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At least 433 records · Page 24Linked to original sources
PubMed1979

[Post surgical ossifications (total prosthesis) of the hips in subjects suffering from vertebral ankylosing hyperostosis].

In a series of 67 patients suffering from vertebral ankylosing hyperostosis (VAH) and who underwent surgery in one or both hips (93) with installing of a prosthesis, we observed in all the subjects post-surgical coxal ossifications, and in 57 of them, large or very large ossifications. These ossifications appeared solely during the first year following surgery, and their final volume was reached during this first year. The appearance of such post-surgical coxal ossifications during the VAH is for us a characteristic of the disease. This observation is a factor that points to a general and non local (vertebral) mechanism of the VAH.

Aged↗
PubMedDate not supplied

Heterotopic ossification in rehabilitation patients who have had internal fixation of an acetabular fracture.

High-energy trauma patients often have multiple injuries and are frequently seen by a physiatrist following their acute care. Acetabular fractures are common in this patient population. Following surgical treatment of acetabular fractures, a very high incidence of heterotopic ossification can occur. We describe 94 patients who underwent posterior surgical fixation of an acetabular fracture. Of these, 87 received heterotopic ossification prophylaxis in the form of irradiation or indomethacin; 5 did not receive prophylaxis. Seven of the 45 patients who were initially started on indomethacin had their medication discontinued for various reasons. Of the 12 patients who did not receive adequate prophylaxis, 5 developed disabling heterotopic ossification. We present our experience with this patient population, and we discuss the importance of adequate prophylaxis for heterotopic ossification.

Acetabulum↗
PubMed1979

[Development of ossification in children with chronic digestive insufficiency (author's transl)].

In 84 children suffering from chronic insufficiency of digestion, ossification of both hands was observed by means of fluoroscopic controls for several years. In 48 of 71 patients there was a retarded ossification; in 23 it was normal, or respectively more advanced. 18 boys and girls succeeded in making up for there retardation by means of consequent diet so that it might be regarded as a "spurt of growth". But in 10 of them retardation was constant, and in 14 children it increased. The causes of insufficient improvement were: late diagnosis and therapy, failures of diet, but also additional diseases--different from digestive insufficiency--, and long-term use of corticosteroides. In 30 of 84 children ossification was always normal or advanced. They had received early and consequent diet for years. Only in few cases, slight or moderate diseases were diagnosed. Development of ossification was parallel to body height, but not to weight gain.

Age Factors↗
PubMed2000

Did ossification of the posterior longitudinal ligament of the spine evolve in the modern period? A paleopathologic study of ancient human skeletons in Japan.

OBJECTIVE: To investigate the historical origins of ligamentous ossifications of the spine in Japan. METHODS: We studied skeletons of Jomonese of the period 5000-2300 years BP, of Japanese of the 17th-19th century Edo Period, and of Ainu of the 18th-20th century in Japan with special emphasis on spinal ligament ossifications as in the posterior longitudinal ligament. A comparison to our previous study on ancient Chinese skeletons was done. RESULTS: Cervical ossification of the posterior longitudinal ligament (OPLL) was the only ossification that increased significantly in prevalence in people of the near-modern period in comparison to the Neolithic gathering-hunting people. CONCLUSION: Socioeconomic changes from a subsistence gathering-hunting economy to the near-modern livelihood depending on rice-eating and a diet high in vegetable protein are speculated to be responsible for the prevalence increase of cervical OPLL.

Adult↗
PubMedDate not supplied

Preossified longitudinal epiphyseal bracket of the foot: treatment by partial bracket excision before ossification.

The longitudinal epiphyseal bracket is a rare ossification defect of tubular bones in the hand and foot. This deformity contains an abnormal secondary ossification center, which may lead to progressive shortening and angular deformity of involved bones. This article describes the results from early treatment of this deformity before the secondary ossification center ossifies. Four patients with seven involved bones (5 metatarsals and 2 phalanges) were treated with surgical excision of the longitudinal epiphyseal brackets, without corrective osteotomy. The average age at surgery was 16 months (range, 6-20 months), and the average follow-up period was 55 months (range, 31-80 months). All five metatarsal patients demonstrated progressive improvement in the deformity. Of the two phalanx patients, one improved and the other did not. Early treatment of the longitudinal epiphyseal bracket before ossification of the secondary center with excision is effective in correcting this deformity. Long-term follow-up assessment until skeletal maturity is necessary to assess the final results of surgery because corrective osteotomy may be necessary for patients who do not have adequate correction.

Bone Diseases, Developmental↗
PubMed2004

[Radiotherapy as prevention of heterotopic ossification--preliminary results].

Heterotopic ossification is a common complication of hip arthroplasty (35-57%) and multifragmental acetabular fractures (50-70%). Due to complication level and cost of surgery in this region, more popular become methods of heterotopic ossification prevention as well as non-steroid anti inflammatory drug intake and radiotherapy (approximately 90% effectiveness in high risk groups). Presented material comprises 22 cases irradiated using a dose of 6-7 Gy delivered in one fraction to prevent ossification or to stop active process. No progress was found and only in one case secondary ossification appeared during follow up. Obtained results allow to form the conclusion that radiotherapy is easy, fast and cheap treatment modality giving good results without adverse effects.

Adult↗
PubMed2004

[Bilateral ankylosing paraarticular ossifications of the hip joint with involvement of the sciatic nerve].

In December 1997 a 48 year-old man was treated by resection of the bilateral paraarticular ankylosing ossifications that developed after 6 weeks of unconsciousness after necrotic pancreatitis. The ossifications on the posterior part of the hip joint involved a highly separated sciatic nerve. There was a bilateral osseous ankylosis of the hip joint and total denervation of sciatic nerve. In April 1999 the ossifications on the right side were removed. The splitted sciatic nerve was in two osseous channels. The head of the femur was vital and immediately following the operation, flexion of the hip joint was possible to 90 degrees. The same procedure was performed on the left hip joint in October 1999. In April 2000, a re-occurance of the paraarticular ossification on the ventral part of the right hip joint was removed from an ilioinquinal approach. In June 2002 the patient was able to stand and walk without crutches. ROM of the knee joints improved bilaterally to 120 degrees of flexion. The flexion of the right hip joint is 70 degrees and in the left hip is 80 degrees. 3 years after decompression of both sciatic nerves involved in heterotopic bone established significant reinervation. The motor function of the proximal femoral muscles and the function of the tibial nerve was renewed. Complete motor denervation syndrom persists in common peroneal nerve. Sensitive inervation was renewed as in n. tibialis as in common peroneal nerve except acral parts of the foot a toes. Concerning function of the sciatic nerves, the overall results can be assessed as partially succesfull because of partial denervation syndrome of sciatic nerves. In definite clinical improvement the recovery of the neurologic status is very important besides the mechanical improvement of range of motion of the hip joint.

Ankylosis↗
PubMed2006

[Comparison of heterotopic ossification between femoral head reconstruction and total hip arthroplasty in patients with ischemic necrosis of femoral head].

OBJECTIVE: To compare heterotopic ossification between femoral head reconstruction and total hip arthroplasty (THA) in patients with ischemic necrosis of femoral head (INFH). METHODS: Between June 1994 and December 2004, the femoral heads were repaired in 1 005 patients with INFH,the total hip was replaced in 485 patients with INFH. The rate of heterotopic ossification was observed in 74 (Ficat II to IV stages) of 1 005 patients and 80 of 485 patients given THA to compared the results of the two methods. RESULTS: These patients were followed up 2 to 10 years(6.5 years on average). The rates of heterotopic ossification were 5.4% (4/74) and 22.5% (18/80), respectively. There was statistically significant difference between two operative methods (P<0.01). CONCLUSION: The rate of heterotopic ossification of femoral head reconstruction is lower than that of THA, so femoral head reconstruction is a better operative method for young patients and THA is suitable for old patients.

Adult↗
PubMed1990

[Heterotopic ossification and ulnar nerve compression syndrome of the elbow. A report of two cases].

Heterotopic ossification is a well known complication in patients after longterm coma following CNS trauma. The association of heterotopic ossification and a nerve compression syndrome situated near the calcifications is less common. The authors present 2 CNS traumatised patients who secondarily developed the association of heterotopic ossification of the elbow with a compressive syndrome of the ulnar nerve. Although heterotopic ossification does not appear to be the direct cause of the nerve compression, it certainly promotes compression it because of the flexion it causes.

Adolescent↗
PubMed1991

[Radiographic studies of ossification of the hoof cartilage of horses and its clinical evaluation].

Radiographic examination is a valuable means for the identification of ossified lateral cartilage. The extent and stages of development of the ossification can be determined. The active stage of development of ossified lateral cartilage, which by itself can provoke lameness, can be defined. By means of the X-ray it is tried to differentiate the three kinds of ossification: the enchondral, the peri- and parachondral ossification of the lateral cartilage. Centres of ossification and fractures of the ossified lateral cartilage are described.

Animals↗
PubMed1991

Postoperative heterotopic ossification in children: a comparison of children with spina bifida and with cerebral palsy.

The authors reviewed 250 consecutive myotomies and tenotomies performed on the hips of 186 children. Two groups were studied: 162 children with cerebral palsy and 24 children with spina bifida. In total 19 children were found to have heterotopic ossification postoperatively. The incidence of heterotopic ossification was 21% in the spina bifida group and 8.6% in the cerebral palsy group. The most severe cases were in children with thoracic myelomeningocele. Only one child with lumbar myelomeningocele had ossification, and it was mild. This difference was statistically significant. Two children with thoracic spina bifida had severe ossification and abduction contractures requiring resection of the bony mass. Recurrence was successfully prevented by a course of radiotherapy.

Cerebral Palsy↗
PubMed1990

Scala vestibuli cochlear implantation for labyrinthine ossification.

Labyrinthine ossification is a common occurrence in patients with profound deafness. This may run as high as 80 percent in patients deafened by meningitis. Ossification sometimes makes cochlear implantation difficult. Two patients are presented with severe scala tympani cochlear ossification who had scala vestibuli electrode implantation. Their functional and audiologic results seem to be equal to those expected with scala tympani implantation. Scala vestibuli implantation seems to be a viable alternative in patients with scala tympani ossification.

Adult↗
PubMed1989

[The importance of magnesium in orthopedics. VI. The importance of magnesium in the treatment of ectopic calcification and ossification].

In a five-year investigation the authors demonstrate their results with Mg treatment in 54 patients with ectopic calcifications and ossifications. Based on the results of experimental work, where the inhibiting action of Mg ions on calcium phosphate precipitation was proved in vitro as well as in vivo, the authors treated by means of local MgSO4 injections and oral administration of Mg lactate 17 patients with ossifying myositis, 16 with calcareal bursitis, 4 patients with paraosteoarthropathy of the elbow after craniocerebral injuries, 6 calcifications of the hip joint after operations and 5 calcifications in the insertions of tendons and ligaments. In all instances diminution to complete disappearance of the calcificates and ossificates was observed. The authors achieved also very favourable functional results. In the majority of patients the mobility in adjacent joints was restored. Clinical experience indicates that Mg prevents the development or suppresses further growth of ectopic calcifications and ossifications. During the formation of the ossificate, which is still immature, Mg causes diminution and sometimes complete absorption of the immature bone.

Adolescent↗
PubMedDate not supplied

[Disseminated ossification of the lung].

Disseminated pulmonary ossification is a rather rare finding. Two classical cases of the dendriform and seven of the nodular one, even if with minimal aspects, were reported. They were found through a revision of 720 postmortem registers and a reexamination of their histological specimens. A typical morphologic picture was observed. About formal genesis of the bone we emphasized the possibility that the ossification occurred in the dendriform also through a cartilaginous phase in addition to a connective one. Various pathological forms of the lung or other organs, that on the basis of the literature are considered responsible or associated with pulmonary ossification, were listed. Eventually, we pointed out that dendriform could be a pathological picture by itself and not a secondary one, that is to say a real idiopathic ossification.

Aged↗
PubMed1989

[Ossification after transplantation of model cartilage in the rat patella].

The cartilage model of the rat's patella constitutes a formation susceptible of inducing ossification, following its transplantation in a variety of sites (muscle, thyroïd, testis, ovary, anterior chamber of the eye, etc.), including those considered inappropriate in other experiments of induced ossification (liver, kidney). So we have an experimental model allowing the influence on the osteogenesis of various factors, local or general, natural or experimental, to be studied. Ossification occurs in this model only in cases of histocompatibility between donor and recipient. It is constant after autotransplantation or isotransplantation. It is never seen after heterotransplantation. In cases of homotransplantation its frequency varies: this is not influenced by the technical conditions of implantation but by tissue compatibility and the age of the animals giving and receiving. A private perichondrium cartilage retains its osteogenic potency. A cartilage killed by alcohol or cold no longer demonstrates its osteoformative capacities, even when put into contact with a living cartilage. Our findings are difficult to reconcile with the hypotheses invoking the osteogenic potency of the periosteum, or the intervention of substances either inducing osteoformation or inhibiting vascular invasion, for the explanation of endochondral ossification. However, they lead one to the opinion that chondrocytes play an active role in its release.

Aging↗
PubMed1986

[Periarticular ossification. Complication of total hip prosthesis].

The authors analyse peri-prosthetic ossification, a complication which can occur in the presence of certain risk factors. Grades I and II calcifications are frequent and do not interfere with the final post-operative result. On the other hand, grades II and IV result in a progressive stiffening of the coxo-femoral joint within one year after the operation. They may be bilateral and can sometimes be responsible for serious handicap. These cases should be re-operated in order to restore joint mobility, but surgical treatment should be completed by radiotherapy according to a defined protocol. Non-steroidal anti-inflammatory agents and diphosphonates also have a preventative action. Subjects at risk (ankylosing vertebral hyperostosis, spondyloarthritis, alcoholism, patients with a history of ossification of the first side) require effective prophylactic treatment. In the authors' own series, 49 cases of ossification were observed in a retrospective analysis of 100 patients, including 6 cases of grades III and IV ossification. They analyse their results in relation to the initial hip pathology treated by prosthesis, but their series is too small to allow an statistically valid conclusions. Complementary studies are required.

Anti-Inflammatory Agents↗
PubMed1986

The prevention of heterotopic ossification in high-risk patients by low-dose radiation therapy after total hip arthroplasty.

A prospective study was done to evaluate the efficacy of treatment with 1,000 rads of radiation in the prevention of heterotopic ossification after total hip arthroplasty in patients who are at high risk. In a previous prospective study, patients who were at high risk for heterotopic ossification after total hip arthroplasty were identified and an effective regimen for its prevention was established. It was demonstrated that treatment with 2,000 rads of radiation that was initiated within four days after the total hip arthroplasty was highly effective in the prevention of heterotopic ossification and in the prevention of recurrence after resection of existing ossification. In the present study, 1,000 rads of radiation was administered in increments of 200 rads over a period of five to seven days and was as effective as treatment with 2,000 rads. The protocol of 1,000 rads is preferable because it reduces the risk of malignancy and the duration of hospitalization.

Aged↗
PubMed1987

Postpatellectomy extensive ossification of patellar tendon. A case report.

Ossification in the quadriceps mechanism after total patellectomy is a common finding. The relationship of knee symptoms and the extent of postpatellectomy ossifications is debatable. Reported is the case of a 74-year-old woman with extensive ossification in the patellar tendon following patellectomy and knee arthroplasty. The ossification was associated with only minimal discomfort. Functional results following patellectomy were not affected in patients previously observed by the authors.

Aged↗