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PubMedDate not supplied

[Effect of acetylcholine and histamine on electrolyte and catecholamine content of vessel walls exposed to x-rays and cystamine].

Experiments on adult rats have shown that a single rectal x-ray irradiation is accompanied by a decrease in the content of adrenaline, noradrenaline and potassium and by a increase in sodium and calcium concentration in vascular tissue. The degree of these shifts depends on the time elapsed after exposure to x-rays. X-Ray injury produces specific changes in the biochemical response of the vascular wall to different doses of acetylcholine and histamine during varying times of x-ray-induced pathology. Pretreatment (before irradiation) with radioprotectors (cistamine) lowers the damaging effect of radiation and promotes the normalization of the vascular tissue response to the administration of mediator agents.

Animals↗
PubMed2001

Binding of Biotin to Gold Surfaces Functionalized by Self-Assembled Monolayers of Cystamine and Cysteamine: Combined FT-IRRAS and XPS Characterization.

As part of our project of developing a new IR-based immunosensor, we investigated the functionalization of gold substrates with thin organic films containing biotin ligands. A two-step procedure was developed consisting of the chemisorption of short amine-terminated organosulfur compounds, followed by their reaction at the solid liquid interface with an activated ester derivative of biotin. Covalent binding of biotin to these attachment layers was assessed by Fourier transform infrared reflection-absorption spectroscopy (FT-IRRAS) and X-ray photoelectron spectroscopy (XPS). The interaction of activated biotin with alcohol- and carboxylic acid-terminated monolayers was also investigated, and, as expected, no binding occurred. Moreover, mixed layers of short alcohol- and amine-terminated thiolates were successfully constructed at the gold surfaces and were shown to be the most efficient for the covalent binding of biotin thanks to the blocking effect of the thioalcohol, which prevented direct adsorption of biotin to the gold surface. Copyright 2001 Academic Press.

Journal Article↗
PubMed1984

In vivo acute hematotoxicity of N,N'-bis[N-(2-chloroethyl)-N-nitrosocarbamoyl]cystamine (CNCC), a new nitrosourea analog.

The in vivo hematotoxic effects on different hemopoietic cell compartments of a new nitrosourea analog CNCC were compared to another glycosidyl derivative, RFCNU. Bone marrow microenvironment in liquid culture, bone marrow and splenic colony-forming units in agar culture (GM-CFUc), relative spleen index, and spleen and bone marrow cellularity were evaluated in young adult (DBA/2 X C57B1/6)F1 mice. The drugs, dissolved in olive oil, were injected ip at either the minimal or the median or the maximal dose of the "maximally efficient dose range." A single administration of CNCC induced a dramatic depopulation of bone marrow and spleen within 12 and 24 hr and significantly reduced the GM-CFUc in both organs. A rapid recovery of both the total cell number and GM-CFUc was observed between Days 2 and 5 (kinetic experiment). The comparison of toxicity of 20 to 50 mg/kg CNCC and 15 to 30 mg/kg (2-chloroethyl)ribopyranosyl-3-nitrosourea RFCNU at Day 1 and Day 5 showed that the bone marrow microenvironment was modified by the effect of oil and was further impaired by CNCC in a concentration-dependent fashion. In contrast RFCNU had less effect on the microenvironment. Similarly, the bone marrow GM-CFUc population was reversibly impaired by CNCC in a dose-dependent fashion, and again RFCNU had less effect. In the spleen both drugs provoked a higher toxic effect than in the bone marrow; on Day 1 they decreased the GM-CFUc population by 1 to 2 log. On Day 5 a compensatory regeneration was obtained in all cases except the highest tolerable CNCC dose, whose effect was more delayed.

Acute Disease↗