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PubMed2004

Utility of intraoperative transesophageal echocardiography for diagnosis of pulmonary embolism.

Pulmonary embolism (PE) is associated with significant perioperative morbidity and mortality. Transesophageal echocardiography (TEE) may permit direct visualization of PE or secondary signs of pulmonary artery (PA) obstruction. However, its utility in diagnosing PE in the intraoperative setting has yet to be defined. Therefore, we performed intraoperative TEE examinations in 46 patients immediately before pulmonary embolectomy. TEE examinations were reviewed for signs of thromboemboli within the right, left, and main PA, and secondary signs of acute PA obstruction (right ventricular dysfunction, moderate-to-severe tricuspid regurgitation, leftward bowing of the interatrial septum). The definitive location of thromboemboli was determined from the surgical record. Echocardiographic evidence for the presence of PE was correctly demonstrated in 46% of all patients (n = 21 of 46). However, the sensitivity for direct visualization of thromboemboli at any specific location was only 26%. TEE was least sensitive for thromboemboli in the left PA (17%). TEE evidence of right ventricular dysfunction was observed in 96%, tricuspid regurgitation in 50%, and leftward interatrial septal bowing in 98% of examinations. Therefore, the use of intraoperative TEE to diagnose acute PE via direct visualization is limited. Indirect TEE evidence of PA obstruction may be helpful in supporting a diagnosis of PE.

Adult↗
PubMed2006

[Pulmonary embolectomy for acute massive pulmonary thromboembolism after failure of thrombolytic therapy].

Acute massive pulmonary thromboembolism (PTE) is associated with an exceptionally high mortality rate and results in death if not diagnosed early and treated properly. We observed 3 cases of acute massive PTE. One of the patients had undergone a surgery for femoral neck fracture. Ten days postoperatively, she developed severe dyspnea with hypoxia, and computed tomography (CT) pulmonary angiography confirmed the PTE diagnosis. She then had cardiac arrest when catheter examination. Although emergency surgical thrombectomy was successful with good postoperative hemodynamic stability and oxygenation, the patient did not recover from the unconsciousness caused by preoperative ischemic brain damage. Subsequently, she died 6 months after surgery. Of the 3 patients, 2 suffered from right ventricular dysfunction without hemodynamic instability. They underwent open thrombectomy after the failure of conservative treatment with a systemic injection of urokinase. Both patients demonstrated a good clinical course and were discharged from hospital in a good general condition 22 and 28 days postoperatively. Herein, we review the current literature on PTE treatment. We concluded that an aggressive surgical intervention might be preferred to thrombolytic therapy for PTE patients with massive thrombosis and progressive right ventricular dysfunction.

Acute Disease↗
PubMed1982

Spectrum of myocardial contusion.

During a consecutive period of 26 months, 42 patients with blunt chest trauma were diagnosed as having a myocardial contusion on the basis of an abnormal electrocardiogram (ECG) in 36 patients, elevated creatine phosphokinase (CPK) in 39 patients, and positive CPK-Muscle Brain (CPK-MB) isoenzyme in 33 patients. Using these screening modalities, the incidence of myocardial contusion in patients with blunt chest trauma increased from 7 per cent when viewed retrospectively to 17 per cent when viewed prospectively. Eight patients had cardiac index determinations only; of these, three were less than 2.9 1/min/M2. An additional 21 patients underwent a standard fluid challenge of 500 cc of 5 per cent plasmanate infused over 30 minutes allowing construction of a Starling Curve. Five patterns of ventricular function curves were observed. Six patients had biventricular dysfunction, six patients had isolated right ventricular dysfunction, three patients had isolated left ventricular dysfunction, three patients had an "unslope-peak-downslope" pattern, and three patients had normal ventricular function studies. Multiple gated acquisition (MUGA) scans were abnormal in ten patients and normal in 12 patients. Major morbidity and mortality due to myocardial contusion occurred in 17 per cent of the (7/42) patients; of these, three had biventricular dysfunction, one had left ventricular dysfunction, and two had a low cardiac index. This experience suggests that screening tests are sensitive in detecting myocardial contusion in blunt chest trauma, but are not predictive of major morbidity or mortality. Only direct hemodynamic measurement with construction of a Starling Curve was useful in determining the severity of the myocardial injury and identifying those patients at greatest risk.

Adolescent↗
PubMed1998

Interventricular septal shift due to massive pulmonary embolism shown by CT pulmonary angiography: an old sign revisited.

The computed tomographic (CT) pulmonary angiogram appearances of acute right ventricular dysfunction due to massive pulmonary embolus in a patient are described. Abnormal findings comprised right ventricular dilatation, interventricular septal shift, and compression of the left ventricle. These changes resolved following thrombolysis. Use of CT pulmonary angiography to diagnose pulmonary emboli is increasing. Secondary cardiac effects are established diagnostic features shown by echocardiography. These have not been previously described but are important to recognise as they may carry important prognostic and therapeutic implications.

Adult↗
PubMed1989

[Right ventricular function in retrograde cardioplegia for myocardial protection--an experimental study].

Anterior cardiac veins which are the main drainage vessels of the right ventricle drain directly into the right atrium. Therefore, the right ventricular wall may not be perfused effectively during open heart surgery by the use of retrograde cardioplegic method resulting in postoperative right ventricular dysfunction. Seventeen mongrel dogs were subjected to this study and were placed on cardiopulmonary bypass using a conventional heart-lung machine. Total aortic cross-clamping time was 60 minutes in all dogs. In Group I (n = 6), 4 degrees C St. Thomas' Hospital solution (15 ml/kg body weight) was injected into the aortic root by the use of a syringe. Cardioplegic solution was replenished every 20 minutes with a half of the initial dose (7.5 ml/kg body weight). Group II (n = 6) were the dogs with the retrograde cardioplegia in which 4 degrees C St. Thomas' Hospital solution (15 ml/kg body weight) was given retrogradely from the coronary sinus by the drip method at the height of 60 cm, and the replenishing dose and interval of cardioplegia were the same as Group I. Group III (n = 5) was the dogs treated with retrograde cardioplegia identical to Group II and the combined use of topical cooling with ice-slush. The hearts were resuscitated after 60 minutes of aortic cross-clamping. Right ventricular functions such as cardiac output, right atrial pressure, right ventricular end-diastolic pressure, right ventricular max dp/dt, and shortening fraction of the right ventricle were measured 15, 30, 45, and 60 minutes after cardiac resuscitation respectively. In Group II, right atrial pressure was significantly elevated from the control value 15 and 30 minutes after cardiac resuscitation. On the other hand, all indices of right ventricular functions in Group III showed insignificant changes. The present experimental study demonstrated the retrograde cardioplegic method could produce right ventricular perfusion resulting in right ventricular dysfunction early after cardiac resuscitation. This deleterious effect however could be prevented by the combined use of topical cooling of the right ventricle with ice-slush.

Animals↗
PubMed2003

Effect of site of venous protamine administration, previously alleged risk factors, and preoperative use of aspirin on acute protamine-induced pulmonary vasoconstriction.

OBJECTIVE: To determine whether the incidence of protamine-induced pulmonary vasoconstriction (PIPV) is influenced by central venous versus peripheral venous infusion of protamine and whether aspirin ingestion within a week of surgery would decrease the incidence of PIPV. DESIGN: Single-institution, prospective, observational, randomized trial. SETTING: University teaching hospital. PARTICIPANTS: One thousand four hundred ninety-seven consecutive patients undergoing cardiopulmonary bypass procedures. INTERVENTION: Protamine neutralization of heparin by infusion pump via either central venous or peripheral venous route. MEASUREMENTS AND MAIN RESULTS: Five previously suspected risk factors (valve surgery, prior protamine exposure, history of pulmonary hypertension, fish allergy, and vasectomy), aspirin ingestion within 7 days of surgery, and demographic information were recorded. PIPV was defined as an abrupt increase in mean PA pressure of 7 mmHg or more with associated right ventricular dysfunction as assessed by observation of the right ventricle in the field and regional wall motion abnormality by transesophageal echocardiogram and hypotension (systolic blood pressure < or = 90 mmHg). Data were collected via continuous strip chart recording. A total of 10 patients (0.6%) developed PIPV during protamine infusion. The incidents were similar with respect to the site of venous administration. Prior exposure to protamine was associated with a greater incidence of PIPV (odds ratio 6.9; p < 0.01). Other previously suspected risk factors did not achieve statistical significance. None of the 766 patients who ingested aspirin experienced PIPV as opposed to 10 of the 731 patients who did not ingest aspirin (odds ratio 0.08; p < 0.001). CONCLUSIONS: Although the site of venous protamine administration does not influence incidence of PIPV, aspirin ingestion within 1 week of surgery may decrease it. These data also confirmed other studies suggesting that previous protamine administration predisposes to this protamine reaction.

Acute Disease↗
PubMed1999

[Current status of diagnosis and therapy of acute pulmonary embolism].

Diagnosing pulmonary embolism (PE) remains a challenge due to the often confusing clinical presentation of the disease. Plasma D-dimer testing with ELISA is increasingly becoming part of the initial diagnostic work up. Due to the high specificity of the assay, a negative test can reliably exclude PE. Importantly, massive PE can be promptly diagnosed or excluded by echocardiography which is a particularly valuable noninvasive method for detection of right ventricular dysfunction at the bedside. High-risk patients can thus be identified and treated immediately without further time-consuming examinations. Confirmation of PE in patients with inconclusive or normal echocardiograms is often based on lung scans, but diagnostic uncertainty is common with this procedure. The popularity of pulmonary angiography is decreasing due to its invasiveness, whereas spiral CT appears to be a promising alternative. Search for (residual) deep vein thrombosis is useful for guiding therapy in stable patients with small pulmonary emboli, since their risk is determined by the potential for PE recurrence. Recent evidence confirmed that right ventricular dysfunction predicts an unfavorable prognosis and might therefore justify thrombolytic treatment of massive PE regardless of systemic hemodynamics. On the other hand, simplified anticoagulation regimens with low-molecular weight heparins have yielded very promising results in stable patients. These diagnostic and therapeutic principles based on cardiovascular risk stratification will hopefully result in a more effective approach to patients with venous thromboembolism in the future.

Acute Disease↗
PubMed2006

[Quantification of right and left ventricular function with magnetic resonance imaging after Senning operation for complete transposition of the great arteries].

INTRODUCTION: The different non-invasive examinations do not result in unambigous results about the long-term determination of right ventricular function providing systemic circulation in children with transposition of the great arteries operated with Senning procedure. AIM: The goal of study was to determine the application of MRI for the observation of right and left ventricular morphology and function, for the recognition of the progression of the disease, and for the necessity of reoperation. METHODS: The authors have observed the morphology and function of the right and left ventricule by ECG triggered short axis MR pictures. For the analysis of MR pictures MASS 5.0 software was used. Authors have determined the end systolic and end diastolic volume, the ejection fraction, the mass, and the stroke volume of the right ventricule, the end systolic and end diastolic volume, ejection fraction, the mass, and the stroke volume of the left ventricle, and the shunt volume. The values of these data corrected to body mass have been calculated. PATIENTS: 176 Senning operations took place between 1980 and 1996. MRI exploration at 21 of the 118 analyzed patients were carried out. RESULTS: The right ventricular ejection fraction value at Senning operated patients is significantly different (49 +/- 9% vs. 70 +/- 4%) from those of healthy children (P < 0.01). Right ventricular stroke volume/m2 and right ventricular end systolic volume/m2 were significantly different compared to normal (43 +/- 10 ml/m2 vs. 48 +/- 7 ml/mn and 46 +/- 16 ml/m2 vs. 21 +/- 5 ml/m2, p < 0.05). Authors found also significant differences in left ventricular ejection fraction in Senning patients as compared to normal (60 +/- 9% vs. 70 +/- 6%, p < 0.01). CONCLUSION: MRI, which is a reliable method of objective determination of right ventricular function, became an available method in Hungary. According to the results, authors might presume that the development of right ventricular dysfunction is expected even among Senning operated children without clinical symptoms, so more frequent control is required. The pathological left ventricular parameters may be explained by ventricular interactions. Authors find MRI an important part of the complex follow-up protocol of Senning operations. MRI data extended by results of other non-invasive explorations are appropriate for the follow-up of right ventricular dysfunction.

Cardiac Surgical Procedures↗
PubMed2005

N-terminal pro-brain natriuretic peptide or troponin testing followed by echocardiography for risk stratification of acute pulmonary embolism.

BACKGROUND: Brain natriuretic peptide (BNP) and N-terminal (NT)-proBNP have recently emerged as promising parameters for risk assessment in acute pulmonary embolism (PE). However, their positive predictive value is low, and the prognostic implications of NT-proBNP or troponin elevation alone are questionable. METHODS AND RESULTS: To determine whether the combination of NT-proBNP testing with echocardiography may identify both low-risk and high-risk patients with PE, we examined 124 consecutive patients with proved PE. All underwent echocardiography on admission to detect right ventricular dysfunction. NT-proBNP and troponin concentrations were measured in one core laboratory. The primary end point was death or major in-hospital complications. The cutoff level of 1000 pg/mL had a high negative predictive value (95% for a complicated course, 100% for death), but NT-proBNP > or =1000 pg/mL did not independently predict an adverse outcome. Combination of NT-proBNP testing with echocardiography identified 3 major risk groups. A positive echocardiogram was associated with a 12-fold elevation in complication risk compared with patients with low NT-proBNP (P=0.002), whereas NT-proBNP elevation without right ventricular dysfunction on echocardiography only slightly increased the risk of an adverse outcome (P=0.17). The combination of cardiac troponin testing with echocardiography yielded similar complication rates in the lowest-risk group and a similar magnitude of risk elevation for the highest-risk patients, but it also increased the number of intermediate-risk groups. CONCLUSIONS: Our results support a simple risk stratification algorithm for patients with PE, with the use of NT-proBNP or troponin testing as an initial step that should be followed by echocardiography if elevated levels of the biomarker are found.

Acute Disease↗
PubMed2006

Early detection of biventricular involvement in myotonic dystrophy by tissue Doppler.

BACKGROUND: Myotonic dystrophy is associated with arrhythmias and risk of sudden death but also with symptoms of heart failure. Our study aimed to identify early biventricular dysfunction in asymptomatic patients with myotonic dystrophy by tissue Doppler. METHODS: Thirty-six patients with myotonic dystrophy (M/F=20/16, mean age=36.4 years), asymptomatic for heart failure, and 36 age- and sex-matched healthy controls underwent Doppler echocardiography and pulsed tissue Doppler of lateral mitral annulus and of tricuspid annulus. RESULTS: The two groups had similar body mass index, blood pressure, heart rate, cardiac mass and endocardial shortening. Standard Doppler showed significantly lower transmitral early (E) diastolic peak velocity, longer transmitral deceleration and isovolumic relaxation times and higher tricuspid inflow atrial peak velocity in myotonic dystrophy than in controls. Tissue Doppler of mitral annulus showed lower myocardial systolic velocity (p<0.02), lower early diastolic velocity (E(m)) (p<0.05) and atrial velocity (A(m)) (p<0.005), but no difference of E(m)/A(m) ratio. At tricuspid annulus, E(m) and E(m)/A(m) ratio were lower (p<0.02 and p<0.005, respectively). The ratio between tricuspid inflow E velocity and E(m), index of the degree of right ventricular filling pressure, was higher (p<0.001) than in controls. Tissue Doppler derived left ventricular and right ventricular measurements were all associated with the disease condition, independent of age and heart rate. CONCLUSIONS: Tissue Doppler identifies subclinical biventricular involvement in myotonic dystrophy. Early left ventricular myocardial systolic and diastolic changes are evident. Right ventricular dysfunction, involving myocardial relaxation and right ventricular filling pressure, might be the arrhythmogenic substratum of these patients.

Adult↗
PubMed1996

Superior vena cava to pulmonary artery anastomosis: an adjunct to biventricular repair.

From May 1981 to September 1995, 38 patients received a superior vena cava-pulmonary artery anastomosis in association with biventricular repair. Patients were divided into four groups on the basis of indication for operation. Group A (19 patients) had a small physiologic right ventricle defined by tricuspid anulus z values or predicted right ventricular volume. Group B (11 patients) had a functionally compromised right ventricle. Group C (four patients) consisted of those receiving a superior vena cava-pulmonary artery anastomosis as a facilitation to biventricular repair. Group D (four patients) was defined by acute postoperative right ventricular dysfunction. Age ranged from 5 months to 51 years (median 3.5 years). There were 14 different underlying primary diagnoses in this cohort and multiple associated anomalies. Operative mortality was as follows: group A, two of 19 (10.5%); group B, two of 11 (18%); group C, none of four (0%); and group D, three of four (75%). Follow-up is complete in 37 of 38 patients (97%), ranging from 1 to 174 months (mean 46.3 +/- 36.9). Twenty-two patients are in New York Heart Association functional class I and eight patients are in class II. No clinical evidence of cyanosis or protein-losing enteropathy has been detected. With the use of this adjunctive approach, acceptable intermediate-term outcomes were obtained in patients having an anatomically or functionally compromised pulmonary ventricle. The anastomosis safely facilitates repair in a subset of patients. Results for this procedure when used as a salvage operation for right ventricular dysfunction have not been satisfactory.

Adolescent↗
PubMed1992

[Two-stage Jatene procedure after Mustard or Senning operation].

We have successfully performed a two-stage Jatene procedure in four patients who showed severe anatomical right ventricular dysfunction after atrial switch (Mustard or Senning) operation for transposition of the great arteries. All four patients developed an adequate left ventricular pressure for the arterial switch operation by one or two-stage pulmonary artery banding. Left ventricular posterior wall thickness increased sufficiently enough after the banding although left ventricular ejection fraction showed significant decrease. After Jatene procedure left ventricular ejection fraction recovered, and RV end-diastolic volume which had been prominently enlarged preoperatively was dramatically normalized. Cardiac index increased from 3.6 +/- 1.6 l/min/m2 preoperatively to 5.3 +/- 6.1 l/min/m2 postoperatively with the decrease in left atrial pressure. Postoperative electrophysiological study revealed the recovery of sinus node function and atrial conduction by means of the take-down of atrial switch operation previously performed. We conclude that the Jatene procedure should be an ideal alternative in patients with right ventricular dysfunction after atrial switch operation. The left ventricle could be prepared by an effective pulmonary artery banding in most instances.

Cardiac Surgical Procedures↗
PubMed2003

Novel management strategy for patients with suspected pulmonary embolism.

AIMS: A simple management strategy is required for patients with acute pulmonary embolism which allows a rapid and reliable diagnosis in order to start timely and appropriate treatment. METHODS AND RESULTS: Two hundred and four consecutive patients with suspected pulmonary embolism were managed according to a standardized protocol based on the clinical pretest probability and the initial haemodynamic presentation (shock index=heart rate divided by systolic blood pressure). Patients with a high pretest probability and a positive shock index (> or =1) (n=21) underwent urgent transthoracic echocardiography. Based on the presence or absence of right ventricular dysfunction, reperfusion treatment was initiated immediately. Patients with a negative shock index (<1) (n=183) underwent diagnostic evaluation including pretest probability, D-dimer, and spiral computed tomography (CT) as first-line tests. Echocardiography was performed only when a central pulmonary embolism was found in the spiral CT(n=33). According to our strategy, 98 patients met the diagnostic criteria of pulmonary embolism: 75 patients (all shock index <1) were treated with heparin alone, 16 (seven had a shock index > or =1) with thrombolysis, four (all shock index > or =1) with catheter fragmentation, and three (all shock index > or =1) with surgical embolectomy. The all-cause mortality rate at 30 days was 5%, and at 6 months 11%. Right ventricular dysfunction on baseline echocardiography was not associated with a higher mortality rate at 6 months (logrank 2.4, P=0.12). CONCLUSIONS: The novel management strategy for patients with suspected pulmonary embolism resulted in a rapid diagnosis and treatment with a low 30-day mortality. In patients with pulmonary embolism and a positive shock index, time-consuming imaging tests can be avoided to reduce the risk of sudden death and not to delay reperfusion therapy.

Acute Disease↗
PubMedDate not supplied

Left ventricular aneurysm and severe cardiac dysfunction: heart transplantation or aneurysm surgery?

We analyzed data from 26 patients with left ventricular aneurysm and severe congestive heart failure to evaluate our selection criteria for aneurysm surgery and heart transplantation. The operative results for patients who underwent aneurysm resection (group A, n = 14) were compared with those of patients who were accepted for heart transplantation (group B, n = 12). All patients were monitored and reinvestigated after surgery. Functional status and left ventricular angiographic and hemodynamic findings were significantly worse in group B than in group A, but with great overlap between the groups. The presence of mitral insufficiency or right ventricular dysfunction (or both), however, was important in our selection for transplantation. Two patients died after aneurysm surgery, whereas one died before heart transplantation. Functional status (p less than 0.004) and left ventricular ejection fraction (p less than 0.05) improved after aneurysm resection, whereas hemodynamic values remained unchanged. Symptoms were relieved (p less than 0.001), and, except for cardiac index, hemodynamic values were normalized in group B. We conclude that the combination of a left ventricular ejection fraction of less than 25%, mitral insufficiency, and right ventricular dysfunction favors heart transplantation in patients with left ventricular aneurysm and end-stage heart disease. The lack of donor organs and acceptable results of aneurysmectomy, however, justify conventional surgery even in high-risk patients.

Adult↗
PubMed1998

Accuracy of echocardiography for detection of aortic arch obstruction after stage I Norwood procedure.

BACKGROUND: Echocardiography has been widely used in postoperative assessment after stage I Norwood procedure, but its accuracy in detecting aortic arch obstruction (AAO) has not been determined. This study was designed to determine the accuracy of echocardiography in the diagnosis of AAO after stage I Norwood procedure, identify echocardiographic predictors of arch obstruction, and examine the time course of its development. METHODS: The records and echocardiography reports of 139 patients who survived stage I Norwood procedure were reviewed. Reference standard for the diagnosis of AAO was catheterization, surgery, or autopsy. RESULTS: AAO was diagnosed by reference standard criteria in 31 (22%) patients. Echocardiography correctly diagnosed AAO in 19 patients, missed the diagnosis in five, and wrongly predicted AAO in eight, yielding a 73% sensitivity, 92% specificity, 70% positive predictive value, and 88% accuracy. Moderate or severe right ventricular dysfunction, moderate or severe tricuspid regurgitation, and an abnormal abdominal aortic Doppler flow pattern were more common in patients with AAO. The probability of AAO developing within 6 months after stage I Norwood procedure was 21.1%, with a very small likelihood after that point. Beyond the first 30 days after surgery, the risk of death was higher in patients in whom AAO developed compared with those in whom it did not (relative risk 5.9, 95% confidence interval 2.7 to 13.2). CONCLUSIONS: Echocardiography is a highly specific modality in detecting AAO after stage I Norwood procedure but its sensitivity is limited. Because of the increased risk of death associated with AAO and because most obstructions develop between 1 and 6 months postoperatively, early cardiac catheterization with possible intervention should be considered in patients with moderate or severe right ventricular dysfunction, moderate or sever tricuspid regurgitation, or an abnormal abdominal Doppler flow pattern during that period.

Aortic Arch Syndromes↗
PubMed1996

Systemic sclerosis associated with right ventricular cardiomyopathy.

Systemic sclerosis is an uncommon multisystem disorder of unknown aetiology which predominantly affects the skin. Cardiac involvement, which is far more common than was originally realized, may affect any part of the heart but most frequently affects the left ventricular myocardium. Right ventricular dysfunction is usually associated with pulmonary vascular disease. We report a case of systemic sclerosis associated with right ventricular cardiomyopathy in whom pulmonary artery pressures were normal.

Adult↗
PubMed1993

Determinants of the recovery of right ventricular performance following experimental chronic right coronary artery occlusion.

BACKGROUND: Patients with acute ischemic right ventricular dysfunction often develop hemodynamic compromise, yet most manifest spontaneous early clinical improvement and later recovery of global right ventricular performance. This study was designed to delineate the determinants of right ventricular performance following chronic right coronary artery occlusion. METHODS AND RESULTS: Thrombotic right coronary artery occlusion was induced in 16 closed-chest dogs. Acute occlusion depressed right ventricular free wall motion (motion score, 1.0 +/- 0.0 to 3.4 +/- 0.1*) and global performance (right ventricular fractional area change, 29.2 +/- 1.8% to 2.3 +/- 1.9%*). There was right ventricular dilatation and reversed septal curvature, with elevated and equalized diastolic filling pressures. At 5 days, despite persistent severe right ventricular free wall dysfunction (motion score, 3.4 +/- 0.1 to 2.7 +/- 0.1*), global right ventricular performance improved (fractional area change, 2.3 +/- 1.9% to 17.0 +/- 3.8%*), in part due to reduced right ventricular free wall dyskinesis associated with increased right ventricular free wall end-diastolic thickness. At 7 weeks, collateral flow had restored right ventricular free wall perfusion to baseline values. The increased right ventricular free wall thickness had resolved, right ventricular free wall motion was improved (2.7 +/- 0.1 to 1.6 +/- 0.1*), and global right ventricular performance had recovered further (17.0 +/- 3.8 to 20.9 +/- 0.9). Right ventricular dilatation was reduced, septal curvature normalized, and there was resolution of equalized filling pressures. Histopathological analysis demonstrated minimal right ventricular infarction. CONCLUSIONS: Acute right coronary artery occlusion results in right ventricular free wall dyskinesis and depressed global right ventricular performance. Global right ventricular function improves early, in part due to reduced right ventricular free wall dyskinesis associated with increased right ventricular free wall diastolic thickness. Collateral restoration of perfusion facilitates late recovery of right ventricular free wall function (*P < .05).

Animals↗