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Dimensions of the pons, the medulla oblongata and the fourth ventricle fundus in people aged 18-91 years.

The structure of human central nervous system has not been fully known yet. There were studies concerning the anatomical structure of the human brain and anatomical and experimental studies performed in animals (4, 7, 10, 18). The new methods of CT and MRI (15) enable the intravital studies of CNS which cause no visible side-effects in patients. The present paper reports the anatomical studies of the human brain stem in autopsy material.

Adult↗

Decrease in muscarinic M2 receptors from synaptosomes in the pons and hippocampus after REM sleep deprivation in rats.

The effects of both REM sleep deprivation and its recovery on pontine and hippocampus muscarinic M2 receptors were investigated in synaptosomes using [3H]-AF-DX 384 as a ligand. Animals were divided into three groups: REM sleep deprivation group (small platforms 6.5 cm of diameter); stress group (large platforms 14 cm of diameter) and cage control group. In a second experiment REM sleep-deprived animals were allowed 48 h of recovery. REM sleep-deprived rats showed a reduction in M2 receptors compared with both intact and stress groups. Changes in M2 receptors were also observed after 48 h of recovery from REM sleep deprivation only in hippocampus. The enhancement of acetylcholine release during both REM sleep deprivation and recovery could explain the present findings.

Animals↗

[Effect of general hypokinesia on the blood vessels of the medulla oblongata, pons and midbrain of the rabbit].

The work was performed on 40 rabbits. After injection of the blood system with Gerota's mass 120 mu horizontal sections were cleared after A. M. Malygin and stained with hematoxylin and eosin after Van Gieson. It was shown that within 1--3 weeks of staying in small cages the animals had dilated vein all areas of the brain under investigation. Within 4-12 weeks there appeared deformity, sharp sinuosity, disorders in usual orientation of vessels. Within 13-16 weeks of hypokinesia both qualitative and quantitative changes in blood vessels became more pronounced. It was also shown that readaptation for 1--3 weeks after 4--13 weeks of hypokinesia failed to repair the normal structure of blood vessels of the brain and that in all the parts under study the reactions of the circulatory bed structure to hypokinesia were of the same type.

Adaptation, Physiological↗