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PubMed1987

Omphalokeratolith.

A 69-year-old woman presented with a firm, black umbilical mass of unknown duration. It was easily removed with a warmed otic glycerin preparation. Histologic examination showed that it contained laminated keratin, amorphous material resembling sebum, numerous terminal hairs, and scattered collections of bacteria. Moderate amounts of argentaffin staining material were detected throughout the specimen, and the black color of the lesion was probably due to melanin and oxidized lipids, much like an open comedone. The mass is appropriately called an omphalokeratolith.

Aged↗
PubMed1989

[Dermatological findings in the annual examination of the patients with yusho in 1987-1988--with special reference to the alteration of the skin symptoms in the patients followed up for 20 years].

We reported on the skin symptoms of the patients with yusho in the 1987 and 1988 annual examinations. We also studied the alteration of the skin symptoms in the patients followed up for 20 years. These patients showed obvious improvement in their skin symptoms during these 20 years. However, about a half of the patients still had comedones and/or acneiform eruptions, although the number of eruptions had decreased. The cases with blood PCB pattern A (typical yusho pattern) demonstrated higher skin severity grading points than those of the other groups (patterns B and C), but even in these cases the skin eruptions had improved.

Female↗
PubMedDate not supplied

Comparison of a salicylic acid cleanser and a benzoyl peroxide wash in the treatment of acne vulgaris.

A four-week crossover study to compare the efficacy of an acne cleanser containing 2% salicylic acid with that of a 10% benzoyl peroxide wash was conducted in 30 patients with acne vulgaris. The results demonstrated that only patients treated with the salicylic acid cleanser had a significant reduction in comedones. Patients treated with the salicylic acid cleanser for the first two weeks showed a significant improvement in acne, but worsened during benzoyl peroxide therapy over the following two weeks. In contrast, patients initially treated with the benzoyl peroxide wash for the first two weeks continued to improve with salicylic acid cleanser over the next two weeks.

Acne Vulgaris↗
PubMed1989

Acne vulgaris.

Acne vulgaris is a disease of the pilosebaceous unit that affects nearly all persons to some degree during the teenage years. It is a disease that should be treated because of the anxiety and disfigurement it causes in the affected patient. Acne therapy is directed against the three probable pathogenic processes in acne: (1) abnormal keratinization of the sebaceous follicle, (2) excessive production of sebum, and (3) proliferation of bacteria in the follicle. Superficial acne consisting of comedones and small papulopustules will frequently respond to topical therapy such as retinoic acid, benzoyl peroxide, and topical antibiotics. Deeper lesions require systemic antibiotics of which tetracycline is the drug of choice. Severe, recalcitrant cystic acne usually responds well to the oral retinoid, isotretinoin. The severe teratogenic effects of isotretinoin on a developing fetus make this a risky drug to prescribe for women with childbearing potential. In such cases the greatest precautions should be taken to avoid pregnancy during a course of isotretinoin. Such precautions include pregnancy testing, contraceptive counseling, and the use of at least two effective forms of birth control in sexually active women.

Acne Vulgaris↗
PubMed1989

[National and international clinical experiences with azelaic acid cream in the treatment of comedo acne].

20% azelaic acid cream was compared clinically with its vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne. It was found that the azelaic acid treatment significantly reduced inflamed and non-inflamed lesions and yielded clinically relevant improvement rates. Its action was significantly more effective than its vehicle. In the study of comedo acne, 20% azelaic acid cream was equally effective as 0.05% tretinoin cream in reducing the number of comedones and with respect to overall response. However azelaic acid cream was better tolerated, causing fewer local side effects than the tretinoin.

Acne Vulgaris↗
PubMed1989

[Stationary trichogenic tumors (trichohamartomas, benign trichoepitheliomas and trichogenic cystic pseudotumors].

Trichohamartomas, benign trichoepiteliomas and cystic pseudotumours could be well distinguished in a group of 194 tumours. A possibility of common hamartoblastic features and transient forms does always exist. Diagnostic difficulties resulted mainly from a big number of specified units. An auxiliary separation into three subgroups is recommendable from didactic as well as practical reasons. The first subgroup comprises evident hamartoblastomas mimicking all the hair complex by their structure (hair follicle naevus, comedonic naevus, trichofolliculoma). The second subgroup comprises benign trichoepitheliomas with hamartoblastic features mimicking external hair sheath in cystology and histology (Wiener's porus pilar acanthoma, follicular poroma, tricholemmoma, folicular infundibulum tumour). Analogical cysts are in the third subgroup (epidermoid, tricholemmal, steatocystoma multiplex).

Epidermal Cyst↗
PubMedDate not supplied

[Condition of the human skin during a stay in a hermetically closed compartment].

The skin of healthy men kept in an enclosed environment was examined. It was found that exposure resulted in increases of the secretions of the sebaceous glands and sebum cutaneum, number and size of comedones, lipolytic activity of microorganisms, concentration of comedonogenic acids and skin irritating acids. It also caused a greater risk of papular and pustular rashes. Changes in lipid metabolism were consistent with the skin clinical state as well as with the subjective sensations of dirty skin, desquamation and itching. The severity of the above changes was correlated with the pretest physiological and hygienic status of the subjects.

Acne Vulgaris↗
PubMed1986

[How do I treat acne and rosacea?].

Regarding treatment of acne vulgaris and rosacea, there is not much difference between hospital and practice nor among practicing dermatologists. Most of the assistants performing the important physical-manual treatment have had the same training. After analytical conversation and etiologic as well as diagnostic classification, the patients undergo the following manual treatment: cleansing, astringing, removing of comedones, massage, face pack, and covering with tinted emulsion. At home, acne: cleansing, massage, skin lotion, vitamin A acid, benzoylperoxide, antibacterial therapy; in serious male cases of acne conglobata, Roaccutan. Rosacea: antiseptic (antibiotic) treatment (topically and systemically), metronidazole (Arilin); in serious male cases, Roaccutan.

Acne Vulgaris↗
PubMed1986

A comparison of clindamycin phosphate 1 percent topical lotion and placebo in the treatment of acne vulgaris.

The efficacy and skin tolerance of 1 percent clindamycin phosphate lotion were compared with those of the placebo for the lotion in a randomized, double-blind, 12-week study in forty-six patients with moderate to severe acne vulgaris. Patients using the 1 percent clindamycin lotion experienced reductions in numbers of pustules, papules, open comedones, and nodulocystic lesions. Papule counts were also reduced in placebo-treated patients. The group using clindamycin lotion had significantly greater reductions in pustule counts at week 12 and papule counts at week 3 than the placebo-treated group. Nearly 90 percent of the evaluable patients at week 12 experienced improvement or marked improvement in their acne according to the physician's evaluation, regardless of treatment group. Both regimens were well tolerated. Although diarrhea was reported by eight patients (three taking clindamycin, five receiving placebo), no patients discontinued the protocol because of diarrhea. This study demonstrated the efficacy of 1 percent clindamycin topical lotion in the treatment of moderate to severe acne vulgaris.

Acne Vulgaris↗
PubMed1987

[An effective topical antiandrogen--17 alpha-propylmesterolone--in acne].

17 alpha-Propylmesterolon, a new topically active antiandrogen, was administered to 25 patients with papulopustular or comedo acne and severe seborrhoea. The patients were supplied with a 3% solution of 17 alpha-propylmesterolone in 70% alcohol and were advised to apply it to the face twice daily for a mean duration of 14 weeks. Clinical follow-ups and thin-layer-chromatography determination of the sebum secretion rate (SER) and the lipid fractions were performed monthly. At the end of the treatment period 72% of the patients had improved. Comedo acne was reduced by 2 grades, papulopustular acne by 1.8 grade. The mean reduction of seborrhoea was 2 grades. SER was reduced in 62.5% of the patients to 76.4 +/- 8.8% of pretreatment values. In addition to sebaceous gland lipids, epidermal lipids were also inhibited effectively. This finding is in accordance with the marked reduction of comedones. Thus, in addition to sebaceous gland inhibition, epidermal structures may also be the target of the antiandrogen.

Acne Vulgaris↗
PubMed1987

[Acne and osteoarticular manifestations].

Certain severe forms of acne vulgaris may be accompanied by disorders of the locomotor system. Fulminant acne is manifest as an acute disorder with an alteration of general health and with fever, the onset of painful, necrotic skin lesions, myalgia and arthralgia with arthritis of one or more joints. Acne conglobata, a chronic disorder, is defined by the presence of comedones in sebaceous gland ducts and its progression to form nodules and pustules, leaving indelible scars. Osteoarticular involvement which occurs during the course of acne conglobata, and whose incidence is difficult to determine, is characterized by the frequent presence of sacroiliac inflammation. However, these two forms of acne are often confused and the authors outline differences between them. A more accurate identification of cutaneous manifestations would perhaps provide an eventual classification of "rheumatic disturbances of acne" whose nosological category has not yet been determined.

Acne Vulgaris↗
PubMed1988

[New lipid biochemical aspects in the pathogenesis of a follicular keratinization disorder in acne vulgaris].

Follicular hyperkeratinization of the epithelium of the acroinfundibulum of sebaceous follicles is one of the primary events in the pathogenesis of acne vulgaris. Oral treatment with 13-cis-retinoic acid can reduce these hyperkeratoses. In order to determine whether follicular hyperkeratinization is related to disturbances of epidermal follicular lipids, we analyzed the lipids of initial comedones from 10 patients with nodulocystic acne before and after a 6th weeks oral therapy with 13-cis-retinoic acid (0.7 mg/kg body weight). The treatment with retinoid resulted in a significant increase of epidermal lipids (free sterols: +34%; ceramides: +19%, whereas the lipids of sebaceous origin decreased (glycerides: -36%). The mass ratio of free sterols to cholesterol sulfate increased by 86% compared to pre-treatment levels. These findings support the hypothesis that local follicular deficiencies of epidermal lipids due to increased sebum secretion might induce abnormal follicular keratinization.

Acne Vulgaris↗
PubMed1986

Facial dermatosis in four dogs with hyperadrenocorticism.

In hyperadrenocorticism in the dog, cutaneous lesions may include alopecia, thin, hypotonic skin, hyperpigmentation, comedones, calcinosis cutis, secondary bacterial and fungal infections, and demodicosis. Skin lesions affecting only the face have not been reported in reviews of hyperadrenocorticism, nor has the disease been included in the differential diagnoses of facial dermatoses. This report involves 4 dogs with hyperadrenocorticism in which cutaneous signs were limited to the face.

Adrenocortical Hyperfunction↗
PubMed1985

[A new drug combination for the topical treatment of acne. Miconazole 2% + benzoyl peroxide 5% versus benzoyl peroxide 5%--a double-blind study].

A double-blind, controlled clinical trial with 60 patients was employed in order to study the relative merits of two treatment schedules in acne vulgaris. One therapy comprised the topical application of a cream containing a combination of miconazole 2% and benzoylperoxide 5% (Acnidazil, Janssen) twice a day. In the other therapy, we applied a cream containing only benzoylperoxide 5%. Both groups of patients showed large and statistically significant reduction in the number of comedones, papules, and pustules during 12 weeks of therapy. Acnidazil, however, was found to have definitely better therapeutical results than benzoylperoxide alone: The lesions improved significantly faster, tolerance was better, and the patients overall evaluation clearly favored Acnidazil. 86,2% of the patients treated with Acnidazil rated the results good to very good, in contrast to 63% of the patients treated with benzoylperoxide only (p = 0.037).

Acne Vulgaris↗
PubMed1988

[Osteosis cutis multiplex, an organoid nevus?].

We report on a 71-year-old woman suffering from histologically proved osteosis cutis multiplex (Arzt's disease). The differential diagnosis includes multiple milia, closed comedones and hidradenomas. We discuss various etiopathologic concepts and a nevogenic origin in particular.

Aged↗
PubMed1971

Pilosebaceous abnormalities in Apert type acrocephalosyndactyly.

Forearm acne is uncommon in the general population and comedones and pustules are rare. Forearm acne was observed in more than 70% of the Apert syndrome patients suggesting that steroid sensitivity of certain tissue and organs and tissue disposition of androgens may be fruitful areas for investigation in the Apert syndrome.

Acne Vulgaris↗
PubMed1983

Bilateral follicular basal cell nevus with comedo-like lesions.

A 12-year-old white boy presented with symmetrically appearing papular, nodular, comedo-like, highly itching lesions involving the skin on his ankles. They had first appeared 3 years earlier. Numerous cutaneous biopsies showed tumoral buds of basalioma cells associated with follicular structures, infundibular cysts and also hypertrophy and hyperplasia of sebaceous glands. To the best of our knowledge, there are no reported cases with the same clinical and histopathological findings as in those reported here. We believe the lesions represent a "bilateral follicular basal cell nevus with comedones".

Ankle↗
PubMed1982

The role of cosmetics in postadolescent acne.

The role of cosmetics in the induction and perpetuation of adult acne has been debated. This study reports the effects of a cosmetic regimen consisting of six formulations of low predicted acnegenic potential on the course of mild postadolescent acne in ten young women. No increase in activity of disease as measured by comedo and inflammatory papule counts was noted in these subjects; on the contrary, a decreasing trend in the total number of comedones and papules was noted throughout the cosmetic use period of the study. The premarketing "in-use" testing of cosmetic formulations intended for use by the postadolescent consumer with mild acne is suggested.

Acne Vulgaris↗