Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ANTISEPTICS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 451 records · Page 25Linked to original sources
PubMed2001

Effectiveness of a nonrinse, alcohol-free antiseptic hand wash.

This study evaluated the efficacy of a novel surfactant, allantoin, and benzalkonium chloride hand sanitizer using the US Food and Drug Administration's method for testing antiseptic hand washes that podiatric physicians and other health-care personnel use. The alcohol-free product, HandClens, was compared with an alcohol-based product, Purell. Independent researchers from the California College of Podiatric Medicine conducted the study using 40 volunteer students from the class of 2001. The results show that HandClens outperformed Purell and met the regulatory requirements for a hand sanitizer. Purell failed as an antimicrobial hand wash and was less effective than a control soap used in the study.

Adult↗
PubMedDate not supplied

Virucidal efficacy of hospital disinfectants and antiseptics.

This article reviews the virucidal efficacy of the five main families of chemical disinfecting solutions: Alcohols, glutaraldehydes, iodophors, bisdiguanides and phenolics currently used in hospitals as disinfectants or antiseptics. Special emphasis was placed on the efficacy of these solutions against difficult-to-kill hydrophilic viruses, some of which are responsible for nosocomial infections in hospitals.

Cross Infection↗
PubMed1999

[The use of Betadine antiseptic in the treatment of oral surgical, parodontological and oral mucosal diseases].

The Betadine is an antiseptic PVP (polyvinil prrolidon)-iodine containing, water soluble solution, which has been in circulation in Hungary for years. Until now Betadine was not applied in the oral cavity for bacterial and fungal infections, although its effectiveness is unquery. The PVP-iodine is water solubilized that's why it does not sting the healthy or ill oral mucosa and has not side effects as discoloration of the teeth and tongue and trouble in the sensation of taste as does chlorhexidine. The only contraindication is iodine allergy. In the present study: in periodontal cases (abscesses, postoperative prevention) and in oral medicine cases alone or in combination with specific treatment schedule was Betadine applied. PVP-iodine as oral rinse was applied in 25 cases. According to our experience Betadine was excellent against bacterial and fungal infections in the oral cavity, which prevent or treat bacterial infections after surgical interventions. By this way the bacterial superinfections of exulcerant oral mucosal diseases avoidable.

Adult↗
PubMed1999

Eradication of MRSA from carriers by means of whole-body washing with an antiseptic in combination with mupirocin nasal ointment.

Patients who are infected or colonised by MRSA should be isolated. However, isolation is very costly in terms of time and work. In order to shorten the period of isolation, attempts are being made to eradicate this organism from patients by means of whole-body washing in addition to nasal mupirocin treatment. The effectiveness of such washes has not yet been adequately confirmed by studies. From September 1997 to August 1998, therefore, in a clinical trial of MRSA eradication, 28 patients were washed for a period of five days with a 1:1 diluted preparation based on octenidine dihydrochloride. At the same time, the nose was treated with mupirocin. Before washing was begun, on day 4 during washing and on days 1, 4 and 7 after washing was completed, smears were taken from each patient from the nose, pharynx, forehead hairline, groin, axilla and wounds, and in the case of women from the sub-mammary area. Elimination of the MRSA was achieved in 21 out of 28 cases; in four cases the washing was discontinued on account of skin redness, in three cases no elimination could be achieved during the control period. In order to ensure the success of eradication and to minimise skin reactions due to the washing, the wash procedure must be standardised, and decontamination controlled microbiologically. The study confirms that MRSA can be eradicated by means of washing with an antiseptic combined with mupirocin treatment.

Administration, Topical↗
PubMed1975

Urinary antiseptics in asymptomatic bacteriuria of pregnancy.

A screening programme for the detection of asymptomatic bacteriuria in patients attending an antenatal clinic is described. The results obtained from the use of urinary antiseptics in a controlled trial over a period of two years are presented. The number of patients developing clinical pyelonephritis, fetal maturity at delivery and birth weight were recorded for treatment and control groups and compared with the equivalent results obtained from the total population of patients seen at the clinic.

Abortion, Spontaneous↗
PubMed2000

Disinfection of dental unit waterlines with an oral antiseptic.

The problem of potential pathogens in biofilm within dental unit waterlines is real. Even though some chemical agents can disinfect biofilms, there remains concern that all remnants of the biofilm matrix are not eliminated, even with periodic treatments, and the bacterial populations in dental unit waterlines recur rapidly. Toxic and caustic residual chemicals are also a concern. In multiple trials following overnight treatment of dental unit waterlines with Listerine Antiseptic (LA), recurrence was investigated by evaluating effluent and biofilm specimens by plate culture. The presence or absence of biofilm within the dental unit waterlines was evaluated, pre- and post-treatment, by scanning electron microscopy. Baseline evaluations of dental unit waterlines determined the effluent and biofilm to harbor an average of 1 x 10(5) CFU per ml and 1 x 10(4) CFU per cm2, respectively, prior to treatment. Overnight, 18-hour treatment with LA rendered effluent and biofilm samples free of recoverable bacteria in all cases immediately following treatment. Viable bacteria in the effluent of treated dental unit waterlines recurred to near pre-treatment levels by Day 7. The minimum inhibitory concentrations for each of the recovered isolates did not change following overnight treatment. Repeated overnight treatments at the beginning of a one-week study were effective in inhibiting recurrence of viable bacteria in the biofilm and effluent indefinitely, but still failed to completely remove the biofilm matrix. New tubing treated prior to use and then daily with LA did not develop a detectable biofilm by scanning electron microscopy during the study. One-month long follow-up clinical trials have demonstrated that a maintenance solution of a 1:50 concentration of LA and sterile distilled water in self-contained dental units with new tubing is effective for prolonged periods in maintaining the effluent within the American Dental Association's recommendation for the year 2000 of < 200 CFU per ml. The clinical significance of these findings is that a solution to the problem of dental unit waterline contamination may be currently available. Since antimicrobial LA is safe for patient use, it may be one of the most viable options suggested to date.

Anti-Infective Agents, Local↗
PubMed2001

[Research on the wisdom between defensins and antiseptics at the skin surface].

The density in the natural bacterial flora is quite controlled at the skin surface. The barrier to their penetration inside the body is a major function of the stratum corneum. Its more or less anfractuous structure, its hydration and acidic pH are important to maintain the microbiological equilibrium. The non-immune innate or inducible natural defenses rely on the production of epithelial peptide antibiotics (defensins, calprotectin) by keratinocytes. The phagocytic and immune defenses are superimposed to such mechanisms. This whole conundrum may be helped by, but it may also suffer from some skin care products and antiseptics.

Anti-Infective Agents, Local↗
PubMed2002

[Hexetidine--an oral antiseptic].

Hexetidine is very safe oral antiseptic with broad antibacterial and antifungal activity in vivo and in vitro. It has local-anesthetics, astringent and deodorant activity. Also, it has very strong antiplac effects. Resistention of microorganisms on hexetidine is short and transient. These characteristics give important therapeutic role in treatment of oral infections.

Anti-Infective Agents, Local↗
PubMed2002

[Interaction of cationic surface-active antiseptics and serum albumin by the bacterial bioluminescence method].

Human serum albumin binding of cationic surface-active antiseptics was studied using a Photobacterium phosphoreum K3 strain isolated by the authors in the Black sea. Binding of cationic surface-active proteins to serum albumin led to disappearance of toxic and antibacterial characteristics of miramistine, ethonium, and decametoxin, but not chlorohexidine. The activity of chlorohexidine was reduced by 45-48% in the presence of albumin. Albumin binding capacity towards miramistine was 7.0-8.7%, towards ethonium 8.2-10%, and towards decametoxin 2.4-3%.

Anti-Infective Agents, Local↗
PubMed2000

[Determination of 4 antiseptics and 6 sunscreen agents in cosmetic products by reversed-phase high performance liquid chromatography].

A method for the quantitative determination of 4 antiseptics (methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, n-propyl p-hydroxybenzoate, n-butyl p-hydroxybenzoate) and 6 sunscreen agents (2-hydroxy 4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy 4-methoxybenzophenone, phenyl salicylate, 2-ethylhexyl 4-dimethyl aminobenzoate, 2-ethylhexyl 4-methoxycinnamate, 2-ethylhexyl salicylate) in cosmetic products was developed successfully. It was based on a reversed-phase high performance liquid chromatographic separation under the conditions of isocratic elution with a mixture of methanol-THF-water (30:100:100, V/V) by using a column packed with 10 microns YWG-C18, and the UV detection at 254 nm and 310 nm. The recoveries(n = 6) ranged from 87.2% to 106.5%, and the relative standard deviations(n = 6) were from 1.2% to 3.3%.

Anti-Infective Agents, Local↗
PubMed2002

[Microbiological validation of the composition of "decaceol", an antiseptic prolonged-release drug].

With the aid of different microbiological methods, antimicrobal properties of decametoxine, a home-produced antiseptic, were studied together with those of the synthetic zoelite NaA-base drug preparation. The antimicrobial activity of the above drug has been shown to be of a synergistic character that makes it a very promising medical agent which will, we believe, come to be widely used in medical practice.

Anti-Infective Agents, Local↗
PubMed1992

[Resistance of hospital strains of microorganisms to antibiotics and antiseptics].

The development of resistance of collection and freshly isolated S. aureus and C. albicans strains to the antiseptic decamethoxim and an original diarylcyclohexane derivative was studied comparatively in vitro. It was shown that the rate of the resistance development was low. After 20 subcultures in the presence of increasing concentrations of decamethoxin, its sensitivity of S. aureus and C. albicans decreased 16-32 and 16-fold respectively. After 20 subcultures in the presence of increasing doses of the diarylcyclohexane derivative, its sensitivity S. aureus and C. albicans decreased 4- and 4-8-fold, respectively. It was found that in the hospital strains of S. aureus and C. albicans, the antibiotic resistance and sensitivity to decamethoxin and the diarylcyclohexane remained high, which indicated that there was no cross resistance to these compounds in the strains studied.

Anti-Infective Agents, Local↗
PubMedDate not supplied

[Activity of frequently used disinfectants and antiseptics against nosocomial bacterial types].

In this study, bactericidal activity of widely used disinfectants and antiseptics (glutaraldehyde, laurylbispropylidentriamin 5 g and benzalkoniumchlorid 20 g, polyvinylpyrolidon iodine, benzalkonium chloride and sodium hypochloride) against some nosocomial bacterial isolates were investigated by qualitative and quantitative suspension test methods. One methicillin-resistant Staphylococcus aureus (MRSA), 6 multi drug-resistant Gram-negative hospital isolates (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloaca, Klebsiella pneumoniae, Citrobacter diversus, Serratia marcescens) and 3 standard strains of American Type Culture Collection (ATCC) bacteria (S. aureus, P. aeruginosa, E. coli) were tested against three different concentrations of disinfectants of which, manufacturer's recommended use-dilution, 1/2 and 1/4 of those recommended dilutions. All tested disinfectants were found effective in all three concentrations against nosocomial isolates in five minutes, by using both qualitative and quantitative suspension methods. When the test was repeated with albumine, bactericidal activities of disinfectants were found the same. Our findings showed that these disinfectants can be still used in safe for the sterilization in hospital, and routine disinfection protocols do not need to be alerted.

Anti-Infective Agents, Local↗
PubMed1995

[Preliminary clinical study of endodontic antiseptic in monotithic type chlorhexidine controlled release delivery system]

The purpose of clinical study was to assess the bacteriological status of the root canal after disinfection with the monotithic type chlorhexidine enrolled release delivery system (CCROS).In experiments the monotithic type CCRDS was found to be more effective than the reservoir type CCRDS.The root canals of 24 teeth with apical periodontitis were completely instrumented and irrigated with sodium hypochloride.After the instrumentations,12 teeth were treated with the monotitihic type CCRDS,12 teeth were treated with formocresol.Bacterological samples from the root canals were taken after 5 days using an anaerobic technique.The results indicated that monotithic type CCRDS was more effective than formocresol in obtaining bacteria-free root canals(Chi-square test P<0.05).The advantages of an antiseptic with along lasting effect for the elimination of bacteria form the root canal and for the prevention of reinfection were emphasized.

Journal Article↗
PubMedDate not supplied

[Comparison of antibacterial effects of different antiseptics after hand washing].

The aim of this study was to compare 4% chlorhexidine gluconate, 7.5% povidone iodine and liquid soap, which are used as hand washing solutions for the immediate, cumulative and residual effects in bacterial growth. For this purpose, 18 volunteers washed their hands with 7.5% povidone iodine, 4% chlorhexidine gluconate and liquid soap by applying standard hygienic hand washing technique. In order to find out the bacterial amount in the hands of study group, glove liquid test was used. For the evaluation of immediate effects, samples were collected just after the washing procedure, for the residual effects samples were collected from gloved hands after 3 hours, and for the cumulative effects, samples were collected after 5 days with daily hand washings. It is found that the immediate effects of 4% chlorhexidine gluconate was superior than others, and 7.5% povidone iodine was superior to liquid soap. There was no difference between 4% chlorhexidine gluconate and 7.5% povidone iodine for residual effects. The cumulative effects were observed for 4% chlorhexidine gluconate and 7.5% povidone iodine, while there was no cumulative effect for liquid soap. According to these results, it can be suggested that 4% chlorhexidine gluconate can be used as a reliable antiseptic agent in the hospitals, especially for laboratories, intensive care units and operating rooms, owing to its favourable immediate, residual and cumulative effects.

Anti-Infective Agents, Local↗
PubMed2005

Antiseptic resistance: what do we know and what does it mean?

Biocides (antiseptics, disinfectants, preservatives, sterilants) are used in clinical medicine as intervention strategies that prevent the dissemination of nosocomial pathogens. Biocides are also used for personal hygiene and to prevent cross-contamination of food-borne pathogens in homes, restaurants, day care centers, and nursing homes. However, laboratory evidence has emerged suggesting that the mechanism of nonsusceptibility to biocides may counter-select for resistance to antibiotics. Nature conserves successful survival strategies. Using existing mechanisms of resistance to antibiotics and their means of dissemination, microorganisms have adopted this same survival strategy for biocide nonsusceptibility. These mechanisms are intrinsic in nature or are acquired. The consequences to biocide efficacy in the clinical setting are probably not significant from the biocide perspective. But, the selective pressure biocides exert on bacterial populations that have mechanisms of resistance similar to those to antibiotics or that are also substrates for antibiotic resistance is of concern.

Adaptation, Physiological↗