Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Instinct”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 451 records · Page 25Linked to original sources

Small passerines can discriminate ultraviolet surface colours.

Hollow-dwelling passerine birds were tested for UV surface colour discrimination by using the instinct to bring food to nestlings that makes a bird search for the nest under changing conditions. The experiments were carried out on breeding pairs of pied flycatcher (Muscicapa hypoleuca), great tit (Parus major) and tree sparrow (Passer montanus) in the wild by the method of alternative choice of entrance into a double nesting-box with the nestlings in one or the other section. The entrances were marked with sheets of painted papers that had different reflectances in UV. For a human observer, all marks looked achromatic. Birds were trained to discriminate the mark coloured with UV-absorbing paint from a neutral one (with equal reflectance throughout the spectrum). Birds easily learned to search for the UV-absorbing mark, and transferred the acquired habit when tested with new marks that differed only slightly from the initial ones in lightness to eliminate brightness cues.

Animals↗

Above- and below-lesion EMG pattern mapping for controlling electrical stimulation of paraplegics to facilitate unbraced walker-assisted walking.

We describe and evaluate above- and below-lesion EMG control of functional electrical stimulation (FES) in upper motor neuron paraplegics, in order to provide them with a patient-responsive system for walking with a walker support. Control is considered in terms of a combination of above-lesion EMG control and below-lesion response-EMG control. The above-lesion EMG is used to control the activation of limb functions involved in standing up and walking with FES, control being accomplished by analysing raw surface-EMG time-series patterns to discriminate between upper-trunk muscle contraction patterns, which in turn, are correlated with intended lower-limb functions involved in walking, so that natural and instinctive balance changes in paraplegics are controlled by the patient from above the lesion. The below-lesion response-EMG is the EMG produced in response to the FES pulses at the stimulation sites, for adjusting stimulation levels as needed when contractions weaken due to muscle fatigue. Above-lesion EMG is a stochastic (random-like) signal, being a response to unsynchronized motor neuron firings, whereas the below-lesion EMG is a deterministic signal responding to synchronized firings that result solely from the FES pulses. We also discuss the merits and difficulties of EMG control, and evaluate patient performance under such control, noting that FES-activated walking without adequate and patient-responsive control is of very limited use to paraplegics.

Electric Stimulation Therapy↗

[Behaviour of rabid animals studied at the Centre National d'Etudes sur la Rage].

The diagnosis department of the Centre National d'Etudes sur la Rage receives, with the anatomical samples, information on the behaviour of the animal suspected of having rabies, and justification for the sacrifice of the animal. Confronted with the observations of foxes in captivity, inoculated for experimental needs, these documents confirm that there are several varieties of rabies found in different species which were studied. One type of rabies, characterized by an attitude of prostration from the beginning to the end of the illness, a type of rabies without agressivity, with abnormal activity, absence of fight instinct, abnormal walking and behaviour, paralysis, and a form of 'furious rabies' during which the animal can not only kill or seriously injure the other animals that he comes into contact with, but inflicts on himself serious injuries, in the fox and mustelids, through biting, and in herbivores through extremely violent head-butting.

Aggression↗

A historical appraisal of America's experience with "pyromania"--a diagnosis in search of a disorder.

When "pyromania" from 1840-1890 is reviewed, it stands out as a concept that at first found favor in an era of moral insanity and moral treatment. During this period pyromania was variously labeled as a form of monomania, moral insanity, impulsive mania, or instinctive mania. As early as 1850, and clearly after the Civil War, however, controversial arguments regarding the locus of personal responsibilty emerged. Arguments were put forward that there could be diseased brains but not diseased minds. Without the proof of an organic lesion in the brain, fire-setting became an act whose locus rested in the individual's moral fabric, and in this historical context became a nonmedical concern punishable by law. Pyromania, at the hands of those physicians who limited insanity to disorders of the brain, might have received the same fate as other diseases of the mind or will: it could have simply been dismissed. But it lingered. The period 1880-1917 witnessed professional attention directed toward prophylaxis, mental hygiene, and a reorientation of American psychiatry toward an endorsement of psychotherapy (Sicherman, 1980). Attention to pyromania was more quiescent than it had been. The development of psychoanalytic theory which followed allowed for the re-emergence of pyromania as a disease entity. The diagnosis then flourished from 1924 until 1957, with descriptions of it including: an irresistible impulse, a urethra-erotic character trait, an obsession, or a psychosexually based impulse neurosis. The period of 1924-1985 can be viewed as a repetition of the period between 1840-1890 in terms of the evolution of the place of pyromania in the lexicon of psychiatry, of its existence as a disease entity, and of its implications for personal responsibility for destructive acts. Supported at the outset of this later period as a disease, this time grounded in psychoanalytic rather than moral theories of responsibility, it loses favor as the psychobiologic position ascends. And like the preceding period, the conception of pyromania as a specific disorder wanes but never dies, as advocacy for the psychodynamic (replacing moral) approach diminishes but does not disappear. The cyclical nature of pyromania has parallels in cycles of reform in standards of civil commitment (Livermore, Malmquist & Meehl, 1958; Dershowitz, 1974), in the use of physical therapies and medications (Tourney, 1967; Mora, 1974), in treatment of the chronically mentally ill (Deutsch, 1949; Morrissey & Goldman, 1984), and in institutional practices (Treffert, 1967; Morrissey, Goldman & Klerman (1980).(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗

Stereotypes of women of Asian descent in midwifery: some evidence.

The subject of this paper is part of a larger study which investigated the delivery of maternity care to women of South Asian descent in Britain (Bowler, 1990). An ethnographic approach was used and the main method of data collection was non-participant observation in antenatal clinics, labour and postnatal wards in a teaching hospital maternity unit. These observations were supported by data from interviews with midwives. It was found that the midwives commonly use stereotypes of women in order to help them to provide care. These stereotypes are particularly likely to be used in situations where the midwife has difficulty (through pressure of time or other circumstances) in getting to know an individual woman. The stereotype of women of Asian descent contained four main themes: communication problems; failure to comply with care and service abuse; making a fuss about nothing; a lack of normal maternal instinct. Reasons for stereotyping are explored. Effects on service provision in the areas of family planning and breast feeding are highlighted.

Asia↗

Sex and respectability in an age of fertility decline: a Sicilian case study.

The paper examines two aspects of coitus interruptus as a sexual practice: (1) how, in the age of fertility decline in Western Europe, its meaning was reinterpreted from an earlier theological view that condemned it as licentious to a nineteenth century view that emphasized restraint, and (2) how it was actually experienced by a socially stratified birth-controlling population in rural Sicily, ca 1900-1970. The sequential experiences of gentry, artisans, and peasants in the Sicilian case study of transition from high to low fertility are consistent with late twentieth-century interpretations of coitus interruptus by Foucault and others as sexually restraining yet empowering. In each group, adoption of the practice enhanced access to respectability in a context of cultural and economic change. Moreover, those who adopted the practice increasingly stigmatized married couples with high birth parities as overly dominated by their sexual instincts and unworthy of respect.

Coitus Interruptus↗

Quantitative improvement in laryngoscopic view by optimal external laryngeal manipulation.

STUDY OBJECTIVE: To determine the improvement in laryngoscopic view obtained using both the Macintosh and Miller blades by applying optimal external laryngeal manipulation (OELM). DESIGN: Prospective, with each patient serving as his or her own control. SETTING: Inpatient operating rooms of a University Medical Center. PATIENTS: 181 informed and consenting adult nonpregnant patients requiring general anesthesia and tracheal intubation. The only exclusion criteria was the need to apply cricoid pressure to prevent aspiration of gastric contents. INTERVENTIONS: Anesthetized, paralyzed patients underwent laryngoscopy without external laryngeal manipulation and the laryngoscopic view was graded ("A") according to visualized structures [1.0-1.9 = all (1.0) or part of the vocal cords (90% = 1.1 and 10% = 1.9); 2 = just the arytenoids; 3 = just the epiglottis; 4 = just the soft palate]. The larynx was then quickly manipulated by the thumb and index and middle fingers of the laryngoscopist's right hand in both cephalad and posterior directions over the hyoid, thyroid, and cricoid cartilages until it was determined which vector and spot produced the optimal laryngoscopic view ("B"). MEASUREMENTS AND MAIN RESULTS: It was found that in every patient with a "A" greater than 1.0, OELM improved the view; i.e., "B" decreased relative to "A." For both the Macintosh blade patients and Miller blade patients with an "A" equal to 2, "B" decreased by one whole laryngoscopic grade in all patients. For both the Macintosh and Miller blade patients with an "A" equal to 3, "B" decreased by at least one whole laryngoscopic grade in all patients and by two laryngoscopic grades in most patients. No patient had an "A" equal to 4. The distribution of optimal-external-laryngeal-manipulation (OELM) spots for all patients was 1%, 40%, 48%, and 11% for the hyoid, high thyroid, low thyroid, and cricoid cartilages, respectively, and the distribution was not significantly different for either the Macintosh and Miller blade groups or for the "A" and "B" subgroups (i.e., "A" < 1.9, = 2 or = 3). CONCLUSIONS: We conclude that OELM can improve the laryngoscopic view by at least one whole grade, that the best way to determine OELM for an individual patient is on an empirical basis by manipulation of the larynx with the laryngoscopist's right hand, and that OELM should be an instinctive and reflex response to any "A" of 2, 3, or 4.

Adolescent↗

Is the myofibrillarlytic myocyte a forme fruste apoptotic myocyte?

BACKGROUND: Myofibrillarlytic (MFL) cells are commonly observed in subendocardial myocardium in myocardial infarction. Because ischemic damage to myocytes is also known to induce apoptosis, we evaluated the prevalence of apoptosis in MFL cells in nine ischemic cardiomyopathic hearts explanted during transplantation. METHODS: Myocytes with partial or complete clearing of cytoplasm, observed commonly in the subendocardium, were recognized as MFL cells. Prevalence of apoptosis was defined by TUNEL and ISOL staining and further characterized by immunohistochemical staining for caspase-3, Bcl2, BCL-X(L), Bax, proliferating cell nuclear antigen (PCNA), and Ki67. RESULTS: Of 4131 MFL cells examined, 1305 (32%) possessed nuclei in a given histologic section; 1140 (88%) of the nucleated myocardial cells were TUNEL positive. Of 842 cells with normal appearance, 257 (31%) cells demonstrated nuclei in the given histologic section. TUNEL staining was observed in 5 (1.9%) in these control areas. All MFL cells stained positive for caspase 3. The antiapoptotic proteins, Bcl2 and BCL-X(L), demonstrated intense upregulation within and surrounding MFL cells, whereas pro-apoptotic protein Bax expression was only seen at control level. The MFL cells had Ki67 negative and PCNA positive nuclei. CONCLUSIONS: The present study demonstrates that the majority of MFL cells are apoptotic and are associated with upregulation of caspase 3. Simultaneous upregulation of Bcl2 represents a survival effort in these myocytes. This is consistent with the review of the literature that MFL cells are viable, persist in myocardium for long time and may be functionally reversible. Evidence for concurrent apoptosis and survival instinct represent a conceptual paradox and suggests that myocytes undergoing apoptosis should be amenable to reconstitution of function.

Apoptosis↗

Beyond Bowditch: the convergence of cardiac chronotropy and inotropy.

The ability of the heart to acutely beat faster and stronger is central to the vertebrate survival instinct. Released neurotransmitters, norepinephrine and epinephrine, bind to beta-adrenergic receptors (beta-AR) on pacemaker cells comprising the sinoatrial node, and to beta-AR on ventricular myocytes to modulate cellular mechanisms that govern the frequency and amplitude, respectively, of the duty cycles of these cells. While a role for sarcoplasmic reticulum Ca(2+) cycling via SERCA2 and ryanodine receptors (RyR) has long been appreciated with respect to cardiac inotropy, recent evidence also implicates Ca(2+) cycling with respect to chronotropy. In spontaneously beating primary sinoatrial nodal pacemaker cells, RyR Ca(2+) releases occurring during diastolic depolarization activate the Na(+)-Ca(2+) exchanger (NCX) to produce an inward current that enhances their diastolic depolarization rate, and thus increases their beating rate. beta-AR stimulation synchronizes RyR activation and Ca(2+) release to effect an increased beating rate in pacemaker cells and contraction amplitude in myocytes: in pacemaker cells, the beta-AR stimulation synchronization of RyR activation occurs during the diastolic depolarization, and augments the NCX inward current; in ventricular myocytes, beta-AR stimulation synchronizes the openings of unitary L-type Ca(2+) channel activation following the action potential, and also synchronizes RyR Ca(2+) releases following depolarization, and in the absence of depolarization, both leading to the generation of a global cytosolic Ca(i) transient of increased amplitude and accelerated kinetics. Thus, beta-AR stimulation induced synchronization of RyR activation (recruitment of additional RyRs to fire) and of the ensuing Ca(2+) release cause the heart to beat both stronger and faster, and is thus, a common mechanism that links both the maximum achievable cardiac inotropy and chronotropy.

Animals↗

A three-dimensional analysis of soft and hard tissue changes after a mandibular setback surgery.

This paper is concerned with a three-dimensional (3D) analysis on soft and hard tissue changes after mandibular setback surgery. For comparing with previous two-dimensional (2D) cephalometric data, we proposed a three-dimensional registration and analysis method based on the cephalometric knowledge. The 3D changes of bone, soft tissue and the ratio of soft tissue to bony movement were investigated in eight skeletal class III mandibular prognathism patients. CT scans of each patient were taken at pre- and post-operative states. Each scan was registered to a universal 3D coordinate system defined by cephalometric landmarks. A grid, parallel to the coronal plane, was also designed for the comparison of the changes. The bone and soft tissue was intersected by the projected line from each point on the grid. The coordinate values of intersected point were measured and compared between the pre- and post-operative models. In addition, the reproducibility of the universal coordinate system and the grid was evaluated. The facial surface changes after setback surgery occurred not only in the mandible but also in the mouth corner region. The soft tissue changes of the mandible were measured relatively by the proportional ratios to the bone changes. The ratios at the mid-sagittal plane were 77-102% (p<0.05). The ratios at all other sagittal planes had similar patterns to the mid-sagittal plane with decreased values. All the results conformed to the previous 2D based clinical knowledge and instinct of orthodontists. It is expected that the proposed approach would be applicable to other oral and maxillofacial surgeries as well as plastic surgeries.

Adult↗

A neuroanatomical model of passivity phenomena.

Any attempt to elucidate the nature and mechanism of passivity phenomena, i.e., experiences that one's conscious actions or thoughts have not been 'willed' by oneself, requires an integrative philosophical-neurobiological approach. The model proposed here adopts some fundamental positions that have long been advocated by philosophers and theoretical psychologists and have now found support from functional neuroanatomy. First, we experience our actions not from the standpoint of the executive but through the perception of its effects. Second, the 'self' is not an agent of behaviour. Third, behaviour is energized and integrated by basic drives (instincts). Fourth, the view that the experience of an acting self is related to drive reduction associated with voluntary actions is perhaps less well developed. The model thus proposes that passivity phenomena are actions that are induced by the perception of salient events but that are not integrated with or conducive to the overall motivational state of the organism. It has been suggested that, following the perception of salient events, competition arises between automatic response tendencies seeking expression. The prefrontal cortex appears to play an important role not only in determining which events are to be perceived but also which of the corresponding response dispositions is to be selected and actualized in overt behaviour. Thus, action selection is the outcome of competition between response tendencies in the context of prefrontal biasing signals that represent drives and strivings for goals. Action selection may be uncoupled from drives and strivings as a result of a lowering of the threshold for action selection--as is suggested to be the case in schizophrenic passivity phenomena--or due to disconnection from prefrontal regions--as may be the case in the alien limb syndrome.

Association↗

Common procedures in hedgehogs, prairie dogs, exotic rodents, and companion marsupials.

Nondomesticated species are commonly being kept as companion animals. These include the African pygmy hedgehog (Atelerix albi-ventris), the North American black-tailed prairie dog (Cynomys lu-dovicianus), and exotic rodents such as the degu (Octodon degus)and duprasi or fat-tailed gerbil (Pachyuromys duprasi). Common companion marsupials include the sugar glider (Petaurus breviceps),Bennett's or Tammar (Dama) wallabies (Macropus rufogriseus rufo-griseus and Macropus eugenii, respectively), the Brazilian or South American gray short-tailed opossum (Monodelphis domestica), and the North American Virginia opossum (Didelphis virginiana). Although many of these animals are now bred domestically and are fairly docile when human-raised, they are essentially wild animals and hence have strong instincts to hide illness and pain.

Animal Diseases↗

Violence among peoples in the light of human frustration and aggression.

This article sets out to provide a general background to the study of aggression in the social sciences, with a particular focus on its link to collective violence. While the study of what happens in the human brain appears to be already highly complex, analysis of violent behavior appears to be even more intricate. A deductive system in the sense of a general and clear system of propositions logically connected to one another is not feasible, principally because contrary to the natural sciences there are no verities but merely "stylized facts." One of these concerns the setting of human aggression in the light of frustration, as argued in the frustration-aggression hypothesis developed by Dollard et al. in 1939. Apart from conceiving of aggression as a pure human instinct, it may also be seen as externally driven, while a third possibility concerns culturally "learned" aggression. Proof of the latter is that the strongest correlation appears to be that between current violence and previous manifestations thereof. Attention is paid to the way in which Gurr has rooted his relative deprivation theory on causes of collective violence among peoples in mechanisms of frustration and aggression. That theory is taken a bit further in terms of "perceived acquirement failure," which appears to be highly connected to the role of the state. Based on certain observations by Hannah Arendt, the argument then proceeds to violence as a manifestation of powerlessness. Finally, this leads to a discussion of justice as a crucial factor in what Durkheim used to call a "right to conflict." In this way, human aggression is placed in a broad socio-economic context.

Aggression↗

[Attachment and suffering mothers].

Attachment between an infant and his/her parents is instinctive and vital for the psychoaffective development of the child. This process is fragile, and parents have to present with adaptive capacities. They need a good mental health to be able to welcome their child and to develop the interactions that will enable the baby to acquire an internal security. When mental disorders, especially maternal disorders, appear during this crucial perinatal period, the relationship between the parents and their baby may become unstable, and the attachment process can be disturbed.

Female↗

A paradigm shift in the conceptualization of psychological trauma in the 20th century.

The inclusion of posttraumatic stress disorder (PTSD) in DSM-III in 1980 represented a paradigm shift in the conceptualisation of post-trauma illness. Hitherto, a normal psychological reaction to a terrifying event was considered short-term and reversible. Long-term effects, characterized as "traumatic neurosis", were regarded as abnormal. Enduring symptoms were explained in terms of hereditary predisposition, early maladaptive experiences or a pre-existing psychiatric disorder. The event served merely as a trigger to something that existed or was waiting to emerge. Secondary gain, the benefits often but not solely financial that a person derived as a result of being ill, was considered the principal cause of any observed failure to recover. The recognition of PTSD reflected a diversion from the role of the group, in particular the "herd instinct", towards a greater appreciation of the individual's experience. From being the responsibility of the subject, traumatic illness became an external imposition and possibly a universal response to a terrifying and unexpected event. This shift from predisposition to the characteristics of the event itself reduced guilt and blame, while the undermining of secondary gain made it easier to award financial compensation.

Conflict, Psychological↗

A novel open field activity detector to determine spatial and temporal movement of laboratory animals after injury and disease.

The wide range of tests for laboratory animal behavior after neurological injury or disease each have their benefits and detriments. The varied behavior an animal exhibits makes it difficult to decide which test to use. However, a fundamental instinct for the laboratory animal is to explore when placed in a new environment. A way to test exploratory behavior is in the open field. Here, we introduce a simple activity box without the use of video equipment to determine the exploratory movement of a rat after traumatic brain injury. The activity box is an open field and the rat explores its surroundings when placed inside. Four infrared beams were placed in both the X and Y-axis inside the box. Using a novel system to determine which beam the rat breaks, we describe where the rat is in space and time while in the activity box. Other models can show the number of beams broken, but here we elucidate the methods to additionally determine the amount of area explored, the total distance traveled by the rat and percent time exploring.

Animals↗

Science as a general education: Conceptual science should constitute the compulsory core of multi-disciplinary undergraduate degrees.

It is plausible to assume that in the future science will form the compulsory core element both of school curricula and multi-disciplinary undergraduate degrees. But for this to happen entails a shift in the emphasis and methods of science teaching, away from the traditional concern with educating specialists and professionals. Traditional science teaching was essentially vocational, designed to provide precise and comprehensive scientific knowledge for practical application. By contrast, future science teaching will be a general education, hence primarily conceptual. Its aim should be to provide an education in flexible rationality. Vocational science teaching was focused on a single-discipline undergraduate degree, but a general education in abstract systematic thinking is best inculcated by studying several scientific disciplines. In this sense, 'science' is understood as mathematics and the natural sciences, but also the abstract and systematic aspects of disciplines such as economics, linguistics, music theory, history, sociology, political science and management science. Such a wide variety of science options in a multi-disciplinary degree will increase the possibility of student motivation and aptitude. Specialist vocational science education will progressively be shifted to post-graduate level, in Masters and Doctoral programs. A multi-disciplinary and conceptually-based science core curriculum should provide an appropriate preparation for dealing with the demands of modern societies; their complex and rapidly changing social systems; and the need for individual social and professional mobility. Training in rational conceptual thinking also has potential benefits to human health and happiness, since it allows people to over-ride inappropriate instincts, integrate conflicting desires and pursue long-term goals.

Curriculum↗

Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse.

The ability to identify, develop, and exploit conditions of safety and security is central to survival and mental health, but little is known of the neurobiology of these processes or associated positive modulations of affective state. We studied electrophysiological and affective correlates of learned safety by negatively correlating an auditory conditioned stimulus (CS) with aversive events (US). This CS came to signify a period of protection, reducing fear responses to predictors of the US and increasing adventurous exploration of a novel environment. In nonaversive conditions, mice turn on the CS when given the opportunity. Thus, conditioned safety involves a reduction of learned and instinctive fear, as well as positive affective responses. Concurrent electrophysiological measurements identified a safety learning-induced long-lasting depression of CS-evoked activity in the lateral nucleus of the amygdala, consistent with fear reduction, and an increase of CS-evoked activity in a region of the striatum involved in positive affect, euphoric responses, and reward.

Acoustic Stimulation↗