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Results for “AVITAMINOSIS”

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At least 469 records · Page 26Linked to original sources
PubMed1989

[The results of research on visual fatigue in children by determining the perception time of a sequential color contrast].

The paper analyses results after a study of visual fatigue by means of determining the perception time of a color successive contrast in children, aged from 10 to 13 years, before and after intensive dosed visual load. The revealed high percentage of visual fatigue in children (40.4-52.5%) is likely to be connected with the fact that the study was made in spring time when signs and body asthenization, avitaminosis are expressed. It was found that perception of a color successive contrast in children with eye myopization is shorter as compared with children with stably normal visual acuity.

Adolescent↗
PubMed1986

Consequences of hunger for individuals and societies.

Famine and the manifestations of acute hunger that result are an unnecessary disgrace to our global society and serious in their political, economic, and social consequences. Probably more damaging is the chronic undernutrition that afflicts such a large proportion of the populations of developing countries and the hidden hungers of iron deficiency, avitaminosis A, and iodine deficiency disorders that are enormously widespread. Famine in the modern world is almost invariably superimposed on chronic undernutrition that is not solved with emergency relief. Adaptation to this undernutrition requires a reduction in physical activity needed for household and community improvement as well as work output. Iron deficiency interferes with cognitive performance, resistance to infection, and capacity for work. Other nutrient deficiencies add to the damage to the individual and society. Prevention of famine and hunger is not primarily a technological issue, but a moral, political, and social one.

Adaptation, Physiological↗
PubMedDate not supplied

[Comparative study of the biological activity and toxic effect of 1alpha-hydroxycholecalciferol and ergocalciferol in rats].

Single administration of 0.25 microgram of sunthetic Ialpha-hydroxycholecalciferol (IalphaOHD3) into nephrectomized rats, maintained at D-avitaminous diet, improved the active transport of calcium ions against the concentration gradient in small intestine of these animals, whereas ergocalciferol was biologically inactive under the same conditions. Administration of IalphaOHD3 during 5 days at a dose 0.025 microgram normalized calcium content in blood serum of rats with D-avitaminosis, Increased doses of IalphaOHD3, administered into intact animals, caused transient hyperphosphatemia, hypercalcemia, calcinosis of internal tissues (kidney heart, aorta) as well as death of some animals. IalphaOHD3 exceeded 400-fold the hypercalcemic and calcinose effects of ergocalciferol. LD50 for IalphaOHD3 was equal to 100 microgram/kg, if it was administered during 5 days per os. Tissue calcinosis was developed after administration of a daily dose 10 microgram/kg, moderate hypercalcemia was caused by a daily dose 1 microgram/kg or 0.25 microgram per an animal; this amount is only 10-fold higher as compared with the physiologic requirement. Ergocalciferol caused hypercalcemia and metastatic calcification only at a dose 4000 microgram/kg. Clinical use of IalphaOHD3 at doses, exceeding the physiologic requirements, has to be prohibited due to high activity of the preparation and to toxicity of its increased doses.

Animals↗
PubMed1979

[Keratomalacia in children with malnutrition].

Twenty-nine malnourished preschoolers in third grade, with a history of globally deficient feeding and very poor individual and environmental hygiene, who presented ocular lesions attributed to avitaminosis A, mainly keratomalacia, were studied. Fifteen patients had keratomalacia with superficial corneal ulceration and fourteen had severe complications such as corneal perforation, descemetocele, expulsion of ocular contents and leukomas adherent to the rest of the eye structures, with final amaurosis. The pathophysiological alterations caused by vitamin A deficiency in ocular structures are synergistic to those inherent to protein deficiency. Treatment should be local, general or surgical; but the main management should be prophylactic, improving the socioeconomic and nutritional conditions of the family. Once severe keratomalacia lesions are established, important visual alterations will persist, from giant leukomas to complete blindness.

Child↗
PubMedDate not supplied

[The role of vitamin A in the functioning of Golgi apparatus].

Vitamin A participation in the Golgi complex functioning has been studied using the mucosa intermediate area of the chicken glandular stomach as a model. It is shown that in case of A-avitaminosis the electrophoretic profile of soluble proteins of mucosa and [I-14C]acetate and Na2(35)SO4 incorporation into it do not change, while in a secretion all these parameters are highly changed. Four glycoproteins are isolated from the mucous secretion, they differ in solubility in 6% perchloric acid and in staining by kumassi and alcine blue. These data and those obtained before underlie the conclusion that the effect of vitamin A on the secretion formation is realized on the level of the Golgi complex function.

Animals↗
PubMedDate not supplied

[Epidemiological aspects of xerophthalmia in Chad].

An epidemiologic survey by random cluster sampling was carried out in Chad. Its purpose was to evaluate the importance of xerophthalmia. 3.002 children under 10 years of age were surveyed for two different periods: in 1984 after the drought striking the Sahelian zone and in 1985 after a normal crop. Computerization of the results according to nutritional circumstances and geographical distribution demonstrated that avitaminosis is a true Public Health problem, whatever climatic zones, food products and nutritional conditions are. However situation worsens during a drought and calls for an emergency distribution of vitamin A to the most-in-need populations.

Chad↗
PubMed1987

Influence of thiamine deficiency on the response to ethanol in two inbred rat strains.

We investigated whether thiamine deficiency (TD), a frequent concomitant of chronic alcoholism, differentially modifies the response to ethanol in two inbred rat strains with highly different genetic susceptibilities to development of TD encephalopathy. Ethanol-induced (3 g/kg i.p.) behavioral impairment and hypothermia were studied after 2, 5 and 7 weeks of TD and after 6 weeks of repletion on normal diet. Controls of the M520/N (TD-sensitive) strain metabolized ethanol more rapidly, had a greater liver to body weight ratio, greater total body water, earlier and lower peak blood ethanol concentrations (BEC), diminished area under the BEC curve and lesser behavioral impairment and hypothermia (even at equivalent BEC values) than those of the F344/N (TD-resistant) strain. In both strains, TD resulted in reduced ethanol metabolic rate and liver to body weight ratio and equivalent ethanol-induced hypothermia and behavioral impairment at lower BEC. Lower and delayed peak BEC and unchanged area under the BEC curve suggest an increased volume of ethanol distribution during TD. Recovery appeared complete after 6 weeks of normal diet. Both strains lost an equivalent proportion of body weight during TD but M520/N rats had lesser decrements in ethanol metabolic rate, had greater reductions in liver weight, peak BEC and baseline body temperature and developed overt encephalopathy whereas F344/N rats did not. Therefore, in the chronic alcoholic, TD may modify ethanol's effects via pharmacokinetic and pharmacodynamic mechanisms. Relatively high ethanol tolerance of the strain with a genetic predisposition to TD encephalopathy is consistent with the hypothesized role of this avitaminosis in the pharmacogenetics of alcoholism.

Animals↗
PubMed1978

[Experimental study of the pathogenesis of dysentery].

It was shown that experimental dysentery could be produced against the background of various pathologic conditions of experimental animals (avitaminosis, concurrent diseases, etc). The studies in vivo and in vitro showed that intraepithelial parasitising of Shigella occurred in dysentery but did not play the leading role in the pathogenesis of the disease. Macrophages played a more important role, particularly in formation of the bacterial carrier state. In order to resolve some disputable problems of the pathogenesis of dysentery it is necessary to take into account the biological properties of the causative agent which change under the influence ov various effects, as well as the state of reponsiveness of the host.

Animals↗
PubMed1986

[Microspectrophotometric research on the rhodopsin and carotenoid content of the retinal visual cells of hens maintained on a vitamin A-deficient diet].

Using microspectrophotometry, a study was made of the retina of adult hens, that had been kept on a diet for 6.5 months with deficiency of vitamin A. It has been shown that despite an expressed drop of quantity of vitamin A in the liver, in the external segments of the retina rods in A-avitaminosis hens, the concentration of rhodopsin remains normal.

Animals↗
PubMedDate not supplied

[Effect of naphthoquinones and tocopherols on the level of integral proteins in mitochondrial membranes and DNA levels in rat and rabbit tissue].

Naphthoquinones and tocopherols are studied for their effect on the state of integral proteins of the mitochondrial liver and myocardium membranes in the experiments on the male rats and rabbits. It is established that deficiency of vitamins K and E in the organism (naphthoquinones and tocopherols) is followed by a decrease in the content of integral proteins and by disturbances in correlation of their fractions. These changes in K, E-avitaminosis are accompanied by a decrease of the DNA content in the tissues. Realization of K and E vitamins on the level of structural biomembrane organization is supposed to be possible.

Animals↗
PubMed1986

[The role of N-quinones in the regulation of glucose-6-phosphate metabolism].

In experimental (white rats, rabbits) and clinical (erythrocytes, blood plasma) studies on 29 healthy subjects and patients it has been demonstrated that primary or secondary n-quinone deficiency is accompanied by increased tissue activity of glycolysis enzymes (aldolase, PGmutase) and aerobic pentose phosphate shunt (6 GPDH). Parallel rise in the amount of glycolysis metabolites (pyruvate and lactate) in the blood and the decline in blood plasma glucose level were observed. The changes in glucose-6-phosphate metabolism are, probably, secondary and reflect tissue structure alterations in the development of K and E avitaminosis.

Animals↗
PubMedDate not supplied

[Effect of vitamin E deficiency on creatine phosphokinase activity and creatine phosphate levels in the heart muscle].

Vitamin E deficient diet of rats developed impairments in energy metabolism of myocardium, involving a decrease in content of creatine phosphate and in the activity of creatine phosphokinase by 20-35%. Concentration of adenine nucleotides was not altered in myocardium and the content of glycogen was only slightly changed. The impairments in activity of creatine phosphokinase and in the content of creatine phosphate might be among the factors responsible for deterioration of the heart muscle contractile functions in avitaminosis E.

Animals↗
PubMedDate not supplied

[Certain characteristics of the rat liver transketolase].

Modification of the method for transketolase purification in the rat liver was used to reveal the existence of two molecular forms of this enzyme. One of the forms does not react to development of avitaminosis in animals caused by oxythiamine in different doses. The method is developed for isolation of the basic transketolase form in the rat liver with the 50-80% yield of activity. Km values of two sites for coenzyme binding on protein do not depend on the extent of holoenzyme reconstruction from apoenzyme.

Animals↗
PubMedDate not supplied

[Comparative study of the vitamin activity of pyridoxal phosphate and pyridoxine used cutaneously].

In white rats with B6-avitaminosis, the B6-vitamin activity of pyridoxal-phosphate and of pyridoxine was studied in their epicutaneous and peroral application. It is revealed that pyridoxal-phosphate in epicutaneous application displays more activity than pyridoxine and pyridoxal-phosphate applied perorally. Pyridoxine in epicutaneous application does not reveal the B6-vitamin activity.

Administration, Oral↗
PubMedDate not supplied

[Effect of vitamin A on lipid metabolism in the erythrocyte membrane].

Metabolism of erythrocyte membrane phospholipids was studied under conditions of distinct A-avitaminosis. Content of sphingomyelin, phosphatidyl serine, phosphatidyl ethanolamine was markedly decreased and of phosphatidyl choline--increased. Content of the phospholipids correlated with incorporation of 2-14C-acetic acid. The rate of Na2H32PO4 incorporation into the phospholipid fractions studied was increased.

Animals↗
PubMedDate not supplied

Congenital ocular anomalies in Pondicherry.

Congenital anomalies of the eye and ocular adnexa occurring in Pondicherry have been described. Anophthalmos, microphthalmos, limbal dermoids, nervus of Ota, anterior lenticonus, buphthalmos, and congenital cataract are very common. Onset of cataract in young individuals was caused by abnormal aminoaciduria. Hereditary factors played a part in 59 percent of the cases who would have become blind if they were not treated. Consanguinity is a major factor in their pathogenesis. Avitaminosis A and systemic infections which are common here may be playing a significant role in their etiology.

Adolescent↗
PubMedDate not supplied

[Effect of tocopherol and protein deficiency on the activity of enzymes and their isoenzymatic spectra in rat testes].

The symptoms of E-avitaminosis against protein deficiency in the ration become manifest much earlier, i. e. in 12--16 weeks of the experiment instead of 24--36 weeks with the primary-deficient ration. This was marked by the development of the creatinuria, the falling blood serum and testes tissue tocopherol, a higher peroxidized erythrocytes hemolysis, the animals demonstrating a disturbed generative function. In the testes of the E-avitaminotic rats an appreaciably increased total activity of glucose-6-phosphate-dehydrogenase (G-6-PDG) and of the acid phosphatase (AP) was demonstrated, whereas the LDG remained essentially unchanged. An investigation of their isoenzymatic spectra revealed a considerable activity of the basic 5 G-6-PDG fractions with the appearance of additional ones, along with the disappearance of the specific LDG fraction--X-2 and a drastic fall in the activity of the specific fraction for the testes--LDG-X-1, with concurrent rise in the activity of the 5 basic fractions. In the isoenzymatic AP spectrum disappeared the AP-3 fraction of the degenerating testes tissues and a redistribution of the activity between the fractions took place.

Acid Phosphatase↗
PubMedDate not supplied

[Content of free and bound thiamine diphosphate in the liver hyaloplasm of vitamine B1 deficient rats].

The amount of free and protein-bound thiamin diphosphate (TDP) in the liver hyaloplasm of B1 vitamin deficient rats has been measured. In the norm the content of protein-bound TDP remains stable (4.5--4.7 micrograms/g tissue) and does not grow upon thiamin injections. The level of the free coenzyme varies appreciably: in the B1-avitaminotic state the content of free TDP decreases, and in the B1-saturated condition it may exceed the norm 4 times. In the liver this enzyme occurs only as a holoenzyme. In case of B1 vitamin deficiency in the diet the transketolase apoform cannot be detected in the liver. A new model for rapid generation of B1-avitaminosis characterized by a significantly lower level of free and bound TDP is described.

Animals↗