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Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

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At least 451 records · Page 25Linked to original sources
PubMed2003

Intravenous pulses of methylprednisolone for systemic lupus erythematosus.

BACKGROUND: Intravenous (IV) pulses of methylprednisolone (MEP) commonly are used to treat severe manifestations of systemic lupus erythematosus (SLE). However, despite wide use of this treatment the best dose, timing, and the situations in which this treatment should be used remain largely anecdotal. AIM: To review the mechanisms of action and evidence for clinical use of IV MEP in the treatment of SLE. METHOD: The literature on MEP use in SLE from 1966 to 2002, using PubMed from the National Library of Medicine, was reviewed. RESULTS: As with other modes of corticosteroid administration, IV MEP has significant anti-inflammatory and immunosuppressive actions. These actions have been shown to be effective in treating SLE in clinical trials, for lupus nephritis. The studies are mainly uncontrolled and retrospective. Long-term observations from a few double-blind prospective trials suggest that monthly pulses of MEP, in addition to IV cyclophosphamide, may be useful. Pulse MEP is beneficial for several serious manifestations of SLE, such as neuro-psychiatric lupus, pulmonary hemorrhage, severe blood dyscrasias, cardiomyopathy, and vasculitis. However, significant side effects may occur, mostly infections, which are worse in patients with hypoalbuminemia. CONCLUSION: IV pulses of MEP rapidly immunosuppress patients with organ and/or life-threatening manifestations of SLE. However, the gold standard 1 g/day for 3 consecutive days is associated with significant infectious complications and lower doses may be just as useful.

Anti-Inflammatory Agents↗
PubMed2002

Supervisory power and its influence on staff members and their customers.

The authors examined supervisors' selective use of legitimate, reward, coercive, referent, and expert powers and these power bases' influence on two outcomes: (a) employee perception of organizational support and (b) employee willingness to engage in service recovery activities with the customer. The authors found that the supervisor's use of expert, referent, and reward powers were positively related to perceived organizational support and that the use of coercive power was important in contributing to service recovery initiatives, particularly with regard to the employee's empathetic presentation to the customer.

Administrative Personnel↗
PubMed2001

Combinatorial approaches to formulation development.

This review describes the use of combinatorial methods for the development of drug formulations. Combinatorial methods are applied to find solutions to various formulation problems, including drug solubilization, controlled release, oral drug administration, and others. Various methods are described, including the synthesis of carrier libraries, high-throughput screening and computational analysis, which are used during the formulation development process, starting from initial assays through the optimization of formulation composition, to the optimization of the manufacturing process. This review also describes an integrated approach to drug formulation development using libraries of block copolymers as the drug carriers.

Animals↗
PubMed1975

The Twin Cities biomedical consortium.

Twenty-eight health science libraries in the St. Paul-Minneapolis area formed the Twin Cities Biomedical Consortium with the intention of developing a strong network of biomedical libraries in the Twin Cities area. Toward this end, programs were designed to strengthen lines of communication and increase cooperation among local health science libraries; improve access to biomedical information at the local level; and enable the Consortium, as a group, to meet an increasing proportion of its members' needs for biomedical information. Presently, the TCBC comprises libraries in twenty-two hospitals, two county medical societies, one school of nursing, one junior college, and two private corporations.

Information Services↗
PubMed1988

The marketing audit: a new perspective on library services and products.

A marketing audit enables a library to look at audiences, services, and products with a structured approach. The audit can be used to assess operations and to provide a framework for ongoing decision making, evaluation, and long-range planning. An approach to the audit process is presented and its application is demonstrated in a case study featuring the American Hospital Association Resource Center.

American Hospital Association↗
PubMed1974

Nonprint media as information resources: software and hardware.

Nonprint materials are rapidly becoming important information and learning resource materials for the health science library. Because of their long experience in organizing and utilizing informational materials, libraries represent highly appropriate repositories and sites for utilization of these new materials. Nonprint materials differ from printed materials in several ways, and this may account for the resistance of some librarians to dealing with them. One of the most important differences is that a machine must serve as mediator between the information and the user of nonprint materials. Also, the great variety of formats and machines can confuse the novice. The librarian must learn to deal with these differences in a creative way through a process of cooperation and collaboration with media and educational technology specialists.

Attitude↗