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PubMed1981

Complement fixation tests for equine piroplasmosis (Babesia equi and B caballi) performed in the UK during 1976 to 1979.

The results of complement fixation (CF) test for equine piroplasmosis on sera from horses destined for international movement from Great Britain and Ireland are presented and analysed. No horses born and continuously resident in the British Isles were found carrying CF antibodies to either Babesia equi or B caballi. Positive animals were found to have association with the following countries where known tick vectors occur: Spain, Portugal, Belgium, France, Poland, USSR and Arabian Gulf countries. Data on the persistence of CF antibodies in animals subjected to repeated testing showed that some animals lost their CF titre within a few months of their first test while others retained a titre for periods up to 13 months of B caballi and 28 months for B equi. Some individuals regained titres on subsequent tests after becoming negative and the results suggest that removal from exposure to infection or, even, treatment does not necessarily eliminate a CF titre within a predictable time limit.

Animals↗
PubMed1974

Evaluation of micro complement fixation tests for antibodies against group A streptococcal M and M-associated antigens in rabbit and human sera.

Variables involved in micro complement fixation (CF) tests for type-specific (TSM) and non-type-specific (NTSM) antibodies against preparations of streptococcal M protein were studied. Sera of rabbits immunized with purified M protein which contained high titers of anti-TSM and low titers of anti-NTSM antibodies reacted type specifically in the CF tests when relatively low concentrations of M protein were employed. In contrast to these artificially induced TSM antibody responses, the sera of rheumatic fever patients demonstrated elevated CF antibody titers (1:80 to 1:320) in the presence of both high and low concentrations of M antigen. The CF test cannot distinguish TSM and NTSM antibodies when the latter predominate. The CF test can be employed with confidence for the detection of NTSM antibodies, provided that the test sera are known to lack type-specific antibodies against the M protein used in the test.

Animals↗