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PubMed2003

Residual gentamicin-release from antibiotic-loaded polymethylmethacrylate beads after 5 years of implantation.

In infected joint arthroplasty, high local levels of antibiotics are achieved through temporary implantation of non-biodegradable gentamicin-loaded polymethylmethacrylate beads. Despite their antibiotic release, these beads act as a biomaterial surface to which bacteria preferentially adhere, grow and potentially develop antibiotic resistance. In routine clinical practice, these beads are removed after 14 days, but for a variety of reasons, we were confronted with a patient in which these beads were left in situ for 5 years. Retrieval of gentamicin-loaded beads from this patient constituted an exceptional case to study the effects of long-term implantation on potentially colonizing microflora and gentamicin release. Gentamicin-release test revealed residual antibiotic release after being 5 years in situ and extensive microbiological sampling resulted in recovery of a gentamicin-resistant staphylococcal strain from the bead surface. This case emphasizes the importance of developing biodegradable antibiotic-loaded beads as an antibiotic delivery system.

Aged↗
PubMed2003

Distinct gene expression of receptor activator of nuclear factor-kappaB and rank ligand in the inflammatory response to variant morphologies of UHMWPE particles.

Recent studies have examined the role of wear debris-induced bone resorption in the aseptic loosening of orthopedic prostheses. Research has shown that inflammation depends not only on the amount of particulate debris, but also the shape and size of the accumulated wear particles. Our previous studies have demonstrated that variant shapes of ultra-high molecular weight polyethylene (UHMWPE) particles induce diverse cellular and apoptotic responses in a murine inflammation model. Since enhanced osteoclastogenesis is recognized as a hallmark of bone loss in prosthetic loosening, we have now investigated the gene expression of receptor activator of nuclear factor-kappaB (RANK) and receptor activator of nuclear factor-kappaB ligand (RANKL) during the inflammatory response to different shapes of UHMWPE particles. Two shapes of UHMWPE particles (globular or elongated) were implanted in established air pouches on BALB/c mice, and pouches harvested 7 days after stimulation with UHMWPE particles. Gene levels of RANK, RANKL, TNFalpha, IL-1beta, and cathepsin K (CK) were quantified by real time RT-PCR, and TRAP staining of pouch membrane was used to evaluate osteoclastogenesis. We found that (i) elongated particles generated significantly higher RANK and RANKL gene expression than globular particles in pouch tissue; (ii) elongated particles provoked significantly higher IL-1beta and TNFalpha gene expression; (iii) a positive association was found between tissue inflammation status and the gene level of RANK/RANKL; and (iv) elongated particles stimulated significantly higher CK gene expression in comparison with globular particles. Histology revealed that clusters of TRAP+ cells were located in regions in contact with elongated particles. Overall, these data suggest that the morphology of wear debris may be a critical factor in the pathogenesis of prosthetic loosening.

Animals↗
PubMed1995

Surgical management of infrainguinal arterial prosthetic graft infections: review of a thirty-five-year experience.

PURPOSE: The purpose was to determine the early and late mortality and morbidity rates associated with infrainguinal arterial prosthetic graft infection (IAPGI) and to identify optimal methods of management. METHODS: The study included 53 men and 14 women (mean age, 61 years) in whom a total of 68 IAPGIs developed in the years 1959 to 1993. IAPGI involved 58 femoropopliteal grafts (85%), six femorodistal grafts (9%), and four other grafts or synthetic patches (6%). Graft material was dacron in 36 (53%), polytetrafluoroethylene in 28 (41%), and human umbilical vein in four (6%). Sixteen IAPGIs (24%) involved limbs that had required amputations before IAPGI was diagnosed. Twenty-six (38%) of the 68 grafts were thrombosed, and 14 (88%) of the 16 amputees had occluded grafts. RESULTS: Staphylococcal organisms were isolated from 34 (58%) of the 59 IAPGIs for which culture data were available. The median intervals until IAPGI was diagnosed were 3 months after implantation and 1 month after the last procedure involving the original graft. Initial management consisted of local measures only in 13 (19%), partial removal or in situ graft replacement in 15 (22%), and total graft excision in 40 (59%). Total excision was performed in 15 (94%) of the 16 patients with prior amputations and in only 25 (48%) of the 52 intact limbs. The overall postoperative mortality rate was 18%; seven (58%) of the 12 early deaths were related to sepsis, and all 12 occurred within the group of 51 patients (24%) for whom limb salvage was still being attempted (p = 0.056). IAPGI ultimately led to amputations in 21 (40%) of 52 intact limbs within the first year. Twenty-three (82%) of the 28 IAPGIs managed with incomplete graft removal required subsequent operations for continued sepsis, compared with five (13%) of the 40 treated with complete excision (p < 0.001). The cumulative 5-year survival rate (77%) for 53 patients who survived operation was less than that (89%) for the normal, age-matched U.S. male population. CONCLUSIONS: IAPGI is associated with substantial early mortality and amputation rates. Complete excision of infected graft material results in a significant reduction in the incidence of recurrent sepsis.

Adult↗
PubMed2000

The predictive value of indium-111 leukocyte scans in the diagnosis of infected total hip, knee, or resection arthroplasties.

To evaluate the usefulness of the indium-111 scan in detecting actually or potentially infected total hip, knee, and resection arthroplasties, 153 scans were performed on 143 patients who underwent reoperation for a loose or painful total joint arthroplasty or a resection arthroplasty between 1990 and 1996. Scans were interpreted as infected, not infected, or equivocal by an experienced nuclear medicine radiologist. Patients were considered to be infected if they met any 2 of the following criteria: i) positive intraoperative cultures, ii) final permanent histologic section indicating acute inflammation, and iii) intraoperative findings of gross purulence within the joint. Twenty-six patients (17%) met the infection criteria at the time of reoperation. Indium scans were found to have a 77% sensitivity, 86% specificity, 54% and 95% positive and negative predictive values, and 84% accuracy for the prediction of infection. Of 6 equivocal scans, none were infected. The results of this study suggest limited indications for the use of the indium-111 scan in the evaluation of painful hip, knee, or resection arthroplasties. A negative indium scan may be helpful in suggesting the absence of infection in cases in which the diagnosis is not otherwise evident.

Adult↗
PubMed2003

Excisional arthroplasty for patellar loosening in total knee arthroplasty.

Four thousand two hundred eighty-seven cases of Anatomic Graduated Components total knee replacements with a cemented, single-peg, all-polyethylene patellar component were performed at our institution over the past 15 years. One hundred eighty cases of patellar component loosening were found. Eleven knees (0.3%) in 11 patients required isolated patellar component reoperation. In all cases, the patellar component was excised and not reimplanted. The average follow-up for the 11 patients was 2.2 years. Five had a complete minimum follow-up of 2 years following reoperation. Pain and function were improved. Complications included infection in 3 knees and extensor lag in 1 knee. Because of the complication rate associated with isolated patellar component excision caused by a loose patellar component, we recommend surgical removal of the patellar component only in cases of severe pain and/or prominence of the component.

Arthroplasty, Replacement, Knee↗
PubMed1995

Postoperative infection following orthopaedic surgery in human immunodeficiency virus-infected hemophiliacs with CD4 counts < or = 200/mm3.

Human immunodeficiency virus-infected hemophiliacs are at risk for bacterial and opportunistic infections with worsening immunosuppression. Thus, the risk of postoperative infection following orthopaedic surgery is of considerable concern. A survey of United States hemophilia treatment centers was conducted to determine the incidence of postoperative infection in human immunodeficiency virus-positive hemophiliacs with CD4 counts of 200 mm3 or less undergoing orthopaedic surgery. A total of 115 centers from 37 states reported that postoperative infection occurred in 10 (15.1%) of 66 patients undergoing 74 orthopaedic procedures, between several weeks and 5 months following surgery. In five (50%), pre-operative infection preceded postoperative joint infection. Staphylococcus was the most common organism isolated in a prosthetic joint infection, in 6 of 10 (60.0%), and the knee was the most commonly affected joint, in 9 of 10 (90.0%). Joint arthroplasty appeared to have 10 times the risk of nonarthroplasty procedures for postoperative infection (9 of 34 [26.5%] and 1 of 40 [2.5%], respectively, P < .01). Two subjects developed chronic osteomyelitis. The rate of postoperative infection in human immunodeficiency virus-positive hemophiliacs with CD4 counts of 200/mm3 or less appears to be high, when compared with the general population. Early, vigorous treatment should be instituted for suspected infection, antibiotic prophylaxis considered for invasive procedures, and surgical intervention individualized based on the balance of risks and benefits.

AIDS-Related Opportunistic Infections↗
PubMed1993

Distal femoral arthroplasty using custom-made prostheses. The first 218 cases.

The first 218 cases of limb salvage using cemented intramedullary Stanmore massive distal femoral arthroplasties with a single-axis hinged knee, followed for an average of 58 months with a maximum of 251 months, were reviewed. Loosening (5%), local recurrence (4%), intramedullary stem fracture (3%), and infection (2%) were the major complications requiring surgical intervention. Loosening and implant fracture were treated by the insertion of a second massive replacement in all but one case. All recurrences and all but one infected case required amputation. Survivorship analysis showed that the overall probability of one of these early prostheses surviving for 10 years was 65%, and for 20 years it was 53%. For cases of bone tumor, the probability of surviving for 10 years was 68% (not including recurrence), for primary knee replacement cases it was 32%, for other bony diseases plus trauma it was 86%, and for cases of revised massive prostheses it was 53%. It was concluded that this type of distal femoral arthroplasty provided good medium-term results, but showed some deficiencies in the long term, particularly in younger patients.

Adolescent↗
PubMed1991

Evaluation of the painful prosthetic joint. Relative value of bone scan, sedimentation rate, and joint aspiration.

Seventy-two joint arthroplasties undergoing total hip or total knee surgery were studied prospectively with plain radiographs, three-phase bone imaging (3PBI), erythrocyte sedimentation rate (ESR), aspiration of the joint for culture, and multiple intraoperative cultures at the time of revision. Intraoperative cultures and the operative appearance were used to form a diagnosis of definite infection (unequivocal microbiology and gross sepsis), possible infection (positive microbiology or gross sepsis), or no infection (neither positive microbiology nor gross sepsis). For the preoperative diagnosis of infection, as opposed to aseptic loosening, 3PBI alone had a sensitivity of 33% and a specificity of 86%. In conjunction with plain radiographs, minimal improvement in accuracy was seen. A preoperative ESR greater than 30 had low sensitivity (60%) and a specificity of (65%). However, the ESR was statistically significantly higher in the joints with definite infection as compared to those joints without infection. The preoperative joint aspiration had a sensitivity of 67% and a specificity of 96% and, therefore, appears to be the most useful single test in the workup of a painful total joint arthroplasty.

Aged↗
PubMed1992

Use of an antibiotic impregnated polymethyl methacrylate intramedullary spacer for complicated revision total hip arthroplasty.

Revision total hip arthroplasty is frequently necessary in the presence of significant proximal femoral bone loss, periprosthetic fracture, or infection. In these situations, optimal reconstruction may sometimes warrant the use of special implants, including bone grafts. The emergent presentation of these cases or unexpected findings at the time of surgery can preclude the use of these treatment options. In cases of periprosthetic sepsis, delayed reimplantation may be the most successful approach to eradicate infection. In seven of these complicated revision total hip arthroplasties, the authors used an antibiotic-impregnated intramedullary polymethyl methacrylate spacer with delayed prosthetic reimplantation to allow for the use of these methods. Benefits of this technique include uncompromised radiographic evaluation of the proximal femur for design of a custom implant, if needed, stabilization of the proximal femur facilitating early mobilization of the patient in the case of periprosthetic fracture, and local delivery of antibiotics to the wound in the case of infection. The author's ability to reconstruct these total hip arthroplasties complicated by bone deficiency, fracture, and sepsis, was significantly improved with this use of this technique.

Adult↗
PubMed1996

Aspiration arthrography of the hip joint. Its uses and limitations in revision hip surgery.

Seventy-one patients undergoing revision hip surgery over a 5-year period from 1988 to 1993 had aspiration arthrography of the hip as a preoperative investigation. Sixteen hips were found to be infected at operation. Preoperative aspiration yielded positive cultures in 11 of these 16 hips. There was identical correlation between the organisms isolated on aspiration and during surgery. There were 5 false positive cultures from the aspirates of the remaining 55 noninfected hips. All of the hips from which a true positive culture was obtained had either clinical or radiologic evidence suggestive of infection. Aspiration arthrography does not have a major role to play as a routine investigation prior to all revision hip surgery. It is recommended that its use be reserved for those hips in which there is either clinical, hematologic, or radiologic evidence of infection.

Adult↗
PubMed1997

Early failure of a carbon-fiber composite femoral component.

Carbon fiber has a theoretical advantage over other materials for hip arthroplasty. It has a modulus of elasticity closer to that of bone than other materials. This property has been used in the production of a femoral component for use in hip arthroplasty. Isoelasticity could avoid the problems of stress shielding prevalent with other uncemented metal prostheses; however, the early failure of one such prosthesis due to implant breakage at the neck-body junction is reported.

Carbon↗
PubMed1997

Synovial tissue examination by frozen section as an indicator of infection in hip and knee arthroplasty in community hospitals.

Twenty-five surgical synovial sections were examined in 18 consecutive patients undergoing revision hip or knee arthroplasty (9 hips and 9 knees). All cases were performed in either of two community hospitals, with frozen-section tissue examined by multiple general pathologists. By protocol, acute inflammation was defined as more than five neutrophils per 60x high-power fields on multiple areas. A positive culture was defined as-organism growth from any surgical specimen. In each case, three surgical cultures and three frozen-section specimens were harvested from the synovium at corresponding periprosthetic surgical sites before antibiotics were administered. The average age of the patients was 68 years (range 40-87 years). There were 11 positive surgical cultures, 9 with positive frozen sections of synovium for acute inflammation (sensitivity, 82%; 95% confidence interval, 78-100%). There were 14 negative cultures; 13 had negative surgical frozen sections (specificity, 93%; 95% confidence interval, 83-100%). The positive predictive value of the test was 82%. There was accurate correlation between frozen section and culture in 22 of 25 cases (88%). In this community hospital setting, frozen section examination of surgical synovial tissue proved to be a reasonably sensitive and specific predictor of deep infection in revision hip and knee arthroplasty.

Aged↗
PubMed1997

Wear of retrieved cemented polyethylene acetabula with alumina femoral heads.

Four yttrium-stabilized alumina ceramic-on-polyethylene articulations obtained from patients who were undergoing revision surgery for sepsis (3) or recurrent dislocation (I) between 34 and 73 months were evaluated to assess their in vivo wear performance. The annual volumetric wear of the acetabular components determined directly by a fluid displacement method ranged from 58 to 140 mm3/y. Scanning electron microscope examination of these four ceramic heads revealed similar surface damage in all cases from a variety of causes. These included differential granular wear (alumina grains and yttrium-stabilized alumina grains at different depths), multidirectional scratches with heaped up boundaries, and incompletely sintered grains, as well as the formation of craters and separation of grain boundaries. The femoral heads in this small series of revision cases show that yttrium-stabilized alumina ceramic heads may develop surface irregularities from either manufacturing processes or in vivo use. The wear rates of this type of alumina-on-polyethylene articulation up to the time of revision were not substantially different from those found in other metal-on-polyethylene articulations retrieved at revision surgery.

Acetabulum↗
PubMed1998

The use of femoral intramedullary nailing as an interim or salvage technique during complicated total hip replacement.

When performing a revision total hip replacement complicated by infection, severe osteolysis, comminuted periprosthetic fracture, and/or extensive bone loss, a single-stage procedure may not be feasible. This study reports four cases of femoral intramedullary nailing as an interim or salvage technique during complicated total hip replacement. This reconstruction provides axial and rotational stability of the femur while maintaining femoral alignment. Furthermore, this reconstruction facilitates early mobilization and rehabilitation of the patient. This interim reconstruction can be converted to a revision total hip replacement at a later time. Alternatively, the stabilized resection arthroplasty may serve as a salvage technique if further reconstruction is not indicated.

Aged↗
PubMed1998

Results of 2-stage reimplantation for infected total knee arthroplasty.

Optimum treatment of the infected total knee arthroplasty has not been clearly established. To clarify the efficacy of two-stage reimplantation, experience with 66 infected total knee arthroplasties in 64 patients who had been treated with 2-stage reimplantation total knee arthroplasty between September 1980 and October 1993 was reviewed. Of these, 55 knees in 54 patients were available for follow-up examinations at an average of 61.9 months (range, 28-146 months). The initial diagnoses were rheumatoid arthritis (14 knees) and osteoarthritis (41 knees). Reimplantation was successful in 80.0% of knees with low-virulence organisms (coagulase-negative Staphylococcus, Streptococcus), 71.4% with polymicrobial organisms, and 66.7% with high-virulence organisms (methicillin-resistant Staphylococcus aureus). Reimplantation was successful in 82% of patients with osteoarthritis and in 54% of patients with rheumatoid arthritis (P = .024). The success rate was 92% if infection occurred after primary arthroplasty but only 41% if after multiple previous knee operations (arthroscopy, osteotomy, or revision total knee arthroplasty) (P < .001).

Adult↗
PubMed1992

Composite grafting of the maxillary sinus for placement of endosteal implants. A preliminary report of 48 patients.

The maxillary sinuses in 48 patients were grafted with dense, non-resorbable hydroxylapatite (HA) particles combined with autologous, cancellous bone. After 3 months of healing, HA-coated titanium endosteal implants were placed in the maxilla, and following an additional 3-5 month healing period, the dentitions were restored with various prostheses. Of the 267 maxillary implants placed, 18 (6.4%) failed. Thirteen (6.4%) of the 203 implants placed in the grafted floor of the sinus failed, and 5 (7.8%) of the 64 implants placed in the anterior maxilla failed. Simultaneous lateral and anterior onlay grafting of the alveolar process with the same composite graft material was required in 36 (75%) patients because the width of the alveolar process was considered insufficient for placement of endosseous implants. The mean follow-up period was 17 months (range 12-32). Results from this preliminary study indicate that composite grafting of the maxillary sinus with onlay grafting of the alveolar ridge will provide the bony structure necessary for placement of endosseous implants. Further follow-up of these patients is necessary to determine the long-term stability of this technique; however, these results are promising.

Adult↗