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At least 451 records · Page 25Linked to original sources
PubMed2004

Computational identification and sequence analysis of stop codon readthrough genes in Oryza sativa.

Using an approach based on the Readthrough Candidate Extraction System (RCES), we extracted 111 candidates from 9620 gene sequences of rice. The results of homology search and sequence analysis demonstrated that these candidates included actual readthrough genes that would be important for further investigating the mechanism of translation termination regulated by readthrough event, and could also give some useful clues for functional genome annotation. Between the candidates and non-candidates of gene sequences in rice, there exist significant base biases at the positions surrounding the stop codons. These positions, especially both -1 and +4, are referred to as part of an extended stop signal. In candidates, G at position -1, and G or C at position +4 are much more favored than that in non-candidates. Both stop sequence patterns, GUAGC and GUGAG, might drive high readthrough efficiency in rice. Secondary structure analysis revealed that the -1 and +1 amino acids around the first stop codon of candidates have a strong bias toward arginine, particularly the +1 position (20.7%), which indicated that the amino acids at the readthrough region being frequently located in the hydrophilic region of beta-turn might be a determinant for efficient translation termination or not.

Base Sequence↗
PubMed2005

Performance study on touch-pens size in three screen tasks.

Experiments were aimed at investigating the performance of various sizes of touch-pens. The touch-pens were of three different lengths (80, 110 and 140 mm) and four different diameters (5.5, 8, 11 and 15 mm). Three screen tasks were used for determining a reference of ideal dimensions of a pen-based product. Sixteen subjects used 12 touch-pens to perform pointing-and-clicking, writing and drawing tasks. The subjects were asked to rank their preference after each task in the test. The results showed that the length of touch-pens should be designed to extend beyond the handbreadth when gripped. A touch-pen that facilitates natural pointing-and-clicking, writing and drawing tasks each requires a suitable diameter size. However, these tasks are typically performed together, in particular, the pointing-and-clicking and writing tasks. The recommended diameter for all three combined tasks is 8 mm. This finding indicates that selecting a touch-pen with a diameter of 8 mm and a length of 100 mm or longer is suitable for all pen-based devices.

Adult↗
PubMed1997

Endo-neuro-sonography: anatomic aspects of the ventricles.

To evaluate the usefulness of transendoscopic sonography, we have studied the use of a new sonographic probe of 6 F diameter in 11 fresh specimens. We achieved a precise imaging of well known anatomic structures and, moreover, obtained an additional dimension in endoscopy, since the sonographic probe adds a transverse scan to the endoscopic view, like a mini-CT at the tip of the probe. In this way, we also examined the guiding characteristics of this imaging technique, both in real time and on-line. Our results promise further interesting aspects of this technique in minimally invasive neurosurgery and suggest that further development and clinical experience seem to be justified.

Cadaver↗
PubMed1997

Enhancing neurosurgical endoscopy with the use of 'virtual reality' headgear.

Widespread use of neurosurgical endoscopy has been hampered by the necessity of looking up from the surgical field to view the endoscopic image on a video monitor. Here is demonstrated a simple, lightweight headpiece with a small, built-in video monitor that reflects the video image to the dominant eye, thus allowing the operator to continuously observe the surgical field either via peripheral vision or via the non-dominant eye. Successful use of the device is documented here in a minimally invasive fenestration of an arachnoid cyst into the lateral ventricle via a flexible endoscopic procedure.

Adult↗
PubMed1997

A simple integrative method for presenting head-contingent motion parallax and disparity cues on intel x86 processor-based machines.

Rogers and Graham (1979) developed a system to show that head-movement-contingent motion parallax produces monocular depth perception in random dot patterns. Their display system comprised an oscilloscope driven by function generators or a special graphics board that triggered the X and Y deflection of the raster scan signal. Replication of this system required costly hardware that is no longer on the market. In this paper the Rogers-Graham method is reproduced with an Intel processor based IBM PC compatible machine with no additional hardware cost. An adapted joystick sampled through the standard game-port can serve as a provisional head-movement sensor. Monitor resolution for displaying motion is effectively enhanced 16 times by the use of anti-aliasing, enabling the display of thousands of random dots in real-time with a refresh rate of 60 Hz or above. A color monitor enables the use of the anaglyph method, thus combining stereoscopic and monocular parallax on a single display without the loss of speed. The power of this system is demonstrated by a psychophysical measurement in which subjects nulled head-movement-contingent illusory parallax, evoked by a static stereogram, with real parallax. The amount of real parallax required to null the illusory stereoscopic parallax monotonically increased with disparity.

Computer Terminals↗
PubMed1997

XPIP 2.2: X Portable Interface Package.

Psychophysical researchers often need to vary stimuli parametrically during experimental design. The X Portable Interface Package, a set of free software libraries for X-Windows, provides a suitable platform for quickly prototyping visual stimuli and administering simple experiments.

Computer Terminals↗
PubMedDate not supplied

Comparing Web and touch screen transaction log files.

BACKGROUND: Digital health information is available on a wide variety of platforms including PC-access of the Internet, Wireless Application Protocol phones, CD-ROMs, and touch screen public kiosks. All these platforms record details of user sessions in transaction log files, and there is a growing body of research into the evaluation of this data. However, there is very little research that has examined the problems of comparing the transaction log files of kiosks and the Internet. OBJECTIVES: To provide a first step towards examining the problems of comparing the transaction log files of kiosks and the Internet. METHODS: We studied two platforms: touch screen kiosks and a comparable Web site. For both of these platforms, we examined the menu structure (which affects transaction log file data), the log-file structure, and the metrics derived from log-file records. RESULTS: We found substantial differences between the generated metrics. CONCLUSIONS: None of the metrics discussed can be regarded as an effective way of comparing the use of kiosks and Web sites. Two metrics stand out as potentially comparable and valuable: the number of user sessions per hour and user penetration of pages.

Adolescent↗
PubMed1986

How to keep up with the medical literature: V. Access by personal computer to the medical literature.

Access to the medical literature through personal computers is now readily available and can greatly reduce logistical barriers to using recently published journal articles to support clinical decisions. In this article, we describe many of the options available to clinicians who wish to do their own computer searching of MEDLINE, the largest of the electronic services for the biomedical literature. The "bare bones" computer equipment needed includes a terminal or personal computer, a modern and telephone line, and a printer. Access to MEDLINE is then gained through subscribing to any of a burgeoning number of database vendors. A comparison of 17 permutations and combinations of software and vendors shows that the software and vendors vary substantially in efficiency, cost, and ease of use. Direct subscription to MEDLINE is least expensive, PaperChase is the simplest service to use, and Colleague and Medis provide both MEDLINE access plus full-text journals online. Basic search techniques are illustrated for three clinical problems.

Computers↗
PubMed1991

[Eyeglass frame for detection of eye, head movements and pupillary diameter].

Up till now, the simultaneous recording of the movements of the eyes, the movements of the head and the diameter of the pupil required the combined use of several apparatus. In this paper we present a new apparatus developed for the simultaneous recording of the movements of the eyes and of the head, and the diameter of the pupil. The apparatus consists of a portable frame (weight 215 g) a 19" rack containing electronics, and a PC for storing and analyzing the recorded data. In comparison with other systems providing similar measuring possibilities the present apparatus has the advantage of smaller dimensions and lower weight.

Computer Terminals↗
PubMed2003

[Development of telepathology systems between different types of terminals based on the standard for image collaboration command protocol].

In Japan telepathology systems have been developed in medical or pathological environment such as a shortage and an uneven distribution of pathologists. More than 100 telepathology terminals are working mainly for intraoperative quick diagnosis. They cannot communicate with different types each other. In March 2000 the Medical Information System Development Center(MEDIS-DC) successfully demonstrated the interconnection between different types of telepathology terminals based on the Standard for Image Collaboration Command Protocol (SICCP). Nikon, NTTdata and Olympus had joined the development. In February 2002 MEDIS-DC examined these systems for pathological consultations in the fields of Okinawa-Kyoto, Kyoto-Mie and Mie-Okinawa. These successful examinations let us know that telepathology systems need new observation methodologies for telecytology and teleconsultation in addition to the flow for intraoperative quick diagnosis, new GUI guidelines for telepathology terminal design and, education and support for users of their smooth operation. Outcomes of MEDIS-DC activities encourageed us to challenge the next generation telepathology. We found some new trends in telepathology or pathology informatics such as virtual slide technologies and the internet applications in US and Europe. In order to keep Japanese priority, MEDIS-DC telepathology comittee has started investigations to construct a strategy for development of Japanese next generation telepathology.

Computer Terminals↗
PubMed2002

Effect of display modality on spatial accuracy of orthopaedic surgery pre-operative planning applications.

Graphical representation of a patient's anatomy is fairly similar in the majority of orthopaedic surgery planning programs. The position of implantable devices is usually established using a three-pane window showing 2D cross sections of the CT data set taken on three user-selectable orthogonal planes. In some cases this orthogonal-plane representation is replaced or extended by interactive 3D visualization, obtained using surface rendering techniques. These ways to represent the CT data come naturally and easily to the programmer. However, the efficacy of these display strategies is questionable. The present study aims to assess if the display modality used to visualize CT data affects the inherent spatial accuracy achievable in a surgical planning application. A group of users was asked to perform repeatedly a specific planning task using various display interfaces to the same underlying software application. The planning task was designed to allow an assessment of the accuracy with which each user was able to position the prosthetic component. A specialized interface, called multimodal display, presented a peak error of 0.45 mm and 0.95 deg, significantly lower than the 2.4 mm and 4 deg for the othogonal slices interface, and the 3.8 mm and 16.7 deg for the 3D-rendering interface. The results of this study indicate an important effect of the type of visualization modality used to represent CT data on final accuracy of the planning operation.

Computer Graphics↗
PubMedDate not supplied

Stroboscopic artifact in digital video-EEG.

Combined digital video-EEG (DV-EEG) systems eliminate many familiar technical artifacts of older analog recorders; however, new and unanticipated technical issues are becoming evident. In this report, a case is described that identifies one of these technical limitations that could represent a pitfall to accurate data interpretation. An EEG was recorded on an 18-year-old man with history of photically sensitive generalized tonic-clonic seizures, revealing photoparoxysmal responses that appeared to outlast photic stimulation. However, in an attempted video-EEG correlation, the digital video recording showed variable appearance or absence of photic bursts that did not correlate with EEG photic tick marks, initially suggesting desynchronization between video and EEG signals. However, the absence of flashes seen on the video record resulted from stroboscopic artifact caused by mismatch between strobe frequency, video sampling rate, and video display characteristics. Stroboscopic aliasing is a DV-EEG specific artifact that can complicate accurate interpretation of photoparoxysmal responses.

Adolescent↗
PubMed1997

The VideoToolbox software for visual psychophysics: transforming numbers into movies.

The VideoToolbox is a free collection of two hundred C subroutines for Macintosh computers that calibrates and controls the computer-display interface to create accurately specified visual stimuli. High-level platform-independent languages like MATLAB are best for creating the numbers that describe the desired images. Low-level, computer-specific VideoToolbox routines control the hardware that transforms those numbers into a movie. Transcending the particular computer and language, we discuss the nature of the computer-display interface, and how to calibrate and control it.

Calibration↗
PubMed1996

Adjustments of posture and viewing parameters of the eye to changes in the screen height of the visual display terminal.

To understand the motions caused by the interaction among the different body parts, adjustments of both eye position and body posture to screen height settings of 80, 90, 100, 110 and 120 cm were determined in 10 subjects. The subjects engaged in a non-keyboard, interactive computer game requiring constant visual monitoring. Changes in body positions were determined by video image analysis for the posture parameters and by video frame analysis for the eye parameters. Analysis of variance and correlation analysis showed that neck angle, thoracic bending and vertical eye position were significantly affected by changes in the screen height of the VDT. The study of the interrelationship of eye position and body posture suggested that changes in body positions served to complement the eye position in attaining a better view of the visual target. Viewing angle was observed to be decided mainly by inclination of the neck and the eye. Thoracic bending was also noted to contribute in setting the viewing angle, although to a lesser extent. On the other hand, viewing distance and trunk inclination showed significant correlation.

Adult↗
PubMed2004

A hybrid Hopfield network-genetic algorithm approach for the terminal assignment problem.

This paper presents a hybrid Hopfield network-genetic algorithm (GA) approach to tackle the terminal assignment (TA) problem. TA involves determining minimum cost links to form a communications network, by connecting a given set of terminals to a given collection of concentrators. Some previous approaches provide very good results if the cost associated with assigning a single terminal to a given concentrator is known. However, there are situations in which the cost of a single assignment is not known in advance, and only the cost associated with feasible solutions can be calculated. In these situations, previous algorithms for TA based on greedy heuristics are no longer valid, or fail to get feasible solutions. Our approach involves a Hopfield neural network (HNN) which manages the problem's constraints, whereas a GA searches for high quality solutions with the minimum possible cost. We show that our algorithm is able to achieve feasible solutions to the TA in instances where the cost of a single assignment in not known in advance, improving the results obtained by previous approaches. We also show the applicability of our approach to other problems related to the TA.

Algorithms↗
PubMed1991

Visual load of working with visual display terminals--introduction of VDT to newspaper editing and visual effect.

In the Japanese newspaper industry, since the late 1970s, computerization has been started in large scale. The system, called Computerized Typesetting System (CTS), has been introduced. With this system, all information in the newspaper is input into a computer, called up on a cathode ray display (CRT) to edit, and then output to film or printing plates by CTS. Thus, the work of newspaper production has undergone a major transformation from industrial work to clerical work. It was reported that newspaper production staff working with VDTs complained more than staff working with the older key system about visual and physical problems which affected their job and their daily life. The complaint rates were highest for editors, who used VDT constantly throughout the day. This study was performed to clarify the health impact of VDT use and to prevent health disorders caused by the introduction of CTS. It is concluded that 5 m corrected vision and sphere refraction of CTS workers who used CTS over 2 or 4 hr daily, significantly became worse in a year after the introduction. Therefore, it is indicated that the control of CTS work time is important to prevent the visual disorder.

Adult↗