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[Factors of domestic behavior variation in farm animals species].

Fear response and domestic behavior of sheep, cattle, horses, and pigs were studied using four different variants of experimental stress conditions. As standard aversive stimulus, the factor of human presence during the feeding time was used under the following conditions: animals were starved for 12-14 or 2 h before the exposure and fed individually or in a group. In the animal species studied, these conditions were found to reveal phenotypic and genotypic differences in fear response to humans, which is correlated with feeding behavior by regulatory mechanisms. A comparative qualitative and quantitative study of the discrete variation of the associated passive-defensive responses and feeding behavior (as related to domestic behavior) was conducted with regard to the effect of the breed and individual genotypes and the feeding and zoosocial deprivation. A classification scheme of the individual diversity of this behavior in farm animal species is proposed, in which ontogenetic and evolutionary relationships earlier found in sheep were taken into consideration. It is suggested that the progressive ecological and zootechnical specialization alters adaptive reaction norms of stress response in breeds and leads to the formation of the homologous variation in a set of coadapted traits, i.e., constitutional types of animals genetically marked by their behavior. A conclusion is made that heritable polymorphism of domestic behavior represents a new source of adaptive variation for improving the total fitness, welfare, and productivity of farm animals by breeding.

Adaptation, Biological↗

[The dynamics of forming an active defensive reflex in cats].

Active defensive reflexes were elaborated in cats with pain stimulations of the forepaw by means of an electrical pricking device with a target attached to it. The elaboration was carried out during action of a flickering light used for the convenience of the EEG analysis. Repeated pain stimulation led to elaboration of an aggressive attacking reaction, chiefly manifested in the paw striking the target. At the beginning of the elaboration, passive-defensive reactions were manifest, which did not completely disappear even after formation of a stable attacking reflex. Two types of active defensive reflexes were elaborated: A-type reflex which helped the animal to get rid of the pain stimulation at the very beginning; B-type reflex which prevented the pain stimulation. The difference beteween these two types is discussed.

Aggression↗

Effects of excitatory amino acids and nitric oxide on flight behavior elicited from the dorsolateral periaqueductal gray.

Microinjection of excitatory amino acids (EAA) into the dorsolateral periaqueductal gray (dlPAG) induces flight reactions while EAA antagonists show anxiolytic effects. Part of the effects mediated by NMDA receptors may involve an increase in nitric oxide (NO) production. We showed that nitric oxide synthase (NOS) inhibitors injected into the dlPAG induced anxiolytic effects. Conversely, SIN-1, a NO donor, produced orientated flight reactions that resemble stimulation of the medial hypothalamus. This compound also produced extensive Fos-like immunoreactivity in this region and in other areas related to defensive reactions such as the medial amygdala and cingulate cortex. Since part of the effects of NO involves increases in guanylate cyclase levels, we found that intra-dlPAG injection of 8-Br-cGMP induced a brief flight reaction followed by increased locomotion. In another experiment, we showed that single or repeated restraint stress produced an increased expression of neuronal NOS in the dlPAG and other areas related to defense, as measured by in situ hybridization, diaphorase histochemistry and immunocytochemistry. Together, these data suggest that NO may participate in the modulation of defensive responses in the dlPAG.

Animals↗

[The selective participation of brain-specific non-histone proteins of chromatin Np-3,5 during the reproduction of a defensive habit to food in edible snails].

The role of brain-specific nonhistone proteins of chromatine Np-3.5 in the processes of reproduction of elaborated defensive habit to food was studied in previously learning snails. It was found, that gamma-globulines to Np-3.5 during tens of minutes inhibited behavioural and neuronal reactions elicited by a definite conditioned stimulus--carrot juice, without changing reactions to other conditioned stimulus--apple juice. gamma-globulines to other nonhistone proteins of chromatine did not influence the reproduction of food rejection habits. It was supposed that brain-specific nonhistone proteins of chromatine Np-3.5 were selectively involved in the molecular processes providing for neurophysiological mechanisms of information extraction from the long-term memory.

Animals↗

Functional specializations within the tectum defense systems of the rat.

Here we review the differential contribution of the periaqueductal gray matter (PAG) and superior colliculus (SC) to the generation of rat defensive behaviors. The results of studies involving sine-wave and rectangular pulse electrical stimulation and chemical (NMDA) stimulation are summarized. Stimulation of SC and PAG produced freezing and flight behaviors along with exophthalmus (fully opened bulged eyes), micturition and defecation. The columnar organization of the PAG was evident in the results obtained. Defecation was elicited primarily by lateral PAG stimulation, while the remaining defensive behaviors were similarly elicited by lateral and dorsolateral PAG stimulation, although with the lowest thresholds in the dorsolateral column. Conversely, the ventrolateral PAG did not appear to participate in unconditioned defensive behaviors, which were only elicited by high intensity stimulation likely to encroach on adjacent regions. In the SC, the most important differences relative to the PAG were the lack of stimulation-evoked jumping in both intermediate and deep layers, and of NMDA-evoked galloping in intermediate layers. Therefore, we conclude that the SC may be only involved in the increased attentiveness (exophthalmus, immobility) and restlessness (trotting) of prey species exposed to the cues of a nearby predator. These responses may be distinct from the full-blown flight reaction that is mediated by the dorsolateral and lateral PAG. However, other evidences suggest the possible influences of stimulation schedule, environment dimensions and rat strain in determining outcomes. Overall our results suggest a dynamically organized representation of defensive behaviors in the midbrain tectum.

Animals↗

[Dopamine metabolism and the GABA level in the structures of the nigrostriatal and mesolimbic systems of the rat brain in experimental pathology of higher nervous activity].

In population of outbred white rats there are individuals predisposed and unpredisposed to development of nonadaptive reactions of inhibitory type during elaboration of unilateral avoidance reflex in conditions of time deficit. Animals with weak adaptive processes are characterized by lowered levels of dopamine and dioxyphenilacetic acid in the striatum, of dopamine in Substantia nigra, of homovanillic acid in the n. accumbens and olfactory tubercle and of GABA--in the striatum, in comparison with the animals which did not show behavioural pathology.

Adaptation, Physiological↗

Defensive conditioning-related functional heterogeneity among nuclei of the rat amygdala revealed by c-Fos mapping.

The amygdala is a complex forebrain structure proposed to play a pivotal role in fear conditioning circuitry. In this study, c-Fos immunomapping was applied to investigate the functional activation of particular amygdalar nuclei following a 50-trial training session of two-way active avoidance reaction. To dissect distinctive responses displayed by the animals and to cluster them into groups of correlated behaviors, factor analysis was employed. The training procedure resulted in an increase of c-Fos expression within the cortical, medial, lateral and basolateral, but not central, nuclei. The expression in the cortical nucleus correlated negatively with grooming behavior, whereas c-Fos immunolabeling of the other three subdivisions of the amygdala could be associated with the number of intertrial responses. No correlation was observed between c-Fos expression and avoidance reactions performed or the amount of shock received by the animal. The results obtained with c-Fos mapping of various regions of rat amygdala, combined with a fine dissection of behavioral repertoire, imply that there are specific functional links between particular parts of the structure and distinctive behaviors that reflect various emotional states of the animal.

Aggression↗

[The role of dopamine and serotonin in modulating the defensive behavior of the edible snail].

Dopamine application in concentration of 10(-5)-10(-6) M into saline around the snail CNS leads to decrease of excitability of LPa7 neurone which is presynaptic in relation to defensive behaviour command neurones, and to decrease of amplitude of monosynaptic excitatory postsynaptic potential (EPSP) in the command neurones elicited by intracellular stimulation of LPa7 neurone. Besides, the dopamine causes a decrease of summated EPSP amplitude in the studied neurones in response to intestinal nerve stimulation (70% in average), a change of rest potential towards hyperpolarization for 6-8 mV, a reduction of the command neurones input resistance (20% in average). The described influences can lead to a general increase of the threshold of defensive system reaction to stimulation. Dopamine action on the defensive behaviour command neurones is significantly weakened in serotonine presence. Against the dopamine background, the efficiency of serotonine influence on the value of EPSP in command neurones in response to testing stimulus is reduced. According to the obtained data, a conclusion is made that interrelation of dopamine and serotonine concentrations can be a base for formation of behaviour choice in snail.

Animals↗

Neglect syndrome for aversive stimuli in a macaque monkey with dorsomedial frontal cortex lesion.

After a session of unit activity recording, one of our monkeys presented an epileptic attack, which provoked contralateral tilting movements. The following days, the animal performed saccades and fixation tasks correctly in all directions, while contralateral arm reaching movements were severely impaired. To establish if the neurological lesion had changed the orienting performance we considered two types of stimuli, pleasant and aversive. Pleasant stimuli, presented in the ipsilateral or contralateral hemifield, readily drew the attention of the animal. If the same stimuli were presented simultaneously in both hemifields, the monkey oriented itself only toward the ipsilateral one. Aversive stimuli evoked an aggressive reaction only when the stimulus was localized in the ipsilateral hemifield. The animal clearly neglected the aversive stimulus presented in the contralateral hemifield. The animal recovered completely in 30 days. The postmortem examination revealed a lesion in the dorsomedial frontal cortex. The combined attentional and motor deficits suggest that this area may be involved in the preparation and execution of movements triggered by the affective meaning of the stimulus.

Animals↗

Posttraumatic stress disorder Part III: health effects of interpersonal violence among women.

TOPIC: The aim of this three-part series is to examine the sufficiency of the posttraumatic stress (PTSD) diagnostic construct to capture the full spectrum of human responses to psychological trauma. Part I (Lasiuk & Hegadoren, 2006a) reviewed the conceptual history of PTSD from the nineteenth century to its inclusion in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 1980), while Part II (Lasiuk & Hegadoren, 2006b) described subsequent refinements to the original PTSD diagnostic criteria and highlighted subsequent controversies. PURPOSE: This paper focuses on interpersonal violence (sexual, physical, and emotional abuse/assault) and its sequelae in women. We argue in support of Judith Herman's (1992) conceptualization of the human trauma response as a spectrum, anchored at one end by an acute stress reaction that resolves on its own without treatment, and on the other by "complex" PTSD, with "classic" or "simple" PTSD somewhere between the two. SOURCES OF INFORMATION: he existing theoretical, clinical and research literatures related to humans responses to trauma. CONCLUSION: The paper concludes with a call for the need to increase a gendered perspective in all aspects of trauma research and clinical service delivery.

Diagnostic and Statistical Manual of Mental Disord↗

[Reactional behavior of young crayfish towards metallic fons (Zn, Cu, Pb, and Cr): effect of temperature and sediments].

Reactional behaviour of two species of young crayfishes to different concentrations in chlorures (Zn, Cu, Pb and Cr) in option with breeding water is analysed. Discrimination capacity is more feeble with O. limosus. Physiological differences are confirmed by the raising of temperature or the presence of sediments. One interpretation of the ecological repartition of the two species A. pallipes and O. limosus is proposed on this basis.

Animals↗

[Comparative study of the psychotropic activity of tuftsin and its analogs].

Tuftsin and its Leu1 and D-Arg4 analogs displayed stimulating activity in experimental behavioral despair in mice. In rats with different types of emotional reactions and with destroyed catecholamine terminals (6-OHDA treatment), tuftsin increased exploratory activity, with fear manifestations being decreased and avoidance behavior improved. This was shown while testing the rats in the "open field" and according to the ability to accomplish an extrapolation task of avoiding critical stress-situation. Leu1-tuftsin increased the emotional stress and sharply hindered the avoidance reaction, while D-Arg4-tuftsin modulated the behavior of the animals with increased emotional reactivity and made the avoidance behavior prompter. Pentapeptide, an inhibitor of tuftsin stimulation of phagocytosis, had no significant effect on the behavior. Modifications in the structure of tuftsin resulted both in the changes in phagocytosis-stimulating activity and the appearance of other psychotropic effects.

Animals↗

The involvement of opioid delta-receptors in stress induced antinociception in mice.

The selective opioid delta-receptor antagonist, ICI 154,129, attenuated the antinociception, assessed by prolongation of reaction time on the hot-plate, of mice which had swum for 3 min at 20 degrees C. This stress-induced antinociception was also sensitive to naloxone suggesting the involvement of both delta- and mu-receptors. A swim of 0.5 min at 30 degrees C did not produce antinociception on the hot plate but the writhing response to i.p. acetic acid was blocked by a non-opioid mechanism.

Animals↗

Animal defensive reactions as a model for trauma-induced dissociative reactions.

Patients with complex dissociative disorders remain in alternating psychophysiological states which are discrete, discontinuous, and resistant against integrative tendencies. In this contribution, a parallel is drawn between animal defensive and recuperative states that are evoked in the face of severe threat and the characteristic responses of dissociative disorder patients as displayed in major dissociative states. Empirical data and clinical observations seem to be supportive of the idea that there are similarities between freezing, concomitant development of analgesia and anesthesia, and acute pain in threatened animals and severely traumatized human beings.

Animals↗

[Effect of aminazine and haloperidol on caudate inhibition of the conditioned reflex reaction of avoidance in cats].

The effect of neuroleptics on the avoidance behaviour under electric low-frequency stimulation of the caudate neucleus was studied in experiments with cats. Chlorpromazine (1 and 3 mg/kg) and haloperidol (0.5 mg/kg) were found to bring disorder in the behaviour of the animals and to intensify the inhibitory function of the caudate nucleus. Chlorpromazine proved in all respects to be a more active substance. The results obtained may be attributed to disruption of the central dopamine- and noradrenergic transmission.

Animals↗

[The neurohormonal characteristics of rats selected for the duration of the passive defense reaction and for the threshold of neuromuscular excitability].

Two strains of rats, "genetic catalepsy" and "low-threshold", simulating some human psychopathological symptoms, were compared. Levels of brain monoamines and blood corticosterone and testosterone showed no common features in the strains studied. The levels of dopamine in amygdala and testosterone blood levels in rats of the two strains significantly deviated in opposite directions from corresponding controls. In "genetic catalepsy" strain noradrenaline content in striatum and diencephalon was decreased, and serotonin striatal level was increased.

Animals↗

[Effect of chronic stimulation of the emotionogenic zones of the hypothalamus on the status of carbohydrate metabolism in the rabbit].

In chronic experiments on rabbits receiving for 3 months low doses of cholesterol (60 mg per 1 kg of body weight daily), a repeated prolonged (2 h daily) intermittent stimulation of negative and positive emotive zones of the hypothalamus through implanted electrodes (eliciting avoidance and self-stimulation reactions correspondingly),--resulted in uniform disturbances of carbohydrate metabolism. There was a significant reduction of glucose tolerance in comparison with the control group of rabbits with implanted electrodes, as well as a gradual development of a slight, but stable neurogenic hyperglycemia. Simultaneously, in both experimental rabbits groups there were an equal increase of alimentary hypercholesterolemia and a development of persistent neurogenic arterial hypertension.

Animals↗

[Neuronal correlates of changes in the defensive behavior of Helix lucorum L. during ontogeny].

In experiments on the isolated nervous system, responses of the same command neurones of avoidance behaviour to electrical stimulation of the intestinal nerve were compared in adult snails (Helix pomatia) and in snails 1-20 days old. Dynamics of spike reactions of the command neurones to rhythmic nerve stimulation differed in adult and newborn snails. In the neurones of young snails, no sensitization, common in the adult animals, was observed. Study of excitatory input in the command neurones during rhythmic nerve stimulation suggests independence of habituation of synaptic input amplitude and spike response sensitization, because dynamics of habituation coincided in the young and adult snails while spike response underwent sensitization only in adult animals.

Animals↗