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PubMed2005

Plasma total homocysteine concentrations in obese and non-obese female patients with type 2 diabetes mellitus; its relations with plasma oxidative stress and nitric oxide levels.

Hyperhomocysteinemia has been identified as independent risk factor for early atherosclerotic vascular disease. The purpose of our study was to investigate the plasma homocystein (Hcy) concentrations and its relationship with lipid peroxidation as thiobarbituric acid reactive substances (TBARS) and nitric oxide (NOx; nitrite plus nitrate) concentrations in age-matched non-obese (n=55) and obese (n=60) female subjects with type 2 diabetes mellitus. Non-obese diabetic patients have significantly higher plasma tHcy and TBARS (p<0.001 and p<0.001), and significantly lower NOx concentrations than the controls (n=25) (p<0.001). The plasma tHcy and TBARS concentrations were higher and nitric oxide concentrations were lower in obese diabetics than in non-obese diabetics (for each comparison; p<0.001). Correlation analysis demonstrated that there was a significant positive correlation between tHcy and TBARS (r=0.452, p<0.01) in diabetics groups. There was no significant correlation between tHcy and plasma NOx, insulin and blood pressure. We thought that Hcy might have a permissive role on the endothelium damage through free radical generating systems and the presence of obesity the free radical induced-damage has been elevated in diabetic patients.

Blood Pressure↗
PubMed1990

[Comparison of beta-blocking agents pharmacokinetics in obese and non-obese subjects].

We compared in obese patients and normal subjects, the pharmacokinetics of three drugs with different solubility: d,l-sotalol markedly hydrophilic, d,l-propranolol highly lipophilic, d,l-bisoprolol moderately lipophilic. In obese subjects the pharmacokinetic data calculated for sotalol (total clearance (CL), volume of distribution (V beta), half-life of elimination (t1/2), were comparable with those measured in the controls. Data on bisoprolol showed that total V beta increased with excess of body weight, but V beta/kg of body weight was lower in obese subjects than in the controls, CL tended to increase and t1/2 was similar. As concerned propranolol, total V beta and V beta/kg were significantly lower in obese than in control subjects. Cl was decreased in obese patients and t1/2 was similar for both groups. It appears that in the obese the diffusion of liposoluble beta-blockers in the fatty excess weight remains limited. It is possible that a vasoconstrictive effect induced by beta-blockers in adipose tissues could restrict their tissular distribution.

Adrenergic beta-Antagonists↗
PubMed1985

External responsiveness to food and non-food cues among obese and non-obese children.

External responsiveness to food and non-food cues was studied among 112 obese and 134 non-obese children ranging in age from 42 to 156 months. Subjects viewed five food and five non-food items and stated a preference between an immediate smaller and a delayed larger choice. Young (ages 3-5 years) children's abilities to delay gratification were significantly lower than were those of school children, a finding consistent with research on delay of gratification. Obese subjects at both ages had lower delay scores for immediate gratification on food items than did non-obese subjects. The delay scores of obese and non-obese subjects on non-food items were not significantly different from each other. Results were discussed in terms of the ontogeny of externality.

Adolescent↗
PubMed1983

Techniques for identification of the young obese Zucker rat and some observations on brown adipose tissue morphology and histochemistry in the young obese Zucker rat.

Several techniques for the identification of the young obese Zucker rat were developed and tested. A procedure utilizing biopsies of hypodermal adipocytes was successful in identifying the obese phenotype in large litters of 7-d and older rats. This technique involves sizing and counting fat cells in esterase stained cryostat sections of skin biopsies. Another procedure involved measuring times to cessation of spontaneous activity upon acute exposure to a cold environment. As early as 3 d, obese rats become inactive (in the cold) in a significantly shorter time when compared to the lean rat. This technique was not a discriminating test for the identification of the obese genotype at 3 d of age. A preliminary analysis of brown fat histology and histochemistry indicated larger and more lipid filled brown adipocytes in the obese animal when compared to lean animals at 10 and 14 d of age. Brown fat from young obese animals was histochemically similar to brown fat in lean rats.

Adipose Tissue, Brown↗
PubMed1979

Attitudes toward obesity and the obese among professionals.

Negative attitudes toward obese patients by health professionals have been attributed to termination of weight reducing attempts. This study measured attitudes concerning the obese held by professional participants in a continuing education conference on causes and treatment of obesity. Substantial variation was found on items comprising obesity-related belief dimensions: (a) Disparaging image of the obese; (b) causes of obesity; and (c) ways to lose weight. Evidence is presented for the association among measures of these dimensions. While background and educational characteristics and conditions of practice were not related to such attitudes, the professional's personal experience with successful weight reduction was the best predictor of favorable attitudes.

Attitude of Health Personnel↗
PubMed1995

The pharmacokinetics of dexfenfluramine in obese and non-obese subjects.

The pharmacokinetics of dexfenfluramine (d-F) and its metabolite dexnorfenfluramine (d-NF) were compared in 10 obese (145 +/- 13 s.d. % of ideal body weight (IBW)) and 10 non-obese healthy volunteers (93 +/- 8% IBW). Each group included five men and five women, aged 28 +/- 8 years. Subjects were given single doses of d-F i.v. (15.5 mg base infused over 3 h) and orally (25.9 mg base in capsules) on separate occasions. After i.v. infusion in obese subjects, the volume of distribution (Vss) of d-F was significantly higher (969.7 +/- 393.3 l; 95% CI 688.6-1250 l) than in controls (668.7 +/- 139.6 l; 95% CI 568.9-768.5 l; P < 0.01). Clearance was not significantly different (43.9 +/- 21.0 l h-1 vs 37.3 +/- 10.6 l h-1) and the terminal half-life tended to be longer (17.8 +/- 9.4 vs 13.5 +/- 3.9 h NS). Combined data from the two groups indicated a positive correlation between Vss and % IBW (r = 0.544; P < 0.02). The oral bioavailability of d-F was 0.61 +/- 0.15 in obese subjects and 0.69 +/- 0.11 in controls. There was no significant difference between obese subjects and controls in Cmax, tmax and t1/2,z (Cmax: 20.1 +/- 6.7 and 27.3 +/- 6.2 micrograms l-1; tmax: 3.5 vs 3.0; t1/2,z: 16.5 +/- 7.1 vs 14.5 +/- 2.6 h respectively). The AUC ratio expressed in molar units for d-F/d-NF was 2.29 +/- 1.78 (i.v.) vs 1.25 +/- 0.64 (oral) in obese subjects and 2.05 +/- 1.26 (i.v.) vs 1.40 +/- 0.87 (oral) in controls.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed1993

[Level of beta endorphins and insulin in blood of obese subjects. Effect of surgical treatment for obesity on higher exchange parameters].

The basal and hyperglycaemia-stimulated secretion of glucose, IRI and beta-endorphin (BE) were studied in subjects who had gone surgical treatment for obesity few years ago and the results were compared with those of obese subjects and lean controls. 58 persons were divided into the following groups: A-obese subjects BMI > 30, B--obese subjects 25 < BMI < 30, C--subjects treated by truncal vagotomy and gastric banding, D--subjects treated by jejunoileostomy, E--control group BMI < 25. Oral glucose (75 g) tolerance test was performed in all subjects. Blood concentration of glucose, and serum concentration of IRI and BE were studied before and 30, 60, 90 and 120 minutes after ingestion of glucose. The basal levels and areas over basal values (AOBV) of investigated parameters were evaluated. Both the basal and glucose stimulated levels of IRI and BE were higher in the obese subjects than in the control group. Truncal vagotomy and gastric banding or jejunoileostomy resulted in reduction of IRI secretion without any decrease in BE levels. The alteration of the opioid system may play some role in the pathogenesis of obesity.

Adult↗
PubMed1996

The role of emotional and socio-cognitive patterns in obesity: eating attitudes in obese adolescents before and after a dietary-behavioural therapy.

The aim was to examine attitudes towards eating in a group of obese and nonobese female adolescents (N = 200), in particular whether obese subjects have characteristic attitudinal patterns associated with obesity. Analysis concluded that our sample, both overweight and normal subjects, share the negative stereotypic attitudes towards obese persons. However, there was a considerable difference in emotional evaluation of eating behaviour. If normal subjects attribute a strong negative emotional connotation, obese subjects not only did not recognise the "abnormality" of overeating, but preferred it. This can be explained by the presence of an association of strength and power with overeating: at the moment of eating, obese subjects feel themselves "strong" and even "superior," thereby compensating for their rather weak and fragile personalities. The emotional evaluation of eating behavior did not change after a 10-week dietary/behavioural treatment.

Adolescent↗
PubMed1996

The role of macronutrient selection in determining patterns of food intake in obese and non-obese women.

OBJECTIVE: Examination of the role of macronutrient selection in determining patterns of food intake in obese and non-obese women. DESIGN: Inventory: food intake diaries of two weekdays and one weekend day; EXPERIMENT randomized. SETTING: Inventory: in daily life. EXPERIMENT: department of Human Biology, University of Limburg. SUBJECTS: 68 subjects: 34 obese and 34 non-obese, age 20-50 years, selected based on accurate completion of food intake diaries (< 10% underreporting); a sub-sample of 32 (16 obese and 16 non-obese) was assigned to the experiment. INTERVENTIONS: An ample choice of food items consisting of mainly one macronutrient each were offered 4 and 6 times per day, with different macronutrient compositions per day, ranging from 1-77 en% fat, 3-45 en% protein, and 19-96 en% carbohydrate. RESULTS: Selection, namely food choice that differs from random consumption, took place at breakfast in favour of carbohydrate, and at dinner in favour of fat. Habituation, namely a decreased response on the same stimulus, occurred after the fourth exposure to a single macronutrient buffet. For protein this was expressed as a significantly increased satiety score per kJ ingested; for fat as a significant drop in hedonic value; for carbohydrate as a significantly increased desire for a different taste, all (P < 0.05). Compensation, i.e. a correction afterwards for an earlier unusual macronutrient composition, resulting in a close to usual macronutrient composition of 24 h food intake, occurred at dinner, for a previous unusually low fat and high carbohydrate intake. CONCLUSIONS: A pattern of macronutrient intake was achieved by selection and compensation. Habituation occurred at the fourth exposure of a single macronutrient.

Adult↗
PubMed1980

The development of obesity in genetically diabetic-obese (db/db) mice pair-fed with lean siblings. The importance of thermoregulatory thermogenesis.

The importance of reduced thermoregulatory thermogenesis as a mechanism for the high metabolic efficiency of the diabetic-obese (db/db) mouse has been investigated. Young db/db mutants were pair-fed to the ad libitum food intake of lean siblings for two weeks at two different environmental temperatures, 23 and 33 degrees C. At 23 degrees C, a temperature at which there is a substantial demand for thermoregulatory thermogenesis, the diabetic-obese animals deposited 51% more total energy and 75% more fat than the lean mice. At 33 degrees C (thermoneutrality) where there is no requirement for thermoregulatory heat, the mutants deposited 25% more fat than lean animals, but there was no significant difference in the total energy gain of the two groups. Pair-feeding resulted in a reduced protein deposition at both temperatures in the diabetic-obese animals compared to the lean. It is concluded that the high metabolic efficiency of the diabetic-obese mutant, like that of the obese (ob/ob) mouse, is caused by a low energy expenditure on thermoregulatory thermogenesis.

Animals↗
PubMed2000

Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK)

This study examined in dietary obese and genetically obese rodents the effects of soy protein isolate (SPI) and its hydrolysate (SPI-H) on the rate of body-fat disappearance. Male Sprague-Dawley rats (4-16 wk old) and yellow KK mice (6-10 wk old) were made obese by feeding high-fat diets containing 30% fat. They were then fed energy-restricted, low-fat (5.0%), and high-protein (35% casein, SPI, or SPI-H) diets for 4 wk at 60% of the level of the energy intake of rodents on laboratory chow. The body-fat contents of rats and mice fed a high-fat diet were 27.3 and 33.6 g/100 g body weight, respectively, at the end of the obese period. For rats, the apparent absorbability of dietary energy and fat was significantly lower in the SPI and SPI-H groups than in the casein group, but vice-versa for nitrogen balance. Body-fat content in mice fed SPI and SPI-H diets was significantly lower than in those fed the casein diet. In rats, plasma total cholesterol level was lower with the SPI-H diet, and plasma glucose level was lower with the SPI and SPI-H diets than with the casein diet. These results indicate that SPI and SPI-H are suitable protein sources in energy-restricted diets for the treatment of obesity.

Adipose Tissue↗
PubMed1998

Perception of body weight and self-reported eating and exercise behaviour among obese and non-obese women in Saudi Arabia.

A case control study was conducted to examine the theorized differences for eating and exercise behaviour among the obese and non-obese women from an urban health center in Saudi Arabia. Perceptions regarding actual and ideal body size were also determined. The obese were significantly more likely to eat under emotional conditions of stress and anger, in secrecy, and indulge in binge eating (P < 0.05). Frequent snacking and drinking of regular soda drinks was also more common in this group compared to the controls (P < 0.05). A weak association was observed for nibbling at food without being aware and preference of sweet foods compared to savoury ones by the obese (P < 0.1). A large group of the study population (75%) were either not exercising at all or doing so infrequently--a feature expected in the middle and lower social class group of women in this region. A sizable proportion of women either overestimated (28.6%) or underestimated (28.9%) their actual body weight with increasing education significantly related to overestimation of weight and vice versa (P < 0.05). A change in the concept of an ideal body image from the overweight female to that of the slim figure was also observed with advancing education. To control and prevent obesity in this region, it is suggested that health education related to an awareness of a healthy body size and appropriate eating and exercise behaviour should be given through primary health centers, other health facilities and schools.

Adolescent↗
PubMed1997

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin.

The ob/ob mouse is genetically deficient in leptin and exhibits a phenotype that includes obesity and non-insulin-dependent diabetes mellitus. This phenotype closely resembles the morbid obesity seen in humans. In this study, we demonstrate that a single intramuscular injection of a recombinant adeno-associated virus (AAV) vector encoding mouse leptin (rAAV-leptin) in ob/ob mice leads to prevention of obesity and diabetes. The treated animals show normalization of metabolic abnormalities including hyperglycemia, insulin resistance, impaired glucose tolerance, and lethargy. The effects of a single injection have lasted through the 6-month course of the study. At all time points measured the circulating levels of leptin in the serum were similar to age-matched control C57 mice. These results demonstrate that maintenance of normal levels of leptin (2-5 ng/ml) in the circulation can prevent both the onset of obesity and associated non-insulin-dependent diabetes. Thus a single injection of a rAAV vector expressing a therapeutic gene can lead to complete and long-term correction of a genetic disorder. Our study demonstrates the long-term correction of a disease caused by a genetic defect and proves the feasibility of using rAAV-based vectors for the treatment of chronic disorders like obesity.

Animals↗
PubMed1995

A note on interpersonal sensitivity and psychotic symptomatology in obese adult outpatients with a history of childhood obesity.

The Symptom Checklist 90-Revised (Derogatis, 1975) was administered to 37 obese adults in outpatient treatment for obesity. Individuals who had become obese during childhood showed greater interpersonal sensitivity and exhibited more psychotic symptoms than those who had become obese later in life. The findings support the belief that morbid obesity is characteristically associated with elevated levels of internal psychological conflict.

Adult↗
PubMed2006

The effect of obesity surgery on obesity comorbidity.

Obesity is epidemic in the modern world. It is becoming increasingly clear that obesity is a major cause of cardiovascular disease, diabetes, and renal disease, as well as a host of other comorbidities. There are at present no generally effective long-term medical therapies for obesity. Surgical therapy for morbid obesity is not only effective in producing long-term weight loss but is also effective in ameliorating or resolving several of the most significant complications of obesity, including diabetes, hypertension, dyslipidemia, sleep apnea, gastroesophageal reflux disease, degenerative joint disease, venous stasis, pseudotumor cerebri, nonalcoholic steatohepatitis, urinary incontinence, fertility problems, and others. The degree of benefit and the rates of morbidity and mortality of the various surgical procedures vary according to the procedure.

Bariatric Surgery↗
PubMed2006

Differential regulation of intestinal lipid metabolism-related genes in obesity-resistant A/J vs. obesity-prone C57BL/6J mice.

The effects of high-fat (HF) feeding on gene expression in the small intestine were examined using obesity-resistant A/J mice and obesity-prone C57BL/6J (B6) mice. Both strains of mice were maintained on low-fat (LF; 5% fat) or HF (30% fat) diets for 2 wk. Quantitative reverse transcription-PCR analysis revealed that lipid metabolism-related genes, including carnitine palmitoyltransferase (CPT) I, liver fatty acid binding protein, pyruvate dehydrogenase kinase-4, and NADP(+)-dependent cytosolic malic enzyme, were upregulated by HF feeding in both strains of mice. The upregulated gene expression levels were higher in A/J mice than in B6 mice, suggesting more active lipid metabolism in the small intestine of A/J mice. The prominent upregulation of the lipid metabolism-related genes were specific to the small intestine; the expression levels were little or unchanged in the liver, muscle, and white adipose tissue. The increase by HF feeding and predominant expression of the intestinal lipid metabolism-related genes in A/J mice were reflected in the enzyme activities; malic enzyme, CPT, and beta-oxidation activities were increased by HF feeding, and the upregulated malic enzyme and CPT activities were significantly higher in obesity-resistant A/J mice compared with those in obesity-prone B6 mice. These findings suggest that intestinal lipid metabolism is associated with susceptibility to obesity.

Adipose Tissue↗
PubMedDate not supplied

Prescribing for obesity. Comment on the Royal College of Physicians' Working Party report on clinical management of overweight and obese patients with particular reference to drugs.

Physicians are reluctant to treat obesity despite the rapid increase in its prevalence in the UK and its associated health problems such as diabetes, coronary heart disease and hypertension. Overweight and obesity are chronic conditions that require long-term treatment. Any therapeutic programme should combine dietary restriction with physical activity and alterations to lifestyle. The use of pharmacological treatment as an adjunct to conventional treatment modalities is justified in certain circumstances. The criteria applied for the prescription of an anti-obesity drug should be comparable to that applied to the treatment of other relapsing disorders. The objective of the Royal College of Physicians' new report, Clinical management of overweight and obese patients with particular reference to the use of drugs, is the provision of such necessary guidance. Based on evidence from clinical trials, the recommendations of the report utilise a 12-week goal (outside a drug trial) of 5% body weight loss from the start of drug treatment. Failure to achieve this goal is an indication for stopping drug therapy. Safety and efficacy demand appropriate use of anti-obesity drugs in a supervised setting with clinicians weighing up likely medical benefit against possible risks.

Anti-Obesity Agents↗