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Binding surface analysis: an intuitive yet quantitative method for the design and analysis of ligand binding studies.

Ligand binding techniques are widely used to measure drug, hormone, and neurotransmitter receptors. Despite its wide application, quantitative methods of data analysis have not been widely adopted. This paper reviews some of the problems associated with semiquantitative methods of data analysis, and describes a mathematically based approach to the design and analysis of ligand binding experiments. Widely spaced concentrations of radiolabeled ligand are displaced by concentrations of cold drug. Analysis of these curves, which describe a "binding surface," with computer curve-fitting programs significantly increases the power of the ligand-binding technique.

Animals↗
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Ledger's cinchona seeds: a composite of field experience, chance, and intuition.

Following a short historical review of the facts which lead to the discovery of the specific action of the cinchona bark, an analysis is made of the obstacles encountered for more than two centuries by scientific expeditions to the identification, among the maze of natural hybrids, of the varieties of cinchona producing large amounts of quinine, and to obtain the best seed to establish plantations in other continents. Charles Ledger, a British general tradesman, was able to achieve that thanks to his alert spirit of observation, his (and that of his Bolivian servant Manuel) long experience of the Andes, and the chance that brought them to fall upon a group of exceptional cinchonas which had grown on an impervious slope of the Andes. Eventually the seeds were collected and Ledger offered them to the British and Dutch governments. Whereas the British failed to recognise their importance, the Dutch did not. They created extensive plantations in Java from which the world's demand for quinine was met, and the Dutch detained the practical monopoly of its production.

Cinchona↗