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A threshold concentration of hexamethylenetetramine salt of 2-chloroethyl-phosphonic acid by influence on water taste is 1 mg/l. This substance slightly accumulates in animal body. Its maximum permissible concentration in water is 1 mg/l.
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Porophor P-18-S LD50 is 712.5 mg/kg. This substance is not characterized by cumulative or irritating properties. It has an expressed neurotropic and allergenic effects, can induce anemia and leukocytosis in animals. Work with this substance is allowed on condition of eye and respiratory route protection. Its MAC for working environment is 3.08 mg/m3.
It was shown in previous studies that fixed ratio combinations of agonists with competitive antagonists emulate partial agonists and, therefore, mediate submaximal concentration-effect (E/[A]) curves. A linear plot was obtained by plotting the relative height (H) of these submaximal curves against phiH, where phi=[antagonist]/[agonist]. In this study, it was shown that in an agonist-effector system comprising a possible threshold value, the use of fixed ratio agonist-competitive antagonist concentrations (artificial partial agonists) induces E/[A] curves of different heights which allows one to quantify the threshold value. A nonlinear parabolic-like plot may be obtained when a threshold value is present in an agonist-effector system. By quantifying the threshold value, the nonlinear plot was converted to a linear plot from which the apparent affinity (KA) and an efficacy related parameter (eES) of an agonist could be estimated. The practical applicability of the method was shown by applying the method to E/[A] curves obtained for agonists (noradrenaline and acetylcholine) obtained in the presence and absence of increasing concentrations of their respective competitive antagonists on different effectors.
Air concentrations of phenol, formaldehyde and ammonia related to the contents of free phenol, formaldehyde in raw material, and solidifying agent-urotropine in bakelite. Due to the solubility of phenol and formaldehyde, in the manufacture process, water was added to lower contents of phenol and formaldehyde in bakelite, and content of urotropine was reduced in bakelite sand presceription to lower air concentrations of phenol, formaldehyde and ammonia. As contents of phenol and formaldehyde in bakelite reduced to 4.9% and 0.037% from 6.32% and 0.062%, respectively, air concentrations of phenol, formaldehyde and ammonia lowered to 0.61 mg/m3, 0.69 mg/m3, and 5.1 mg/m3 from 2.94 mg/m3, 1.72 mg/m3, and 12.9 mg/m3, respectively, and incidence rate of skin disease in the employees of the workplace decreased to zero from 80.2%. It is recommended that a hygienic standard for allowable concentration of mixed toxic chemicals in the workplace air for bakelite manufacturing be formulated as soon as possible.