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PubMed2005

[Comparison among the three different approaches in the management of adenoid hypertrophy].

OBJECTIVE: To compare the advantage and disadvantage among Transnasal Endoscopic Adenoidectomy (TEA), Endoscopic-assisted Transnasal Adenoidectomy (ETA) and traditional Transoral Curette Adenoidectomy (TCA). METHOD: Clinical data of 130 cases who received adenoidectomy were studied and the effective rate of hearing, snoring, nasal obstruction, rhinorrhea and residual of adenoid were compared among the three groups after operation. There were 82 male and 48 female with average age of 7.58 years (range 3-29 years). Of 130 cases, there were 79 cases in TCA group, 24 cases in TEA group and 27 in ETA group. RESULT: The effective rate of nasal obstruction in ETA group was significantly higher than that in TCA group ( P < 0.05) with average following-up 21.4 months (range 6-44 months). Residual adenoid was found in 20 cases in TCA group and none in the other two groups. CONCLUSION: Endoscopic-assisted transnasal adenoidectomy using power system is the best approach of choice in the management of adenoid hypertrophy. Transnasal endoscopic adenoidectomy has benefit when another endoscopic sinonasal procedure is planned.

Adenoidectomy↗
PubMed2005

[The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance].

PURPOSE: To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma (SACC) and its significance. METHODS: The expression levels of FAK and PTEN in 50 cases of SACC were detected by strepravidin-peroxidase immunohistochemical technique. SPSS10.0 software was used for Chi-square test, paried Student t test and correlation analysis. RESULTS: The expressions of FAK in salivary adenoid cystic carcinoma was 94%, and the negative expressions of PTEN was 70%.There was a significant difference between normal salivary gland and salivary adenoid cystic carcinoma (P<0.01). A significant negative relation was found between the expression intensity of FAK protein and PTEN protein(P<0.01).No correlation between the expression intensity in cribriform,tubular, and solid group was found. CONCLUSIONS: Activation of FAK may play a strong role in the development of SACC. PTEN was abnormally expressed in SACC. No significant different expression of FAK and PTEN were found in different clinic pathological types.

Carcinoma, Adenoid Cystic↗
PubMed1991

Adenoid cystic carcinoma of the minor salivary glands.

Management of minor salivary gland adenoid cystic carcinoma is a controversial problem. Few clinicians obtain adequate experience in the treatment of this disease, which is often frustrated by early and late distant metastases. Fourteen cases of minor salivary gland adenoid cystic carcinoma recorded in the Delaware Registry over a 20-year period (1968 to 1988) were reviewed retrospectively. These cases were evaluated for their duration of symptoms; size, location, and histologic subtype of the lesion; perineural invasion; lymph node metastases; and treatment to determine the relationship of these factors to survival. Location and histologic subtype of the lesion and duration of symptoms were found to have a more significant impact on survival than size of the lesion, perineural invasion, or lymph node metastases. Surgery is the mainstay of therapy for minor salivary gland adenoid cystic carcinoma, with resection that includes disease-free margins but spares function being advocated. Although adjunctive radiation therapy has not been shown to increase survival, it is reasonable in lesions with perineural invasion and/or lymph node metastases.

Carcinoma, Adenoid Cystic↗
PubMed2006

[Comparison of the powered-assisted adenoidectomy with adenoid curette adenoidectomy].

OBJECTIVE: To compare the outcomes of powered-assisted adenoidectomy with adenoid curette adenoidectomy. METHOD: Thirty-four cases with adenoidal hypertrophy were retrospectively analyzed in Shanghai Sixth Peoples Hospital between June 2003 to June 2004. All the patients were followed up six to twelve months. Of 34 cases, 18 children underwent powered-assisted adenoidectomy, and the rest underwent conventional transoral adenoidectomy using a curette. The surgical results were assessed by acoustic rhinometry. RESULT: The averaged time for endoscopic powered-assisted adenoidectomy was 5 minutes and 15 seconds and the time for conventional adenoidectomy was 8 minutes and 22 seconds. There was a significant difference (P < 0.01) between them. The blood loss during powered-assisted and conventional adenoidectomy was 50 (10-125) ml and 75 (5-175) ml respectively, but there was no difference (P > 0.05). One case after powered-assisted adenoidectomy happened bleeding, and one case after conventional adenoidectomy happened dehydration. There were increases in the cross-sectional area at the adenoid, (0.75 +/- 0.58) cm2 preoperatively and (1.94 +/- 0.63) cm2 three months postoperatively, (1.99 +/- 0.44) cm2 one year after operation in powered-assisted group, and (0.80 +/- 0.53) cm2 preoperatively and (1.83 +/- 0.81) cm2 three months postoperatively, (1.89 +/- 0.37) cm2 one year after operation in conventional group. Comparing the preoperative and postoperative cross-sectional area in both groups by acoustic rhinometry, a significant difference (P < 0.01) was found. CONCLUSION: Powered-assisted adenoidectomy has the advantages of shorter surgical time, and less blood loss. Acoustic rhinometry is a kind of objective parameter for assessing the outcome of adenoidectomy.

Adenoidectomy↗
PubMed2006

[Six cases of adenoid cystic carcinoma in external auditory canal].

OBJECTIVE: By investigating the clinical and pathological features of adenoid cystic carcinoma in external auditory canal, we can improve our ability of diagnosis and treatment. METHOD: A retrospective analysis was performed on 6 patients with adenoid cystic carcinoma in external auditory canal, including clinical manifestations, the therapy as well as the follow-up results. All cases underwent subtotal temporal bone resection or other aggressive surgical excision. RESULT: All cases were alive for a period from 8 to 21 months after subtotal temporal bone resection or other aggressive surgical excision, without any signs of regional lymph node metastasis and distal metastasis. CONCLUSION: Adenoid cystic carcinoma in external auditory canal grows slowly, so patients can live with the tumor for a long time. But the long-term prognosis is poor. It is necessary to manipulate aggressive surgical excision at the first time to improve cure rate.

Adult↗
PubMed2006

Asynchronous adenoid cystic carcinoma of the prostate and transitional cell carcinoma of the urinary bladder.

Histologic variants of prostatic carcinoma are readily recognized. In this report, we describe a rare variant, adenoid cystic carcinoma, in a 75-year-old man previously diagnosed to have transitional cell carcinoma of the urinary bladder. The diagnosis of adenoid cystic carcinoma was made by the characteristic microscopic features of the tumor morphologically and immunohistochemically. Two months later he was found to have metastatic disease. The patient's treatment consisted of chemotherapy in combination with prednisone and hormonal therapy. Five and a half months after diagnosis, he died with metastatic disease. Making this case unique is the asynchronous occurrence of this variant with transitional cell carcinoma of the urinary bladder, which has never been reported in the literature. We discussed the histopathologic and immunohistochemical features of adenoid cystic carcinoma of the prostate with review of literature.

Aged↗
PubMed2006

Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case.

Adenoid cystic carcinoma is the most frequent malignant neoplasm of minor salivary glands (76.5%); it is clinically characterized by slow growth, and its most frequent localization is the hard palate. Histopathologically it presents three patterns, cribriform, tubular and solid; the solid type is related to a poor prognostic contrary to the cribriform type, which has a better prognosis. Surgical excision with wide margins is the treatment of choice, if it metastasizes to lymph nodules, post surgical radiotherapy is recommended. A 19 year-old man presented a recurrent lesion on the dorsum of the tongue previously diagnosed as monomorphic adenoma. In a second biopsy it was diagnosed as adenoid cystic carcinoma. The following immunohistochemical studies were ordered: CALP, CEA, Epithelial Membrane Antigen, Glial Fibrilar Acid Protein, Ki67; all of these studies were positive and with different intensities, corroborating the diagnosis of adenoid cystic carcinoma. The patient had a recurrence after 2 years.

Adult↗
PubMed2006

Adenoid cystic carcinoma of ceruminous gland: a case report.

Adenoid cystic carcinoma of the external auditory canal (EAC) is a very rare malignant tumor and its diagnosis is frequently missed because of the superficial nature of biopsies. A 30 year old male presented with 6 months history of recurrent painful right ear discharge. On examination there was a nodule of 2 cms in diameter. The microscopic examination of the punch biopsy specimen of tumor revealed typical features of an adenoid cystic carcinoma. While reporting the biopsies of external auditory canal one should keep the adenoid cystic carcinoma as one of the possible differentials, especially if the biopsy is superficial, problem is recurrent and histopathological features suggest the granulation tissue.

Adult↗
PubMed1990

[Adenoid cystic carcinoma of the lacrimal gland: report of a case].

Adenoid cystic carcinoma of the lacrimal gland is rarely reported in Japan compared with other countries in Europe and the U.S.A. Here is a report of this rare case. A 26-year-old female had complained of left visual disturbance and left exophthalmos with orbital pain. CT scan and MRI revealed a lacrimal gland tumor in that eye. The tumor was removed via a left frontal craniotomy, and diagnosed as adenoid cystic carcinoma. After operation, she was locally irradiated with a total dose of 5,000 rads using 15 MeV Lineac source. Chemotherapy was started with 5-FU after radiation therapy. An abnormal uptake was observed in the sternum in the bone scintigraphy performed after operation, suggesting metastasis. Visual disturbance improved and exophthalmos and orbital pain disappeared. At the last follow-up at 8 months after operation, she had no signs and symptoms of recurrence or metastasis. Adenoid cystic carcinoma is reported to be the most frequent among the malignant tumors of the lacrimal gland in the Western countries. Prognosis is generally unfavorable with the mortality of 45% to 70%. The 5-year and 10-year survival rate are 45% and 25%, respectively. The mean post-operative survival time is 4.5 years. Since the tumor grows infiltratively into the surrounding tissues, radical excision with total exenteration of the orbit is the treatment of choice. However, it is a difficult decision whether or not to remove the eye with the intact visual function. As for operation, an approach from above through the frontal craniotomy provides a wider operative field and an easier access to the tumor than the lateral approach employed by ophthalmologists.

Adult↗
PubMed1978

Adenoid cystic carcinoma with orbital and cranial metastases: case report.

Adenoid cystic carcinoma of the paranasal sinuses was demonstrated in a patient who subsequently developed a metastatic lesion to both orbits resulting in total blindness. While there are reports of extension of adenoid cystic carcinoma of the lacrimal gland to the adjacent orbit, this patient is an example of orbital extension of an adenoid cystic carcinoma of minor salivary gland originating in a paranasal sinus. The frequency and classification of this tumor also is reviewed.

Blindness↗
PubMed1990

[A case of peripheral adenoid cystic carcinoma].

A case of peripheral adenoid cystic carcinoma in a 70-year-old woman is presented. She had a coin lesion in the left upper lung field on chest X-ray film. Before one month on admission to our hospital, she noticed a tumor in the left thigh and underwent simple resection. Histological diagnosis was liposarcoma. Lung metastasis of the liposarcoma or primary lung cancer were suspected. Lung wedge resection was performed and adenoid cystic carcinoma was diagnosed. Generally adenoid cystic carcinoma originates from bronchial gland, arising in the trachea or main bronchus. In this case, the tumor originated from the peripheral lung field.

Aged↗
PubMed1990

[Adenoid cystic carcinoma of the nasopharynx with intracranial metastasis--a case report].

Adenoid cystic carcinoma of the nasopharynx is an occurrence with only 44 previously reported cases in the English literature. We report herein one additional case. This 62-year-old female patient suffered from right facial numbness for 1 year. A CT scan of the brain showed tumor shadow in right C-P angle. Subsequently, the patient underwent a temporal craniotomy. A mass was noted in medial temporal fossa, encasing the trigeminal nerve. The tumor was totally removed and pathologic examination showed a picture of metastatic adenoid cystic carcinoma. High resolution CT scan of nasopharynx after surgery revealed bulging of fossa of Rosenmüller, although no gross abnormality was found in the mirror examination of nasopharynx. Thus, nasopharyngeal biopsy was done resulting in a diagnosis of adenoid cystic carcinoma which was considered to be the primary site of origin. The patient received radiotherapy and she was followed up in our clinic.

Brain Neoplasms↗
PubMed1988

[Esophageal carcinoma with adenoid cystic differentiation--an immunohistochemical study of two cases with special reference to their histological origin].

Two cases of an esophageal carcinoma with an adenoid cystic differentiation are presented. The first was diagnosed histologically as typical adenoid cystic carcinoma, and the other as being a basal cell carcinoma with an adenoid cystic differentiation. We further investigated these tumors and normal esophageal specimens to determine their histological origin by immunohistochemical staining with either polyclonal or monoclonal antibodies to different classes of human keratin. It was found that both tumors were similar in their reactivities with the anti-keratin antibodies to basal cells of the surface squamous epithelia, but not to the cells composing the esophageal glands, suggesting that they were of basal cell origin.

Aged↗
PubMed1989

The problems of tonsils and adenoids.

The tonsils and adenoids are secondary lymphoid organs which have evolved to protect the human host against microbial invaders entering the body via the cephalic gateway of the body, i.e. the nasopharyngeal aperture. There are special epithelial cells and macrophages which modify the microbial antigens to present to the B and T-lymphocytes of the tonsils and adenoids. The lymphocytes produce immunoglobulins which are transported to the circulation and also topical secretory IgA which is secreted into the salvia and mucous secretions to protect the human host. The changes in these secretions as a result of recurrent tonsillitis and hypertrophy of the adenoids and tonsils are discussed. Because these are part and parcel of the defence system of the body, their surgical removal may deprive the human host of one of its defence systems.

Adenoids↗
PubMed1987

Derivation of a murine monoclonal antibody useful for immunohistochemical diagnosis of human adenoid cystic carcinoma and stomach cancer.

A monoclonal antibody, NCC-SG-007, was raised with a formalin-fixed adenoid cystic carcinoma of the salivary gland as the immunogen. The reactivity of the antibody was tested on paraffin sections using the avidin-biotin-peroxidase complex (ABC) method. NCC-SG-007 reacted with 36% of the adenoid cystic carcinomas, 42% of the pleomorphic adenomas and 14% of the mucoepidermoid tumors of the salivary gland which were tested. The antibody also reacted with some normal tissues and various other tumors. Surprisingly, NCC-SG-007 showed a reactivity as high as 94% with gastric carcinomas. The antigenic determinant was revealed to be a carbohydrate chain with no terminal sialic acid, the molecular weight of which was estimated to be 1.5 X 10(6) daltons. This antigen differed from other previously reported gastrointestinal cancer-associated antigens. The antibody should be useful for studying adenoid cystic carcinomas of the salivary gland and gastric cancers.

Animals↗
PubMed1988

[The value of radiation therapy in the management of adenoid-cystic carcinoma of the head and neck].

There are different opinions about the importance of radiotherapy in the treatment of adenoid-cystic carcinomas. A report is given on the experiences gained with highdose radiotherapy in twelve patients suffering from adenoid-cystic carcinomas. In spite of the unfavorable composition of the group of patients (6/12 were classified stage T3 or T4, 5/12 were only irradiated after a local recurrence had appeared), local tumor control was achieved in all patients by percutaneous irradiation with a focal dose of 80 Gy or interstitial irradiation with a focal dose of 70 Gy. On the basis of these results as well as of recent communications in literature, it is concluded that adenoid-cystic carcinomas can be locally cured by radiotherapy.

Carcinoma, Adenoid Cystic↗
PubMed1986

Histologic factors influencing prognosis of adenoid cystic carcinoma of the head and neck.

Histologic specimens from 61 cases of adenoid cystic carcinoma of the head and neck were reviewed in order to determine prognostic factors of this peculiar neoplasm. After the tumor was reviewed and classified according to several criteria, follow-up information, which was available in 54 cases, was analyzed and compared with each histological subgroup. As for the histologic pattern, the prognosis of adenoid cystic carcinoma with a solid pattern was worse than that without a solid pattern in respect of 5- and 10-year survival rates. However, there was no difference in 15-year survival between the two groups. Tumors with severe cell atypia showed more malignant behavior than those with moderate or mild atypia (p less than 0.001). Increased mitotic activity of more than two cells in mitosis per high power field was also found to be a sign of poor prognosis (p less than 0.001). Presence of perineural invasion was not correlated with the final outcome of the disease. Cell atypia and mitotic activity as well as the histologic pattern should be evaluated for assessing the degree of malignancy of adenoid cystic carcinoma.

Adolescent↗
PubMed1983

Adenoid cystic carcinoma of the larynx.

Adenoid cystic carcinoma, or cylindromas, constitute a large and distinct group of neoplasms with characteristic microscopic features recognizable in tissues as varied as the nasal passages, tongue, and bronchi. Cylindromas of the larynx are rare and only 60 cases have been reported in a review of the literature in 1977. In this report, a case of adenoid cystic carcinoma originating in the subglottic area of the larynx is discussed, with emphasis on the clinical and pathologic characteristics. In the past, the histogenesis of cylindroma has been the subject of considerable controversy, but recent light microscopic and ultrastructural studies strongly implicate the seromucinous glands of the respiratory and upper digestive tracts as the tissues from which these neoplasms derive. In general, cylindromas of the upper alimentary and respiratory passages are best treated by wide surgical excision. Some clinicians have combined surgery with postoperative radiation therapy in an attempt to prevent or delay recurrence and metastases. Chemotherapeutic agents have also been employed in the postoperative management of adenoid cystic carcinoma although the longterm results of this treatment modality remain to be determined.

Aged↗