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At least 451 records · Page 25Linked to original sources
PubMed2006

[Mechanism of actions and clinical applications of proton pump inhibitors].

Proton pump inhibitors (PPIs) are widely used in clinical practice from early 1990s for the treatment of acid- related diseases. PPIs are superior to histamine2-receptor antagonists or anticholinergic agents. These drugs have proven to be effective, safe and well-tolerated during the past two decades. This brief review presents the pharmacodynamics and pharmacokinetics of PPIs and presents clinical applications of the drugs in acid-related diseases.

Gastric Acid↗
PubMed2006

[The clinical application of spiral CT virtual endoscopy of middle ear].

OBJECTIVE: To explore the clinical application of CT virtual endoscopy (CTVE) of ossicular chain in middle ear, and to establish the accurate method of observing ossicular chain and middle ear anatomy. METHOD: Volume scanning with spiral CT unit was performed in forty normal cases without illness of ear. Endoscopic 3D processing was carried out on a separate workstation equipped with a flying through program. From three isolated points(A, B and C), ear drum and ossicles were observed with CTVE method. The status of auditory ossicles connection were focused. RESULT: In CTVE via A, B and C points, the indication rates of the malleus, the indus, the drum cape, the canalis facialis horizontal section, and the prominence of horizontal semicircular canals were prosperously 100%. The indication rates of round window and the fenestra ovalis were 90%, 93%, 98% via A, B and C points respectively. And the indication rates of complete demonstration of ear ossicles were 100%, 95%, 93%, respectively. CONCLUSION: With appropriate approach, CTVE has advantage of showing ear ossicles and their connections, which is a good supplement of routine CT.

Adolescent↗
PubMed1993

Clinical applications and basic studies of laser in dentistry and oral surgery.

In our clinical use of lasers, mainly CO2 laser for oral surgery, we found that the laser had many advantages over an electrome and the laser improved the local control rate for malignant tumors. Low-power laser has been used to treat hypersensitive dentin, to relieve pain caused by neurotic disease around mouth, and to promote the healing of those diseases. The results obtained from the clinical applications showed that irradiation of the hypersensitive dentin with low-power laser was significantly effective in desensitization. An in vitro study showed no effects of diode or He-Ne laser irradiation on the growth of cells, but showed changes in the initial cell adhesion rate. He-Ne laser irradiation to the wound in the skin of hamsters caused to change the activities of the types I and III collagenase. This fact suggest that laser irradiation acted to promote the healing of wound.

Animals↗
PubMed1993

[Prognostic systems in intensive care: general principles, development, and clinical applications].

In this review article, we present the need for prognostic scoring in clinical medicine, specially in Intensive Care Medicine (ICM). The general principles of prognostication in ICM are discussed, and three general scoring systems are presented: ACUTE PHYSIOLOGY AND CHRONIC HEALTH EVALUATION (APACHE) in its 3 versions, SIMPLIFIED ACUTE PHYSIOLOGY SCORE (SAPS) and MORTALITY PREDICTION MODEL (MPM). The use of these prognostic systems is then evaluated not only as a support for medical decision-making, and resource allocation, but also as a tool for clinical studies in terms of patient randomization. Finally, the future developments and clinical application of these risk stratification systems are presented and discussed.

Critical Care↗
PubMedDate not supplied

[Biofeedback. I. Current status of its clinical application].

The aim of this article is to restate the question of the clinical application of biofeedback and its prospects after having defined it. After the huge success that biofeedback has known, some decantation is occurring. One is stricken by the absence of methodological closeness of too many studies, in this field, which very much limits the conclusions one can make presently. The best and most reliable results have been obtained by the biofeedback training of electromyogramme (elimination of subvocalization in reading, direct paralyzed muscles training, tension headaches treatment). The results are encouraging, but not yet enough backed up, as to regards to the improvement of various forms of epilepsy by the biofeedback training of the EEG sensorimotor rhythm, the premature ventricular contractions, sinus tachycardia and migraine headaches. In the other fields, the research status does not yet allow any valid conclusion.

Asthma↗
PubMedDate not supplied

Clinical applications of electrical impedance tomography.

This article is a preliminary review of the possible clinical applications of electrical impedance tomography (EIT). The applications to, for example, the central nervous, respiratory, cardiovascular and digestive systems are covered. It is concluded that the area of greatest potential application of EIT is monitoring cardiopulmonary function, but that studies on much larger groups of patients than have been carried out hitherto are required to fully assess the potential of EIT as a clinical tool.

Body Composition↗
PubMed2004

Telemedicine in the USA with focus on clinical applications and issues.

Telemedicine usually refers to the use of information-based technologies, such as, computer and communications systems, to provide healthcare across geographic distances. Although telemedicine has the potential to improve healthcare, the number of clinical applications is still small and constrained by custom, regulatory, reimbursement and technical issues. In this review paper, a short historical review of telemedicine is provided, followed by an overview of clinical telemedicine applications, including cardiology, dermatology, emergency medicine and trauma care, homecare, pathology, psychiatry, radiology and surgery. Current telemedicine issues in clinics and technological problems to be decided, improved, and challenged, are reviewed. This is followed by conclusions.

Humans↗
PubMed1990

Principles and clinical application of advanced urodynamic analysis of voiding function.

There are no reliable, sensitive, and specific clinical measures or symptoms from which to judge the severity of prostatic outflow obstruction. Urodynamics has developed the methodology for analyzing and measuring the mechanics of urinary tract voiding function in detail. There is a consensus in the urodynamic research community about realistic models of detrusor muscle mechanics and bladder outlet hydrodynamics, as is reflected in the very similar concepts proposed for clinical application. The pressure-flow diagram offers a simple graphical procedure for detailed assessment of the individual voiding balance. Most clinically relevant is the specific characterization of outlet function, because detrusor contraction strength cannot be pharmacologically influenced. It is difficult to accept that the best way to measure "prostatic obstruction" is symptom assessment rather than urodynamic measurement of the clearly mechanical entity "outlet obstruction". Urodynamics has evolved into scientifically accurate and specific techniques for voiding analysis. It is unreasonably to continue to use terms such as "outflow obstruction" or "weak detrusor" and all their synonyms in an undefined, speculative way. If we maintain that the clinical relevance of BPH is entirely related to outflow obstruction, then we must demonstrate obstruction objectively before surgery. If we aim at the treatment of symptoms alone, then we must become more specific in terminology and demonstrate that transurethral prostatic resection is indeed the optimum therapy for unobstructed symptomatic patients with BPH. Similarly, we must use the advanced urodynamic concepts to investigate the efficacy of newly suggested alternatives to resection such as prostatic balloon dilatation or pharmacologic therapy.

Humans↗
PubMed1995

Potassium channel openers: clinical applications in ischemic heart disease--overview of clinical efficacy of nicorandil.

Nicorandil is a balanced arterial and venodilator that may also possess cardioprotective properties via its activation of ATP-sensitive potassium channels. It has a number of beneficial hemodynamic effects and has been shown to be effective in treating angina with similar efficacy as the currently available antianginal agents. In addition, it may have useful effects in unstable and variant angina. In this review we examine the hemodynamic effects of nicorandil and discuss the currently available data on its clinical efficacy, both in isolation and in comparison with other agents.

Angina Pectoris↗
PubMed1989

Clinical applications of SPECT.

The clinical use of single photon emission computed tomography (SPECT) has grown steadily over the last decade. SPECT is now an essential technique for certain studies such as cerebral blood flow imaging. Many other common nuclear medicine studies give better results when they are performed with SPECT. These include myocardial perfusion imaging with thallium-201 or the new technetium-99m perfusion agents, myocardial infarct imaging with infarct-avid agents, imaging of tumors or infections with agents such as gallium-67 or indium-111 WBC's, and certain cases of bone imaging. Still other studies such as liver/spleen imaging, most brain studies, and perhaps renal imaging may benefit from SPECT even though planar imaging gives satisfactory results. Future developments in 3D display techniques and faster computers may extend the clinical usefulness of SPECT to other areas such as pulmonary perfusion imaging and gated cardiac blood pool imaging.

Forecasting↗
PubMed2004

A novel spatio-temporal decomposition of the EEG: derivation, validation and clinical application.

OBJECTIVE: To obtain clinically useful graphical and numerical data on the distribution of activities in the EEG using a novel type of spatio-temporal decomposition. METHODS: The EEG is divided into 1/4 s epochs. An approximation to the spatial distribution of the locally dominant activity in each epoch is represented as a point in a spatial component space. Points representing epochs dominated by activity from the same source form a cluster. The centres of these clusters represent the global spatial component of each source. As each spatial component is identified, its corresponding temporal activity is removed from the record, allowing activity from sources with smaller amplitude to become dominant in the reduced record. Successive components are identified in the reduced record. The method was applied to 40 normal EEGs and features were identified, which were common to them all. The method was also applied to 4 separate records with different forms of focal abnormality. RESULTS: The method successfully separated components from the EEG representing alpha rhythm, eye artefact, electrode artefact and EEG. In 40 normal EEGs the method isolated spatial components that were common to all EEGs, and in 4 abnormal EEGs it achieved a high degree of mutual separation of alpha rhythm, focal spikes, focal theta and focal delta activities. CONCLUSIONS: The method achieved a high degree of mutual separation of the EEG components and successfully differentiated the artefacts due to eye movement, ECG and electrode faults. The clinical implications are discussed.

Adult↗
PubMed1996

Guidelines for the use of tacrine in Alzheimer's disease: clinical application and effectiveness. Johns Hopkins Dementia Research Clinic.

The efficacy of tacrine for treatment of Alzheimer's has been demonstrated in several clinical trials but has not been assessed in cases complicated by medical and psychiatric comorbidities. Additionally, the benefit-risk ratio of tacrine is small, so it is best administered with carefully developed guidelines that specify this ratio for patients and families. On the basis of guidelines developed for the Johns Hopkins Dementia Research Clinic, tacrine treatment was offered to 162 patients with probable Alzheimer's. Only 35 accepted, and only 22 continued on tacrine beyond 3 months. The latter group declined by 1.36 points over 1 year on the Mini-Mental State Examination, significantly less than expected. The authors conclude that, if used in the context of clinical guidelines, tacrine is an effective treatment for Alzheimer's.

Aged↗
PubMed1994

Clinical applications of enteral nutrition.

Clinical and experimental evidence confirms that delivery of nutrients via the gastrointestinal tract reduces septic morbidity in critically injured patients. Early enteral feeding seems to maintain mucosal integrity and to support the gut as an important immunologic organ that may affect other areas of the body. There is increasing evidence to suggest that specific nutrients are especially beneficial in maintaining intestinal host-defense function in times of critical illness and injury.

Clinical Trials as Topic↗
PubMedDate not supplied

MR-guided intravascular catheter manipulation: feasibility of both active and passive tracking in experimental study and initial clinical applications.

PURPOSE: To evaluate clinically the feasibility and usefulness of MR-guided intravascular procedures with either active or passive tracking. METHODS: With an active MR tacking system and a 0.2 Tesla open MR imager, real-time and biplane displays of positions of a receive-only coil at the tip of catheters were obtained. For passive tracking, 4 Fr catheters with suitable susceptibility for passive tracking were used. Passive tracking with a 1.5 Tesla MR imager could be performed with parameters of TR 15-50 msec, TE 2.2-2.7 msec, and FA 30 degrees. The temperature of each tracking catheter was monitored in vitro. Clinical trials were performed on six patients (three each). The catheter was introduced to the superior mesenteric artery (SMA) under MR guidance by active or passive tracking to perform MR imaging during arterial portography. RESULTS: The temperature increased minimally. In humans, the SMA and celiac artery could be easily introduced on active tracking. MR-guided manipulation of catheters by active or passive tracking in the model and in dogs' vessels was very successful. Introduction of the catheter into the SMA was successful in two cases of active tracking and in all cases of passive tracking. CONCLUSION: The MR-guided intravascular manipulation of catheters by active or passive tracking may be a clinically feasible method.

Catheterization, Peripheral↗
PubMed1991

Powdered diatrizoic acid for radiography of the respiratory tract. Part II. Clinical application.

The diagnostic and clinical value of 41 examinations using insufflation and/or inhalation of powdered diatrizoic acid for tracheobronchography, tracheography, laryngography, nasopharyngography, and sinusography was investigated in 35 patients. Diatrizoic acid was found to be useful when applied by insufflation for demonstration of the nasopharynx, trachea and greater bronchi, especially in patients with airway stenosis and low pulmonary reserve. Double contrast images were obtained with good demonstration of anatomic details and adequate diagnostic value. Visualization of the peripheral bronchi by insufflation was satisfactory only when excessive secretions were not present. The inhalation method was adequate only for visualization of the trachea and main bronchi. The method was found to be safe since diatrizoic acid produced no toxic, allergic or febrile reactions and was given in relatively small amounts without impairment of respiratory function.

Administration, Inhalation↗
PubMed1991

One-step chromogenic equivalent of activated partial thromboplastin time evaluated for clinical application.

We evaluated the clinical usefulness of a recently developed semi-automated one-step chromogenic equivalent of activated partial thromboplastin time (APTT; Behring). This simple test is easily adaptable for automation. Generally, the results with this chromogenic one-step APTT were at least as precise as those obtained with comparative coagulometric methods. The chromogenic one-step APTT showed, both in vitro and in vivo, adequate sensitivity to congenital intrinsic factor deficiency but no sensitivity to Factor VII deficiency. Unlike a two-step coagulometric APTT (Dade), the one-step chromogenic APTT seemed sensitive to activation products of the contact system, which are present in immunoadsorbed factor-deficient plasma. The in vitro sensitivity of the chromogenic APTT to heparin was comparable with that of a coagulometric APTT, but the sensitivity to heparin in patients' samples differed slightly. The chromogenic APTT is relatively insensitive to anomalies in the fibrinogen-fibrin conversion. Finally, we observed discrepancies between the chromogenic and coagulometric APTT results for plasma of patients with disseminated intravascular coagulation. We conclude that this one-step chromogenic APTT warrants further evaluation for possible use as a routine test for the clinical laboratory.

Amino Acid Sequence↗
PubMed1990

Quantitative evaluation of hyaline cartilage disorders using flash sequence. II. Clinical applications.

In a prospective clinical study 24 normal volunteers and 106 patients with acute and chronic arthritis, osteoarthritis and post-traumatic alterations of the knee joints were examined. Using the parameters A and M 98 per cent of the pathologic cartilages and 74 per cent of the normal cartilages could be identified. In addition 78.5 per cent were correctly categorized in 5 cartilage classes. The A/M classification proved to be a fast and specific method for evaluation of cartilage disorders with special promise for follow-up examinations during therapy.

Adolescent↗
PubMed1989

[Clinical applications of the heart-lung transplant. Clinical results 5 years after the start of the program at Papworth].

In this study is reviewed the experience at Papworth Hospital, Cambridgeshire, and Great Ormond Street Hospital, London, with combined heart-lung transplantation. Between April 1984 and June 1989, 73 patients have undergone heart-lung transplantation. Donors and recipients were carefully matched with regards to serology, morphology and cytomegalovirus compatibility. Heart preservation was based on use of cold St. Thomas' cardioplegic solution; a pulmonary preservation fluid has been developed that allows distant organ procurement with a single pulmonary artery flush technique (Papworth solution). The recipients were: 21 pts with Eisenmenger's syndrome, 15 pts with pulmonary hypertension, 37 pts with pulmonary disease (including 22 cystic fibrosis). The results are: no surgical mortality; no acute cardiac rejection episodes. Twenty-three patients died (16 with infections, 3 with obliterative bronchiolitis, 2 with cerebral embolism and 2 others). The actuarial survival rate at one year is 73.2%; 63% at two years and 47.4% at four years. The use of transbronchial biopsy of the lung has provided accurate early and safe diagnosis of pulmonary rejection. Development in organ preservation and patient management, as well as careful selection of recipients and donors, have led to the effective use of resources and thereby to these good results.

Adolescent↗