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[The monochord, its path from Pythagorean musicology to testing the upper auditory tone limit. Pictures from the history of otorhinolaryngology, represented by instruments of the Ingolstadt German Medical History Museum].

The monochord consists of a frame with a string or pianowire stretched across it. The length of the wire can be varied by a movable bridge. The string or wire is plucked, hit, or bowed, producing transverse vibrations. In this mode the number of vibrations per second is dependent on the length, tension, and thickness of the string. In ancient times, the Pythagoreans used such an instrument to study the natural laws underlying musical intervals; in the 19th century it also served for various other physical experiments. F. A. Schulze, physicist in Marburg, Germany, introduced the monochord for testing the upper tone limit in 1908. He produced longitudinal vibrations by rubbing the wire with a piece of felt moistened with benzol. The vibrations of this mode are dependent only on the length of the wire and the elasticity of the material; they are independent of its tension and thickness. H. J. L. Struycken, otologist in Breda, Holland, presented an improved type of monochord in 1910 which also allowed testing bone conduction. K. L. Schaefer, physiologist in Berlin, modified Struycken's instrument in such a way that bowing the wire or hitting it with a small hammer also produced transverse vibrations. This enlarged the range of tones in the lower region. In this combined version the monochord was an indispensable piece of hearing testing equipment before the era of electronic audiometers. The technical development and clinical application of the monochord is described in detail.

Audiometry, Pure-Tone↗

Medical museums.

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Classification↗

Evaluating bacterial pathogen DNA preservation in museum osteological collections.

Reports of bacterial pathogen DNA sequences obtained from archaeological bone specimens raise the possibility of greatly improving our understanding of the history of infectious diseases. However, the survival of pathogen DNA over long time periods is poorly characterized, and scepticism remains about the reliability of these data. In order to explore the survival of bacterial pathogen DNA in bone specimens, we analysed samples from 59 eighteenth and twentieth century individuals known to have been infected with either Mycobacterium tuberculosis or Treponema pallidum. No reproducible evidence of surviving pathogen DNA was obtained, despite the use of extraction and PCR-amplification methods determined to be highly sensitive. These data suggest that previous studies need to be interpreted with caution, and we propose that a much greater emphasis is placed on understanding how pathogen DNA survives in archaeological material, and how its presence can be properly verified and used.

Adult↗