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Results for “PROGESTATIONAL HORMONES”

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At least 433 records · Page 24Linked to original sources
PubMed1976

Plasma steroid concentrations in conscious and anesthetized rabbits.

The ovarian steroids, estrogen, androgen, and progestin, were measured in the peripheral plasma of adult female rabbits that were either conscious or anesthetized with sodium pentobarbital (nembutal) or halothane. Concentrations of estrogen, androgens, and progestin were determined before and at 10 and 45 min after systemic injection of either buffer or LH. In the controls androgen levels were significantly different between animals anesthetized with nembutal and halothane. However, the greatest treatment effect was noted in plasma progestin concentrations which were significantly elevated in halothane-anesthetized animals in comparison to the conscious and nembutal-anesthetized animals. Following LH, the androgen and progestin levels were significantly elevated over basal levels. Most likely the treatment effect observed in the controls was still present but was overridden by the increased release of steroids following gonadotrophin stimulation. This study suggests that halothane, in contrast to nembutal, does significantly elevate peripheral progestin and androgen levels.

Androgens↗
PubMed1981

Minimal dose combined hormonal replacement therapy for menopausal women.

The problem of managing postmenopausal women with hormonal replacement therapy is reviewed. A case is clearly made for using progestogen in every instance when women receive oestrogen in the menopause. By this means the incidence of carcinoma is reduced to at least the rate found in non-treated patients and perhaps even lower. The biochemical changes leading to this reduction are summarized, and a suggestion is made regarding the optimal dosage of progestogen. This paper presents evidence to suggest that minimal doses of progestogen given for at least ten days in each month will protect endometrial target cells.

Biopsy↗
PubMed1977

[Neurohumoral influences of steroid hormones on sexual responsiveness in women (author's transl)].

An analysis has been carried out on the basis of endocrinological and psychosomatic studies of the influence of steroid hormones, acting via probable transmitter substances, on the sexual response in women. From a review in the literature it can be concluded that among other factors the endocrine state of the women determines her sexual response and behaviour. However, the present lack of specific psychological tests is pointed out, as well as the absence of relevant hormonal data to the sexual sphere, both normal and pathological.

Aging↗
PubMed1977

[Sex hormones].

Explore the source record for details and available documents.

Androgens↗
PubMed1989

Response to the antiprogestagen RU 486 (mifepristone) during early pregnancy and the menstrual cycle in women.

RU 486 has wide potential utility as an abortifacient drug when used within the first 6 weeks of pregnancy and has the ability to induce an abortion in about 80% of subjects. Administration of low doses of prostaglandins together with RU 486 increases the success rate. It is possible that alterations in metabolism of RU 486 may explain non-responsiveness to the drug in some women. Mid-luteal phase administration of RU 486 produces bleeding within 72 h and in one-third of subjects there was luteolysis with decrease in serum FSH, oestradiol and progesterone concentrations. Administration of RU 486 in the late luteal phase does not disturb menstrual cycle length, bleeding patterns, ovulation, or hormonal parameters in treatment or posttreatment cycles. However, the drug alone cannot be used as a 'menses regulator' or 'once monthly pill' since some pregnancies do continue. Possibly the efficacy of RU 486 may be enhanced when it is combined with prostaglandins or other agents. Administration of RU 486 in the follicular phase blocks ovulation, delays the LH surge, and is associated with low concentrations of oestradiol. This is presumably the result of gonadotrophin inhibition.

Abortion, Induced↗
PubMed1989

Endogenous and exogenous endocrine factors.

The relationship between breast cancer risk and age at menarche, age at first pregnancy, use of birth control pills, and use of postmenopausal replacement estrogens is reviewed.

Adolescent↗