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Results for “RETINAL VESSELS”

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At least 451 records · Page 25Linked to original sources
PubMed1975

Optic nerve transection in cats: effect on retinal vessels.

Unilateral optic nerve transection without damage to the intraocular circulation was performed on thirteen cats. Fluorescein angiograms, trypsin digestion, and histologic preparation of the retinas were carried out. No changes in the retinal circulation and angioarchitecture were observed. These findings were compared to those reported in humans with comparable optic nerve lesions. We conclude that optic nerve transection does not cause retinal vascular alteration and this fact may be of pertinence to posterior ocular damage in glaucoma.

Animals↗
PubMed1993

Retinal vessel circulation patterns visualized from a sequence of computer-aligned angiograms.

PURPOSE: To present a computer method that can be used to combine the images from a sequence of fluorescein angiograms of the retinal microcirculation so that a composite image can be generated and a color image illustrating circulation at all points in the vascular network can be computed. This should enable more accurate comparison of retinal vascular occlusions that occur during cardiopulmonary bypass surgery. METHODS: Photographic negatives of the macular region from two angiographic sequences, one taken before surgery and the other taken just before the end of bypass, were digitized, background shade corrected, and registered. Composite images were generated as minimum projection images and the filling images generated from parameters of a smooth curve fit to the filling data at every point. RESULTS: The composite images showed a filling pattern that more accurately reflected the maximum fluorescence at every point than any single image. The images generated from the filling data provide a new way to visualize and quantify changes in the retinal circulation. CONCLUSIONS: The technique demonstrates that problems arising from selection of a single frame from a filling sequence can be overcome by combining images. The technique used to generate the color-coded filling image should prove useful for any image sequence in which differential filling is of interest.

Blood Flow Velocity↗
PubMed1995

Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels.

In rat diabetic retinas, we immunohistochemically looked for vascular endothelial growth factor (VEGF) which is also known as vascular permeability factor (VPF). In nondiabetic retinas, VEGF immunoreactivity was weak and restricted to the nerve fiber and ganglion cell layers. On the other hand, in diabetic retinas, VEGF immunoreactivity was markedly increased and was observed in all layers of the retina, especially in the perivascular area. Hyperpermeability of these vessels was confirmed by immunohistochemically detecting extravasation of albumin. These findings indicate that vascular endothelial growth factor plays an important role in blood-retinal barrier breakdown in diabetic retinopathy.

Actins↗