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PubMed1981

Phylogeny of NK cell reactivity against human and nonhuman primate lymphoblastoid cell lines: evolving and conserved target antigens.

Both human and nonhuman primate natural killer (NK) cells display little or no killing against allogeneic B lymphoblastoid cell lines. However, the same B cell lines are killed in baboon-human (B alpha H) or human-baboon (H alpha B) xenogeneic combinations. Competition-inhibition experiments indicate that the xenogeneic determinants recognized by NK cells are found principally if not exclusively on B rather than T target cells. Cell lines from closely related chimpanzee or orang-utan species can block some killing of human target cells, but lines from more distantly related species including gibbon, macaque, baboon, and marmoset do not inhibit cytotoxicity. This suggests that some NK target structures are susceptible to evolutionary change. Gibbon or marmoset lines infected with Epstein Barr virus (EBV) do not block killing, suggesting that host rather than viral determinants are being recognized. In contrast to the foregoing pattern, 2 cell lines derived from the same baboon differed in susceptibility to NK lysis irrespective of the effector cell species. The viral producer line 13CB-1 was more susceptible to lysis than its viral nonproducer partner 26CB-1. Thus, some NK target antigens may be highly conserved whereas others evolve with the species.

Animals↗
PubMed1990

A social tethering system for nonhuman primates used in laboratory research.

A housing and tether system was designed to permit sampling of body fluids, chronic monitoring of physiologic parameters (e.g. blood pressure, heart rate), performance of species typical behavioral interactions (aggression, affiliation, reproduction, etc), physical exercise (work on a motorized treadmill), assessment of water and diet consumption, as well as feces and urine collection. The system provided primates with the opportunity to engage in species typical social behavior and thereby minimized conditions which have been identified as contributing to the development of abnormal behaviors associated with individual housing. The system consisted of two parts: (a) a specialized cage system for housing small social groups of primates and (b) a tether and indwelling catheter system. Each modular system permitted four adult baboons (Papio cynocephalus anubis) to be tethered and housed in a social group. Each cage was 2.44 x 2.44 x 1.22 m (L x W x H) and could be subdivided by means of woven wire wall partitions. The tether system consisted of a backpack, a cloth jacket, a stainless-steel flexible cable containing electrical cables and catheters, and a saline infusion pump mounted on top of the cage. The system provides laboratory primates with the ability to socially interact with other nonhuman primates. The social cage tether system represents an example of a housing environment which could conform to both the letter and spirit of the new animal welfare legislation and still remain compatible with the objective of obtaining scientific data.

Animal Welfare↗
PubMed1994

The effects of an immunomodulatory LFA3-IgG1 fusion protein on nonhuman primates.

LFA3TIP, a fusion protein comprised of the first extracellular domain of LFA-3 fused to the hinge, CH2 and CH3 domains of human IgG1, inhibits proliferation of human T cells in vitro. LFA3TIP also inhibits responses of human CD2 transgenic mice by rapidly and totally depleting peripheral T cells. These effects require binding of the LFA-3 and CH2 domains of LFA3TIP to CD2+ T cells and Fc gamma R+ accessory cells, respectively. As CD2 is well conserved in primate species, we evaluated the effects of LFA3TIP in nonhuman primates. We report in vitro results leading to the selection of the baboon as a model for analysis of LFA3TIP, and in vivo effects of single and multidose regimens of LFA3TIP administration. This is the first report of the in vivo administration of an immunomodulatory fusion protein to primates. LFA3TIP is shown to mediate effects on primate T lymphocytes without apparent related toxicities or immunogenicity. Results are discussed in context of potential mechanisms of LFA3TIP immunotherapy.

Adjuvants, Immunologic↗
PubMed1996

Characterization of prostatic basal cell hyperplasia and neoplasia in aged macaques: comparative pathology in human and nonhuman primates.

There are very few reports of proliferative prostatic lesions occurring spontaneously in nonhuman primates. We found that 15 of 19 glands in aged macaques contained one or more epithelial lesions in the cranial lobe. These originated in the basal cell compartment and were characterized as hyperplasia and benign neoplasia. The adenomas contained variable gland formation, with morphologic and immunohistochemical evidence of secretory, mucigenous, neuroendocrine, transitional, and squamous cell differentiation. These cell types are resident in the normal prostate or appear in metaplastic lesions, and their presence in the macaque tumors is consistent with differentiation of a stem cell along multiple phenotypic pathways. The macaque growths are similar to human prostatic basal cell lesions and could provide insights into their pathogenesis as well as cellular ontogeny and general mechanisms of carcinogenesis in this organ.

Aging↗
PubMed1993

Development and structure of the placenta and fetal membranes of nonhuman primates.

This survey examines placental and fetal membrane structure, function, and development in nonhuman primates. It will focus on these aspects of fetal membranes in species exemplifying the two main types of primate placentation. The chorioallantoic placentas of most strepsirhine primates (e.g., lorises and lemurs), are diffuse, villous and epitheliochorial in structure. Villi are stout, usually unbranched and interdigitate with indentations in the uterine lining. Early in gestation trophoblast cells are columnar but with advancing gestational age considerable thinning of the interhemal membrane occurs. The villous tips have indented regions that appear to be involved in absorption of histotroph. Accessory placental structures known as areolae or chorionic vesicles occur in many strepsirhines. These are cup-shaped specializations that develop opposite the mouths of uterine glands and appear active in absorption of glandular secretions. In addition, most strepsirhines are characterized by a large yolk sac early in gestation, a transient choriovitelline placenta, and most have a large allantoic sac. In strepsirhines, amniogenesis occurs by folding. In contrast, the chorioallantoic placentas of most haplorhines are discoidal, villous, and hemochorial. The species emphasized in the review are macaque monkeys. The placental villi are covered by a layer of syncytiotrophoblast; the latter is active in maternal-fetal transport and hormone synthesis. In some haplorhines, extravillous trophoblast invades deeply into the endometrium and also into spiral arteries supplying the placenta. Other fetal membranes include 1) nonvillous chorion (chorion laeve); there is evidence supporting both an absorptive and synthetic role for trophoblast of the chorion laeve; 2) yolk sac, which is unusual in that a secondary yolk sac is formed. The yolk sac has both synthetic and absorptive functions in early gestation; and 3) amnion; amniogenesis in haplorhines occurs by cavitation.

Animals↗
PubMedDate not supplied

Use of the NCTR Operant Test Battery in nonhuman primates.

A battery of behavioral tasks, designed to monitor complex "cognitive" functions in nonhuman primates, has been in use for several years at the National Center for Toxicological Research. Subjects performing in this Operant Test Battery (OTB) work for food reinforcers and correct performance in each task contained in the OTB is thought to depend upon a relatively specific brain function. The specific tasks and the functions that they are thought to model are: delayed matching-to-sample (DMTS), short-term memory and attention; incremental repeated acquisition (IRA), learning; temporal response differentiation (TRD), time perception; progressive ratio (PR), motivation; and conditioned position responding (CPR), color and position discrimination. Data from various studies indicate that, in general: 1) OTB responding between subjects follows a normal or near-normal distribution; 2) performance in one task does not correlate very highly with performance in any of the other tasks; 3) females acquire correct OTB responding more rapidly than do males; and 4) the profile of disruption of task performance by acute drug administration varies depending upon drug class.

Animals↗
PubMed2006

In vivo spermatotoxic effect of chromium as reflected in the epididymal epithelial principal cells, basal cells, and intraepithelial macrophages of a nonhuman primate (Macaca radiata Geoffroy).

OBJECTIVE: To understand, through a simulation experiment in a nonhuman primate model, the potential in vivo spermatotoxic toxic effect of hexavalent chromium (CrVI) in men who are occupationally or environmentally exposed to it. DESIGN: Controlled laboratory study. SETTING: Research laboratory in a department of endocrinology in a university in India. ANIMAL(S): Male bonnet monkey, Macaca radiata Geoffroy. INTERVENTION(S): Monkeys were exposed ad libitum to 100, 200, and 400 ppm CrVI, dissolved in drinking water, for a chronic period of 180 days. MAIN OUTCOME MEASURE(S): Examination of epididymis with a transmission electron microscope and assessment of the effect of CrVI in terms of accumulation of sperm-derived lipofuscin (LF) material in the principal cells, basal cells, and intraepithelial macrophages of the epithelium. RESULT(S): The abundance of basal cells and intraepithelial macrophages and the content of LF material in these cell types increased. The principal cells phagocytosed from the lumen the dead sperm resulting from CrVI exposure and processed them partially into LF material, which was acquired by the basal cells and intraepithelial macrophages and processed further. The LF material-laden basal cells and intraepithelial macrophages appeared to leave the epithelium, accompanied by recruitment of fresh basal cells and intraepithelial macrophages. CONCLUSION(S): Occupational or environmental exposure to CrVI, as would occur in the tannery, soap, and other industries in developing and underdeveloped countries, can be toxic in vivo to spermatozoa.

Animals↗
PubMed1991

A system to acquire and record physiological and behavioral data remotely from nonhuman primates.

We describe an integrated system to record physiological and behavioral variables from nonhuman primates in social groups. The system records data simultaneously from two animals in family groups of five. It synchronizes behavioral and physiological data within 16 ms, either on-line or from recordings. Behavioral data are entered by trained observers on-line or from videotape. Recordings of physiological data are produced on-line as stripchart records, tape recordings on the audio channels of video cassettes, and magnetic disk files. The physiological data include two arterial blood flows, arterial blood pressure and heart rate. The data are transmitted from freely behaving animals to a central site via radio telemetry. The infrared link controls the radio transmitter and physiological signal processing electronics, as well as two sources of drugs for each animal. All of the electronics are contained in a small, light backpack that can be worn by either male or female baboons.

Animals↗
PubMed1995

Red cell polymorphisms in nonhuman primates: a review.

Development as well as current status of the knowledge of nonhuman primate blood groups are discussed together with some practical implications of the red cell antigen polymorphisms in anthropoid apes, Old and New World monkeys and prosimians. Recent data on molecular biology and genetics throw light on the relationships among simian and human red cell antigens and their evolutionary pathways.

Animals↗
PubMed1998

Gastrointestinal tumors observed in nonhuman primates at the German primate center.

Twenty-six gastrointestinal tumors were observed in twenty-three nonhuman primates during routine necropsies at the German Primate Center, Göttingen. The majority (15 cases) were colorectal mucoid adenocarcinomas in cotton-top tamarins (Saguinus oedipus), which in two animals were associated with gastric adenomas. Three cases of small intestinal mucoid adenocarcinomas occurred in common marmosets (Callithrix jacchus). One colonic leiomyoma was observed in a dwarf galago (Galagoides demidovii) and another one in a cotton top tamarin. Singular findings were a tubular adeno-carcinoma of the ileo-caecal valve in a saddle-backed tamarin (Saguinus fuscicollis) and a lymphosarcoma of jejunum, ileum, and colon in another saddle-backed tamarin. Multiple tubular adeno-carcinomas of the colonic diverticles occurred in an aged rhesus monkey (Macaca mulatta). The findings are discussed in comparison to the situation in man.

Animals↗
PubMed1979

Rearing of conventional and gnotobiotic nonhuman primates (Pan troglodytes, Papio cynocephalus, Saguinus nigricollis).

Rearing techniques for conventional and gnotobiotic nonhuman primates are described. Up to four months of age there was no significant difference in weight gain between conventionally and gnotobiotically reared chimpanzees or baboons. After four months, gnotobiotic chimpanzees exceeded their conventional counterparts in weight gain, whereas conventional baboons showed higher weight gain than gnotobiotic baboons. Gnotobiotic chimpanzees and baboons had significantly lower absolute numbers of neutrophils than their conventional counterparts, but the absolute numbers of lymphocytes were not different. The gnotobiotic rearing of marmosets is also reported.

Animal Feed↗
PubMed2003

Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation.

Anti-CD154 variably prolongs allograft survival in nonhuman primates. Rodent studies suggest that adding pretransplant donor-specific transfusion (DST) and/or rapamycin to anti-CD154 improves survival. The CD154-specific Ab IDEC-131 was tested alone and in combination with rapamycin for its ability to inhibit rhesus MLRs. The ability of the Ab to block endothelial activation was also assessed. IDEC-131 was then tested alone and in combination with DST and/or rapamycin for its ability to prevent rejection of full-thickness, MHC-mismatched rhesus skin allografts. Animals were monitored for donor-specific hyporesponsiveness by MLR and alloantibody determination. IDEC-131 modestly inhibited rhesus MLRs and inhibited CD154-dependent endothelial cell activation. Rapamycin combined with IDEC-131 additively inhibited MLRs. IDEC-131 modestly prolonged allograft survival when compared with no treatment, rapamycin alone, or DST plus rapamycin. Adding DST to IDEC-131 did not prolong survival beyond IDEC-131 alone. IDEC-131 plus rapamycin was effective in prolonging graft survival, although animals had episodes of acute rejection before graft demise. Therapy with IDEC-131, rapamycin, and DST induced long-term allograft survival without intermittent acute rejection. However, no evidence for MLR inhibition was seen, and most animals eventually developed alloantibody. All animals ultimately rejected their grafts after drug withdrawal. IDEC-131 modestly prolongs rhesus skin allograft survival. Rapamycin and rapamycin plus DST improves the efficacy of IDEC-131 in prolonging allograft survival. IDEC-131, rapamycin, and DST are a promising combination for clinical evaluation in allotransplantation.

Administration, Oral↗
PubMed1979

A rapid procedure for shortening canine teeth of nonhuman primates.

A modified pulp cap procedure was utilized to shorten canine teeth of nonhuman primates. A temporary cap was made by cutting the tooth with a diamond-faced cutting disc, making a conical cavity in the tooth with a carbide dental burr, and filling the cavity with a rapid-hardening filler material. A permanent pulp cap was made by repeating the above technique, making three anchor holes, connecting the holes with a furrow, and capping with quick-setting dental restorative material or amalgam. These procedures provided a simple, rapid and uncomplicated alternative to canine tooth extraction.

Animals↗
PubMed1982

Gastrointestinal neoplasms in nonhuman primates: a review and report of eleven new cases.

Reported gastrointestinal neoplasms in nonhuman primates are reviewed, and the clinical and pathologic features of 11 new cases are described. The 11 monkeys had a total of 12 malignant gastrointestinal neoplasms; one had two primary carcinomas, one in the colon and one in the duodenum. Ten of the 12 tumors were adenocarcinomas: two in the duodenum, one in the jejunum, four in the distal ileum or region of the ileocecal valve and three in the large intestine. The remaining two lesions were a histiocytic lymphosarcoma of the stomach and a poorly differentiated sarcoma of the cecum. The 11 animals included nine Macaca mulatta, one Saguinus oedipus oedipus and one Galago crassicaudatus. All were adults and most were aged. There were six females and five males. Clinical signs included progressive weight loss, a palpable abdominal mass and intermittent diarrhea. Grossly, five of the adenocarcinomas were annular, and constricted the intestinal lumen. Microscopically, the carcinomas generally were well differentiated, and two produced mucin in quantities warranting the modifier "mucinous" adenocarcinoma. All tumors were locally invasive and six of nine monkeys with carcinomas had metastases, with the regional lymph nodes the principal site of involvement.

Adenocarcinoma↗
PubMed1980

Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates.

The carcinogenic potential of cycasin and methylazoxymethanol (MAM) acetate was investigated in nonhuman primates. Old-world monkeys (rhesus, cynomolgus, and African green monkeys) received cycasin and/or MAM acetate by oral or ip routes up to 11 years. Eighteen monkeys survived longer than 2 months after initiation of treatment with cycasin (50-75 mg/kg) or MAM acetate (1.5-3.0 mg/kg) given orally 5 days/week; 9 of the animals were necropsied. Histopathologic examination of a liver tumor from 1 of these monkeys revealed well-differentiated hepatocellular carcinoma. A second monkey had multiple tumors, including hepatocellular carcinoma, intrahepatic bile duct adenocarcinoma, renal carcinoma and adenomas, and adenomatous polyps of the colon. Although liver tumors were not observed in the other monkeys, all but 1 monkey had hepatic lesions such as toxic hepatitis and cirrhosis. These monkeys had received cycasin and/or MAM acetate for an average of 57 months (range, 2-133 mo). A group of 10 monkeys received MAM acetate by weekly ip injections (3-10 mg/kg). Six of these animals developed tumors after receiving an average of 6.14 g (range, 3.58-9.66 g) of MAM acetate for an average of 75 months (range, 50-89 mo). Four of the monkeys developed hepatocellular carcinomas, and 2 had multiple primary tumors including hepatocellular carcinomas, renal carcinomas, squamous cell carcinomas of the esophagus, and adenocarcinomas of the small intestine. Our results showed that long-term administration of cycasin and/or MAM acetate by oral and ip routes was hepatotoxic and carcinogenic in old-world monkeys.

Animals↗
PubMed1982

Gastrointestinal neoplasms in nonhuman primates: a review and report of eleven new cases.

Reported gastrointestinal neoplasms in nonhuman primates are reviewed, and the clinical and pathologic features of 11 new cases are described. The 11 monkeys had a total of 12 malignant gastrointestinal neoplasms; one had two primary carcinomas, one in the colon and one in the duodenum. Ten of the 12 tumors were adenocarcinomas: two in the duodenum, one in the jejunum, four in the distal ileum or region of the ileocecal valve and three in the large intestine. The remaining two lesions were a histiocytic lymphosarcoma of the stomach and a poorly differentiated sarcoma of the cecum. The 11 animals included nine Macaca mulatta, one Saguinus oedipus oedipus and one Galago crassicaudatus. All were adults and most were aged. There were six females and five males. Clinical signs included progressive weight loss, a palpable abdominal mass and intermittent diarrhea. Grossly, five of the adenocarcinomas were annular, and constricted the intestinal lumen. Microscopically, the carcinomas generally were well differentiated, and two produced mucin in quantities warranting the modifier "mucinous" adenocarcinoma. All tumors were locally invasive and six of nine monkeys with carcinomas had metastases, with the regional lymph nodes the principal site of involvement.

Adenocarcinoma↗
PubMed1977

Computer program for maintenance of individual animal records in a nonhuman primate colony.

A computer program was developed to maintain animal records for a nonhuman primate colony used in research. The program was designed for use with an existing laboratory notebook system. The computer program identifies each notebook entry containing information about each animal and keeps other information, including animal name, sex, species, projects to which the animal is assigned, location of the animal, dates and body weights. The program is interactive and easy to use. Information stored in the system is readily accessible to all investigators using the animals. In 17 months of use, 1382 master file entries were developed for 113 monkeys.

Animals↗