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Patterned response of lamina V cells: cutaneous and dorsal funicular stimulation.

Single unit activity was recorded in spinal lamina V (LV) in unansthetized cats. Poststimulus-time histogram (PSTH) analysis of responses to intracutaneous stimulation demonstrated similar firing patterns for all cells. In addition to a direct relationship between stimulus intensity and the duration of cellular response, modulation of firing frequency and distinct delayed PSTH peaks in 77 percent of the units were observed. The pattern of delayed peaks was associated with the same high intensity intracutaneous stimulation reported as painful when applied to human observers. A background of dorsal funicular stimulation selectively inhibited the delayed response of LV cells to high intensity stimulation. Thus, LV cells, by their duration of firing, trasmit information related to stimulus intensity, and by their patterned responses, have the potential to relay other information, possibly related to their nociceptive role. As delayed LV activity is associated with a high proportion of small fibers in the afferent input, presynaptic inhibition of A-delta and C fibers might account for the selective inhibition associated with dorsal funicular stimulation.

Action Potentials↗

Patterns of bulbar respiratory neurons during and after artifical hyperventilation.

Single bulbar respiratory unit activity was recorded in urethane-anesthetized rabbits. During artificial ventilation, reflex contractions of the diaphragm were elicited by the forced deflations of the respirator. Out of 44 neurons, four I, one E and two EI units exhibited a shift of their discharge relative to the contractile phase of the diaphragm, compared to normal respiration. During hypocapnic apnea, some I, IE and E neurons became silent. Other cells belonging to all phase types, however, continued to fire tonically at a rate less than the peak rate in normal bursts. When rhythmic respiration resumed after termination of the apneic pause, five (I, IE and E) units exhibited a transient phase shift of their burst discharge compared to normal respiration. The results of simultaneous recordings of two neurons belonging to different phase types are compatible with the assumption that inspiratory units are periodically inhibited by inspiratory-expiratory cells.

Animals↗

Organization of geniculate inputs to visual cortical cells in the cat.

Neuronal connectivity between a geniculate cell and a striate cortical cell was examined by cross-correlograms between their impulse activities. Delayed positive correlations were found in 82 pairs, and the onset delay of the positivity was short enough in 65 pairs to infer that the geniculate cell monosynaptically excited the cortical cell. These monosynaptic excitations were found in both simple and complex cells. By determining connectivity of a cortical cell with multiple geniculate cells, the convergence of X and Y geniculate cells and that of on-center and off-center geniculate cells was demonstrated in several striate cells.

Action Potentials↗