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At least 433 records · Page 24Linked to original sources
PubMed1999

Parental occupation and other factors and cancer risk in children: II. Occupational factors.

A population-based case-control study was conducted on 593 cancer cases in children from 0 to 14 years of age diagnosed in Moscow from 1986 to 1988. The study included 1181 healthy controls matched by age, gender and residence. Parental exposures prior to conception, including exposures to petroleum products, organic solvents, unspecified chemicals, soldering aerosols, ionizing radiation, electromagnetic fields (EMF), visual display units (VDU) and high temperature in the work environment, were significantly more frequent among the cases than among the controls (p < 0.05). Leukemia risk was associated with paternal exposure to ionizing radiation [odds ratio (OR) 6.7; 95% confidence interval (CI) 2.8-15.8], EMF (OR 4.6; 95% CI 1.8-11.9), VDU (OR 2.4; 95% CI 1.0-5.8) and unspecified chemicals (OR 2.0; 95% CI 1.02-4.1). Leukemia risk was also higher when mothers were exposed to solvents (OR 3.1; 95% CI 1.5-6.3), unspecified chemicals (OR 2.0; 95% CI 1.0-4.3), ionizing radiation (OR 10.3; 95% CI 1.3-83.4) and EMF (OR 5.2; 95% CI 1.6-16.8). Increased risk of non-Hodgkin's lymphoma was shown to be related to maternal exposure to oil products (OR 3.3; 95% CI 1.01-10.7) and unspecified chemicals (OR 3.3; 95% CI 1.01-10.7). Exposure to VDU was found to be associated with increased risk of neuroblastoma (6/1; OR 13.8; 95% CI 1.9-100.0).

Adult↗
PubMed1992

Occupational dimethylformamide exposure. 2. Monomethylformamide excretion in urine after occupational dimethylformamide exposure.

The relationship between the 8-h time-weighted average (TWA) intensity of exposure to N,N-dimethylformamide (DMF) vapor (with little possibility of skin contact with liquid DMF) and the subsequent excretion of N-monomethylformamide (MMF) precursor in shift-end urine samples was examined in 116 workers exposed to DMF and 92 workers exposed to DMF in combination with toluene. Urinary MMF level was examined also in 42 non-exposed subjects. The TWA vapor concentration in breathing zone air of each worker was successfully measured by means of a recently developed diffusive sampler in which water was used as an absorbent. The examination of gas chromatographic (GC) conditions for MMF determination showed that the formation of MMF was not saturated when the injection port temperature was set at 200 degrees C, reached a plateau at 250 degrees C, and showed no additional increase at 300 degrees C. There was a linear relationship between DMF in air and MMF in urine with a regression equation of y = 1.65 x + 1.69 (r = 0.723, P less than 0.01), where y is MMF (unit; mg/l, uncorrected for urine density) in urine and x is DMF (ppm) in air, when only those exposed to DMF were selected, and the injection port temperature was set at 250 degrees C. From this equation, it was possible to estimate that about 10% of the DMF absorbed will be excreted into urine as the MMF precursor. The slope of the regression line was significantly smaller among those exposed to DMF and toluene in combination as compared with those with DMF exposure only.

Adult↗