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PubMed2004

[Clinical-epidemiological aspects of pityriasis versicolor (PV) in a fishing community of the semiarid region in Falcon State, Venezuela].

Between August 2001 and May 2002, the prevalence and several epidemiological and clinical characteristics of pityriasis versicolor (PV) were studied in 902 individuals aged two months- 60 years, 426 females and 476 males, from a fishery community of Río Seco, a semiarid region in the state of Falcon, north-western Venezuela. The overall prevalence of the disease was 15.52% (140/902). The frequency of infection was higher in females (65.7% vs. 34.3%), children under one year of age and adolescents (27.9% y 32.1%, respectively), and dark skin (67.9%). The most commonly affected anatomical areas were the face (57.9%) and thorax (27.1%). The most important clinical features of the disease were: hypochromic (91.4%), multicentric (73.6%), pruritic (92.9%), fine scaled (80.7%) and irregularly shaped borders (91.4%). On the basis of these results, the possible risk factors on transmission dynamic and maintenance of the disease endemically is discussed.

Adolescent↗
PubMed1992

Therapeutic efficacy and safety of the new antimycotic sertaconazole in the treatment of Pityriasis versicolor.

The activity of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl) ethoxy-methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32,2) was studied in a randomized parallel double-blind clinical trial on 21 patients suffering from Pityriasis versicolor (confirmed by KOH microscopic examination and exploration with Wood's light). The patients were divided into two treatment groups: one with 11 patients receiving sertaconazole 1% cream and the other with 10 patients receiving sertaconazole 2% cream. The cream was applied twice a day during 4 weeks. The data were assessed clinically and microscopically (optical and fluorescence). All the patients were cured (100% cure), showing excellent efficacy. A check-up performed after the end of the treatment showed no relapses of infection. The drug safety was optimum, since no local or general undesirable effects were recorded, nor were there any changes in the analytical parameters studied in the 21 patients. Because of its high antifungal activity and excellent safety, sertaconazole represents an important advance in the topical therapy of this disease.

Adult↗
PubMedDate not supplied

[Itraconazole in the treatment of pityriasis versicolor: comparison between 5 and 7 days of treatment].

The authors present the results obtained in the treatment of pityriasis versicolor with Itraconazole, comparing two schemes of treatment, in an open trial: 200 mg daily, for 5 and 7 days. The clinical diagnosis was confirmed by Wood's light and mycologically, by direct examination. The patients were controlled 21 and 35 days after beginning the treatment. The evaluation of the results showed that both schemes were effective. At the second control, there was clinical and mycologic cure in 90% of the patients from the 5-day group and in 95% of the patients from the 7-day group. The tolerance was good: 2 patients from the 7-day group and 1 patient from the 5-day group showed side-effects. Since there was no significant difference between the two schemes of treatment, the authors recommend the shortest one, that is, 200 mg daily for 5 days.

Adolescent↗
PubMed1990

[Pseudoatrophic pityriasis versicolor].

The pseudoatrophic pityriasis versicolor is an atypical form of this disease with cutaneous atrophy provoked by the prolonged application of topical corticosteroids. The term "pseudoatrophic" is indicative of its reversible character.

Administration, Topical↗
PubMed1989

[Prospective study of pityriasis versicolor incidence in a population of the city of Santo André (state of São Paulo)].

The authors studied prospectively the incidence of pityriasis versicolor (PV) in the population of Santo André, São Paulo State, Brazil, researching Malassezia furfur on the skin of suspected cases. They consider M. furfur as the only etiologic agent for PV diagnosed by the "cellophane tape" method (Porto, 1953). The work registered 132 positive cases (3.1%) in 4,267 examined people. The study revealed a bigger incidence in males (4.34%, among the negroes (4,475) and in the group between 10 and 15 (4,205). As M. furfur is an opportunistic agent, the authors emphasized that it is of great interest not only for cutaneous pathology, but also for the study of systemic infections, mainly in children with low immunity.

Adolescent↗
PubMed1988

[Local therapy of pityriasis versicolor with 3 imidazole derivatives--results of a therapeutic study. Studies of the rate of recurrence].

In a clinical study from October 1985 to July 1987, we tested the efficacy of 3 different imidazole compounds in 112 male patients suffering from pityriasis versicolor. The diagnosis was made according to clinical criteria and confirmed by microscopical investigation. Our results prove the necessity of daily treatment over a period of at least 2 weeks. After 2 weeks, the microscopical examination should be repeated. Sprays and shampoos seemed equally effective. The relapse rate turned out to be rather high. The symptom-free interval between therapy and relapse could not be correlated to any of the forms of treatment. Those patients who had to be treated for more than 2 weeks were most likely to develop a relapse within a shorter period.

Administration, Topical↗
PubMed1985

[Pityriasis versicolor in children].

Four cases of pityriasis versicolor in children from two to five months of age are reported and a bibliographic revision is made in this particular age group.

Facial Dermatoses↗
PubMed1985

An open, multicentre assessment of the effectiveness of bifonazole in the treatment of tinea (pityriasis) versicolor.

One hundred and twenty-one patients with tinea (pityriasis) versicolor, confirmed by pretherapeutic clinical and mycological examination, were treated with a single daily application of bifonazole (BAY h 4502) 1% gel for 2 weeks. Weekly clinical controls were performed during the treatment period and at least two clinical and mycological post-therapeutic controls were given. Overall results were very good in 98 patients, good in 15, moderate in 7 and failure in 1 patient. Local tolerance was very good; only 1 patient presented with slight erythema and pruritus during the treatment.

Adolescent↗
PubMed1977

A clinical study of Pityriasis versicolor in Madras.

One hundred subjects with extensive pityriasis versicolor determined clinically and confirmed by wet preparations (potassium hydroxide positive) were studied. Its incidence in relation to sex, seasons and age groups was analyzed. More than fifty patients sought medical advice on grounds of cosmetic handicap. The most pronounced clinical feature was to be found on the trunk. One case was Confluent and Reticulated Papillomatosis of Gugerot-Carteaud (CRP) (16). Among the factors of susceptibility, pulmonary tuberculosis (P.T.) emerged statistically significant.

Age Factors↗
PubMed1984

Ketoconazole--an effective treatment for disseminated pityriasis versicolor.

Long-standing disseminated lesions of pityriasis versicolor (PV) were found in 101 patients. As they had failed to respond to various topical agents, we treated them with 200 mg/day of ketoconazole. All of them were under clinical and mycological surveillance at weekly intervals. In successive mycological examinations during the course of therapy, an increased ratio of filaments/spores was observed, and the last positive examinations invariably showed the presence of only a few filaments and no spores. The mean duration of therapy, until a negative mycological smear was obtained, was 2.2 weeks. Side effects were insignificant, and did not necessitate interrupting treatment except in one patient, who developed an allergic eruption after a single 200-mg dose of the drug. The transient minor disturbances in liver function tests noted in six patients were considered drug related, but ketoconazole administration was continued in all these patients, and the values normalized gradually during treatment. We conclude that ketoconazole is a well-tolerated and highly effective drug in the systemic therapy of disseminated PV.

Administration, Oral↗
PubMed1983

[10-day therapy of pityriasis versicolor with ketoconazole].

Apart from the standard treatment of pityriasis versicolor with selenium disulphide preparations, the 30-day-therapy with ketoconazole has been considered an alternative so far. According to our investigations, the duration of treatment may be shortened to ten days. After discontinuation of the drug, the fungal elements are reduced and finally disappear. This effect is attributed to the active substance being deposited in the sebaceous glands and secreted onto the skin. An influence of the product on phagocytosis is also discussed.

Adult↗
PubMed1978

[Ulstrastructural study of various evolutive stages of pityriasis versicolor (author's transl)].

Small size, less numerous and sometimes clustered melanosomes, were seen within the melanocytes. The others organites alos showed abnormalities: smaller mitochondria, abundant cytofilaments. Sometimes total degeneration of the melanocyte was seen. These alterations are variable, depending upon the evolutive stage of pityriasis versicolor: either hypopigmented undergoing treatment or not, or hyperpigmented. Reactions of several cellular types of the dermoepidermal unit could be observed: more numerous Langerhans cells located near the base of the epidermis, abundant nerve fibers in the superficial dermis and active fibroblasts of foetal type. A slight inflammatory infiltrate was present in some cases. It is suggested that a toxic effect of the fungus is responsible for the changes of the morphological aspects of the melanocyte.

Adult↗