotherapy on the basis of a two-barrier model of diffusion and diffusion-osmotic migration of antibiotic anions].
One-, two-, three-, and four-component low-amplitude field phoretic effects on permeability of placental and muscular biological barriers to levomycetin, benzylpenicillin, and oxacillin anions were studied. Experimental data on exposure to constant electric fields, sinusoidal alternating magnetic field, thermal heating, and vibroacoustic and UHF effects were used to determine the mean coefficients of acceleration of antibiotic anion migration through placental and muscular barriers. The effect of physical fields was interpreted in terms of the sensitivity coefficient, total factor of systemic response of human body, and trade-off optimization index. The results of calculation of trade-off optimization index showed that the maximal relative therapeutic efficiency was observed for optimal numbers of combined fields (2-3) both for placental and muscular barriers. The obtained results showed that optimal stimulated migration of antibiotic anions in placental or muscular barrier was already observed in two-component physical fields, such as magnetoelectric, UHF-magnetic, UHF-electric, UHF-vibroacoustic, magnetovibroacoustic, electrovibroacoustic, etc. Clinical use of stimulated anion migration is illustrated by the example of its physiotherapeutic effect in male urology, ophthalmology, dentistry, and dental implantation.