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PubMed2002

Developmentally regulated monocyte recruitment and bone resorption are modulated by functional deletion of the monocytic chemoattractant protein-1 gene.

Tooth eruption involves the movement of a tooth from its site of development within the alveolar bone to its functional position in the oral cavity. Because this process is dependent upon monocytes and formation of osteoclasts, it represents an excellent model for examination of these processes under developmental regulation. We investigated the functional role of monocyte chemoattractant protein-1 (MCP-1) in monocyte recruitment and its impact on bone resorption by examining each parameter in MCP-1(-/-) mice as compared with wild-type controls during tooth eruption. The peak number of monocytes occurred on day 5 in the MCP-1(-/-) mice and on day 9 in the wild-type mice. The peak number of osteoclasts followed the same pattern, occurring sooner in the MCP-1(-/-) (day 5) than in wild-type mice (day 9). Consistent with this, MCP-1(-/-) mice had an accelerated rate of tooth eruption in the early phase when the teeth first entered the oral cavity as compared with the wild-type mice. However, there was accelerated eruption in the wild-type group in the later phase of tooth eruption. When examined at the molecular level, inducible nitric oxide synthase (iNOS) and interleukin-11 and -6 were expressed at considerably higher levels in the experimental group with accelerated tooth eruption. This is the first report identifying these factors as potential modulators of bone resorption that can accelerate the rate of tooth eruption. We conclude that, at early timepoints, monocyte recruitment occurs by MCP-1-independent mechanisms. However, at a later timepoint, MCP-1 may play a contributory role in the recruitment of monocytic cells, allowing the wild-type animals to catch up.

Animals↗
PubMed1996

The rhythms of human premolar eruption: a study using continuous observation.

New optical technology now allows for precise observation of erupting human premolars. Continuous overnight tracking of an erupting tooth with a video microscope system shows that eruption occurs almost exclusively during the early evening. During the day, slight intrusion is likely to occur. When Moiré magnification is used to provide extremely high resolution (0.05 micrometer), slight movements of the erupting tooth in concert with the arterial pulse can be observed, and a previously unknown cyclic movement with a period of 20 to 50 seconds is seen consistently. Rhythms in skeletal growth and tooth eruption suggest that treatment to influence jaw growth and move teeth may be most effective at specific times of the day.

Bicuspid↗
PubMed2001

Dental caries patterns and oral health behaviors in Arizona infants and toddlers.

OBJECTIVES: The aim of this study was to use tooth eruption sequence, and a tooth- and surface-specific caries analysis method to determine: (1) the temporal relationship between tooth eruption and caries onset; (2) the validity of pre-existing concepts of caries progression; and (3) the relationship of certain putative health behaviors with caries prevalence. METHODS: A total of 2,428 Arizona children aged 6-36-months, who were recruited from WIC programs (a federal program for low-income children at nutritional risk), health fairs and private day care centers, received visual dental caries examinations. Additionally, an oral health behavior survey was administered to the parents of the 1,529 children recruited from the WIC programs. RESULTS: Dental caries was detected soon after tooth eruption, and by 34-36 months of age 25% of this population had caries. Maxillary anterior caries developed as early as 10-12 months of age. Fissure caries of the molars, either by itself or with maxillary anterior caries, was seen as early as 13-15 months of age. Posterior proximal caries was seen as early at 19-21 months, and only was present in conjunction with the other patterns. Over 40% of the 13-36-month-old children whose parents completed the survey still used a bottle. Night-time bottle use was associated with maxillary anterior caries in 24-36-month-old children, but no association was found in younger children or with posterior caries patterns. Survey responses also showed that fewer than 15% of these children reported having had a dental visit. CONCLUSIONS: Dental caries was a significant health issue for these children under 3 years of age, and factors other than bottle feeding may play an important role in its etiology. Prevention of dental caries in children under age three will depend on a better understanding of the etiology as well as improved access to care.

Age Factors↗
PubMedDate not supplied

Eruption cysts: retrospective clinical study of 36 cases.

The eruption cyst is a lesion associated with an erupting tooth. It appears as a transparent, bluish, blue or blue-black swelling of the alveolar mucosa, over a temporal or permanent tooth in eruption. The analysis of the thirty-six eruption cysts cases studied, corresponding to twenty-seven patients, revealed that their most frequent location is in the maxillary permanent dentition, and that they mostly occur in a single presentation, and in an age-range of between five and nine years. Six cases out of the twenty-seven patients studied showed the characteristic of presenting two or more eruption cysts, and in three of these cases, the lesions were bilateral, symmetrical and simultaneous. Two other patients had been previously diagnosed with cyst diseases. This would suggest that, in addition to the possible infection-trauma origin, there is in some cases the possibility of a predisponent tendency.

Age Distribution↗
PubMed2002

Late lower arch crowding: the aetiology reviewed.

This article reviews the causes of the crowding that commonly occurs, particularly in the lower arch, after eruption of the second permanent molars. Factors discussed include mesially directed forces, in treated and untreated subjects, distally directed forces, occlusal changes, direction of eruption, tooth morphology, periodontal forces, and degenerative connective tissue changes.

Adolescent↗
PubMed2002

Submerged teeth.

Submersion occurs when a previously erupted tooth becomes embedded in the oral tissues. The purpose of this paper is to examine the distribution, the degree of re-impaction, the rate of congenital absence of the successor buds and the treatment in 28 submerged teeth in 17 patients.

Adolescent↗
PubMed1979

[Interferences with the development of the jaws and teeth in mixed dentition].

On the basis of results from animal experiments, the authors emphasize a series of factors interfering considerably with tooth eruption. It is dealt with tooth eruption disorders and dental malformations due to premature loss of teeth, fused deciduous teeth, certain dystrophies, submersion of deciduous teeth, dysembryoplasias, and rickets.

Dentition, Mixed↗
PubMed2000

Delayed eruption of permanent teeth in hyperimmunoglobulinemia E recurrent infection syndrome.

OBJECTIVE: To determine the incidence of abnormal tooth eruption in patients with hyperimmunoglobulinemia E (hyper-IgE) syndrome. STUDY DESIGN: This study evaluated 34 individuals with hyper-IgE syndrome (age range, 2-40 years). A comprehensive dental history and a head and neck evaluation were performed on all patients. Dental age was assessed in patients younger than 17 years by 2 methods: (1) clinical assessment of tooth eruption and (2) a radiographic method. Relationships between the chronologic age, dental developmental age, and age at tooth eruption were determined. Other oral or dental anomalies were recorded. RESULTS: Of patients older than 7 years, 75% reported problems with permanent tooth eruption, as evidenced by retained primary teeth or the need for elective extractions of primary teeth to allow eruption of permanent teeth. None of the patients experienced problems with eruption of primary teeth. Eruption of the first and second permanent molars also occurred on time. Dental maturity scores were established for 14 patients 17 years of age or younger. In each case, the difference between chronologic age and the estimated dental developmental age was less than 12 months; however, we found a significant discrepancy between the chronologic age and the mean age of tooth eruption in 80% of these patients when using a particular set of standardized values. Persistence of Hertwig's epithelial root sheath was observed on histologic examination. Chronic multifocal oral candidiasis was a consistent feature in patients with hyper-IgE recurrent infection syndrome. Other oral anomalies were also noted. CONCLUSION: We confirmed that a disorder of tooth eruption is part of the hyper-IgE syndrome. This problem occurs because of delayed primary tooth exfoliation rather than a developmental delay in the formation of the permanent dentition. The persistence of Hertwig's epithelial root sheath is unusual and may be associated with the lack of resorption of the primary teeth. Dentists should be aware of this feature of hyper-IgE syndrome because timely intervention will allow normal eruption to occur.

Adolescent↗
PubMed2004

Eruption times of permanent teeth in teenage boys and girls in Izmir (Turkey).

In a study in the Aegean city of Izmir, Turkey, during the summer of 2002, 2101 patients (1046 boys and 1055 girls) were examined. The examination occurred within the framework of a dental check-up performed at two schools and one pre-school unit. The age span ranged from 3.98 to 24.91 years. Sex, age and present permanent teeth were recorded. Wisdom teeth were excluded. The sequence of tooth eruptions differs significantly in the lower and upper jaw, whereas no significant differences existed when comparing the sides of each jaw. The times of tooth eruption is earlier in females than in males. The entire tooth eruption process of the second dentition occurs in females earlier than in males. The tooth eruption in the lower and upper jaw of male and female probands is symmetrical. In comparing the upper and the lower jaw of both genders, it becomes evident that there is a tendency for earlier tooth eruptions in the lower jaw. In respect to the tooth eruption sequence, a change was noted in the upper jaw. Contrary to the reports of other authors, the second premolar has changed places with the canine and erupts prior to this tooth. Otherwise no major differences concerning the sequence of tooth eruptions, when compared to the results gained from other populations, were observed. Concerning the entire dentition, no acceleration of the tooth eruption could be noted. The computed differences of teeth eruption as a mean value calculated over all teeth, was +/- 1 year at maximum, compared to studies from different continents. Oral examination of teeth is a simple tool to calculate tooth eruption intervals. This first investigation on a population of Izmir revealed a change in the eruption sequence of permanent teeth. These findings are relevant for dental treatment planning and forensic odontology and should be reconfirmed at certain intervals.

Adolescent↗
PubMed1994

Age and order of eruption of primary teeth in Spanish children.

A longitudinal study on primary tooth eruption was performed in 114 Spanish children in two Primary Care Centers over 3 yr. Data from periodic observations and data collected by previously instructed parents was studied. Ages of tooth eruption were calculated for both sexes. Comparison between the two sides of the jaws showed a nonsignificant tendency towards earlier left side eruption. Comparison between maxillary and mandibular showed a significant earlier mandibular eruption for central incisors and second molars and a significant earlier maxillary eruption for lateral incisors. Comparison between sexes showed a tendency towards earlier eruption in boys for all teeth, significant only for mandibular central incisors, maxillary and mandibular lateral incisors and mandibular canines. Order of tooth eruption and its most frequent changes were also studied. When these findings were compared to studies performed in other populations it was concluded that ages and order of primary tooth eruption in Spanish children are similar to those found in other populations.

Age Factors↗
PubMed1999

Response of erupting human premolars to force application.

To test the hypothesis that human tooth eruption requires a critical time period during which no force is applied to the erupting tooth, the eruption of a maxillary second premolar in the prefunctional stage was recorded during the afternoon or evening hours in eight children, using an optical device based on the principle of Moiré magnification, while intermittent loads of 300-400 mN were applied to the teeth. When a tooth was erupting actively, light force applications either had no discernible effect or decreased the eruption rate for 2 min or less. When a tooth was intruding spontaneously rather than erupting, a varied response was observed, but the rate of intrusion never increased after force application. Often intrusion showed or halted, and especially during the evening, eruption was likely to occur after a force application during an initial period of intrusion. The conclusion is that, although light force applications significantly displace an erupting premolar, they have little or no effect on net eruption, and that a critical time period without force application is not necessary for eruption to occur.

Adolescent↗
PubMed2005

Eruption times of permanent teeth in children and young adolescents in Athens (Greece).

In a study in Athens, Greece, during the summer of 2003, 2,304 patients (1,168 boys and 1,176 girls) were examined by a young dentistry. The examination occurred within the framework of a routine dental check-up performed at the National and Kapodistrian University of Athens. The age span ranged from 3.00 to 24.93 years of age. Sex, age and present permanent teeth were recorded. Wisdom teeth were excluded. The sequence of tooth eruption differs significantly in the lower and upper jaw, whereas no significant differences existed when comparing the sides of each jaw. The tooth eruption in the lower and upper jaw of male and female probands is symmetrical. In comparing the upper and the lower jaw of both genders, it becomes evident that there is a tendency for earlier tooth eruptions in the lower jaw. In respect to the tooth eruption sequence, a change was noted in the upper jaw. Contrary to the reports of other authors, the second premolar has changed places with the canine and erupts prior to this tooth. This could also be demonstrated in recent studies from New York and Bremen (Germany). Otherwise no major differences concerning the sequence of tooth eruptions were observed, when compared with the results gained from other populations. Concerning the entire dentition, no acceleration of the tooth eruption could be noted. The computed differences of teeth eruption as a mean value calculated over all teeth was +/-1 year at maximum, compared with studies from different continents. Oral examination of teeth is a simple tool to calculate tooth eruption intervals. This first investigation in a population of Athens revealed a change in the eruption sequence of permanent teeth. These findings are relevant for dental treatment planning and should be reconfirmed at certain intervals.

Adolescent↗
PubMed2006

The equine periodontium as a continuously remodeling system: morphometrical analysis of cell proliferation.

OBJECTIVE: The hypsodont equine cheek tooth erupts continuously throughout life. Tooth eruption is inevitably associated with a remodeling of the periodontium. One major process of remodeling in the PDL is cell proliferation. The aim of this study was to detect cell proliferation at different sites of the equine PDL in order to examine the dynamics of the periodontal cell population. DESIGN: Specimens from nine warm-blood horses were taken-- containing the PDL interposed between the cementum and the alveolar bone--at three designated levels: subgingival, middle, and apical. Cell proliferation was detected immunohistochemically by use of anti-Ki-67 in combination with an elaborate morphometrical procedure using an image-analysis program. Three zones of the PDL were distinguished in each specimen: a zone next to the dental cementum, a central zone, and a zone next to the alveolar bone. The PDL was divided into three levels and three zones, resulting in nine defined regions of interest. RESULTS: The proliferation index was high at the apical level and in the zone next to the alveolar bone. The opposite was true of cell density, which was high at the subgingival level and in a zone next to the dental cementum. CONCLUSIONS: Evaluation and statistical analysis of the parameters proliferation index and cell density in distinct, biologically appropriate sites of the equine PDL suggest the presence of dynamic processes like cell migration by which the cells of the PDL move from an area next to the alveolar bone towards the dental cementum, and in an apico-occlusal direction. Furthermore, our study confirms the close relationship between cell proliferation, cell migration, and eruption.

Animals↗
PubMedDate not supplied

Natal and neonatal teeth: review of the literature.

Child development from conception through the first years of life is marked by many changes. Tooth eruption follows a chronology corresponding to the date when the tooth erupts into the oral cavity. These dates have been established in the literature and are subjected to small variations depending on hereditary, endocrine and environmental features. At times, however, the chronology of tooth eruption suffers a more significant alteration in terms of onset, and the first teeth may be present at birth or arise during the first month of life. The expectations about the eruption of the first teeth are great and even greater when the teeth appear early in the oral cavity. The objective of the present study was to present a review of the literature with important aspects about natal and neonatal teeth.

Diagnosis, Differential↗
PubMed2003

Development of a novel mouse osteoclast culture system including cells of mandibular body and erupting teeth.

Osteoclasts are multinucleated cells with the specialized function of resorbing calcified tissues. These cells develop from hemopoietic cells of the monocyte-macrophage lineage with the support of osteoblasts/stromal cells. Tooth eruption is a vertical movement of teeth via creation of an eruption pathway in and through the alveolar bone. The precise cellular and molecular determinants of tooth eruption are not yet clear, and a cell culture system that can reproduce the activity of osteoclast formation during tooth eruption is expected to be a useful tool to clarify the mechanism of eruption pathway formation. To this end, mandibular bodies, including incisors and molars, were isolated from 9- to 11-day-old mice undergoing active tooth eruption. Primary cells were obtained from mandibular bodies by enzymatic digestion and cultured in alphaMEM containing 15% FBS without any cytokine or growth factor or hormone in the culture (AFT culture, for alveolar bone, dental follicle, and tooth). A progressive increase in the number of tartrate-resistant acid phosphatase-positive multinucleated osteoclastic cells was observed in AFT culture. The osteoclastic cells generated were immunopositive for cathepsin K and calcitonin receptor, and formed resorption pits when cultured on dentine slices. Parathyroid hormone-related protein (PTHrP), expressed by the enamel organ of tooth, is reported to be an essential factor in creation of the eruption pathway. To verify this point, cells were isolated from mandibular bodies from which all teeth and dental follicles had been removed and cultured similarly (A culture, for alveolar bone). Osteoclastic cells were not formed and PTHrP production was hardly detected in the medium of A culture, in contrast to the high level of PTHrP in AFT culture. Since our previous study demonstrated that neonatal homozygous PTHrP-knockout mice show impaired osteoclastogenesis around tooth germs, AFT culture was performed by using this sample to examine whether this culture system can reproduce the status of osteoclastogenesis observed in vivo. The result showed that none of the osteoclastic cells were generated from cells of homozygous mice. We here report a novel mouse osteoclast culture system that reproduces the activity of osteoclast formation around erupting teeth without addition of any cytokine or growth factor or hormone to the medium. Histological examination of various transgenic and mutant mice now offers valuable findings on studies of tooth eruption and the present culture system using these animals would be a powerful tool in clarifying the cellular and molecular mechanisms of eruption pathway formation.

Animals↗
PubMed1987

Biochemical and scanning electron microscope study of lipids chloroform-methanol extracted from unerupted and erupted human tooth enamel.

Almost twice as much fatty acid was extracted without demineralization from the mature enamel of erupted teeth treated with 2:1 chloroform-methanol as from the enamel of unerupted teeth (32.64 micrograms/g versus 15.60 micrograms/g). Palmitic C16:0, stearic C18:0, oleic C18:1 omega 9 and linoleic acids C18:2 omega 6 were the chief fatty acids detected by gas-liquid chromatography. The percentage of free fatty acids and diglycerides was larger in unerupted than erupted teeth, whereas that of triglycerides, phosphatidylethanolamine and phosphatidylcholine was larger in erupted teeth. These changes may be due to bacteria and other contaminants (saliva and pellicle). The large amounts of free fatty acids, diglycerides, cholesterol and phospholipids as intrinsic components were probably due to the persistence of membrane remnants entombed during enamel formation, as indicated by the visualization of holes and by the increase in the size and number of focal holes after lipid-solvent interaction with the enamel surface. These defects always occurred in rods and never in inter-rod material. Other minute defects, including empty-widened intercrystal spaces, were also observed inside some rods.

Adolescent↗
PubMed2004

Natal and neonatal teeth.

Tooth eruption follows a chronology corresponding to the date when the tooth erupts into the oral cavity. This date has been established in the literature and is subject to small variations depending on hereditary, endocrine and environmental features. Any disturbance during the development of the teeth -systemic or local- can affect not only the morphology, structure of dental hard tissues or number of teeth but also the time of eruption. The presence of a tooth in the mouth at birth or during the first month of life has been studied and denominated as natal and neonatal teeth. The aim of this paper is to review current information on this topic and to give treatment alternatives if it is necessary.

Humans↗