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PubMed1975

Stimulus complexity, EEG abundance gradients, and detection efficiency in a visual recognition task.

Occipital EEG was monitored while subjects inspected 27 projected patterns. The number (N) and variety (V) of elements in the patterns were varied systematically. There were three levels of N (6, 12 or 24 elements) and three levels of V (circles, squares or hexagons occupying all, one half or one third of the element locations for all levels of N). Subjects were instructed that they would be required in a post-test to recognize the patterns, among patterns which had not appeared; they were also informed that the patterns had been constructed according to a set of simple rules, but the nature of these rules was not made fully explicit. The EEG was quantified by means of low-frequency analysis, yielding measures of abundance (theta, alpha and beta) and mean dominant frequency. For the recognition task, nine stimulus items were embedded among 45 items. Recognition efficiency was measured by means of the signal detection theory discrimination index (d'). The results were as follows: (i) Both N and V were inversely related to alpha abundance (P less than 0-01); (ii) the strongest relationship between stimulus parameters and the EEG held for N and EEG beta activity (13-5-19-5 Hz;P less than 0-001), where again the EEG and N were inversely related; (iii) there was a significant (P less than 0-05) direct relationship between N and theta activity; (iv) contrary to prediction, mean dominant alpha frequency decreased as N increased; (v) d' correlated significantly with a number of effects for N, i.e. subjects who exhibited greatest EEG discriminability of items during exposure of the patterns, subsequently obtained the higher detection scores in the recognition task. The work described therefore demonstrates that only only do stimulus parameters have systematic effects upon brain activity as measured by the EEG, but that such effects have functional value and reflect aspects of efficiency. The results are fully compatible with arousal theory constructs relating physiological reactivity and performance.

Adolescent↗
PubMed1988

Physiology based simulation model of triangle shape recognition.

The present paper considers the relation between the shape of a triangle and probability of its recognition. An effect of triangle size on perception of its shape is examined in the first experiment. In the second the loci of eye fixations during triangle recognition task are recorded and analysed. A simulation model of the recognition process is proposed. The model is based on two main assumptions: 1. an accuracy of shape processing is related to the cortical magnification factor, 2. a subject's response depends on actual position of eye fixation. The validity of the model is verified by comparing the theoretical and experimental response distributions. Some psycho-physiological implications are then discussed.

Computer Simulation↗
PubMed2005

Metabolomic networks in plants: Transitions from pattern recognition to biological interpretation.

Nowadays techniques for non-targeted metabolite profiling allow for the generation of huge amounts of relevant data essential for the construction of dynamic metabolomic networks. Thus, metabolomics, besides transcriptomics or proteomics, provides a major tool for the characterization of postgenomic processes. In this work, we introduce comparative correlation analysis as a complementary approach to characterize the physiological states of various organs of diverse plant species with focus on specific participation of metabolites in different reaction networks. The correlations observed are induced by diminutive fluctuations in environmental conditions, which propagate through the system and induce specific patterns depending on the genomic background. In order to examine this hypothesis, numeric examples of such fluctuations are computed and compared with experimentally obtained metabolite data.

Algorithms↗
PubMed1993

Simulation of stochastic micropopulation models--III. COGNET: an artificial neural network for visual recognition.

COGNET, based on a neural network first described by Fukushima, demonstrates the relationship between connectionist and other micropopulation models. Its success and physiological orientation led to an implementation using the SUMMERS simulation shell. After self-supervised learning, COGNET uses forward and backward propagation of signals to recognize partial and noisy patterns, and to reconstruct the originals. Stochastic features include variable thresholds for neuronal firing and occasional cell death. The successful implementation of COGNET demonstrates the generality of the concepts embodied in SUMMERS, which in turn promotes the reusability of software and facilitates the extension of computational models in biomedical research. COGNET itself forms a framework for building other physiologically oriented neural network models.

Computer Simulation↗
PubMedDate not supplied

Properties of simulated neurons from a model of primate inferior temporal cortex.

The physiological properties of neurons in inferior temporal (IT) cortex of the macaque monkey suggest that this cortical area plays a major role in visual pattern recognition. Based on the properties of IT, and one of its major sources of input, V4, a model is proposed that can account for some of the shape recognition properties of IT neurons including selectivity for complex visual stimuli and tolerance to the size and location of the stimuli. The model is composed of three components. First, stimulus location tolerance is modeled after the complex-cell-like properties observed in some V4 neurons. The second component of the model is an attentionally controlled scaling mechanism that facilitates size-invariant shape recognition. The transition from edge orientation-selective neurons in V4 to neurons with more complicated stimulus preference in IT is explained by the third component of the model, a competitive learning mechanism. Single-unit analysis of receptive field properties, stimulus selectivity, and stimulus size and position tolerance was performed on "neurons" from the simulation. Comparison of results from the simulation and a study of actual IT neurons shows that the set of mechanisms incorporated into the simulation is sufficient to emulate the physiological data.

Animals↗
PubMed1997

[The physiological pattern of lumbar intervertebral disk height].

UNLABELLED: Purpose of this study is to present a new method of quantifying objectively the height of all discs in lateral radiographs of the lumbar spine and of analysing the normal craniocaudal sequence pattern of lumbar disc heights. METHODS: The new parameter is the ventrally measured disc height corrected for the dependence on the angle of lordosis by normalisation to mean angles observed in the erect posture of healthy persons. To eliminate radiographic magnification, the corrected ventral height is related to the mean depth of the cranially adjoining vertebra. In this manner lumbar disc heights were objectively measured in young, mature and healthy persons (146 males and 65 females). The craniocaudal sequence pattern was analysed by mean values from all persons and by height differences of adjoining discs in each individual lumbar spine. RESULTS: Mean normative values demonstrated an increase in disc height between L1/L2 and L4/L5 and a constant or decreasing disc height between L4/L5 and L5/S1. However, this "physiological sequence of disc height in the statistical mean" was observed in only 36% of normal males and 55% of normal females. CONCLUSION: The radiological pattern of the "physiological sequence of lumbar disc height" leads to a relevant portion of false positive pathological results especially at L4/L5. An increase of disc height from L4/L5 to L5/S1 may be normal. The recognition of decreased disc height should be based on an abrupt change in the heights of adjoining discs and not on a deviation from a craniocaudal sequence pattern.

Adolescent↗
PubMed1985

Urologic considerations in the newborn.

The management of the neonate will continue to hold a special interest for the urologic surgeon because of the many unique aspects of neonatal physiology and pathology that must be considered. I would anticipate that the number of referrals will continue to increase, from awareness of familial patterns of urologic disorders, from recognition of obstructive uropathy with prenatal ultrasound, and from improved survival of very sick neonates by our pediatric colleagues. The urologist who wishes to participate in the care of these sick newborns must become familiar with the unique aspects of care that these babies demand. The future promises to be challenging, but exciting.

Amniocentesis↗
PubMed2006

Intestinal epithelial cell signalling and host-derived negative regulators under chronic inflammation: to be or not to be activated determines the balance towards commensal bacteria.

Advancing knowledge regarding the cellular mechanisms of intestinal inflammation has led to a better understanding of the disease pathology in patients with chronic disorders of the gut including inflammatory bowel disease, coeliac disease, lymphocytic colitis and irritable bowel syndrome. An emerging new paradigm suggests that changes in the homeostasis of bacteria- and host-derived signal transduction at the epithelial cell level may lead to functional and immune disturbances of the intestinal epithelium. It has become clear from numerous studies that enteric bacteria are a critical component in the development and prevention/treatment of chronic intestinal inflammation. Signal-specific activation of mitogen-activated protein kinases (MAPK), interferon-regulated factors (IRF) and the transcription factor NF-kappaB through pattern recognition receptor signalling effectively induce inflammatory defence mechanisms. Unbalanced activation of these innate signalling pathways because of host genetic predispositions and/or the lack of adequate anti-inflammatory feedback mechanisms may turn a physiological response into a pathological situation including failure of bacterial clearance and development of chronic inflammation. Host-derived regulators from the immune and enteric nerve system crosstalk to the innate signalling network of the intestinal epithelium in order to shape the extent and duration of inflammatory processes.

Animals↗
PubMed2001

Physiological evidence of gender differences in word recognition: a magnetoencephalographic (MEG) study.

Magnetic field recordings were made in order to describe brain processes during a word recognition experiment. We investigated 26 healthy young subjects (14 females) and focused on gender differences related to recognition performance and brain activity. From about 200 ms to 350 ms after word onset the event-related field (ERF) patterns differed significantly between women and men, although the mean recognition performances did not. Differences were due to different strengths of activation as well as due to the involvement of different neural structures as underlined with statistical analysis. We interpret that our physiological findings demonstrate that different mental strategies are used for correct word recognition in the brains of women and men as assessed with magnetoencephalography (MEG). Our data might be linked to previous findings about the hemispheric asymmetry in male subjects (left lateralized) compared to women in whom both hemispheres seem to be equally involved in word processing.

Adult↗
PubMed1989

A microcomputer program for real-time data acquisition in the perinatal physiology laboratory.

This report describes a real-time data acquisition system using the IBM PC-AT microcomputer, and software specifically engineered for the perinatal physiology laboratory. The system samples up to sixteen analog signals at a rate ranging from 1 to 1024 Hz. Calibrated digital values are displayed on the computer monitor and stored on disk. The system can perform algebraic computations and estimate derivatives. Pattern recognition algorithms are included for the detection and characterization of uterine contractions and fetal breathing movements. Two different noise-rejection filters are implemented. Output of signals via a digital-to-analog converter is supported. The system has been used to record a broad variety of physiologic variables in a number of different studies.

Algorithms↗
PubMedDate not supplied

Expression of heterologous proteins in Pichia pastoris: a useful experimental tool in protein engineering and production.

The use of the methylotrophic yeast, Pichia pastoris, as a cellular host for the expression of recombinant proteins has become increasing popular in recent times. P. pastoris is easier to genetically manipulate and culture than mammalian cells and can be grown to high cell densities. Equally important, P. pastoris is also a eukaryote, and thereby provides the potential for producing soluble, correctly folded recombinant proteins that have undergone all the post-translational modifications required for functionality. Additionally, linearized foreign DNA can be inserted in high efficiency via homologous recombination procedures to generate stable cell lines whilst expression vectors can be readily prepared that allow multiple copies of the target protein, multimeric proteins with different subunit structures, or alternatively the target protein and its cognate binding partners, to be expressed. A further benefit of the P. pastoris system is that strong promoters are available to drive the expression of a foreign gene(s) of interest, thus enabling production of large amounts of the target protein(s) with relative technical ease and at a lower cost than most other eukaryotic systems. The purpose of this review is to summarize important developments and features of this expression system and, in particular, to examine from an experimental perspective the genetic engineering, protein chemical and molecular design considerations that have to be taken into account for the successful expression of the target recombinant protein. Included in these considerations are the influences of P. pastoris strain selection; the choice of expression vectors and promoters; procedures for the transformation and integration of the vectors into the P. pastoris genome; the consequences of rare codon usage and truncated transcripts; and techniques employed to achieve multi-copy integration numbers. The impact of the alcohol oxidase (AOX) pathways in terms of the mut+ and mut(s) phenotypes, intracellular expression and folding pathways is examined. The roles of pre-pro signal sequences such as the alpha mating factor (alpha-MF) and the Glu-Ala repeats at the kex2p cleavage site on the processing of the protein translate(s) have also been considered. Protocols for the generation of protein variants and mutants for screening for orphan cognate binding partners and the use of experimental platforms addressing the molecular recognition behaviour of recombinant proteins such as the extracellular domains of transmembrane receptors with their physiological ligands are also described. Finally, the palindromic patterns of glycosylation that can occur with these expression systems, in terms of the role and location of the sequon in the primary structure, the number of mannose units and the types of oligosaccharides incorporated as Asn- or O-linkages and their impact on the thermostability and immunogenicity of the recombinant protein are considered. Procedures to prevent glycosylation through manipulation of cell culture conditions or via enzymatic and site-directed mutagenesis methods are also discussed.

Gene Expression↗
PubMed2005

Face adaptation depends on seeing the face.

Retinal input that is suppressed from visual awareness can nevertheless produce measurable aftereffects, revealing neural processes that do not directly result in a conscious percept. We here report that the face identity-specific aftereffect requires a visible face; it is effectively cancelled by binocular suppression or by inattentional blindness of the inducing face. Conversely, the same suppression does not interfere with the orientation-specific aftereffect. Thus, the competition between incompatible or interfering visual inputs to reach awareness is resolved before those aspects of information that are exploited in face identification are processed. We also found that the face aftereffect remained intact when the visual distracters in the inattention experiment were replaced with auditory distracters. Thus, cross-modal or cognitive interference that does not affect the visibility of the face does not interfere with the face aftereffect. We conclude that adaptation to face identity depends on seeing the face.

Adaptation, Physiological↗
PubMed2006

Prism adaptation changes perceptual awareness for chimeric visual objects but not for chimeric faces in spatial neglect after right-hemisphere stroke.

Prism adaptation can ameliorate some symptoms of left spatial neglect after right-hemisphere stroke. The mechanisms behind this remain unclear. Prism therapy may increase exploration towards the contralesional side, yet without improving perceptual awareness, as apparently for the left side of chimeric face stimuli (Ferber et al. 2003). However, other prism studies suggest that perceptual awareness might be improved (e.g., Maravita et al., 2003). We tested the impact of prism therapy on visual awareness for the left side of chimeric objects as well as chimeric faces, in three neglect patients. Prism therapy dramatically improved awareness for the identity of the left side of chimeric non-face objects, but had no effect on judging expressions for chimeric faces. The latter may thus be unique in showing no prism benefit.

Adaptation, Physiological↗
PubMed2006

Towards adaptive classification for BCI.

Non-stationarities are ubiquitous in EEG signals. They are especially apparent in the use of EEG-based brain-computer interfaces (BCIs): (a) in the differences between the initial calibration measurement and the online operation of a BCI, or (b) caused by changes in the subject's brain processes during an experiment (e.g. due to fatigue, change of task involvement, etc). In this paper, we quantify for the first time such systematic evidence of statistical differences in data recorded during offline and online sessions. Furthermore, we propose novel techniques of investigating and visualizing data distributions, which are particularly useful for the analysis of (non-)stationarities. Our study shows that the brain signals used for control can change substantially from the offline calibration sessions to online control, and also within a single session. In addition to this general characterization of the signals, we propose several adaptive classification schemes and study their performance on data recorded during online experiments. An encouraging result of our study is that surprisingly simple adaptive methods in combination with an offline feature selection scheme can significantly increase BCI performance.

Adaptation, Physiological↗
PubMed2006

Visual quality determines the direction of neural repetition effects.

One ubiquitous finding in functional magnetic resonance imaging studies is that repeated stimuli elicit lower responses than novel stimuli. In apparent contradiction, some studies have reported the exact opposite effect--greater responses to repeated than novel stimuli--in many of the same brain regions. Interestingly, these latter enhancement effects are typically obtained when stimuli have been degraded. To explore this observation, the present study examines the degree to which visual quality mediates repetition effects in a stimulus-selective ventral visual area. Subjects were presented with grayscale photographs of scenes that were either near or substantially above visual threshold, as determined by calibrating image contrast to behavioral performance. The presentation of 2 identical high-contrast scenes elicited lower blood oxygen level-dependent (BOLD) responses than the presentation of 2 different high-contrast scenes (repetition attenuation). Conversely, the presentation of 2 identical low-contrast scenes elicited greater BOLD responses than the presentation of 2 different low-contrast scenes (repetition enhancement). Neurophysiological studies suggest that repetition attenuation in ventral visual areas may reflect the reactivation of perceptual representations that have become sparse and selective as a result of prior experience, whereas repetition enhancement may reflect spared access to existing representations by severely degraded input.

Adaptation, Physiological↗
PubMed2006

Duration-dependent FMRI adaptation and distributed viewer-centered face representation in human visual cortex.

Two functional magnetic resonance imaging (fMRI) face viewpoint adaptation experiments were conducted to investigate whether fMRI adaptation in high-level visual cortex depends on the duration of adaptation and how different views of a face are represented in the human visual system. We found adaptation effects in multiple face-selective areas, which suggest a distributed, viewer-centered representation of faces in the human visual system. However, the nature of the adaptation effects was dependent on the length of adaptation. With long adaptation durations, face-selective areas along the hierarchy of the visual system gradually exhibited viewpoint-tuned adaptation. As the angular difference between the adapter and test stimulus increased, the blood oxygen level-dependent (BOLD) signal evoked by the test stimulus gradually increased as a function of the amount of 3-dimensional (3D) rotation. With short adaptation durations, however, face-selective areas in the ventral pathway, including the lateral occipital cortex and right fusiform area, exhibited viewpoint-sensitive adaptation. These areas showed an increase in the BOLD signal with a 3D rotation, but this signal increase was independent of the amount of rotation. Further, the right superior temporal sulcus showed little or very weak viewpoint adaptation with short adaptation durations. Our findings suggest that long- and short-term fMRI adaptations may reflect selective properties of different neuronal mechanisms.

Adaptation, Physiological↗
PubMed2006

Cingulate activation increases dynamically with response speed under stimulus unpredictability.

Functional magnetic resonance imaging studies of cognition require repeated and consistent engagement of the cognitive process under investigation. Activation is generally averaged across trials that are assumed to tax a specific mental operation or state, whereas intraindividual variability in performance between trials is usually considered error variance. A more recent analysis approach postulates that these fluctuations can reflect variation in the very process taxed by the particular trial type. In the present study, participants responded to targets presented randomly in 1 of 4 peripheral locations. By employing a function of reaction time (RT) of individual trials as a linear regressor, brain regions were identified whose activation varied with RT on a trial-by-trial basis. Whole-brain analysis revealed that the anterior cingulate, posterior cingulate, and left angular/superior temporal gyri were more active in trials with faster RT but only when the target location was unpredictable. No such association was seen in trials where the target location was predicted by a central cue. These results suggest a role for the cingulate and angular gyri in the dynamic regulation of attention to unpredictable events. This is in accordance with the function of a default network that is active in the absence of top-down-focused attention and is thought to continuously provide resources for broad and spontaneous information gathering. Exploiting intertrial performance variability may be particularly suitable for capturing such spontaneous and elusive phenomena as stimulus-driven processes of attention.

Adaptation, Physiological↗