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Results for “SPECIFIC GRAVITY”

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At least 433 records · Page 24Linked to original sources
PubMed1985

An evaluation of test sticks used for the measurement of the specific gravity of urine from patients with stone disease.

A test stick for the measurement of the SG of the urine of stoneformers was examined. In 230 spontaneously voided urines and 45 25 h-urines the SG was measured by the test stick and compared with urinometer measurements. The two methods showed a good correlation (r = 0.86). Due to the principle of reaction of the SG-teststick a direct relationship of the SG-values to the sodium concentration and to the ionic strength of urine was found. There is no correlation between the relative supersaturation of CaOx and the SG-determination (urinometer, test stick). The handling of the SG-test stick is simple and can be easily performed by the patient.

Calcium↗
PubMed2003

Detection, quantification, and pharmacokinetics of furosemide and its effects on urinary specific gravity following IV administration to horses.

Furosemide is a potent loop diuretic used for the prevention of exercise-induced pulmonary hemorrhage in horses. This drug may interfere with the detection of other substances by reducing urinary concentrations, so its use is strictly regulated. The regulation of furosemide in many racing jurisdictions is based on paired limits of urinary SG (<1.010) and serum furosemide concentrations (>100 ng/ml). To validate this regulatory mechanism, a liquid chromatography/mass spectrometry/mass spectrometry method employing a solid-phase extraction procedure and furosemide-d5 as an internal standard was developed. The method was used to determine the pharmacokinetic parameters of furosemide in equine serum samples and its effects on urinary SG after IV administration (250 mg) to 10 horses. Pharmacokinetic analysis showed that serum concentrations of furosemide were well described by a two-compartmental open model. Based on results in this study, it is very unlikely for horses to have serum furosemide concentrations greater than 100 ng/ml or urine SG less than 1.010 at 4 hours after administration (250 mg IV). However, it should be remembered that urine SG is a highly variable measurement in horses, and even without furosemide administration, some horses might naturally have urine SG values less than 1.010.

Animals↗
PubMed1989

[Effects of the specific gravity on spinal anesthesia with 0.5% tetracaine].

In a double-blind study, 0.5% tetracaine 10 mg in hyperbaric or isobaric solution was administered intrathecally at random to 102 adult patients. Except the variable under study, identical technique was used for every patient enrolled. Other influential factors were also under careful control. The extent and pattern of anesthesia were compared. The time for maximal spread was short, the mean times was 7.74 min and 7.8 min for hyper-and isobaric groups respectively, there was no differences statistically. (P less than 0.05). The maximum cephalad spread was T5 (mean, range T12-T3) for the hyperbaric solution and T7 (mean, range T10-T3) for the isobaric solution. The difference was 2 dermatomes and was statistically significant (P less than 0.01). Forty three patients (86%) in the hyperbaric group and 16 patients (30%) in the isobaric group had a sensory blockade higher than T6 level. The hyperbaric group has a much higher percentage of high blockade. The isobaric group has a more predictory lower blockade, but occasionally blockade up to T3 did occur. The 2-segment regression times were also statistically significant. That of hyperbaric group was 88.9 min (mean, range 60-150 min) and 180.5 min (mean, 75-270 min) in isobaric group with a P value less than 0.01. Statistically significant differences in regard to maximum motor blockade and its onset times were found between the two groups. Maximum motor blockade assessed by modified Bromage scale was degree 2 (mean, range 1-3) for the hyperbaric group and degree 3 (mean, range 2-3) for the isobaric group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Spinal anesthesia with bupivacaine for transurethral resection of prostate: effects of specific gravity, volume and dose].

The investigation was carried out in 80 patients scheduled for transurethral resection of prostate (TUR-P). All patients were ASA I or II, and received no premedication. Before anesthesia, elastic bandages were applied to both lower extremities and 6 mL/kg of G/S (5% Glucose in 0.9% saline solution) was administered by intravenous infusion. The patient was placed in the lateral position and dural puncture was performed at the L3-4 interspace using a standard midline approach with a 23 gauge spinal needle. The patients were allocated randomly to four groups, each group consisting of 20 patients. Three mL of 0.5% Bupivacaine was administered in group A; 3 mL of 0.5% Bupivacaine with 1 mL 10% G/W (Glucose water) in group B; 2 mL of 0.5% Bupivacaine with 1 mL 10% G/W in group C and 3 mL of 0.5% Bupivacaine in 8% glucose in group D. Assessment of the sensory and motor blockade and measurement of arterial pressure and heart rate were performed after injection. All data were analyzed by ANOVA. A p value of less than 0.05 was considered statistically significant. The results showed that the duration of analgesia with plain Bupivacaine was shorter than with hyperbaric Bupivacaine (2.59 +/- 0.81 h vs 3.12 +/- 0.72 h, P less than 0.05). The maximum cephalad spread of analgesia was lower with plain Bupivacaine (T 9 +/- 2 vs T 7 +/- 2, P less than 0.05). Patients receiving either 3 mL or 4 mL of hyperbaric bupivacaine were similar in regard to duration and maximum cephalad spread of analgesia, but the effect on the cardiovascular system was more severe in the group receiving 4 mL.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1982

Measurement of edema in the nervous system. Use of Percoll density gradients for determination of specific gravity in cerebral cortex and white matter under normal conditions and in experimental cytotoxic brain edema.

A method is presented by which density measurements can be performed on samples from cerebral cortex and white matter of normal and intoxicated animals using nontoxic ingredients as an alternative to the bromobenzene-kerosene technique described by Nelson et al. (1971). A continuous density gradient is prepared in a calibrated glass cylinder by using a new product, Percoll, which consists of colloidal silica particles coated with polyvinyl pyrrolidone. The gradient is stable and the same column can be used for repeated experiments over a long period of time. Interactions between the gradient media and the samples are evaluated and various methodological aspects concerning removal and handling of the tissue samples are presented. Experiments with acute triethyltin (TET) intoxication in the mouse and the hamster show that the Percoll technique can be used as an alternative to the bromobenzene-kerosene method in quantitative studies on cytotoxic brain edema.

Animals↗
PubMed1978

[Enzyme activities in platelets of different specific gravity in thrombocytosis of various etiology (author's transl)].

Platelets of patients with thrombocytosis following splenectomy, in chronic granulocytic leukaemia and in polycythaemia vera were separated into five fractions by centrifugation in discontinuous Ficoll density gradient. Platelet volume, content of protein and enzyme activities of lactic dehydrogenase, phosphoglycerate kinase and glyceraldehyde phosphate dehydrogenase were distinctly higher for the three groups in the heavy fraction IV compared with the light fraction I. With regard to the platelet volume, however, these differences were compensated almost completely like in the normal persons.

Blood Platelet Disorders↗
PubMed1979

Clinical significance of specific gravity of spinal anaesthetic agents. Two double-blind studies with hyperbaric 5% lidocaine.

In two double-blind studies two hyperbaric 5% lidocaine solutions containing glucose in concentrations of 75 mg/ml and 50 mg/ml, respectively, were compared. The onset and total onset time, spread, intensity, duration of analgesia and motor block were studied. The spinal anaesthesia was given with the patient either sitting or in the lateral recumbent position. A tendency to a longer duration of anaesthesia near dermatomes Th X-L II and L IV-L V was noted in the group of patients in the sitting position and receiving lidocaine with a lower glucose concentration. Otherwise there were no differences between the two lidocaine solutions. The result shows that the glucose concentration can be reduced from 75 to 50 mg/ml in "heavy" lidocaine without any clinical disadvantage. This means a more isotonic solution in relation to the cerebrospinal fluid, resulting in milder osmotic effects on interspinal structures.

Aged↗