[Suggestions for the seventh edition of the German Pharmacopeia, with special reference to ethereal oils and volatile substances].
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Ethnicity↗
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Antifungal activities of the oils of Nigella sativa seeds.
Antifungal activities of the oils of N. sativa seeds were tested against twenty fungi including pathogenic and industrial strains. All the oils were found to have significant activities against the fungi, but the volatile oil showed stronger and wider range of antifungal activities. MIC values of the volatile oil was also determined against three pathogenic fungi and lowest MIC was found against Aspergillus fumigatus.
Journal Article↗
[Fatal poisoning caused by oil of epazote, Chenopodium graveolens].
We present a case of acute lethal poisoning by oil of "epazote" (oil of chenopodium), in a 2 y 9 m female. The volatile oil was administered according to the advice of a "curandera" (female healer), in a total quantity of 40 ml. Clinical features of the poisoning were: vomiting, deep coma, seizures, mydriasis, apnea, metabolic acidosis, neurogenic shock and death. The EEG suggested a diffuse encephalopathy, the CT scan with an image of severe brain edema and ventricular collapse. Relevant postmortem findings were brain edema and neuronal necrosis, pneumonia, enteritis, pericholangitis, mild pancreatitis and tubular necrosis. The phytochemical analysis of volatile oil identified ascaridol, the main active compound of the chenopodium herbs, in a quantity of 39 mg/ml (1,560 mg in the dose administered), and Chenopodium graveolens as the plant employed to prepare it. According to the age of the patient, 60 mg of ascaridol would be the recommended dose formerly used in the treatment of parasitic disease. Thus 1,560 mg was 26 times higher than the recommended dose, and exceeded by 56% the dose of 1,000 mg reported as lethal in humans.
Child, Preschool↗
[Determination of chemical constituents of essential oil from the fruit of Eucalyptus globulus by GC-MS].
OBJECTIVE: The chemical components of essential oil from fruit of Eucalyptus globulus were analyzed by GC-MS. METHOD: The essential oil were extracted by steam distillation, then separated by capillary gas chromatography. The amount of the component from essential oil were determined by normalization methods. Chromatographic conditions were: capillary column DB-WAX (0.32 mm x 30 m, 0.25 microm) was used, column temperature: initial temperature at 40 degrees C for 3 min,ramping 5 C x min(-1) to 250 degrees C (holding for 10 min) the detector MS. RESULT: 31 component from the fruit of E. globulus were identified, which accounted for over 93.7% of total volatile oil. CONCLUSION: The methods is reliable, stabilize and can be applied to identify the volatile oil from the fruit of E. globulus.
Cyclohexanols↗
Chemical composition and antibacterial activity of essential oil of Pulicaria odora L.
The chemical composition of the volatile oil constituent from Pulicaria odora L. roots has been analyzed by GC/MS. Twenty-seven components were identified, being thymol (47.83%) and its derivative isobutyrate (30.05%) the main constituents in the oil. Furthermore, the oil was tested against seven bacteria at different concentrations. Results showed that the oil exhibited a significant antibacterial activity.
Anti-Bacterial Agents↗
[Allelopathy of Ageratum conyzoides. VI. Effects of meteorological conditions on allelopathy of Ageratum conyzoides].
In the field, allelopathic potential of A. conyzoides correlated significantly with sunshine time, temperature and rainfall. Allelopathic potential of A. conyzoides grew in favorable combinate condition of temperature, rainfall and sunshine time, allelopathic potential of A. conyzoides reduced, and vice versa. Allelopathic potential of A. conyzoides decreased because of favorable growing seasons in spring and summer. On the contrary, autumn and winter were unfavorable growing seasons, and the allelopathic potential of A. conyzoides increased. Under laboratory experiments, the volatile oil of A. conyzoides made the tested plants not survive at high concentrations of 300 micrograms.ml-1, but volatile oil of A. conyzoides inhibited the tested plants slightly at low concentrations of 60 micrograms.ml-1. However, under high or low temperatures and shading conditions, inhibitory effects of allelochemicals of A. conyzoides on tested plants intensified significantly at low concentration. It revealed that under unfavorable growing conditions, tested plants resistant ability to the allelochemicals of A. conyzoides decreased. When A. conyzoides and tested plants both grew under unfavorable meteorological conditions, allelopathic potential of A. conyzoides increased, and the tested plants resistant ability to allelochemical decreased. Thus, other plants growing among A. conyzoides in natural community were difficult to grow, and it was relatively improved competitive ability of A. conyzoides in natural communities. Joint effect of allelopathic potential and some meteorological factors such as sunshine time, temperatures, and rainfall was one of the important factors that A. conyzoides was dominated in natural communities.
Asteraceae↗
Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents.
Total equivalent antioxidant capacity (TEAC) and phenolic content of 26 common spice extracts from 12 botanical families were investigated. Qualitative and quantitative analyses of major phenolics in the spice extracts were systematically conducted by reversed-phase high-performance liquid chromatography (RP-HPLC). Many spices contained high levels of phenolics and demonstrated high antioxidant capacity. Wide variation in TEAC values (0.55-168.7 mmol/100 g) and total phenolic content (0.04-14.38 g of gallic acid equivalent/100 g) was observed. A highly positive linear relationship (R2= 0.95) obtained between TEAC values and total phenolic content showed that phenolic compounds in the tested spices contributed significantly to their antioxidant capacity. Major types of phenolic constituents identified in the spice extracts were phenolic acids, phenolic diterpenes, flavonoids, and volatile oils (e.g., aromatic compounds). Rosmarinic acid was the dominant phenolic compound in the six spices of the family Labiatae. Phenolic volatile oils were the principal active ingredients in most spices. The spices and related families with the highest antioxidant capacity were screened, e.g., clove in the Myrtaceae, cinnamon in the Lauraceae, oregano in the Labiatae, etc., representing potential sources of potent natural antioxidants for commercial exploitation. This study provides direct comparative data on antioxidant capacity and total and individual phenolics contents of the 26 spice extracts.
Antioxidants↗
Response of coriander to the mode of phosphorus application.
Three modes of phosphorus application, partly or fully through the soil or foliage, were conducted to evaluate the effect of P application mode on green and fruit yields of coriander and their chemical constituents. The highest values in plant height, green and dry matter production as well as fruit yield, were recorded when P was given partly through soil and foliage. Generally, the three methods of P application increased carbohydrate and protein concentrations in shoots and fruits as compared to the control, in the two seasons in both cuts. The addition of P partly through soil increased the volatile oils concentration of shoots and fruits in the two cuts in both seasons, over the all treatments. The identification of volatile oils in shoots and fruits varied according to the mode of P application.
Journal Article↗
Composition and some biological activities of the essential oils from an African pasture grass: Elionurus elegans Kunth.
The volatile oils of the aerial parts and roots from a pasture plant, Elionurus elegans, were studied by GC-MS analyses. Both organs studied contained only terpenic constituents. The main components found in the extract essential oils of the aerial parts were campherenone (43.0%), caryophyllene oxide (4.9%), and bisabolone (4.9%), whereas those found in the root essential oils were campherenone (39.0%), epi-beta-santalene (12.0%), and caryophyllene oxide (4.6%). Furthermore, the oils were tested for antibacterial and antifungal activities. The results obtained led to a nonsignificant inhibitory effect, although an increase of the lag stage was shown for the kinetics growth of Candida albicans, Saccharomyces cerevisiae, Enterococcus hirae, and Staphylococcus aureus. When alpha-tocopherol is used as a control, the antioxidant activities of the oils obtained from the aerial parts and roots were 30 and 46% IC(50), respectively.
Antioxidants↗
Antimicrobial activity of essential oil from Schinus molle Linn.
The essential oil from the fresh leaves of Schinus molle isolated by hydrodistillation was tested for antibacterial activity using the hole plate diffusion method and for antifungal activity using the mycelium or single cell growth inhibition method. Results obtained showed that the volatile oil exhibited significant activity against the following bacterial species: Klebsiella pneumoniae, Alcaligenes faecalis, Pseudomonas aeruginosa, Leuconostoc cremoris, Enterobacter aerogenes, Proteus vulgaris, Clostridium sporogenes, Acinetobacter calcoacetica, Escherichia coli, Beneckea natriegens, Citrobacter freundii, Serratia marcescens, Bacillus subtilis and Brochothrix thermosphacata. The fungal species Aspergillus ochraceus, Aspergillus parasiticus, Fusarium culmorum and Alternaria alternata exhibited significant sensitivity to the volatile oil.
Bacteria↗
Terpenoids from Guarea guidonia.
The volatile oil and the methanol extract from the leaves of Guarea guidonia, Meliaceae, were individually submitted to chromatographic separation. A sesquiterpene (2S*)-eudesma-5,7-dien-2-ol, together with six known ones, were isolated from the volatile oil. The methanolic extract afforded two known and two new triterpenes (23S*)-cycloart-24-ene-3 beta,23-diol and (23R*)-cycloart-24-ene-3 beta,23-diol, besides three known sesquiterpenes, one known diterpene and two steroids. Their structures were established on the basis of spectrocopic data, mainly by 1H and 13C NMR spectroscopic analyses.
Brazil↗
[Effect of essential oils on the course of experimental atherosclerosis].
The effect of volatile oils of lavender, monarda, and basil on the course of experimental atherosclerosis was studied in rabbit experiments. Inhalation of the volatile fractions of essential++ oils of lavender and monarda in a concentration of 0.1-0.2 mg/m3 of air has no effect on the content of cholesterol in the blood, but reduces its content in the aorta and reduces affection of the aorta by the atherosclerotic plaques, i.e. these oils produce an angioprotective effect.
Animals↗
Antiplatelet activity of Varthemia iphionoides.
Aqueous and alcoholic extracts, volatile oil and four flavonoids, xanthomicrol (1), kumatokenin (2), jaceidin (3) and 3, 3'-di-O-methylquercetin (4), isolated from Varthemia iphionoides were investigated for their in vitro anti-platelet activity. Aqueous extract and compounds (1), (2) and (4) showed anti-platelet activity. Volatile oil and the alcoholic extract did not exhibit any anti-platelet activity. Structures of the isolated compounds (1)-(4) were determined by spectroscopic methods (UV, IR, MS, (1)H-NMR).
Asteraceae↗
Chemical composition and biological activity of the essential oils of Senecio aegyptius var. discoideus Boiss.
The essential oil of Senecio aegyptius var. discoideus flowers, leaves, stems and roots were isolated by hydrodistillation. Analysis of the oils by capillary GLC and GLC-mass spectrometry were performed and 34 out of 37 compounds were identified. The main component was isolated and characterized as 1,10-epoxyfuranoeremophilane using a combination of GLC, GLC-MS, and NMR analyses. The oils of flowers, leaves and stems were rich in monoterpene hydrocarbons while the root oil mainly contains furanoeremophilanes. Flower and leaf volatile oils showed significant level of antifungal activity against C. albicans, moderate effect against Gram positive bacteria, however, it has weak activity against Gram negative bacteria. The isolated sesquiterpene (1,10-epoxyfuranoeremophilane) exhibited substantial inhibitory activity against Gram negative bacteria.
Chromatography, Gas↗
The antioxidative activity of traditional Japanese herbs.
The objective of this research was to examine the radical scavenging activity of traditional Japanese herbs. Samples used in the experiments were gennoshoko (Geranium nepalense var. thunbergii), yomogi (Artemisia vulgaris var.indica), senburi (Swertia japonica), iwa-tobacco (Conandron ramondioides), sarunokoshikake (Elfvingia applanata), kanzo (Glycyrrhiza uralensis Fisch) and matatabi (Actinidia polygama). The water-soluble components of the herbs were extracted in boiling water, and the volatile oil was extracted by a distillation apparatus or steeping in some organic solvents such as petroleum ether and ethyl ether. The radical scavenging activity was determined by the decrease of free radicals of DPPH detected by both colorimetric assay and HPLC method at 517 nm. The extracts of gennoshoko, yomogi and iwa-tobacco showed remarkable radical scavenging activity. The volatile oil of yomogi obtained by distillation or steeping in organic solvents had especially strong antioxidative activity.
Antioxidants↗
[Original studies on anti-tumor and immunological effect of extracts from Thymus quinquecostatus Celak in mice].
OBJECTIVE: To study the anti-tumor and immunological effect of extracts from Thymus quinquecostatus Celak on mice transplanted S180 tumor cells. METHODS: Different doses of volatile oil and alcohol extracted substances from Thymus quinquecostatus Celak were given to mice bearing S180 tumor for 9 days. Tumor inhibition rates and coefficients of spleen and thymus were determined. RESULTS: Tumor inhibition rates of the groups with alcohol extracts (40 g crude drug.kg(-1).d(-1) and 20 g crude drug.kg(-1).d(-1)) were 51.5% (P<0.01) and 36.4% (P<0.05) respectively, and those of the groups with volatile oil (40 g crude drug.kg(-1).d(-1) and 20 g crude drug.kg(-1).d(-1))were both 39.4% (P<0.05). CONCLUSION: The extracts from Thymus quinquecostatus Celak have anti-tumor activities. The coefficient of spleen in group with alcohol extracts (40 g crude drug.kg(-1).d(-1))was close to normal value, and its coefficient of thymus was between that of the negative control group and the group with cyclophosphamide (0.02 g.kg(-1).d(-1)). The anti-tumor activity of the alcohol extracts was significantly higher than that of the control group and the tumor inhibition rate was depending on drug concentration. Depending on index of immunity,the extracts from Thymus quinquecostatus Celak may have some influences on immunity.
Animals↗
Antimutagenicity of Japanese traditional herbs, gennoshoko, yomogi, senburi and iwa-tobacco.
The multistage induction theory is generally regarded as the mechanism of carcinogenesis. In order to prevent the initiation stage of carcinogenesis, it is meaningful to discover the functional components of edible plants. The objective of this research was to test the antimutagenicity of the functional components of several typical traditional herbs used in Japan. The traditional herbs, gennoshoko (Geranium nepalense var. thunbergii), yomogi (Artemisia vulgaris var. indica), senburi (Swertia japonica), iwa-tobacco (Conandron ramondioides), sarunokoshikake (Elfvingia applanata), kanzo (Glycyeehiza uralensis Fisch) and matatabi (Actinidia polygama) were examined by Ames mutagenesis assay test with Salmonella typhimurium TA98 and TA100 against mutagens, Trp-P-1, Trp-P-2 and B(a)P. The water-soluble components or volatile oil of the herbs were extracted in boiling water. The extracts of gennoshoko showed strong antimutagenicity against B(a)P with S. typhimurium TA98 and TA100, as well as Trp-P-1 and Trp-P-2 with S. typhimurium TA98. Yomogi, senburi and iwa-tobacco were also proved to have good antimutagenicity against Trp-P-1 and Trp-P-2 with S. typhimurium TA98, but weaker antimutagenicity against B(a)P. Other herbs did not show any obvious antimutagenicity against these mutagens. In addition, the volatile oil of yomogi also had remarkable antimutagenic effect against the mutagens we used with S. typhimurium TA98.
Antimutagenic Agents↗
Repellency of essential oils of some plants from the Kenyan coast against Anopheles gambiae.
Volatile oils extracted by hydrodistillation from six plant species growing in the Kenyan coast, Croton pseudopulchellus Pax, Mkilua fragrans Verdc. (Annonaceae), Endostemon tereticaulis (poir.) Ashby, Ocimum forskolei Benth., Ocimum fischeri Guerke and Plectranthus longipes Baker (Labiateae), were evaluated for repellency on forearms of human volunteers against Anopheles gambiae sensu stricto. All oils were found to be more repellent (RC50 range = 0.67-9.21 x 10(-5) mg cm(-2)) than DEET (RC50 = 33 x 10(-5) mg cm(-2)). The individual components of the oils were identified by GC-MS and GC co-injections with authentic standards. The repellency of 15 of the main constituents of the different oils (which had not been previously assayed) was evaluated. Although some of these showed relatively high individual repellencies, none was comparable to the parent essential oils. Partial synthetic blends of selected constituents with moderate or relatively high individual repellency against the vector were also assayed. Four of these exhibited activities comparable to or higher than those of the corresponding parent oils, indicating interesting blend effects in the repellent action of the oils against the mosquito. The implication of these results in the utilization of the plants is discussed.
Animals↗