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At least 433 records · Page 24Linked to original sources
PubMed1985

Mouse testis weight loss and survival of differentiated spermatogonia following irradiation with 250 kV X-rays and 5.5 MeV fast neutrons.

Twenty eight after whole body irradiation of male BALB/c mice with 0.1-4.0 Gy of 250 kV X-rays or with 0.05-1.0 Gy of 5.5 MeV fast neutrons a decrease in testis weight and number of spermatozoa were observed. After plotting the testis weight loss against the radiation dose a mono-component curve characterized by D0 equal to 6.2 Gy and 1.31 Gy for X-rays and neutrons, respectively, was obtained. Relative biological effectiveness (RBE) was 4.25. Similar relation between the number of spermatozoa and the dose had a form of a two component curves. The sensitive components of the testis were characterized by the A-type curves with D0 equal to 0.49 Gy and 0.10 Gy for X-rays and neutrons, respectively. The resistant components were characterized by the B-type curves with D0 equal to 5.07 and 0.97 Gy for X-rays and neutrons, respectively. The RBE was 4.57. The obtained RBE values allowed to modify the total neutron dose and its fractionation in the therapy of malignant tumors at the Institute of Oncology, Krakow.

Animals↗
PubMed1979

Cytotoxic effects of chemotherapeutic drugs on mouse testis cells.

Studies of testicular cell killing in mice by several chemotherapeutic drugs have been performed to EVALUATE THE HARMFUL EFFECTS OF ONCOLYTIC AGENTS ON REPRODUCTION. Seven drugs, Adriamycin, 1-beta-D-arabinofuranosylcytosine, bleomycin, cyclophosphamide, hydroxyurea, vinblastine, and vincristine, given as single injections, were cytotoxic to differentiated spermatogonia. Adriamycin was also highly effective in killing stem cells. The other drugs produced little or no stem cell loss even at doses toxic to the animals. Negligible killing of spermatocytes and spermatids was noted at any dose level. The results demonstrated that oncolytic agents preferntially killed cells at specific stages of the spermatogenic pathway in mice at doses within the clinical range for humans.

Animals↗