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Results for “Capillary Permeability”

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PubMed1986

Endoneurial capillary permeability to [14C]sucrose in frog sciatic nerve.

Using an in situ perfusion technique, we measured the [14C]sucrose permeability-surface area product (PA) in endoneurial capillaries of 48 frog sciatic nerves, as 6.6 +/- 0.6 (S.E.M.) X 10(-5) s-1, and the vascular space as 1.31 +/- 0.10%. Assuming A = 30 cm2/g, P = 2.2 X 10(-6) cm/s. P for sucrose was greater than P in some barrier tissues with tight junctions, but was less than P in all capillaries examined so far except rat cerebral capillaries. These observations demonstrate that endoneurial capillaries are an effective part of the blood-nerve barrier to water-soluble non-electrolytes. The findings are consistent with capillary impermeability to microperoxidase and with capillary ultrastructure.

Animals↗
PubMed2000

In vivo sequential study of skeletal muscle capillary permeability in diabetic rats: effect of anthocyanosides.

Alterations in the capillary filtration of macromolecules are well documented in diabetic patients and experimental diabetes. Various flavonoids including anthocyanosides and ginkgo biloba extracts have been shown to be effective against experimentally induced capillary hyperfiltration. The aim of the present study was to test the effects of anthocyanosides on capillary filtration in diabetic rats. For this purpose, we have validated the use of our previously described in vivo method for measurement of the capillary filtration of albumin (CFA) in rats. Male Wistar rats with streptozotocin (STZ)-induced diabetes were randomized in 3 groups to receive either ginkgo biloba (group A), Vaccinium myrtillus (group B), or no treatment (group C). The isotopic test of CFA consisted of intravenously injecting 99mtechnetium-labeled albumin, inducing venous compression on a hindquarter, and measuring radioactivity externally on the limb before, during, and after removal of venous compression. After removal of the tourniquet, the radioactivity curve decreased. Interstitial albumin retention (AR) and the ratio of the amplitudes of the low- and high-frequency peaks (LF/HF ratio), an index of lymphatic function obtained by the fast Fourier transform of the last part of the radioactivity curve, were calculated. In STZ-treated animals, the isotopic test was performed at a mean age of 97 days (time 1) and after 6 weeks (time 2) and 12 weeks (time 3) of treatment, ie, 6 and 12 weeks after time 1. At time 1, AR was significantly higher in the 3 diabetic groups than in the control rats, without a significant difference between these groups. In group B, AR decreased significantly (P = .015) at times 2 and 3. In group C, AR increased significantly (P < .0005) from time 1 to time 3. In group A, AR increased slightly (NS) between time 1 and time 3. In groups A and C, the LF/HF ratio significantly increased with time (P < .0005) and the levels at time 3 were significantly higher versus control rats (P < .0001). In group B, the LF/HF ratio remained unchanged from time 1 to time 3 and similar to the values found in the control rats. In conclusion, these data show that (1) this new in vivo noninvasive method can be used to study CFA in skeletal muscle in diabetic rats, (2) it is reproducible and may be repeated over several months to evaluate spontaneous microcirculatory changes, and (3) anthocyanosides appear to be effective in preventing the increase in CFA and the failure of lymphatic uptake of interstitial albumin in diabetic animals.

Animals↗
PubMed1994

[Capillary permeability and micro-lymph drainage].

Vital microscopic findings confirm the existence of an organized prelymphatic system favoring the fluid and substance drainage by the initial lymphatics. By means of open connections of solphasic tissue channels with the initial lymphatics-together with the system of open junctions-the contribution to the maintenance of the interstitial fluid balance is essentially increased. In connection with the permeability for fluid and proteins of the capillary bed itself this contribution appears important. The trans-interstitial fluid transport is favored additionally by the fluid movement along the connective tissue fibres.

Animals↗