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PubMed2002

Generalized lichen nitidus successfully treated with an antituberculous agent.

We describe a Japanese girl with generalized lichen nitidus. She had been exposed to Mycobacterium tuberculosis at 6 years of age via her teacher. At 8 years of age, she developed severe contact dermatitis on sun-exposed areas after contact with Japanese lacquer trees. Shortly after, numerous tiny, shiny, flesh-coloured papules developed over the upper part of her body. At 10 years of age, she was exposed to a school outbreak of M. tuberculosis. Her eruption showed no response to topical corticosteroids or oral tranilast, but most of the papules completely disappeared after she had received oral isoniazid for 6 months.

Antitubercular Agents↗
PubMed2002

Onychomycosis: strategies to improve efficacy and reduce recurrence.

Fungal infections may be difficult to treat for several reasons. It is important to obtain the correct diagnosis, and select the appropriate antifungal agent and route. General considerations that may be associated with recurrent infections are, a genetic predisposition and suboptimal bioavailability of drug, resulting in insufficient concentration at the target site. The aetiologic organism, the severity of disease, other coexisting diseases, concomitant drug intake, and the presence of fungal infection at other sites are some factors that determine the choice of antifungal therapy and its route of administration, oral vs. topical lacquer. Local factors such as the thickness of the nail, presence of lateral onychomycosis, longitudinal spike, dermatophytoma and severe onycholysis are some factors that may determine the choice of secondary measures such as mechanical or topical treatment. Booster or supplemental therapy may be of benefit when the response to initial treatment is poorer than expected and unlikely to result in complete response. Steps should be taken to reduce the possibility of recurrence once cure has been achieved.

Administration, Oral↗
PubMed2000

Redox cycling of phenol induces oxidative stress in human epidermal keratinocytes.

A variety of phenolic compounds are utilized for industrial production of phenol-formaldehyde resins, paints, lacquers, cosmetics, and pharmaceuticals. Skin exposure to industrial phenolics is known to cause skin rash, dermal inflammation, contact dermatitis, leucoderma, and cancer promotion. The biochemical mechanisms of cytotoxicity of phenolic compounds are not well understood. We hypothesized that enzymatic one-electron oxidation of phenolic compounds resulting in the generation of phenoxyl radicals may be an important contributor to the cytotoxic effects. Phenoxyl radicals are readily reduced by thiols, ascorbate, and other intracellular reductants (e.g., NADH, NADPH) regenerating the parent phenolic compound. Hence, phenolic compounds may undergo enzymatically driven redox-cycling thus causing oxidative stress. To test the hypothesis, we analyzed endogenous thiols, lipid peroxidation, and total antioxidant reserves in normal human keratinocytes exposed to phenol. Using a newly developed cis-parinaric acid-based procedure to assay site-specific oxidative stress in membrane phospholipids, we found that phenol at subtoxic concentrations (50 microM) caused oxidation of phosphatidylcholine and phosphatidylethanolamine (but not of phosphatidylserine) in keratinocytes. Phenol did not induce peroxidation of phospholipids in liposomes prepared from keratinocyte lipids labeled by cis-parinaric acid. Measurements with ThioGlo-1 showed that phenol depleted glutathione but did not produce thiyl radicals as evidenced by our high-performance liquid chromatography measurements of GS.-5, 5-dimethyl1pyrroline N-oxide nitrone. Additionally, phenol caused a significant decrease of protein SH groups. Luminol-enhanced chemiluminescence assay demonstrated a significant decrease in total antioxidant reserves of keratinocytes exposed to phenol. Incubation of ascorbate-preloaded keratinocytes with phenol produced an electron paramagnetic resonance-detectable signal of ascorbate radicals, suggesting that redox-cycling of one-electron oxidation products of phenol, its phenoxyl radicals, is involved in the oxidative effects. As no cytotoxicity was observed in keratinocytes exposed to 50 microM or 500 microM phenol, we conclude that phenol at subtoxic concentrations causes significant oxidative stress.

Antioxidants↗
PubMed2003

[Isocyanates: occupational exposures and disorders].

Isocyanates are extensively used for the production of different foams and elastomers. They also serve as glues, lacquer hardeners, inks, adhesives, fillers, finishes, sealants, coating and insulation materials. Usually, their application results in inhalative, partly also in cutaneous uptake. This review describes occupational exposures to isocyanates as well as hazardous effects. Isocyanates are used in the automotive/mechanical engineering/building and construction/mining/casting/electricity and electronic/plastics/printing/timber and furniture/white goods and textile industry, partly also in medicine. Hazardous exposures to thermal degradation products of isocyanate-based polyurethanes and other materials have also be taken into consideration. Obstructive airway diseases are the major disorder caused by isocyanates. Rare cases suffer from extrinsic allergic alveolitis or eczema. In addition to regulation-based primary prevention qualitative medical surveillance mostly prevents disorders. There is also a need for the establishment of a validated biomonitoring of endangered employees.

Humans↗
PubMed1996

[Cancer of the oral cavity in machine workers].

BACKGROUND: So far, only few studies exist which investigated the influence of occupational factors on the risk of oral cancer. PATIENTS: A case control study enrolling 100 patients with carcinomas of the oral cavity and 400 randomized control persons was performed to analyze occupational risk factors for oral cancer. RESULTS: Twenty-two percent of the tumor patients and only 8.5% of the control persons were employed as machine workers. The relative risk for squamous cell carcinoma of the oral cavity was 3.4 (K.I.: 1.7-7.0) for machine workers (adjusted for alcohol and tobacco). Single case analysis showed that 96.3% of the machine workers with oral cancer and only 17.3% of the machine workers in the control group were exposed to dust, especially metal dust (55.5% vs. 9.7%). Also the exposure to paint, lacquer, and varnish containing chromium and nickel was significantly higher in machine workers with cancer of the oral cavity than in the machine workers without cancer (29.6% vs. 10.9%). CONCLUSIONS: The findings suggest that exposition to various types of dust, especially metal dust, increases the risk of oral cancer in machine worker patients.

Adult↗
PubMed2002

Eyelid dermatitis: experience in 203 cases.

Allergic contact dermatitis has been considered the most common of the many dermatologic conditions found with eyelid dermatitis. This is a retrospective study of 203 patients who presented with persistent or recurrent eyelid dermatitis with or without dermatitis elsewhere. Almost all underwent patch testing and, when indicated, radioallergosorbent test, skin prick and intradermal tests, and in many cases, usage tests as part of the workup. Relevant allergic contact dermatitis was found in 151 of 203 patients (74.%): 46 (23.%) had protein contact dermatitis, but only 7% had protein contact dermatitis without concurrent allergic contact dermatitis. Less than 1% had irritant dermatitis alone. Twenty-three patients had atopic eczema, of whom 16 also had allergic contact dermatitis, protein contact dermatitis, or both. Other conditions included seborrheic dermatitis (n = 11), psoriasis (n = 7), dry eyes (n = 9), and dermatomyositis or overlapping connective tissue disease (n = 7). Important sources of contact sensitivity include cosmetics, metals, topical medications including corticosteroids, eye medications, dust mites, animal dander, and artificial nails; only 5 cases were caused by nail lacquer. Eyelid dermatitis is a multifaceted clinical problem, but in this group of patients, allergic contact dermatitis was a common cause, even among those with atopic eczema.

Cosmetics↗
PubMedDate not supplied

Respiratory hazards associated with exposure to formaldehyde and solvents in acid-curing paints.

Thirty-eight employees exposed to formaldehyde when working with acid-hardening lacquers and 18 nonexposed control persons employed at the same company were examined to determine lung function (spirometry and nitrogen washout), total immunoglobulin blood concentration, and work-related symptoms. The mean exposure to formaldehyde during an 8-hr workday was 0.40 mg/m3 air, and the mean exposure to peak values was 0.70 mg/m3. Mean exposure to solvents was low, i.e., approximately 1/10 of the hygienic effect. Eye, nose, and throat irritation was more common in exposed persons than in controls. Monday morning, after two exposure-free days, forced vital capacity (FVC) values were found to have declined by 0.24 L and forced expiratory volume in 1 sec (FEV1.0) by 0.21 L, compared with normal values. There was a weak correlation between the individual concentration of IgG and decrease in FVC and FEV1.0. No significant changes were noted in any other lung function variable before a workshift, and no lung function changes were noted over a full workshift. Deviations in FVC and FEV1.0 values did not correlate to peaks or mean exposures or employment time.

Adult↗
PubMed2003

Benzophenone in cartonboard packaging materials and the factors that influence its migration into food.

Benzophenone may be present in cartonboard food-packaging materials as a residue from UV-cured inks and lacquers used to print on the packaging. It may also be present if the cartonboard is made from recycled fibres recovered from printed materials. A method has been devised to test for benzophenone in cartonboard packaging materials and to test for migration levels in foodstuffs. Packaging is extracted with solvent containing d10-benzophenone as the internal standard. Foods are extracted with solvent containing d10-benzophenone and the extract defatted using hexane. The extracts are analysed by GC-MS. For analysis of food, the limit of detection was 0.01 mg x kg(-1) and the limit of quantification was 0.05 mg x kg(-1). The calibration was linear from 0.05 to 20 mg x kg(-1). The method for food analysis was validated in-house and it also returned satisfactory results in a blind check-sample exercise organized by an independent laboratory. The methods were applied to the analysis of 350 retail samples that used printed cartonboard packaging. A total of 207 (59%) packaging samples had no significant benzophenone (<0.05 mg x dm(-2)). Seven (2%) were in the range 0.05- 0.2 mg x dm(-2), 60 (17%) were from 0.2 to 0.8 mg x dm(-2) and 76 (22%) were from 0.8 to 3.3 mg x dm(-2). A total of 71 samples were then selected at random from the 143 packaging samples that contained benzophenone, and the food itself was analysed. Benzophenone was detected in 51 (72%) of the foods. Two food samples (3%) were in the range 0.01-0.05 mg kg(-1). A total of 29 (41%) were from 0.05 to 0.5 mg kg(-1), 17 (24%) were from 0.5 to 5 mg x kg(-1) and three (4%) food samples exceeded 5 mg x kg(-1). The highest level of benzophenone in food was 7.3 mg x kg(-1) for a high-fat chocolate confectionery product packaged in direct contact with cartonboard, with room temperature storage conditions and with a high contact area:food mass ratio. When the mass fraction of benzophenone migration was calculated for the different contact and storage regimes involved, the attenuation effects of indirect contact and of low temperature storage were cumulative. Thus, there was a sixfold reduction in migration for indirect contact compared with direct contact, a sixfold reduction for chilled/frozen storage compared with ambient storage, and 40-fold reduction for the two contact conditions combined.

Benzophenones↗
PubMed2004

Migration from can coatings: part 2. Identification and quantification of migrating cyclic oligoesters below 1000 Da.

Metal cans for food use can be coated with lacquers based on polyester resins. Recent research has focussed on the identification and quantification of migrants released by coatings that are potentially absorbable (below 1000 Da). The presented method describes a procedure that was optimized to hydrolyse the polyester migrants into their monomers, polyvalent acids and polyols. The polyols were identified by gas chromatography with flame ionization detection GC-FID and the acids by high-performance liquid chromatography (HPLC) coupled with an ultraviolet and an electrospray ionization-mass selective detector (HPLC-ESI-MSD/UVD), respectively. With the knowledge of the polyester monomers, it was possible--at least tentatively--to identify the main components in the migrate as cyclic oligoesters by HPLC-ESI-MSD/UVD. A cyclic oligomer, CYCLO [3IPA (isophthalic acid) 3EG (ethylene glycol)] was synthesized and characterized by infrared, nuclear magnetic resonance and mass spectrometry as well as by elementary analysis for further confirmation. To determine the amount of migrating cyclic oligoesters, the response of the migrating substances was compared using different detectors, UVD, MSD and evaporative light scattering detector (ELSD). The response of the ELSD was dependent on the molecular weight of the analytes that reduced the accuracy of this detection type. The wavelength with the same absorption coefficient for IPA and terephthalic acid (TPA) was obtained at 232 nm. The UV(232nm) response of an oligoester is proportional to the number of its IPA/TPA moieties, which was verified for several TPA/IPA esters. The amount of the migrating oligoesters was determined using an UV(232nm) calibration of a commercially available TPA ester and the number of IPA/TPA moieties molecules gained from the ESI-MSD spectra. According to this method, the amount of migrating oligoesters below 1000 Da in the 95% ethanol migrate varied from 0.1 to 0.6 mg dm(-2) (0.6-3.6 mg kg(-1) food) in the examined coatings. The determined amounts account for about 50% of the total migrate below 1000 Da.

Chromatography, Gas↗
PubMed2004

Migration from can coatings: part 3. Synthesis, identification and quantification of migrating epoxy-based substances below 1000 Da.

Bisphenol A-derived glycidyl ethers as well as its reaction products with other lacquer components can migrate into the packed food from epoxy-based can coatings. A sensitive and selective method is presented using high-performance liquid chromatography coupled with ultraviolet light, fluorescence and electrospray ionization-mass selective detection for the identification and quantification of all migrants with a bisphenol A backbone and a molecular weight below 1000 Da, an estimated boundary for the absorption in the gastrointestinal tract. The identification of migrants was confirmed by microreactions of technical bisphenol A diglycidyl ether with solvents and phenols, which provided the fragmentation pattern of the mass selective detection and relative retentions of 42 different bisphenol A-related substances. It was shown by calibration of different isolated and synthesized bisphenol A derivatives that the fluorescence response relies on the amount of bisphenol A moiety in the respective molecule. Therefore, all migrating bisphenol A-related substances below 1000 Da were determined as bisphenol A diglycidyl ether equivalents using a calibration (fluorescence detection) of the commercially available bisphenol A diglycidyl ether monomer. The limit of quantification was set at 5 microg bisphenol A diglycidyl ether equivalents kg(-1) (or 0.8 microg dm(-2)). This method was validated for epoxy coatings (0.1 microg dm(-2) limit of detection and 24 microg bisphenol A-related substances below 1000 Da dm(-2) standard deviation, corresponding to 4.4% relative standard deviation). The quantification could be extended by combining the fluorescence response and structural information gained from the mass spectra, which provides more accurate results for each migrant. The calculation is based on the calibration of the bisphenol A chromophore content of the molecule. According to this method, the amount of migrating bisphenol A-related substances below 1000 Da in the acetonitrile extract (assuming a worst case) varied from about 0.4 to 0.7 mg dm(-2) in the examined coatings. The determined amounts comply with about 50% of the total migrate below 1000 Da.

Benzhydryl Compounds↗
PubMedDate not supplied

Lead, chromium, tin, iron and cadmium in foods in welded cans.

The levels of lead, chromium, tin, iron and cadmium in fruit and vegetables in welded tinplate cans were determined by atomic absorption spectrophotometry. The levels found were compared with those in foods in soldered tinplate cans and fresh foods. The results show that the lead levels in foods in welded cans were much lower than those in similar foods in soldered cans. Foods in unlacquered welded cans contain much more lead, chromium and tin than foods in lacquered welded cans. The cadmium and iron levels in canned fruit and vegetables in welded cans were similar to those found in the corresponding fresh foods.

Cadmium↗
PubMedDate not supplied

Migration of epoxidised soya bean oil into foods from retail packaging materials and from plasticised PVC film used in the home.

Epoxidised soya bean oil (ESBO) is used as a plasticiser and heat stabiliser in a number of feed contact materials, in particular in poly(vinyl chloride) (PVC) films and gaskets. The level of ESBO migration into foods has been determined using a combined gas chromatographic/mass spectrometric (GC/MS) analytical procedure. The study has included both the use of ESBO-containing materials for retail packaged foods and the domestic use of plasticised PVC films for applications such as wrapping food and covering food for re-heating in a microwave oven. Levels of ESBO in fresh retail meat samples wrapped in film ranged from less than 1 to 4 mg/kg, but were higher (max. 22 mg/kg) in retail cooked meat. Migration into sandwiches and rolls from 'take-away' outlets ranged from less than 1 to 27 mg/kg depending on factors such as the type of filling and the length of the contact time prior to analysis. The levels of migration of ESBO into cheese and cakes were consistent with previous experience with plasticiser migration--direct contact with fatty surfaces leading to the highest levels. When the film was used for microwave cooking in direct contact with food, levels of ESBO from 5 to 85 mg/kg were observed, whereas when the film was employed only as a splash cover for re-heating foods, ESBO levels ranged from 0.1 to 16 mg/kg. For a variety of baby foods there was no significant difference in ESBO levels between foods packaged in glass jars with PVC gaskets and foods in cans containing ESBO in the can lacquer. In both cases ESBO levels were low, ranging from less than 0.1 to 7.6 mg/kg. It is not clear for these retail samples, if the low levels observed (average 1.9 mg/kg) result solely from migration or contain some contribution from naturally occurring epoxides.

Epoxy Compounds↗
PubMed2004

A glycosylated byssal precursor protein from the green mussel Perna viridis with modified dopa side-chains.

Foot tissue of the green mussel Perna viridis contains a variety of byssal precursor proteins with the unusual redox-active amino acid, Dopa (-beta-3,4-dihydroxyphenyl-alpha-alanine). Eight proteins were detectable in acidic extracts of the Perna foot by a redox cycling assay with nitroblue tetrazolium. In one of these, however, P. viridis foot protein-1 (Pvfp-1), activity was not due to Dopa, but to another redox-active derivative. Based on specific colorimetric derivatization with Arnow's reagent, ninhydrin and phenylisothiocyanate (Edman), mass spectrometry, the redox-active derivative in Pvfp-1 is not consistent with any known modification. Another uncommon modification of Pvfp-1 involves O-glycosylation of threonine by mannose, glucose or fucose. As in previously characterized fp-1s, the primary sequence of the Pvfp-1 (apparent mass 89 kDa) has two consensus decapeptide motifs; one is APPKPX1TAX2K and the other is APPPAX1TAX2K, where P is Pro/Hyp, and X1 and X2 are difucosylated threonine and a redox sensitive derivative of tyrosine or Dopa, respectively. Of these two unusual residues, X2 is unique to Pvfp-1, whereas O-glycosylated Thr has been previously detected in freshwater mussel fp-1. The sequence homology of Pvfp-1 with the common structural motifs of the fp-1 protein family strongly suggests that the Pvfp-1 functions as the byssal coating (lacquer) protein.

Adhesiveness↗
PubMed2000

Toxicity review of ethylene glycol monomethyl ether and its acetate ester.

Ethylene glycol monomethyl ether (EGME) and its acetate ester (EGMEA) are highly flammable, colorless, moderately volatile liquids with very good solubility properties. They are used in paints, lacquers, stains, inks and surface coatings, silk-screen printing, photographic and photo lithographic processes, for example, in the semiconductor industry, textile and leather finishing, production of food-contact plastics, and as an antiicing additive in hydraulic fluids and jet fuel. EGME and EGMEA are efficiently absorbed by inhalation as well as via dermal penetration. Dermal absorption may contribute substantially to the total uptake following skin contact with liquids or vapours containing EGME or EGMEA. EGMEA is rapidly converted to EGME in the body and the two substances are equally toxic in animals. Therefore, the two substances should be considered as equally hazardous to man. Effects on peripheral blood, testes, and sperm have been reported at occupational exposure levels ranging between 0.4 and 10 ppm EGME in air, and with additional, possibly substantial, dermal exposure. Severe malformations and disturbed hematopoiesis have been linked with exposure to EGME and EGMEA at unknown, probably high, levels. Embryonic deaths in monkeys and impaired spermatogenesis in rabbits have been reported after daily oral doses of 12 and 25 mg per kg body weight, respectively. In several studies, increased frequency of spontaneous abortions, disturbed menstrual cycle, and subfertility have been demonstrated in women working in the semiconductor industry. The contribution of EGME in relation to other exposure factors in the semiconductor industry is unclear.

Animals↗
PubMed2006

Human health risk on environmental exposure to Bisphenol-A: a review.

Bisphenol-A (BPA), identified as an environmental hormone (i.e., endocrine disruptor), is an industrially important chemical that is being used as a primary raw material for the production of engineering plastics (e.g., polycarbonate/epoxy resins), food cans (i.e., lacquer coatings), and dental composites/sealants. From the ecotoxicology, human health and regulatory points of view, it is urgent to restrict the emissions and releases of the estrogenic chemical from the industrial processes and commercial products. This article reviews BPA in the current literature in terms of physiochemical properties, industrial/commercial uses, environmental distributions in the atmospheric/aquatic/terrestrial phases, possible human toxicity, and its exposure standards and limits. Emphasis is put on the most significant distribution in the aquatic environment, and occupational and non-occupational human exposures. Overall, it is strongly convinced that BPA is not a carcinogenic risk to humans, and is also rapidly glucuronidated and excreted through the route of urine.

Air Pollutants, Occupational↗
PubMed2005

Using gas chromatography for indoor-air quality control in conservation and renovation studios.

Investigations were carried out in the Department of Conservation of Painting and Polychrome Sculpture and in the Screen Printing Studio of the Faculty of Art at Nicolaus Copernicus University. Concentration of the vapours of organic solvents was measured in 2 workshops: the Art Conservation Studio and the Screen Printing Studio. This study attempts to evaluate the work environment in both studios by analysing the concentration of vapour solvents over 5 to 7 years of measurements. Volatile solvents--aliphatic and aromatic hydrocarbons, alcohols, esters and ketones--were detected in investigated workplaces. These compounds have a wide range of applications in cleaning and removing old varnishes, lacquers and paints; inhalation is the main route of exposure. Vapour was collected using an active sampling method.

Air Pollution, Indoor↗
PubMed1989

"Worst case" aerosol testing parameters: II. Efficiency dependence of commercial respirator filters on humidity pretreatment.

Previous studies have shown that relative humidity has a degrading effect on the performance of commercially available particulate air-purifying respirator filters. That degradation results from a reduction of charge within the filter. This study was done to evaluate the time-dependent effects of relative humidity pretreatment and the reduction of charge on filter penetration against a most penetrating, "worst case" aerosol challenge. Filters of the dust and mist; dust, fume, and mist; paint, lacquer, and enamel mist; and high efficiency types were tested after being pretreated in an environment of 38 degrees C and 85% relative humidity for periods up to 42 days. After various intervals of pretreatment (1, 7, 14, 28, and 42 days), the filters were tested against neutralized worst-case sodium chloride (NaCl) and dioctyl phthalate (DOP) aerosols for percent penetration. The results showed a drop in filter efficiency of approximately 2%-6% depending on preconditioning time, except for the high efficiency filters tested which showed no detectable change.

Aerosols↗
PubMed1990

Exposure to organic solvents--I. A survey on the use of solvents.

Organic solvent neurotoxicity is a serious occupational health problem in Denmark. To obtain a precise description of the use of solvents, a questionnaire investigation of a random sample of 1000 companies was made. Information about 2000 liquid products, in particular various kinds of degreasers, paints and lacquers, was collected. Approximately two-thirds of all products contained more than 1% of organic solvents, and of these two-thirds contained more than 20%. A total of 93 different solvents were used, ethanol, industrial gasoline, toluene, isopropyl alcohol and acetone being the commonest. Chlorinated hydrocarbons are not often used now, owing to the replacement of organic solvent-based products by water-based products.

Denmark↗