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At least 451 records · Page 25Linked to original sources

Immunity status in children with Bacille Calmette-Guerin adenitis. A prospective study in Tehran, Iran.

OBJECTIVE: To determine the immunity status of children with Bacille Calmette-Guerin (BCG) lymphadenitis (patient group) and unaffected children (control group) in Iran. METHODS: We performed this longitudinal case-control study on 75 children between 2 months to 14 years old in Rasool Akram and Markaz Tebbi Hospital, Tehran, Iran during the period of 2 years (2000-2002). RESULTS: Ninety percent of patients had normal immunoglobulin, 10% had low level, 96.1% had normal nitro blue tetrazolium test and 3.9% had lower activity. There was a significant difference in the total lymphocyte CD3, CD8, CD19, CD16/CD56 and natural killers (NK) cell but no significant difference in the CD4/CD8 ratio and CD4 between case (n=75) and control (n=100) groups. Thirty-eight cases with mild lymphopenia, isolated CD4, CD3, CD19, NK cells (CD16/CD56) deficiency in 3 (22%); idiopathic disseminated BCG infection (unknown immunodeficiency type) in 3 (22%) patients were observed. Thirty-eight cases were diagnosed as mild immune deficient without any previous recurrent infections (mild lymphopenia; Isolated CD4; CD3 or CD19 deficiency. Natural killers (CD16/CD56) deficiency in 3 (22%); idiopathic disseminated BCG infection (unknown immunodeficiency type) in 3 (22%) patients. The natural killers (CD16/CD56) deficient cases responded well to 3 antimycobacterial drugs without immunomodulator. Natural killers cell deficiency not yet reported as a risk factor for progression and complication of BCG infection. All cases of idiopathic disseminated BCG infection (unknown immunodeficiency type) with nonlethal and indulgent BCG infections responded well to needle aspiration and antimycobacterial drugs with immunomodulator (gamma interferon). CONCLUSION: In cases with multiple and recurrent BCG lymphadenitis without any previous recurrent infection complete immunological studies should be carried out. Most cases with mild immune deficiency usually response well to needle aspiration alone or combine with antimycobacterial drugs. The combination of IFN-gamma and chemotherapy in cases of idiopathic disseminated infections caused by BCG and without previous recurrent other infection except mycobacterium species, can limit the disease.

Adolescent↗

[BCG-induced axillary lymph-adenitis in the adult].

Axillary lymphadenopathy is very common, with a wide and well-known differential diagnosis. We present for the first time in the contemporary English medical literature the case of a 50-year-old woman with unilateral axillary lymph node enlargement due to BCG injection 2 months earlier. The difficulty in diagnosis is because BCG inoculation is rare in adults, and the latent period is long, up to 8 months. This was the cause of initial misdiagnosis. We conclude that unilateral axillary lymphadenopathy in adults travelling to third-world countries, should raise the question of BCG-induced lymphadenopathy.

Axilla↗

Immunohistology of tuberculous adenitis in symptomatic HIV infection.

Monoclonal antibodies and immunoperoxidase staining were used to characterize the cellular subpopulations in lymph nodes from 10 patients with tuberculous lymphadenitis, seven of whom had symptomatic human immunodeficiency virus (HIV) infection. CD4+ cells were significantly fewer in nodes of patients with HIV infection than in those of immunocompetent patients. CD8+ cells were distributed throughout the granuloma in patients with HIV infection, but confined to the periphery in normal hosts. Blastoid Ta1+ cells, putatively antigen-reactive T lymphocytes, were seen in immunocompetent patients but not in those with HIV infection, suggesting that these cells fail to mature appropriately in the latter group. The immunopathological features noted above provide preliminary evidence that the cell-mediated immune response to tuberculosis is abnormal in patients with HIV infection, and may in part explain both the severe and the unusual manifestations of tuberculosis in these individuals.

AIDS-Related Complex↗

Adenitis, adenopathy, and abscesses of the head and neck.

The emergency clinician will continue to be called on to evaluate inflammatory processes of the head and neck on a regular basis. We have attempted to describe the broad range of these problems, as well as our current considerations for diagnosis and management. Our goal has been to promote accurate diagnosis to allow early detection of situations calling for prompt medical or surgical intervention.

Anti-Bacterial Agents↗

A Banyan in Aden.

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Anecdotes as Topic↗