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PubMedDate not supplied

Localized in vivo high-resolution NMR imaging using gradient subencoding technique.

A new spatial localization technique for in vivo high-resolution imaging is presented here. In contrast to other localization techniques that use a series of rf pulses to define a volume of interest, only one rf pulse is utilized in the proposed method for selection of a region to be imaged. Instead of rf pulses for region selection, subencoding gradient pulses are used for the localization together with a convolution process on each phase-encoding gradient by a set of additional gradients (e.g., y direction). Then the 2-D localization is completed by restricting the bandwidth in the readout direction (e.g., x direction). The latter is simply achieved by using a low-pass filter in the receiver system. By applying this technique on a human body, localized in vivo high-resolution images are obtained for the knee with much improved resolution. 100 x 100 microns in-plane (x,y plane) resolution images obtained from the human knee demonstrate that localized in vivo high-resolution imaging for both human and animals is possible with an in-plane resolution of below 100 microns.

Image Processing, Computer-Assisted↗

PubMed1999

Visual representation of space in congenital and acquired strabismus.

The aim of the present work was to readdress the problem of altered spatial localization in strabismic subjects and to assess whether and how spatial representation is affected by the degree of plasticity of the brain. We therefore compared targeting performance in adult subjects affected by acquired strabismus versus children affected by congenital strabismus. Our data confirm the correlation between deviation of the eye and targeting errors, but they also show that this correlation is not present when strabismus occurs early in life. We suggest that the neuronal machinery involved in the building of an internal representation of space reaches its full maturity several years after birth and that this might explain the limited differences observed in targeting errors between normal and strabismic children.

Adult↗

PubMed2001

A new approach to analysing texture-defined motion.

It has been widely accepted that standard low-level computational approaches to motion processing cannot extract texture-defined motion without applying some pre-processing nonlinearity. This has motivated accounts of motion perception in which luminance- and texture-defined motion are processed by separate mechanisms. Here, we introduce a novel method of image description where motion sequences may be described in terms of their local spatial and temporal gradients. This allows us to assess the local velocity information available to standard low-level motion mechanisms. Our analysis of several texture-motion stimuli shows that the information indicating correct texture-motion velocity and/or direction is present in the raw luminance measures. This raises the possibility that luminance-motion and texture-motion may be processed by the same cortical mechanisms. Our analysis offers a way of looking at texture-motion processing that is, to our knowledge, new and original.

Electrophysiology↗

PubMed2001

Nonlinearity and disorder: classification and stability of nonlinear impurity modes.

We study the effects produced by competition of two physical mechanisms of energy localization in inhomogeneous nonlinear systems. As an example, we analyze spatially localized modes supported by a nonlinear impurity in the generalized nonlinear Schrödinger equation and describe three types of nonlinear impurity modes, one- and two-hump symmetric localized modes and asymmetric localized modes, for both focusing and defocusing nonlinearity and two different (attractive or repulsive) types of impurity. We obtain an analytical stability criterion for the nonlinear localized modes and consider the case of a power-law nonlinearity in detail. We discuss several scenarios of the instability-induced dynamics of the nonlinear impurity modes, including the mode decay or switching to a new stable state, and collapse at the impurity site.

Journal Article↗

PubMed2002

Controlling dynamics in spatially extended systems.

Spatially extended systems exhibit a variety of spatiotemporal dynamics--from stable to chaotic. These dynamics can change under pathological conditions and impair normal functions. Thus, having the ability to control the altered dynamics for improved functioning has the potential for wide ranging applications in real and artificial systems. Here we propose a simple and general method that can be used to target the spatiotemporal dynamics, both globally and in spatially localized regions, in either direction--i.e., towards the stable or unstable manifold-by simply changing the strength and the sign of an externally applied perturbation or pinning. The method is applicable to both chaotic and nonchaotic systems, with discrete and continuous local dynamics, and for different topologies of interactions. We also apply it to simulate an experiment on epileptogenic neuronal activity in rat hippocampal tissue [B. J. Gluckman et al., J. Neurophys. 76, 6202 (1996)]. This unified approach for differential targeting of global and local dynamics promises to be useful for systems spanning large spatial scales and having structural and functional heterogeneity.

Journal Article↗

PubMed1996

Calcium channels in neuroblastoma cell growth cones.

The concentration of free calcium ions in the cytosol has been shown to influence many components of growth cone behaviour, including the extension of filopodia and veils, the addition of new membrane to the plasmalemma, the retraction and disappearance of filopodia, and gross collapse and retraction of the growth cone. A spatially localized modulation of these processes by very local calcium changes has been proposed to underlie the steering of growth cones by gradients of neurotransmitters, voltage and cell adhesion molecules. Such local control can be studied in mouse neuroblastoma cells, where depolarization causes calcium to rise in a limited number of spatially restricted hotspots, triggering a localized advance. We have studied the simple, club-shaped growth cones that are characteristically found on advancing neurites. Depolarization caused calcium to increase most at the distal, leading tip. Agents that disrupt calcium-induced calcium release do not affect growth cone calcium dynamics, ruling out a local release of calcium at the tip as a cause of the gradient. Using cell-attached patch recording, we find that L-type calcium channels are present at a higher density at the distal tip than in the proximal growth cone. Our results show that the calcium gradients seen in depolarized growth cones are a direct consequence of a gradient of calcium channel density.

Animals↗

PubMed1996

Parallel discrete event simulation of Lyme disease.

Our research concerns the dynamic processes underlying the rapid increase in the geographic distribution of Lyme disease, currently the most frequently reported vector-borne disease of humans in the United States [10, 1]. More specifically, we ask how spatially localized ecological interactions drive the Lyme disease epidemic at extended spatial and temporal scales. We have developed a parallel discrete event simulation system in C++ for the IBM SP2. The simulation model discussed here models the mouse-tick interaction, an essential element of the epidemic's ecology. The main entities of the simulation are ticks in various stages of development (larval, nymphal, and adult) and mice. We track the behavior of mice and the spread of disease over the course of 180 days (late spring, summer, and early fall). Our goal is to understand patterns in the Lyme disease epidemic at the regional scale through studying the spread of the pathogen across a single white-footed mouse deme.

Animals↗

PubMed1996

Strong activation of parallel fibers produces localized calcium transients and a form of LTD that spreads to distant synapses.

The temporal and spatial changes in intracellular calcium levels during separate activation of parallel fiber (PF) and climbing fiber (CF) inputs to cerebellar Purkinje cells were studied. PF stimulation (1 Hz), at relatively high stimulus strengths, led to accumulations of calcium that were similar in peak levels to those following CF stimulation but that remained spatially localized. Such stimuli consistently induced a durable depression of PF synaptic transmission that partially occluded further depression by conventional conjunctive stimuli and that was independent of nitric oxide. This depression was accompanied by a reduction of synaptic efficacy in spatially isolated PF inputs to the same cell that was independent of postsynaptic calcium but that was mediated by nitric oxide. These data indicate that LTD comprises at least two separate processes and that parameters of PF stimulation that are capable of raising calcium levels in Purkinje cell dendrites are also able to induce long-term changes in synaptic efficacy.

Animals↗

PubMed1972

Excitatory and inhibitory interactions in localized populations of model neurons.

Coupled nonlinear differential equations are derived for the dynamics of spatially localized populations containing both excitatory and inhibitory model neurons. Phase plane methods and numerical solutions are then used to investigate population responses to various types of stimuli. The results obtained show simple and multiple hysteresis phenomena and limit cycle activity. The latter is particularly interesting since the frequency of the limit cycle oscillation is found to be a monotonic function of stimulus intensity. Finally, it is proved that the existence of limit cycle dynamics in response to one class of stimuli implies the existence of multiple stable states and hysteresis in response to a different class of stimuli. The relation between these findings and a number of experiments is discussed.

Evoked Potentials↗

PubMed2003

Expression and cellular localization of insulin-like growth factor-II protein and mRNA in Sparus aurata during development.

The spatial localization of IGF-II protein and mRNA was investigated during larval and postlarval developmental stages of the gilthead sea bream (Sparus aurata) by immunohistochemistry and in situ hybridization, using specific antisera and riboprobes. Steady-state levels of IGF-II mRNA in larvae were determined by Northern blot analysis and were found to be increased. Immunoreactivity towards IGF-II was found in larval skin, muscle, gills, gut, olfactory epithelium and kidney. After metamorphosis, the strongest immunoreactivity was found in red skeletal muscle. Positive reaction with IGF-II antibodies was also found in the olfactory epithelium and in the epithelia of pharynx, oesophagus, stomach and kidney. In the adult, the most intense signal was observed in the red and pink musculature and in heart musculature. Immunostaining was also found in saccus vasculosus, thymus, spleen and ovary. IGF-II mRNA was detected by in situ hybridization in the brain, olfactory epithelium, eye, pharynx, skeletal musculature and liver. The spatial distribution of IGF-II shown in this study is consistent with previous findings on the cellular localization of IGF type 1 receptor in the sea bream and supports a role for IGF-II during development and growth of sea bream. Furthermore, these results suggest that IGF-II acts in an autocrine/paracrine manner.

Animals↗

PubMed2006

Competing populations on fragmented landscapes with spatially structured heterogeneities: improved landscape generation and mixed dispersal strategies.

Interactions between two species competing for space were studied using stochastic spatially explicit lattice-based simulations as well as pair approximations. The two species differed only in their dispersal strategies, which were characterized by the proportion of reproductive effort allocated to long-distance (far) dispersal versus short-distance (near) dispersal to adjacent sites. All population dynamics took place on landscapes with spatially clustered distributions of suitable habitat, described by two parameters specifying the amount and the local spatial autocorrelation of suitable habitat. Whereas previous results indicated that coexistence between pure near and far dispersers was very rare, taking place over only a very small region of the landscape parameter space, when mixed strategies are allowed, multiple strategies can coexist over a much wider variety of landscapes. On such spatially structured landscapes, the populations can partition the habitat according to local conditions, with one species using pure near dispersal to exploit large contiguous patches of suitable habitat, and another species using mixed dispersal to colonize isolated smaller patches (via far dispersal) and then rapidly exploit those patches (via near dispersal). An improved mean-field approximation which incorporates the spatially clustered habitat distribution is developed for modeling a single species on these landscapes, along with an improved Monte Carlo algorithm for generating spatially clustered habitat distributions.

Computer Simulation↗

PubMed1990

The localization of low- and high-frequency vibrotactile stimuli.

Four experiments were conducted to determine whether spatial localization on the skin varied in acuity as a function of frequency of vibratory stimulation. The glabrous skin of the palm over the hypothenar eminence was selected as the site for stimulation by two frequencies, one at 25 Hz to stimulate non-Pacinian receptors, and one at 250 Hz to excite Pacinian receptors. Because the Pacinian receptors have larger receptive fields than the non-Pacinians, it was thought that the subjects' ability to localize would be poorer when the Pacinians were the class of receptor stimulated. In addition to frequency of vibration, the presence of a surround, the site of stimulation, the separation of the stimulator pair used in the 2AFC method, and the use of an impulse stimulus were all conditions varied to determine whether a simple direct correlation exists between receptor category and spatial acuity for vibratory stimuli. A significant difference in acuity was found as a function of vibration frequency at a proximal locus on the palm, but this vanished at a distal locus. The results have been interpreted to suggest that receptor density and its gradient across the skin areas involved may be as important as receptor type in the determination of spatial acuity.

Adult↗

PubMed1996

B1-insensitive, single-shot localization and water suppression.

A technique for single-shot, localized, water-suppressed in vivo 1H NMR with high immunity to B1 inhomogeneities is described. The single-shot localization is based on complete outer-volume suppression which is achieved with optimized, adiabatic BIR-4 pulses in combination with BO gradient modulation. B1-insensitive water suppression is achieved with BISTRO, a train of selective adiabatic full-passage pulses interleaved with BO gradient crushers. Computer simulations based on the Bloch equations, experimental images of the localized volume, and in vivo 1H spectroscopy experiments demonstrate the excellent spatial localization and water suppression.

Artifacts↗

PubMed2001

Solving the binding problem of the brain with bi-directional functional connectivity.

We propose a neural network model which gives one solution to the binding problem on the basis of 'functional connectivity' and bidirectional connections. Here, 'functional connectivity' is dynamic neuronal connectivity peculiar to temporal spike coding neural networks with coincidence detector neurons. The model consists of a single primary map and two higher modules which extract two different features shown on the primary map. There exist three layers in each higher module and the layers are connected bi-directionally. An object in the outer world is represented by a 'global dynamical cell assembly' which is organized across the primary map and the two higher modules. Detailed, but spatially localized, information is coded in the primary map, whereas coarse, but spatially extracted information or globally integrated information is coded in the higher modules. Computer simulations of the proposed model show that multiple cell assemblies sharing the same neurons partially can co-exist. Furthermore, we introduce a three-dimensional J-PSTH (Joint-Peri Stimulus Time Histogram) which is capable of tracking such cell assemblies, altering its constituent neurons as in our proposed model.

Action Potentials↗

PubMed2002

Junctional signaling microdomains: bridging the gap between the neuronal cell surface and Ca2+ stores.

Growing evidence suggests that plasma membranes are locally differentiated into microdomains that are important interaction sites for organization of signaling molecules. These signaling microdomains create local conditions that enhance molecular interactions, excluding others, thereby ensuring speed, spatial localization, and specificity of signal transduction. With the special emphasis on InsP(3) and Ca(2+) signaling pathways, we will discuss here the evolving concept of signaling microdomains that provide a key framework for understanding the differential regulation of many cellular target proteins.

Calcium↗

PubMed2000

Description of random radiating and nonradiating sources

An alternative description of spatially localized random nonradiating sources is derived, for any degree of spatial-temporal coherence. A description of a complementary class of random sources (purely radiating sources) that lacks a nonradiating part is also obtained.

Journal Article↗

PubMed1995

Acute ethanol impairs spatial memory but not stimulus/response memory in the rat.

The present studies investigate how acutely administered ethanol (ETOH) affects the use of spatial memory. Previous electrophysiological results have shown that acutely administered ETOH alters the firing of hippocampal neurons and that prenatal or chronic exposure to ETOH produces deficits on spatial learning tasks, tasks dependent on the hippocampus. In contrast, it has also been demonstrated that acutely administered ETOH does not impair spatial localization. In the current studies, rats were trained to perform a spatial or stimulus/response task under saline. After training, rats were injected with ETOH, and the use of spatial or stimulus/response memory was tested. Acutely administered ETOH impaired the use of spatial memory, but not the use of stimulus/response memory. Because the use of spatial memory requires an intact hippocampus, the present studies suggest that acutely administered ETOH selectively impairs behaviors dependent on the hippocampus.

Animals↗

PubMed1976

Linear and nonlinear spatial subunits in Y cat retinal ganglion cells.

1. The mechanism which makes Y cells different from X cells was investigated. 2. Spatial frequency contrast sensitivity functions for the fundamental and second harmonic responses of Y cells to alternating phase gratings were determined. 3. The fundamental spatial frequency response was predicted by the Fourier transform of the sensitivity profile of the Y cell. The high spatial frequency cut-off of a Y cell's fundamental response was in this way related to the centre of the cell's receptive field. 4. The second harmonic response of a Y cell did not cut off at such a low spatial frequency as the fundamental response. This result indicated that the source of the second harmonic was a spatial subunit of the receptive field smaller in spatial extent than the centre. 5. Contrast sensitivity vs. spatial phase for a Y cell was measured under three conditions: a full grating, a grating seen through a centrally located window, a grating partially obscured by a visual shutter. The 2nd/1st harmonic sensitivity ratio went down with the window and up with the shutter. These results implied that the centre of Y cells was linear and also that the nonlinear subunits extended into the receptive field surround. 6. Spatial localization of the nonlinear subunits was determined by means of a spatial dipole stimulus. The nonlinear subunits overlapped the centre and surround of the receptive field and extended beyond both. 7. The nature of the Y cell nonlinearity was found to be rectification, as determined from measurements of the second harmonic response as a function of contrast. 8. Spatial models for the Y cell receptive field are proposed.

Action Potentials↗