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At least 469 records · Page 26Linked to original sources
PubMedDate not supplied

[Monitoring of sE-selectin serum levels in three different dermatoses].

PURPOSE: To determine the behaviour of serum levels of soluble E-selectin (sE-selectin), the soluble isoform of E-selectin, before/during/after therapy in patients with three. PATIENTS AND METHODS: Using commercially available ELISA kits, serum levels of sE-selectin have been determined in 15 patients with psoriasis, 15 with pemphigus vulgaris and 15 with bullous pemphigoid, and compared with those of 30 healthy subjects. RESULTS: The results showed increased serum levels of sE-selectin in the three groups of patients as compared with those of 30 healthy subjects (p < 0.01). In addition, serum levels were significantly correlated with the disease activity expressed as Psoriasis Area and Severity Index (PASI score) (R = 0.56, p = 0.014) in psoriasis, and as number of the visible lesions (blisters/erosions), in the two bullous dermatoses (R = 0.81, p < 0.01). After therapy, the marker levels were significantly decreased (p < 0.01). CONCLUSIONS: Overall, these data suggest that serum determinations of sE-selectin could represent a clinically useful indicator to monitor therapy.

E-Selectin↗
PubMed1998

[Skin microcirculation, adherence molecules and inflammatory dermatoses].

Skin is a peculiar organ with regard to its microcirculation. The dermal vasculature is enriched with abundant anastomoses. It forms a single compartment where blood can be pulsed in any direction without always following an arteriolovenular gradient. Under various pro-inflammatory stimuli, endothelial cells express diverse adhesion molecules whose specificity leads to the intradermal collection of specific leukocytic lineages. Such basic mechanism is at the origin of all inflammatory dermatoses. It is possible and even probable that some antihistamines, flavonoids and antiseptics modulate in a beneficial way the expression of some adhesion molecules.

Anti-Infective Agents, Local↗
PubMed2006

Unusual palmoplantar blistering in the setting of hemodialysis: a case report and review of the dermatoses associated with hemodialysis.

We describe a 70-year-old White female on maintenance high-flux hemodialysis for chronic renal insufficiency with an abrupt onset of asymptomatic palmoplantar blisters. The lesions were tense, noninflamed and 0.2-1.0 cm in dimension. Concomitant photo-distributed blistering of the dorsal hands and forearms was not present. A cutaneous biopsy demonstrated nonspecific histological and direct immunofluorescent findings. Serum indirect immunofluorescence and tissue cultures for bacteria, fungi and viruses were negative. Fecal porphyrins were normal but an elevated plasma uroporphyrin level of 17.0 microg/dL (normal: < 1.0 microg/dL) was observed. The duration of each hemodialysis treatment, which the patient had continued to receive three times per week, was changed from 2 to 2.5 h. Within 2 weeks no new blisters occurred. Within 6 weeks complete clinical and biochemical remission was noted. During this time course no topical steroid or antifungal therapy was employed nor was the patient's oral medication regimen altered.

Aged↗
PubMed1989

Occupational dermatoses in farmers growing okra (Hibiscus esculentus L.).

By questionnaire survey, 32 out of 52 workers (61.5%) reported previous or current skin diseases from okra cultivation. The sites of skin lesions were mainly the arms, fingers and fingertips. Positive patch test reactions with preparations of okra leaves or immature pods in 111 workers, compared to 63 control subjects, were significantly higher in okra workers than in controls (p less than 0.01), ranging from 9.8 to 30.0%. 37 out of 111 workers (33.3%) were diagnosed as having allergic contact dermatitis (n = 17; 15.3%) and irritant contact dermatitis (n = 18; 16.2%) from okra cultivation.

Agriculture↗
PubMed1975

[Dyshidrosis as a pacemaker for occupational dermatoses].

Out of 335 persons of less than 25 years, 236 had an intermittent dyshidrosis; half of them showed an allergic contact eczema of the hands. Microscopical and cultural investigations revealed a foot mycosis in 24 persons, and in 13 a candidiasis of the hands. Hence, dyshidrosis is obviously not of mycotic origin. 113 out of 150 sensitized persons of this group of age were dyshidrotics; 50% of them had not yet finished their apprenticeship. Obviously, dyshidrosis favours an early sensitization in professions in which allergens are frequently encountered.

Adolescent↗
PubMedDate not supplied

Occupational dermatoses among office personnel.

As offices have become more complex environments, the number of skin problems among office workers has increased. Among the agents implicated are carbonless copy paper, duplicating machines, formaldehyde, video display terminals, and rubber bands. Accurate diagnosis can be difficult but usually results in complete cure.

Dermatitis, Contact↗
PubMed1982

[Dermatoses in the spinning and weaving industry].

In order to detect cutaneous alterations among the workers of a textile industry, the authors proceeded to a dermatologic examination of 1207 persons, with special emphasis on skin conditions of the fingers and toes. The most noticeable and specific alteration related to the work was a linear hyperkeratosis of the lateral aspects of the first and second finger of the right hand--the fingers of prehension--submitted to repeated micro-traumas due to the manipulation of the threads. In second place in order of frequency were the intertriginous inflammation of the toes, due to the high level of temperature and humidity prevalent in some areas of the plant, besides the use of inadequate shoes and socks. Some suggestions are made for reducing the incidence of dermatologic risks.

Adolescent↗