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[Histogenesis of the thymus gland normally and under a change in the level of sympathetic mediation].

Under study was the dynamics of the ultrastructure of the reticular epithelium and lymphocytes of the thymus in postnatal ontogenesis of Balb/c mice. Special attention was given to secretory granules, vacuoles, folliculoid structures, intercellular contacts and cytoplasmic communications (bridges). In parallel the developmental dynamics of the capillary ultrastructure and the state of the adrenergic innervation apparatus were studied. The morphological data are compared with the functional dynamics of the thymus. The postnatal dynamics of means of the transmission of immunological information in the thymus was found. No adrenergic innervation was shown to be present in the thymus of newborns. The role of this mediation as a factor of thymus morphogenesis was confirmed.

Age Factors↗

Age-related changes in the thymus gland: CT-pathologic correlation.

Recent reports suggest that computed tomography (CT) is useful for thymoma detection in patients with myasthenia gravis. However, that usefulness may be conditioned by the state of the normal thymus. To examine this concept, the CT findings in 64 consecutive patients with histologic confirmation of thymic status after thymectomy or thymic biopsy during mediastinal exploration were reviewed. The normal thymus has a bilobed, arrowhead-shaped cross section at all ages, with gradual focal or diffuse fatty infiltration of the parenchyma usually occurring between 20 and 40 years of age. A thymoma is usually a spherical or oval mass, often producing a focal, distinct bulge in the adjacent pleural reflection. The differentiation of thymoma from normal thymus should be possible in most patients if age-related changes in the normal gland are appreciated.

Adolescent↗