Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “LIPOSARCOMA”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 451 records · Page 25Linked to original sources
PubMed1999

Distant metastasis of liposarcoma to the dura and skull: a case report.

A case of metastatic liposarcoma of both skull and brain originating from the lower extremity is described. A 44-year-old male underwent removal of a myxoid type liposarcoma in his left upper thigh and a second operation for local recurrence. A metastatic liposarcoma was also discovered in the mediastinum and treated by radiotherapy. Six years after the initial onset, he presented with progressive consciousness disturbance, motor aphasia, right hemiparesis and subcutaneous swelling in the left frontal region. Neuroimaging showed a large tumour extending both intracranially and extracranially across the eroded skull. The intracranial portion of the tumour had invaded the frontal lobe. The tumour was subtotally removed. The operative findings suggested that the tumour had metastasized to the dura mater or the skull initially, and invaded the surrounding tissues. The histological appearance was the same as those of the previous tumours.

Adult↗
PubMed2000

[Liposarcoma in the area of the head-neck].

Liposarcoma is the second most common soft tissue sarcoma occurring in adults, though it rarely involves the head and neck region. Fewer than 100 such cases have been described in the literature. We present two additional cases and a review of the literature. Prognosis is mainly determined by histologic grade. A high incidence of local recurrence is typical of all subtypes. Complete surgical excision is the most effective treatment. In the head and neck region the extent of the excision is limited by the proximity of neurovascular structures. The benefits of adjuvant radiotherapy in head and neck liposarcoma remain uncertain. Studies on liposarcoma at other sites indicate that addition of radiotherapy to surgery may result in longer local recurrence-free survival, though without improvement of overall survival.

Adult↗
PubMed2000

[Retroperitoneal tumors. Retroperitoneal myxoid liposarcoma. Report of a new case].

OBJECTIVE: To describe an additional case of a large retroperitoneal liposarcoma. METHODS/RESULTS: A case of a large retroperitoneal liposarcoma in a young male is presented. Treatment was by surgery. The clinical and pathological features, diagnosis, course and treatment of this lesion are discussed. CONCLUSIONS: Retroperitoneal tumors constitute a heterogeneous group of uncommon neoplasms of unknown etiology. Liposarcoma is the most frequent lesion in this group. It is usually asymptomatic and is often identified by the presence of a large abdominal mass. It is considered to be a peculiar lesion because of its biological and morphological features and course.

Adolescent↗
PubMed1999

[Retroperitoneal mixoid liposarcoma: a difficult diagnosis with often unfavorable prognosis. Case report].

Liposarcoma is the most common adult soft tissue sarcoma. The hallmark is the immature fat cell or lipoblast. It occurs in late adult life, frequently in the lower extremities, in the retroperitoneal, perineal and mesenteric region. Retroperitoneal liposarcoma doesn't produce symptoms until it is very large. A review of the literature is made and the case of a 65-years old man, submitted to surgical treatment for a bulky retroperitoneal mixoid liposarcoma is reported.

Aged↗
PubMed2000

[Liposarcoma of the spermatic cord in the left scrotum and inguinal region: a case report].

We report a rare case of liposarcoma of the spermatic cord in the left scrotum and inguinal region. The patient was a 75 year old male, who visited our hospital with the complaint of painless left scrotal swelling and inguinal mass which had been noticed for 3 to 4 years. Ultrasonography and computed tomography (CT) showed a heterogenous mass in the left inguinal region and intrascrotum. We suspected a left testicular tumor and removed it by high inguinal orchiectomy. Histological examination revealed a well-differentiated liposarcoma of sclerosing type. Tumor local recurrence was not recognized at 8 months after operation. This is the 43rd case of liposarcoma of the spermatic cord in the Japanese literature.

Aged↗
PubMed2001

[Primary pulmonary myxoid liposarcoma discovered fortuitously].

We report a fortuitous discovery of primary pulmonary myxoid liposarcoma in an HIV-positive patient. Primary pulmonary localizations are uncommon. Generally, pulmonary localizations are metastatic. There is a male predominance and diagnosis is generally made around 40 years of age. The two main features of liposarcoma are the large tumor size and the complex histology that evolves over time. Pathology findings are rarely reproducible and vary from one pathologist to another. Macroscopically, liposarcomas can mimic benign tumors. The risk of recurrence is high after simple enucleation due to microscopic extracapsular extensions. Surgery remains the predominant treatment. Wide complete excision, if possible, provides long-term survival.

Diagnosis, Differential↗
PubMed2002

[Spermatic cord liposarcoma: report of a new case].

OBJECTIVE: To report an additional case of liposarcoma of the spermatic cord. METHODS: A 69-year-old male presented with an indolent left inguinal mass that he had noted one month earlier and had gradually increased in size. Two irregular mobile nodular left inguinal lesions were detected on physical examination. Analytical tests were normal. An ultrasound showed three nodular lesions in the left spermatic cord. CT attenuation values indicated predominantly fat tissue in the lesion. The patient underwent a radical left orchidectomy and funiculectomy. RESULTS: The histopathological analysis of the surgical specimen showed a well-differentiated liposarcoma of the spermatic cord. CONCLUSIONS: Liposarcoma of the spermatic cord is uncommon. Some imaging techniques are useful in making the diagnosis. Like other authors, we believe that orchifuniculectomy is the treatment of choice in these patients.

Aged↗
PubMed2002

Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma.

Sixteen dedifferentiated and pleomorphic liposarcomas were analyzed by comparative genomic hybridization (CGH) to genomic microarrays (matrix-CGH), cDNA-derived microarrays for expression profiling, and by quantitative PCR. Matrix-CGH revealed copy number gains of numerous oncogenes, i.e., CCND1, MDM2, GLI, CDK4, MYB, ESR1, and AIB1, several of which correlate with a high level of transcripts from the respective gene. In addition, a number of genes were found differentially expressed in dedifferentiated and pleomorphic liposarcomas. Application of dedicated clustering algorithms revealed that both tumor subtypes are clearly separated by the genomic profiles but only with a lesser power by the expression profiles. Using a support vector machine, a subset of five clones was identified as "class discriminators." Thus, for the distinction of these types of liposarcomas, genomic profiling appears to be more advantageous than RNA expression analysis.

Algorithms↗
PubMed2002

[A patient with mediastinal liposarcoma showing dedifferentiation].

A 70-year-old man visited our hospital with fever and general malaise. Chest CT scanning showed a large tumor shadow in the anterior mediastinum. The tumor was resected. It consisted of a portion rich in fat on the anterior mediastinal side and a solid portion on the left thoracic cavity side. Pathological examination demonstrated liposarcoma (myxoid type). The solid portion was considered to have resulted from dedifferentiation of the cystic portion. Mediastinal liposarcoma accounts for less than 1% of all mediastinal tumors. To our knowledge, there have been no previous reports of patients with myxoid-type mediastinal liposarcoma showing dedifferentiation.

Aged↗
PubMedDate not supplied

[Retroperitoneal tumors: a case of liposarcoma].

The Authors report a case of retroperitoneal sarcoma, in the histological subtype "liposarcoma", occasionally diagnosed in a 57 year old woman, who presented aspecific symptoms, characterized by dry cough, vomiting and chest pain. Chest TC showed a neoplasm of the retroperitoneum, close to liver, right colon, duodenum and right kidney. The arteriography of the right renal artery showed a neovascolarization inside the mass. A surgical resection was performed. The histological examination confirmed the diagnosis of liposarcoma. Liposarcomas account for 30% of the retroperitoneal soft tissue sarcomas; symptoms and diagnosis are late and the surgical resection of primary neoplasm, metastases and local recurrences representing the only therapeutic choice.

Female↗
PubMed2003

[Liposarcoma of the pleural cavity; report of a case].

A 43-year-old-woman who had sever anterior chest pain visited our hospital on April 3, 2000. A well-defined abnormal shadow was seen in the middle and lower field of the right lung on chest X-ray. Computed tomography showed a large fat density mass in the right pleural cavity with a septum enhanced by contrast medium. Percutaneous needle biopsy revealed lipoma or liposarcoma. Complete resection could be done with combined resection of right lung, lpericardium, parietal pleura and diaphragm. Final histologic diagnosis was well differentiated liposarcoma. There are few reports of liposarcoma arising in the thoracic cavity, we present our case and review the 23 cases reported from the Japanese literatures.

Adult↗
PubMed2003

Synchronous primary heart liposarcoma and papillary renal carcinoma--a case report.

A case of synchronous primary cardiac dedifferentiated liposarcoma and papillary renal carcinoma is presented. The occurrence of typical areas of round cell liposarcoma made the pathological diagnosis of the sarcoma relatively easy; however the neoplasm was not diagnosed correctly before the autopsy. Cardiac liposarcoma is a very rare primary malignant neoplasm and its diagnosis based on image procedures may be extremely difficult especially at non-advanced stage of disease.

Carcinoma, Papillary↗
PubMed1992

In vitro differentiation of myxoid liposarcomas maintained in organ culture system.

Liposarcoma falls into the differential diagnosis of myxoid malignant mesenchymal tumors. On the other hand, its relation with white or brown fat is controversial. Two cases of liposarcoma have been studied by organ culture, a method which provides cell and tissue redifferentiation in vitro. Both cases developed successively cytoplasmic glycogen granules and lipid droplets as well as a single lipidic vacuole in the late phase of cultivation as a marker of fat differentiation. Our results support the possibility of identifying myxoid liposarcomas as well as their origin from white fat tissue.

Adipose Tissue↗
PubMedDate not supplied

[Retroperitoneal liposarcoma].

Liposarcoma is the most frequent histotype of the rare and malignant retroperitoneal tumours. This neoplasm has a remarkable tendency to recurrence after surgical excision, rarely to metastasize. Recurrence usually shows a more aggressive behaviour than primitive disease with a higher tendency to penetrate into adjacent organs. The symptomatology often appears late and the first sign is frequently a palpable abdominal mass. Preoperative study involves using CT and MRI. The surgical resection is the only tool able to modify natural history with regard to survival and local recurrence. Prognosis is severe, with a survival of 5 years, variable from 12 to 50% in the different series. A very important prognostic factor is the degree of tumour and radical surgical treatment. From 1990 to 2001, 32 operations for malignant retroperitoneal tumors were performed by our surgical unit in 19 patients; in 7 of them the tumor was a liposarcoma (4 male and 3 female). Total operations for retroperitoneal liposarcoma were 15, in 4 patients a second operation was performed for recurrence, in 3 a third operation and in 1 a fourth. Eleven cases out of 15 have undergone exeresis of sarcoma. Average survival consisted in 4 years and 2 months. Intraoperative radiotherapy, performed in 3 patients, perhaps is able to offer some advantages in relation to local control of the disease and of the survival. A possible resection of eventual recurrence justifies a early follow up with CT and MRI.

Female↗
PubMed2003

[Liposarcoma of the perirenal cell].

OBJECTIVES: To show the imaging tests characteristics and differential diagnosis of masses located within the retroperitoneal perirenal area. METHODS: Diagnostic imaging tests (KUB x-ray, ultrasound, helical CT scan with IV contrast) and follow-up in one case of perirenal cell liposarcoma. RESULTS: The study of the surgical specimen after renal tumorectomy in a patient with a solitary kidney resulted in the present diagnosis. CONCLUSIONS: Liposarcoma is a malignant neoplasia derived from fatty tissue. Approximately 13% are located in the retroperitoneal area, and less than 1/3 arise from perinephric fat. We report one case of liposarcoma located in the perirenal cell as an incidental finding during contralateral psoas muscle abscess follow-up in a patient with a solitary kidney after surgery for xanthogranulomatous pyelonephritis. Successive controls during the last year allowed us to evaluate the evolution of this lesion's.

Female↗
PubMed2003

Primary liposarcoma of the omentum: a case report and review of the literature.

A case of round cell liposarcoma of omentum in a 45-year-old man is reported. The patient presented with abdominal pain, swelling and fever of 4-month duration. Abdominal ultrasonography and computed tomogram confirmed the presence of an abdominal mass, but the omental origin of the tumour was revealed only on laparotomy. In addition to the main tumour mass, multiple nodules were present in the omentum. The tumour was excised with omentum. Histopathology of the tumour revealed a round cell liposarcoma. The patient expired 9 months after operation. Eight other cases of liposarcoma of omentum reported in English literature are reviewed.

Humans↗
PubMed2004

[Retroperitoneal liposarcoma--case report].

The authors present surgical therapy of liposarcoma in retroperitoneum. These mesenchymal tumors occur rarely in the population. The strategy for therapy requires determination of the relations to adjacent organs on the basis of precise preoperation examination of the patient. Surgery is considered as the basic therapy, provided radical extirpation of the tumor is possible. Our case report describes a huge liposarcoma in retroperitoneum with histology evolving from myxoid to low differentiated liposarcoma of retroperitoneum. The repeated relapse of the tumor was, as fart as possible, treated by extirpation of the tumor.

Aged↗
PubMedDate not supplied

Thrombectomy discloses intravascular growth of chondroid liposarcoma mimicking a long distance vena cava thrombosis.

A 22-year-old woman with a newly detected chondroid liposarcoma located in the iliac muscle was diagnosed as having bilateral pulmonary embolism. Gadolinium-enhanced MRI further revealed a long distance thrombus reaching from the iliac vein to the right atrium. The thrombus was attributed to a hypercoagulability state which has been described for chondroid liposarcoma. High-dose chemotherapy with autologous stem cell support reduced the tumor burden and led to a symptom-free interval of 6 months. Despite therapeutic anticoagulation, repeated imaging showed no reduction or remodeling of the thrombus. However, when the thrombus progressed again, the patient underwent cardiac surgery and histology revealed the intravascular growth of the known chondroid liposarcoma. We conclude that in sarcoma patients intravascular tumor growth must be kept in mind when imaging is suggestive for thrombosis.

Adult↗