Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “DERMATOSES”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 451 records · Page 25Linked to original sources
PubMed1981

[Dynamics of lysosomal enzymes in patients with allergic dermatoses before and after high altitude climate therapy].

Lysosome enzymes were measured in patients with allergic dermatosis before and after high altitude climate therapy. The activity of five acid lysosomal hydrolases in the serum of patients with allergic dermatoses before and after 30 days were investigated. In all cases a reduction of the activity of alpha-glucosidase was observed. A similar reduction of the activity of beta-glucuronidase and beta-galactosidase was observed.

Adult↗
PubMed1981

Effect of glucocorticosteroid therapy on the immune system of patients with nonimmunologically mediated dermatoses.

Humoral and cellular immunologic studies were carried out to define the effect of steroid treatment on the immune system of patients with non-immunologically-mediated dermatoses. The cellular immune response as measured by PHA and Con A induced lymphoblastogenesis was highly impaired, being reduced in 79% and 66%, respectively, of the cases. The peripheral and bone marrow lymphocyte subpopulation and PPD skin reaction were only slightly affected by steroid administration. Histologic studies of lymph node biopsies showed atrophy, fibrosis and fat degeneration. The immunoglobulin and complement levels and humoral antibody responses to typhoid vaccine, diphtheria toxoid and bacteriophage phi--x 174 were mildly affected. The impairment of immune systems induced by steroids was largely reversible, while the PHA induced blastogenesis and pathological changes in the lymph nodes were irreversible. In comparison with experimental animal studies using massive doses of steroids, the immune system in man was not significantly affected by administration of small doses on a long term basis in clinical practice.

Adolescent↗
PubMedDate not supplied

[Serum IgD levels in various dermatoses (author's transl)].

Serum IgD levels were determined by radial immunodiffusion among 349 patients with various dermatoses and 40 normal blood donnors. An increase of serum concentrations was found in atopic patients 62,5 p. 100 of which had levels over 50 mg/1 compared to 20 p. 100 in controls. No correlation was found between IgD and IgE levels in these patients. An increase (but statistically not significant) was also found in chronic urticaria whereas levels were normal in acute urticaria. No difference was found in contact dermatitis nor in psoriasis. High levels occurred in most of patients with primo-secondary syphilis and in acne pustulosa, whereas low IgD levels were found in most patients with malignant proliferative diseases (mycosis fongoide, malignant melanoma, carcinoma). However, the number of patients tested in these groups is too small to allow definitive conclusions. In our experience, determination of serum IgD values is not very useful for diagnosis in dermatologic patients.

Acute Disease↗
PubMed1994

[Adhesion molecules and inflammatory dermatoses].

In inflammatory dermatoses, adhesion molecules are involved in the interaction of leukocytes with endothelial cells, extra-cellular matrix and epidermal cells. In dermatosis where epidermal cells are the main targets of inflammation, the keratinocytes are activated and participate to the local immune reaction through the secretion of cytokines and the expression of the adhesion molecule ICAM-1 and the HLA-DR antigens. Induction of ICAM-1 by IFN gamma or TNF alpha on keratinocytes that do not express this molecule in normal skin may account for the recruitment of T cells into the epidermis. In the dermis, an up-regulation of ICAM-1 expression occurs on endothelial cells activated by cytokines (IL-1, TNF alpha...) and is usually correlated with an induction of ELAM-1 and less frequently VCAM-1. These adhesion molecules are involved in the recruitment of inflammatory cells but also in the control of their retention and migration through the skin.

Cell Adhesion Molecules↗
PubMed1976

[Topical treatment of dermatoses with difluocortolone valerate fatty ointment].

The aim of the study was to compare the therapeutic effect of the new corticoid, diflucortolone valerate, with the effect of fluocinolone acetonide. The study was conducted as a randomised double-blind trial in 60 patients with various dermatoses. The results were good in 89% of the cases treated with diflucortolone valerate fatty ointment, while the same result was achieved in only 63.5% of the cases treated with fluocinolone acetonide ointment. No side effects were observed during the use of diflucortolone valerate fatty ointment, while local side effects occurred in 2 cases during the use of fluocinolone acetonide ointment.

Administration, Topical↗
PubMed1976

[Treatment of inflammatory dermatoses with difluocortolone valerate].

The authors investigated the therapeutic effect of diflucortolone valerate as an ointment in 40 patients with inflammatory dermatoses of various etiology. They described the antiphlogistic and antipruritic effect of the preparation as excellent and practically devoid of any side effects and cosmetic problems.

Adolescent↗
PubMed1994

[The manifestation of immune reactions and the chromium content of the blood in patients with occupational allergic dermatoses].

One of the mechanisms responsible for occupational dermatoses of constructors in contact with Cr-containing substances is supposed to be antibodies production as a result of Cr ion migration in the blood. The authors' measurements led them to the conclusions that no significant rise in blood Cr content occurs with an increase in the service duration, there is a close relationship between Cr blood concentrations and specific skin tests as well as between blood Cr and allergic manifestations. In patients with initial and established forms of occupational dermatosis the number of positive responses to Cr skin tests and frequency, intensity of allergic reactions grow with elevation of Cr concentrations in the blood. It is inferred that the test for blood chromium may serve an additional criterium of early diagnosis of occupational dermatosis.

Chromium↗
PubMed1994

[Prevalence and etiology of occupational dermatoses in workers of railway transport in 1958-1992].

Dermatoses are among the most prevalent occupational diseases on the railway transport; in 1961-1975 their share in total morbidity was 40%. The structure of diseases was as follows (%): contact dermatosis 87.4, eczema 6.8, allergic drug-induced dermatitis 1.4, folliculitis, toxicoderma, chemical burns, radial dermatitis and other kinds of dermatosis 0.84. The main causes of diseases were the use of many chemicals in transport processes and of Diesel engines on trains.

Dermatitis, Occupational↗
PubMed1993

[Dexamethasone-cyclophosphamide pulse therapy in bullous autoimmune dermatoses].

The problem in the treatment of bullous autoimmune dermatoses with long-term corticosteroids is that the high doses cause side-effects. An alternative form of therapy with high-dose dexamethasone-cyclophosphamide pulses was used to treat 20 patients between 33 and 86 years: 7 patients had bullous pemphigoid, 6 pemphigus vulgaris, 5 pemphigus foliaceus, and 2 cicatricial pemphigoid. On each of days 1-3 100 mg dexamethasone was administered i.v. and on day 1, 500 mg cyclophosphamide i.v. In the therapy interval between the pulses 50 mg cyclophosphamide per day. Initially the pulses were repeated every 2 weeks and later at 10-week intervals. After 6 months of this regimen 13 patients were symptom-free, 4 had improved, and 3 showed no change. The efficacy of treatment was equal in newly diagnosed and previously treated cases. (Side-effects were leucopenia (n = 3), myalgia and arthralgia (n = 2), taste disturbance (n = 2), diffuse hair loss (n = 2), thrombophlebitis (n = 1), herpes zoster (n = 1) and a delayed-type hypersensitivity reaction to mesna. Owing to the rather short follow-up, no conclusions on long-term side-effects of this therapy are possible. However, dexamethasone-cyclophosphamide pulse therapy appears so far to be a good alternative to the standard continuous corticosteroid treatment.

Adult↗
PubMed1993

Common dermatoses in the elderly.

Common dermatoses in the elderly include xerosis, pruritus, contact dermatitis, acne rosacea, stasis dermatitis, bullous pemphigoid and herpes zoster. Physicians must be able to recognize these pathologic changes superimposed on the intrinsic and extrinsic effects of aging. Diagnosis is dependent on clinical appearance and supportive laboratory studies. Management is based on correct diagnosis.

Aged↗
PubMed1995

[Chronic bullous dermatoses of childhood in the differential diagnosis of bullous dermatitis in children].

We report a case of chronic bullous dermatosis of children, a benign dermatologic disease of infancy of unknown etiology, characterized, on IIF, by linear deposits of immunoglobulins in the Basement Membrane Zone of cutis, and clinically by a ring shaped disposition of bullae (rosette-like). This work concerns a ten year old girl admitted to the pediatric ward at E. Agnelli Hospital of Pinerolo (Turin) about one year ago, who started having perioral bullous eruption, subsequently spread all over the body skin, with general symptoms of fever and itching. Round erythematous plaques, crusts, and a ring disposition of sausage-shaped subepidermal bullae were suggestive of CBDC. Diagnosis was confirmed by cutaneous biopsy and DIF. Corticosteroids, given for about six mths., and DDS in the last four mths. of treatment, quickly changed the course of the disease, which has not recurred for about one year. Differential diagnosis with other bullous dermatoses of 2nd and 3rd childhood has been addressed to bacterial and viral diseases as well as to toxico-allergic and autoimmune diseases, the latter rarely seen by Pediatricians. Among those we discuss on clinical and anatomopathological aspects of Dermatitis herpetiformis, Erythema multiforme, Pemphigus and Pemphigoid, with regard to different anatomic sites of bullous lesions and to pathogenesis involved immunoglobulins and skin antigens.

Biopsy↗
PubMed1995

[Clinical and epidemiologic aspects of paraneoplastic dermatoses in hospitalized patients treated at the Clinic for Dermatologic and Venereal Diseases in Novi Sad over a 10-year period (1980-1990)].

Authors report results of a retrospective investigation on frequency of paraneoplastic dermatoses, their clinical characteristics, time of onset and course regarding 10 - year material on hospitalized patients at the Clinic for Infectious and Dermatovenerous Diseases in Novi Sad. Out of 9086 hospitalized patients in 14 patients (0.16%) paraneoplastic dermatisis was diagnosed. Out of 14 patients in 5 patients (35.71%) Herpes zoster was diagnosed; in 4 patients (28.57%) bullous dermatosis; in 2 patients (14.29%) paraneoplastic acrokeratosis; in 1 patient (7.14%) exudative multiform erythema in 1 patient (7.14%) erythema figuratum and in one more patient necrotic Herpes labialis was diagnosed. Concerning malignant neoplasms of internal organs together with paraneoplastic dermatosis in most cases (4 - 28.57%) chronic lymphocyte leucosis was found, and in remaining 10 (71.43%) carcinomas were diagnosed at different internal organs. In 7 cases (50%) malignancy proceeded paraneoplastic dermatosis, in 4 cases (28.57%) the malignancy was diagnosed at the same time as paraneoplastic dermatosis and in 3 cases (28.43%) malignancy was established after the onset of paraneoplastic dermatosis. Authors point to the fact that usual skin changes, characteristic for the dermatologic diseases mentioned, in cases when they are associated with visceral malignomas, are characterized by a more serious clinical picture, a longer course of the disease and resistance concerning usual therapy.

Aged↗
PubMed1996

[Occupational dermatoses in the region of Tarnów in the years 1979-1994].

An analysis of the occupational diseases diagnosed in years 1979-1994 in the region of Tarnów revealed insignificant participation of skin diseases in the general number of occupational diseases. The resolute advantage of eczema over other skin diseases among the occupational dermatoses has been ascertain. These diseases appear most often in the workers of architecture, metal, machine and rubber industry as well as in health service. The most frequent cause of the allergic occupational eczema was the metal, epoxy resin and rubber components contact allergy. Polyvalent allergy predominated the monovalent one. This is caused by late occupational skin diseases recognition.

Architecture↗
PubMed1997

[Ivermectin and tropical dermatoses].

Among tropical dermatoses, the main indications of ivermectine are tropical parasitoses such as filariasis and cosmopolitan diseases due to ectoparasites such as scabies. The efficacy and tolerance of ivermectine in filariasis (onchocerciasis, lymphatic filariasis, loiasis) have been the topic of numerous articles and reviews. More recent studies showed that ivermectin was also efficient in the therapy of scabies, cutaneous larva migrans and larva currens.

Antinematodal Agents↗
PubMed1997

Diagnostic value of indirect immunofluorescence on sodium chloride-split skin in differential diagnosis of subepidermal autoimmune bullous dermatoses.

OBJECTIVE: To determine the diagnostic value of indirect immunofluorescence on sodium chloride-split skin (SSS) in differentiating the pemphigoid group of subepidermal autoimmune bullous dermatoses, including bullous pemphigoid (BP), cicatricial pemphigoid, and pemphigoid gestationis, from epidermolysis bullosa acquisita (EBA). DESIGN: Serum samples were tested using immunofluorescence on SSS and immunoblot assay on epidermal and dermal extracts, a recombinant protein corresponding to the C-terminal end of the 230-kd BP antigen, and purified laminin-5. SETTING: An immunodermatology laboratory. PATIENTS: One hundred forty-two serum samples from patients with BP (n = 98), cicatricial pemphigoid (n = 23), pemphigoid gestationis (n = 10), EBA (n = 10), and anti-type IV collagen (n = 1). MAIN OUTCOME MEASURES: Binding sites of serum to the epidermal and/or dermal sides of SSS were correlated with their antigenic specificities. RESULTS: Epidermal staining on SSS was highly specific for pemphigoid. Alternatively, a poor correlation was found for the dermal-reacting serum samples and the diagnosis of EBA; of the 19 serum samples with dermal staining on SSS, only 10 reacted with the EBA antigen. The remaining serum samples were from patients with cicatricial pemphigoid having antibodies to the alpha 3 or beta 3 chains of laminin-5 (n = 5) or patients with BP having antibodies to the 180-kd BP antigen (n = 2). One sample recognized exclusively a 185-kd dermal antigen corresponding to type IV collagen. One more BP serum sample with dermal staining did not recognize any dermal or epidermal antigen. CONCLUSION: In case of immunofluorescent dermal staining, the precise diagnosis should be confirmed by identification of the involved antigen, since it may reveal antibodies to laminin-5 or type XVII or IV collagen, in addition to the EBA antigen.

Antibody Specificity↗
PubMedDate not supplied

[Epidemiologic characteristics of viral dermatoses--results of a retrospective study].

INTRODUCTION: A great number of skin diseases are caused by viruses (1, 2, 3). Virus infections can cause skin diseases due to three mechanisms: direct inoculation, systemic infection and local spreading of the internal focus. The aim of this study was to determine the characteristics of virus-associated dermatoses (VD). MATERIAL AND METHODS: Ambulant patients of policlinical department of the Clinic of Infectious and Dermatovenereological Diseases Novi Sad were included in this study. Epidemiologic characteristics were analyzed by retrospective studying of medical documentation. RESULTS: During a five-year-period (1991-1995), 1,461 cases of VD were registered or 7.09% of the total number of patients examinated in this period (N = 20.596). Majority of the observed patients were males (N = 788-53.25%) and female patients were less frequent (N = 683-46.75%, table 1). Table 2 shows the age distribution of our patients. Most of the patients were in the 20-29 year age group (N = 443 or 30.32%). The mean age of patients was X = 36.14 years (SD = 19.02). Table 3 shows the occupational structure of our patients. The most frequent was the group of employed (N = 773 or 50.17%). Table 4 shows the structure of the patients according to pathogenic agents. The most frequent was the group of warts and condylomata (N = 900 or 61.60%). It is apparent that the number of VD is increasing. DISCUSSION: According to collected data, patients with VD make up a great group being treated at dermatological clinics. Our findings (7.09%) are compatible to the standard results. A relative high mean age of our patients is determinated by the fact that the children are managed at the Institute of Health Care of Mother and Child Novi Sad (the warts are most frequent in this population) or in other dermatological ambulants. There is no evidence that actual socio-political events affect the spreading of VD. Most patients belong to the urban population making up dominant groups (employed, scholars, pensioners). CONCLUSION: The number of patients with VD is increasing. Although from year to year the number of diseased increases or decreases, generally speaking there is an increasing trend of VD.

Adolescent↗