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Relationships between grief and family system characteristics: a cross lagged longitudinal analysis.

The present study explored the question of whether the grief process affects the characteristics of relationships within the family system or, alternatively, whether family characteristics affect the experience of grief symptoms. Sixty-one people who had recently experienced the death of a parent (82%) or spouse (18%) completed a questionnaire to assess their current grief symptomatology and characteristics of the relationships within their family 4-5 weeks after the death, and again six months later. Results from cross-lagged panel analyses suggested that increased expression of family affect, family cohesion, and both higher total Family Environment Scale and Family Assessment Measure Version III General scores were predictors of fewer grief symptoms over time. Overall, these results suggest that knowledge of a variety of aspects of a family's structure and process shortly after a death may help predict the later grief of the loss of a loved one.

Adaptation, Psychological↗

A longitudinal analysis of nursing home placement for dependent elders cared for by spouses vs adult children.

Five-wave panel data from 531 informal caregivers and frail elders were analyzed using an event history framework to identify how changes in the caregiving situation are related to nursing home placement. The results indicate that the predictors of placement differ substantially for elders cared for by spouses vs those cared for by adult children. In addition, the findings suggest dramatically different descriptions of the caregiving role over time for the two groups of caregivers. There were differences not only in the conditions under which caregiving ends, but also apparent differences in when caregiving begins and how it is perceived by the caregiver. Differences in the probability of placement of elders cared for by spouses vs adult children are interpreted within the framework of these contextual differences in the caregiving role.

Adolescent↗

Learned helplessness, test anxiety, and academic achievement: a longitudinal analysis.

The stability of individual differences in test anxiety and learned helplessness over a 2-year period and their relation to concurrent and future school achievement were examined. Several issues regarding the assessment of learned helplessness are also addressed. 82 children were administered measures of test anxiety and helplessness in the third grade and again in the fifth grade. Teachers also provided reports of learned helpless and mastery-oriented behaviors at these 2 grade levels. It was found that: (a) both self-report and teacher-report measures of helplessness were stable over the 2-year period; (b) helplessness in the third grade was related to achievement test scores in the fifth grade; and (c) teacher reports may be a viable means of identifying helplessness. These findings are discussed in terms of cognitive developmental changes in children's understanding of effort and ability, and their implications for the assessment of learned helplessness are outlined.

Achievement↗

Personality and self-reported delinquency: a longitudinal analysis.

This study assessed the personality factors associated with self-reported delinquency. Respondents were 282 14-year-olds who were traced for follow-up 2 years later. The follow-up success rate was more than 80%. In line with previous work which has adopted a trait personality perspective to understanding antisocial and delinquent behaviours, it was predicted that psychoticism, extroversion, and low self-esteem as measured at Time 1 would be significant predictors of self-reported delinquency at Time 2. However, the results of structural equation modelling suggested that the three personality variables explained just over 16% of the variance of delinquency at Time 1, but only 6.61% of the variance of delinquency at Time 2. Alone, psychoticism explained 15.3% of the variance of delinquency at Time 1, but only 4.36% of the variance of delinquency at Time 2. Possible explanations for these findings are discussed and some suggestions for future research are made.

Adolescent↗

A longitudinal analysis of stress process among mothers of infants.

A model of stress process among mothers of infants was retested. In that model, stressors (work status or infant difficultness) influence maternal identity through perception of stress. Also, maternal identity may be buffered from stressor effects by health-promotive lifestyle. This model previously received partial support in a one-panel mail survey. The present study reports maternal outcomes from a 6-month follow-up of the original sample. One hundred nineteen (69%) mothers of infants aged 8-20 months participated in the follow-up study. Despite subject attrition, most findings from the original study were replicated in this study. As before, work status and perceived stress each contributed to predicting identity. Health-promotive lifestyle acted directly, not as a buffer, on maternal identity. When extraneous influences were controlled, neither perceived stress nor health-promotive lifestyle was significantly correlated across a 6-month period.

Adult↗

Ethnic differences in self-rated health among older adults: a cross-sectional and longitudinal analysis.

The objectives of this study were to examine whether self-rated health differs among older adults of different ethnic backgrounds and to explore what factors may account for potential differences. The study was based on the 1983 and 1996 waves of the Aging in Manitoba study. A self-report measure of ethnic background was used to categorize participants into four groups: British/Canadian, Northern/Central European, Eastern European, and Other. In both 1983 and 1996, older Eastern European adults had significantly reduced odds of rating their health as good or excellent relative to British/Canadian adults. Controlling for demographic variables, socioeconomic status, language spoken, and health status attenuated but did not eliminate the difference. Global, subjective ratings of health are frequently used to measure health. The ethnic differences found here suggest, however, that ratings may be influenced by cultural factors, which may warrant some caution in making comparisons across ethnic groups.

Aged↗

Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis.

OBJECTIVE: To examine the relation between serum insulin-like growth factor I (IGF-I) levels and both incident and progressive radiographic knee osteoarthritis (OA) in the Framingham Osteoarthritis Study. DESIGN: Subjects had bilateral weight-bearing, anterior-posterior knee radiographs performed in 1983-1985 and again in 1992-1993. IGF-I levels were measured from blood specimens obtained in 1988-1989 by a competitive binding radio-immunoassay (RIA) after separation with octadecasilyl-silica cartridges of serum IGF-I from binding proteins. Participants without baseline radiographic OA [Kellgren and Lawrence grades (K&L) = 0-1] were classified as having incident disease if they had K&L > or = 2 grades at follow-up. Progressive OA was defined as an increase in K&L score of > or = 1 in knees with baseline OA (K&L > or = 2). All analyses were knee-based and sex-specific. We examined IGF-I tertiles in relation to the risk of incident and progressive radiographic OA separately, adjusting for age, body mass index (BMI), and baseline K&L score, and used generalized estimating equations to adjust for the correlation between fellow knees. RESULTS: Four hundred and forty-one participants had knee radiographs and serum IGF-I levels measured. No associations were found for serum IGF-I levels and incident [women: OR = 0.9 (0.6-1.7), men OR = 1.2 (0.6-2.6)] or progressive [women OR = 0.9 (0.6-1.6), men OR = 0.9 (0.3-3.0)] radiographic knee OA in either sex. Neither did we observe any association between IGF-I and worsening of individual radiographic features of OA (i.e., osteophyte growth and joint space loss). CONCLUSION: In summary, this longitudinal study did not demonstrate any association of serum IGF-I and incident or progressive radiographic knee OA. Further studies are needed to clarify the role of IGF-I in OA.

Case-Control Studies↗

A longitudinal analysis of maternal aggression in Rockland-Swiss albino mice.

Female Rockland-Swiss albino mice were treated for aggression during 6 successive pregnancies and lactation periods or until they ceased to re-mate. Fighting behavior was limited only to the lactation phase of each reproductive cycle. Although most animals exhibited fighting during every lactation period they completed, some exhibited fighting in some lactation periods but not in others. The intensity of aggression, as measured by the time spent fighting, was highest during the beginning of each lactation period and declined by the end of each period. Moreover, the intensity of aggression increased across the first 3 lactation periods and then declined on later lactation periods to a point below initial levels. Finally, the fighting behavior exhibited by multiparous animals was not due simply to previous fighting experience in that some multiparous mice exhibited postpartum aggression on the 6th lactation period in the absence of fighting experience during earlier lactation periods.

Aggression↗

Salty taste acceptance by infants and young children is related to birth weight: longitudinal analysis of infants within the normal birth weight range.

BACKGROUND: Birth weight and sodium intake are both associated with risk for hypertension. It is not known whether birth weight influences response to salty taste. OBJECTIVE: To assess the relationship between birth weight and salty taste acceptance of infants and young children. DESIGN: Acceptance of salty taste was assessed at 2 (n = 80) and 6 (n = 76) months in infants (birth weight >2.5 kg) enrolled in a prospective cohort study. Acceptance was expressed as proportional intake following 1-min ingestion tests with water and salt solutions (0.17 and 0.34 mol/l NaCl, in water). Birth weight was obtained by maternal report. Questionnaires completed by mothers and food-ranking procedures performed by children evaluated salt liking and preference in a subset (n = 38) of subjects at preschool age (36 or 48 months). SETTING: Nonprofit basic research institute in Philadelphia, PA, USA. RESULTS: Regression analysis revealed significant negative associations between birth weight and acceptance of salty taste at 2 months (0.17 mol/l, P < 0.0001; 0.34 mol/l, P < 0.01) but not at 6 months. Relationships were not affected by adjustment for potential confounders. In preschoolers, greater liking of (P < 0.05) and preference for (P < 0.01) salty foods was associated with lower birth weight in simple, but not adjusted, models. CONCLUSION: Measures related to salty taste preference were inversely related to birth weight over the first 4 years of life. Additional studies should substantiate these findings and explore whether early response to salty taste predicts future sodium intake, blood pressure, or other public health-related outcomes. SPONSORSHIP: National Institutes of Health (DC 00882).

Birth Weight↗

Contrast sensitivity in Alzheimer's disease: a 1-year longitudinal analysis.

Spatial contrast sensitivity was evaluated in normal elderly adults and a group with probable Alzheimer's disease (AD) in three sessions over a 1-year period. There was evidence of a reduction over 1 year in contrast sensitivity for static, high spatial frequencies in both groups of subjects. A striking difference between the subject groups was observed in their response to flickered stimuli. Although normal elderly adults yielded good stability in sensitivity for both static and flickered spatial frequencies over the 1 year, AD patients experienced a significant decline in response to flickered (7.5 Hz) stimuli. The significant decline in sensitivity for low contrast, high temporal events in AD patients is consistent with reports of cell loss at the retinal and cortical levels of the magnocellular (M) channel in AD. Thus, the spatial contrast sensitivity change in AD may reflect a more rapid loss of cells specifically in the M channel over a 1-year period.

Adult↗

Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys.

A model is proposed in which a neurovirulent, microglial-passaged, simian immunodeficiency virus (SIV) is used to produce central nervous system (CNS) pathology and behavioral deficits in rhesus monkeys reminiscent of those seen in humans infected with human immunodeficiency virus (HIV). The time course of disease progression was characterized by using functional measures of cognition and motor skill, as well as neurophysiologic monitoring. Concomitant assessment of immunological and virological parameters illustrated correspondence between impaired behavioral performance and viral pathogenesis. Convergent results were obtained from neuropathological findings indicative of significant CNS disease. In ongoing studies, this SIV model is being used to explore the behavioral sequelae of immunodeficiency virus infection, the viral and host factors leading to neurologic dysfunction, and to begin testing potential therapeutic agents.

Animals↗

Prenatal alcohol exposure and preschool physical growth: a longitudinal analysis.

This report examines the effects of fetal alcohol exposure on size and growth in an urban cohort followed prospectively through early childhood. Indices of prenatal drinking were related to measurements of weight, stature (length), and head circumference obtained at birth and during five subsequent in-home assessments. Small but statistically significant relationships were detected between short-term recall estimates of drinking during pregnancy and weight and length at birth. The strength of these relationships diminished during the preschool assessments. However, estimates of catch-up growth associated with alcohol exposure were not statistically significant. With the exception of a single case with a profile of signs characteristic of fetal alcohol syndrome, an adverse effect of prenatal alcohol exposure on head circumference was not indicated.

Alcohol Drinking↗

Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis.

The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA.

Adolescent↗

[Survival rate of drug addicts. Longitudinal analysis of 530 outpatient clients for the admissions years 1969 to 1977].

The mortality amongst 530 out-patient drug-addicts, dependent mainly on opiates and being first registered between 1969 and 1977, was analysed. This grand total (27% females, median age 19 years, 73% males, median age 20 years) was subdivided into three groups with variable observation follow-up according to the time-shift of consumed main drugs. Until the demarcation day 31 December 1982 81 clients (15%) died. Mortality rates were determined according to the death cases for the three groups. In comparison with the mortality of the age-matched whole population male heroin addicts had a twelve-fold and females a 29-fold death rate. Survival curves of all three groups showed a rather linear course indicating a surprisingly long period of danger. For optimisation of advice methods and for treatment of drug-addicts long-term analyses of larger unselected groups involving further parameters are required.

Adolescent↗

Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia.

We studied the evolution and compartmentalization of nef/long terminal repeat (nef/LTR)-deleted human immunodeficiency virus type 1 (HIV-1) from a long-term survivor who developed HIV-associated dementia (HIVD). Analysis of sequential blood-derived HIV-1 isolated before and during HIVD revealed a persistent R5X4 phenotype and a progressive loss of nef/LTR sequence; in contrast, HIV-1 present in cerebrospinal fluid during HIVD had an R5 phenotype, distinct nef/LTR sequence of unique deletions and additional nuclear factor- kappa B sites and specificity factor-1 sites, and enhanced transcriptional activity, compared with the blood-derived isolates. Thus, nef/LTR-deleted HIV-1 strains may undergo compartmentalized evolution in long-term survivors and cause neurologic disease.

AIDS Dementia Complex↗

Personal and environmental risk factors as predictors of alcohol use, depression, and treatment-seeking: a longitudinal analysis of late-life problem drinkers.

We examined how personal risk factors (prior functioning, male, unmarried, early onset of drinking problems, and avoidance coping) and environmental risk factors (negative life events, chronic stressors, and friends' approval of drinking) predicted changes in older problem drinkers' (N = 659) adaptation over a 1-year interval. Personal risk factors independently predictive of poorer outcomes included poorer prior functioning, being male, and more use of avoidance coping strategies. Of environmental risk factors, negative life events, chronic health and spouse stressors, and having more friends who approved of drinking were independent predictors of poorer follow-up functioning and treatment seeking. Interactions between personal and environmental risk factors helped predict subsequent alcohol consumption and treatment seeking. For example, lighter drinkers were more likely than heavier drinkers to curtail alcohol use in response to new health events; friends more strongly influenced the treatment seeking of unmarried problem drinkers and individuals who used more avoidance coping strategies.

Adaptation, Psychological↗

Longitudinal analysis of herpes simplex virus-specific CD4+ cell clonotypes in infected tissues and blood.

BACKGROUND: Genital infection by herpes simplex virus (HSV)-2 offers a unique model for study of the effects of a remitting and exacerbating infection on the survival and persistence of antigen-specific T cells. METHODS: We used complementarity-determining region 3 (CDR3) length analysis to examine the complete T cell receptor (TCR) beta -chain repertoire in skin-lesion biopsy samples from subjects with genital herpes. RESULTS: We found that herpetic skin lesions consistently demonstrated oligoclonal CDR3 DNA length distribution, indicating the presence of T cell expansions. Sequence analysis of representative HSV-specific lesional CD4(+) cell clones and TCR beta -variable (TCRBV) sequencing confirmed that the oligoclonal expansions were largely related to HSV-specific T cell proliferation. To assess the persistence of HSV-specific CD4(+) cells that localize to genital lesions, we developed a sensitive and highly specific clonal tracking technique using a combination of TCRBV-specific polymerase chain reaction, followed by liquid hybridization with clonotype-specific probes. CONCLUSION: Two different patterns of clonal persistence were observed. Some long-lasting clones appear to home to different epithelia, such as skin and genital mucosa, and to circulate in the peripheral blood, whereas others detected in lesions were absent or very rare in the peripheral blood.

Animals↗

Longitudinal analysis of deciduous tooth emergence: IV. Covariate effects in Japanese children.

Emergence of the deciduous teeth is generally considered to be robust to moderate environmental insults, malnutrition, and disease. Consequently, deciduous tooth emergence has been used to assess growth and development and for age estimation in children. In this paper, we examine the way in which nutritional status and other covariates affect deciduous tooth emergence in a sample of 114 Japanese children born in Tokyo in 1914 and 1924. Parametric survival analysis was used to quantify the effects of nutritional status, breastfeeding behavior, and sex on the hazard of deciduous tooth emergence. Children of poor nutritional status exhibited significantly delayed emergence of all deciduous teeth, with effects that ranged from 14-29% increases in mean emergence times. Children of medium nutritional status exhibited increases in mean emergence times of 5-9% for the canines and lower molars, and 13-17% for the incisors. Partial breastfeeding had no effect on tooth emergence, but children who were not breastfed at all showed delayed emergence of the upper incisors. No significant sex differences in emergence were found. The findings contradict the idea that moderate malnutrition has little effect on deciduous tooth emergence. Furthermore, nutritional differences may account for some of the observed differences among populations in the timing of tooth emergence.

Breast Feeding↗