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The isolation and identification of Haemophilus spp, from unusual lesions in children.

From a high proportion of children sent to hospital H. influenzae can be isolated if suitable culture media are used. A number of H. influenzae strains were isolated from unusual sites, such as (1) blood cultures after tonsillectomy or tonsillotomy in five cases; (2) urine or the urinary tract in eight cases; (3) the lumen of appendices removed at operation in 11 cases (4%); (4) osteomyelitis or pyarthrosis in six cases; (5) miscellaneous infections including two perianal abscesses, three cases of paronychia, one infected thyroglossal cyst, and several skin infections.It is suggested that infections of the skeletal system and the urinary tract arise from haematogenous spread of H. influenzae, as demonstrated by positive blood cultures after tonsillectomy and in two cases of skeletal infection. Infection of the appendix, perianal abscesses, paronychia, and skin infections probably arise by the direct route, either by immediate contact or by passage of viable organisms through the alimentary canal.

Abscess↗

[Skin and soft tissue infections caused by Haemophilus influenzae type b over a 30 year period].

INTRODUCTION: The skin and soft tissue infections caused by Haemophilus influenzae type b (Hib) are usually mild but can be potentially serious due to the high probability of bacteremia. Prompt instauration of empiric intravenous antibiotic therapy according to the localization and characteristics of the lesion is mandatory to prevent severe complications. PATIENTS AND METHODS: Of 257 children admitted to the Children's Hospital of La Fe due to invasive Haemophilus influenzae type b disease (1973 to 2003), we reviewed 15 cases (5.8%) of skin and soft tissue infections, their outcome, complications and sequelae. RESULTS: Ten children (66.7%) were aged < 2 years old. In eight patients (53.3%) there was a history of upper respiratory tract infection. Localization was in the head in 9 children (60%) and blood culture was positive in 10 patients (66.7%). Meningitis was a complication in 2 children (13.3%) and limited mobility of the hand was a sequel in one child (6.6%). After the universal establishment of the Hib vaccine in 1997, 3 new patients were admitted; 2 children with an infected thyroglossal cyst and another with cellulitis in the left leg. Of these children, one had received only the three primary doses of the vaccine but not the booster dose, and the remaining two were unvaccinated immigrant children. CONCLUSION: Skin and soft tissue infections caused by Hib are potentially severe diseases with a risk of complications and sequelae. Due to the increase in unvaccinated immigrants and possible vaccine failures, universal immunization and epidemiological surveillance of carriers should be carried out to achieve total eradication.

Child↗

Expression of 'visceral' cytokeratin and ultrastructural findings in solid cell nests of the thyroid.

Solid cell nests of the thyroid display histological features that resemble squamous epithelium. In the present study we investigated whether these ultimobranchial nests express a renal tubular cell cytokeratin which is found to be widely distributed in epithelia but does not appear in squamous tissue. All 17 solid cell nests studied, in contrast to squamous epithelium lining an intrathyroid thyroglossal cyst, stained positively for this intermediate filament. These findings, together with the gland-like features shown ultrastructurally by these ultimobranchial remnants, further support the view that solid cell nests of the thyroid should not be regarded as a kind of intrathyroid squamous inclusion. In addition, they were electron-microscopically comparable to mammalian ultimobranchial tissue.

Humans↗

Surgical approach for congenital midline cervical cleft.

This is a report of a case of a rare congenital midline cervical cleft and a description of the surgical approach. Congenital midline cervical cleft is a very rare developmental anomaly. It represents a failure of the branchial arches to fuse in the midline and presents at birth with a ventral midline defect of the skin of the neck. Associated clinical features could include mandibular spurs, cleft mandible, microgenia, thyroglossal cyst, cleft lip or bronchogenic cysts. The authors present a case of a midline cervical cleft that was diagnosed and managed at an early age. They discuss the clinical presentation and embryological development of this rare condition. The operative findings, surgical excision and repair of the long vertical defect by Z-plasty are discussed in detail. The authors report a very satisfactory result following excision and Z-plasty closure of this rare congenital anomaly.

Branchial Region↗

Case report: lingual thyroid, a cause of neonatal stridor.

Stridor implies partial airway obstruction, resulting from intrinsic or extrinsic abnormalities of the upper respiratory tract. In a neonate whose airway is small, soft and easily occluded this may be potentially life threatening. Its immediate diagnosis with prompt therapy is a rewarding challenge. When stridor occurs in a neonate with congenital hypothyroidism, surgically amenable cause of obstruction due to an ectopic thyroid or thyroglossal cyst has to be seriously considered. We report a case of neonatal stridor caused by a lingual thyroid, and discuss the imaging approach.

Congenital Hypothyroidism↗

Cysts.

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Bone Cysts↗

[Cancers in medial neck cysts--3 case reports].

1% of thyroglossal duct cysts are supposed to develop carcinoma. In most cases papillary carcinoma is found deriving from ectopic thyroid tissue. As far as squamous cell carcinomas are concerned, worldwide only eleven cases have been reported so far. In this article, three cases of carcinoma in a thyroglossal duct cyst are presented (1 case of squamous cell carcinoma, 2 cases of papillary carcinoma). The diagnostic procedures as well as the therapeutic strategies are discussed. The diagnosis of a thyroglossal duct cyst should be confirmed by ultrasonography. This can provide information about the presence or absence of a normal thyroid gland and makes radioisotope scanning unnecessary.

Adult↗

The diagnosis and treatment of midline neck masses in children.

Frustration in differentiating before operation among the various causes of midline neck masses stimulated us to review the clinical, operative, and pathologic findings in 176 children hospitalized for a midline cervical lump. The preoperative diagnosis was correct in 61% of these cases, the surgeon's postoperative diagnosis was correct in 83%, and the pathologist's diagnosis was correct in 98%. Only recurrence following prior excision and persistent sinus following drainage of a midline cyst were pathognomonic preoperative indicators of a thyroglossal duct cyst; these findings were present in only 6% of the cases. The age of the child, a history of inflammation or of fluctuation in size, the dimensions of the mass, and the relationship of the mass to the hyoid were useful in differentiating among groups of children with a thyroglossal cyst, an epidermoid cyst, or an enlarged perihyoid lymph node. The duration of the presence of the mass and its movement with swallowing were not helpful. Using the preoperatively recorded historical and physical findings in these children with a known cause for their midline neck mass and applying Bayes' theorem, one can only achieve a correct preoperative diagnosis with an 80% accuracy based on the best available data. Consequently, additional information obtained at surgical exploration is needed to establish a secure diagnosis and to ensure appropriate treatment.

Adolescent↗