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At least 433 records · Page 24Linked to original sources
PubMed2005

Enteric nervous system.

PURPOSE OF THE REVIEW: The purpose of this review is to provide a synopsis of how the field of enteric neurobiology has advanced during the past 2 years. RECENT FINDINGS: With more than 500 studies from which to choose, the authors have focused on several themes that illustrate recent progress. There has been an explosion of interest in the development of the enteric nervous system driven by the need to understand development abnormalities, particularly in Hirschsprung disease, and fueled by technical advances for investigating how neural crest-derived cells migrate, proliferate, and differentiate into enteric neurons and glia. The use of neural stem cells as a therapeutic strategy aimed at repopulating regions of bowel, where enteric neurones are reduced or absent, is on the horizon. Enteric reflexes involve interactions between sensory neurons, interneurons, and motor neurons. Recent findings suggest this distinction may be blurred, with neurons having multifunctional properties, perhaps because enteric neurons, unlike their central nervous system counterparts, are directly exposed to mechanical forces that they regulate. Another topic the authors have highlighted is pharmacology, with new tools for investigating ion channels, receptors, and transporters, leading to an expanding list of molecular mechanisms that regulate neuronal excitability. Long-term alterations in the expression of these molecules during disease or injury may underlie many gastrointestinal disorders that currently have unknown etiology. The authors finish with a look to the future and what may be the subject of this review next time. SUMMARY: Basic science information gathered during the past 2 years provides insight into pathophysiologic processes and will pave the wave for improved understanding of both organic and 'functional' gastrointestinal disorders.

Animals↗
PubMed2006

Enteric nervous system.

PURPOSE OF REVIEW: Our aim was to provide a synopsis of how the field of enteric neurobiology has advanced during the past year. RECENT FINDINGS: With such a large number of studies to choose from and given our emphasis in last year's issue on developmental aspects of the enteric nervous system, we have focused on several key themes reflecting the current interest in the way the enteric nervous system is altered in disease. SUMMARY: The new basic science information gathered during the past year provides insight into pathophysiological processes and will pave the way for improved understanding of both organic and 'functional' gastrointestinal disorders.

Animals↗
PubMed2003

Majorization criterion for distillability of a bipartite quantum state.

Bipartite quantum states are classified into three categories: separable states, bound entangled states, and free entangled states. It is of great importance to characterize these families of states for the development of quantum information science. In this Letter, I show that the separable states and the bound entangled states have a common spectral property. More precisely, I prove that for undis-tillable-separable and bound entangled-states, the eigenvalue vector of the global system is majorized by that of the local system. This result constitutes a new sufficient condition for distillability of bipartite quantum states. This is achieved by proving that if a bipartite quantum state satisfies the reduction criterion for distillability, then it satisfies the majorization criterion for separability.

Journal Article↗
PubMed2004

Capacity of oscillatory associative-memory networks with error-free retrieval.

Networks of coupled periodic oscillators (similar to the Kuramoto model) have been proposed as models of associative memory. However, error-free retrieval states of such oscillatory networks are typically unstable, resulting in a near zero capacity. This puts the networks at disadvantage as compared with the classical Hopfield network. Here we propose a simple remedy for this undesirable property and show rigorously that the error-free capacity of our oscillatory, associative-memory networks can be made as high as that of the Hopfield network. They can thus not only provide insights into the origin of biological memory, but can also be potentially useful for applications in information science and engineering.

Association↗
PubMed2005

Entropy, entanglement, and area: analytical results for harmonic lattice systems.

We revisit the question of the relation between entanglement, entropy, and area for harmonic lattice Hamiltonians corresponding to discrete versions of real free Klein-Gordon fields. For the ground state of the d-dimensional cubic harmonic lattice we establish a strict relationship between the surface area of a distinguished hypercube and the degree of entanglement between the hypercube and the rest of the lattice analytically, without resorting to numerical means. We outline extensions of these results to longer ranged interactions, finite temperatures, and for classical correlations in classical harmonic lattice systems. These findings further suggest that the tools of quantum information science may help in establishing results in quantum field theory that were previously less accessible.

Journal Article↗
PubMed2005

Direct measurement of nonlinear properties of bipartite quantum states.

Nonlinear properties of quantum states, such as entropy or entanglement, quantify important physical resources and are frequently used in quantum-information science. They are usually calculated from a full description of a quantum state, even though they depend only on a small number of parameters that specify the state. Here we extract a nonlocal and a nonlinear quantity, namely, the Renyi entropy, from local measurements on two pairs of polarization-entangled photons. We also introduce a "phase marking" technique which allows the selection of uncorrupted outcomes even with nondeterministic sources of entangled photons. We use our experimental data to demonstrate the violation of entropic inequalities. They are examples of nonlinear entanglement witnesses and their power exceeds all linear tests for quantum entanglement based on all possible Bell-Clauser-Horne-Shimony-Holt inequalities.

Journal Article↗
PubMed2006

Entanglement of remote atomic qubits.

We report observations of entanglement of two remote atomic qubits, achieved by generating an entangled state of an atomic qubit and a single photon at site , transmitting the photon to site in an adjacent laboratory through an optical fiber, and converting the photon into an atomic qubit. Entanglement of the two remote atomic qubits is inferred by performing, locally, quantum state transfer of each of the atomic qubits onto a photonic qubit and subsequent measurement of polarization correlations in violation of the Bell inequality [EQUATION: SEE TEXT]. We experimentally determine [EQUATION: SEE TEXT]. Entanglement of two remote atomic qubits, each qubit consisting of two independent spin wave excitations, and reversible, coherent transfer of entanglement between matter and light represent important advances in quantum information science.

Journal Article↗
PubMed1997

Health, Society and Alcohol.

The European Conference, Health, Society and Alcohol held in Paris, 12-14 December 1995, was a meeting point between science and policy. Science informed the policy process. As a tool for policy implementation, the Conference adopted the European Charter on Alcohol, a set of ethical principles and strategies for action. Of a number of important issues that frame policy, three deserve mention. First, market forces, as opposed to health and social policy decisions are increasingly influencing the policy debate. Second, existing policy options to reduce alcohol-related harm are unlikely to lead to an increased risk of coronary heart disease among older age groups. And third, policy developments and changes in drinking patterns in countries of southern Europe are an important driving force in European policy on alcohol.

Alcohol Drinking↗
PubMed1992

Diagnostic reasoning among second-year nursing students.

This paper reports on a study investigating the relationship of nursing students' approaches to learning and processing of information, science content knowledge, ability in interpreting and organizing clinical data (nursing assessment), and logical reasoning ability with the accuracy and quality of the nursing diagnosis made in a simulated diagnostic reasoning task. One hundred and sixty-nine second-year pre-service nursing students participated in the study. Results of path analyses indicated a set of pathways from surface approach to low-quality nursing diagnosis that reflected less competent diagnostic reasoning; and a second set from deep/achieving approach through content knowledge and logical reasoning to higher-quality nursing diagnosis that reflected more competent diagnostic reasoning. The implications of these findings for nurse education are discussed.

Adolescent↗
PubMed1994

Computer education: attitudes and opinions of first-year medical students.

Students' attitudes toward medical informatics were evaluated with self-administered questionnaires, answered by 140 (77%) first-year medical and dental students. Fourteen per cent classified their computer literacy as negligible and 49% as deficient. Ninety-six per cent had used a computer before and 59% used one regularly. Nineteen per cent had computer education in secondary school and a further 16% attended courses given by a computer company. Only 16% read regularly about informatics. These results are similar to those observed in more industrialized countries, except that high-school education is more deficient. To 93% of these students, computer literacy is important for doctors, and to 85% computers may be very useful in many areas of health care. In the opinion of 66% of students, the computer-based patient record will be available within the next 3 to 10 years. Women showed lesser computer literacy (77% computer illiteracy to 39% in men), but there were no relevant differences in attitudes, behaviour and beliefs towards medical informatics between gender, for the same level of computer literacy. Computer education in the undergraduate curriculum was demanded by 92%, and 75% of these preferred an elective course. Weekly hours suggested for lectures should be 1 (54%) or 2 (42%), and for hands-on practice 2 (54%) or 4 (31%) hours. The curriculum should include medical applications (83% of students), information science theory and technology (44%), micro-informatics (44%), bibliographic database search (27%), programming languages (23%) and statistical packages (23%). Gender, computer literacy or course did not correlate significantly with students' opinions about the contents of undergraduate education.

Attitude of Health Personnel↗
PubMed2004

Clinical librarianship in the UK: temporary trend or permanent profession? Part I: a review of the role of the clinical librarian.

BACKGROUND: This paper is the first of a two-part series of articles presenting the role of the clinical librarian (CL) in the UK today. It situates the CL concept historically, and specifically reports the findings from a study in 2002 (Skinner, The Role of the Clinical Librarian in the UK. MSc Dissertation. Loughborough University: Department of Information Science). RELEVANCE: The impetus for the 2002 study was the awareness of an increase in job advertisements within the NHS for roles seeking to enhance the practice of evidence-based medicine, which included elements of clinical librarianship. Therefore the research was undertaken to establish whether this increase was coincidental, or the beginning of a new professional role for librarians. METHODS: A content analysis of CL job advertisements, examining job titles and duties was undertaken. Twenty-three advertisements were scrutinized, and these results are presented here. As a complementary investigation, a postal questionnaire was sent to a sample of practising CLs in the UK. RESULTS: Several duties can be classified as core to the role of the CL. However there is a great diversity of duties attached to this core, reflecting an absence of nationally accepted practice. CONCLUSION: Further work was necessary to assess current practice and how clinical librarianship can continue to grow at local and national levels. This is addressed in Part Two of this series.

Evidence-Based Medicine↗
PubMed2006

Opportunity for change in the future roles for the health library and information professional: meeting the challenges in NHS Scotland.

BACKGROUND: NHS Education for Scotland (NES) is the Special Health Board responsible for supporting best practice in education, training and development for all staff groups within NHS Scotland. As part of its remit, the Knowledge Services Group within NES is responsible for the e-Library, a national electronic resource providing and supporting access to the evidence base. The Knowledge Services Group also supports the national development of library services to NHS Scotland. AIMS: This article aims to provide a reflective overview of some recent challenges within the health library and information field in Scotland, and the positive role opportunities these have afforded. METHODS: The information was gathered through extensive professional interaction with staff across the sector over the first year of establishing the new role of Librarian Staff Development Manager. FOCUS: New roles have emerged for health library and information professionals generally; for example, in response to new technology or new user groups. The development of the NHS Scotland e-Library provides examples of role development that emerges symbiotically from core skills applied to a new situation or applied in an innovative way. Role development among health library and information professionals operating at the local service level can be both reactive and proactive. Working together, the partnership between the national Knowledge Services Group and local library and knowledge services for NHS Scotland has resulted in the emergence of additional new roles, extending the role portfolio of the local professional (for example, the Librarian-Tutor role) and supported by other national infrastructures (for example, the competency framework initiative).

Access to Information↗
PubMed2006

Prevalence of basic information technology use by U.S. physicians.

BACKGROUND: Information technology (IT) has been advocated as an important means to improve the practice of clinical medicine. OBJECTIVES: To determine current prevalence of non-electronic health record (EHR) IT use by a national sample of U.S. physicians, and to identify associated physician, practice, and patient panel characteristics. DESIGN, SETTING, AND PARTICIPANTS: Survey conducted in early 2004 of 1,662 U.S. physicians engaged in direct patient care selected from 3 primary care specialties (family practice, internal medicine, pediatrics) and 3 nonprimary care specialties (anesthesiology, general surgery, cardiology). MEASUREMENTS: Self-reported frequency of e-mail communication with patients or other clinicians, online access to continuing medical education or professional journals, and use of any computerized decision support (CDS) during clinical care. Survey results were weighted by specialty and linked via practice zip codes to measures of area income and urbanization. RESULTS: Response rate was 52.5%. Respondents spent 49 (+/-19) (mean [+/-standard deviation]) hours per week in direct patient care and graduated from medical school 23 (+/-11) years earlier. "Frequent" use was highest for CDS (40.8%) and online professional journal access (39.0%), and lowest for e-mail communication with patients (3.4%). Ten percent of physicians never used any of the 5 IT tools. In separate logistic regression analyses predicting usage of each of the 5 IT tools, the strongest associations with IT use were primary care practice (adjusted odds ratios [aORs] ranging from 1.34 to 2.26) and academic practice setting (aORs 2.17 to 5.41). Years since medical school graduation (aOR 0.85 to 0.87 for every 5 years after graduation) and solo/2-person practice setting (aORs 0.21 to 0.55) were negatively associated with IT use. Practice location and patient panel characteristics were not independently associated with IT use. CONCLUSIONS: In early 2004, the majority of physicians did not regularly use basic, inexpensive, and widely available IT tools in clinical practice. Efforts to increase the use of IT in medicine should focus on practice-level barriers to adoption.

Attitude of Health Personnel↗
PubMed2005

No old man ever forgot where he buried his treasure: concepts of cognitive impairment in old age circa 1700.

Cognitive impairment in old age is one of the most important topics in modern geriatrics. This article discusses the historical dimensions of this phenomenon. To this end, a number of primary sources ranging from antiquity to the modern era are evaluated. Although a physiology and pathology of old age were conceptualized in Greco-Roman times, cognitive impairment in old age remained a marginal issue until the 17th century. Alternatively, after 1500, medicine boasted detailed theories on the physiology and pathology of old age. There are several possible explanations for this unusual situation. Underlying conflict between idealistic and materialistic views of man played a decisive role, for these concepts differed considerably regarding the intellectual and mental functioning of the soul as well as the effects of the passage of time. After Cartesianism and Iatromechanism had pushed these traditional boundaries back, the problem of cognitive impairment in old age was increasingly regarded as a physical illness and began to receive more attention. Just as its philosophical and theological context shaped early modern medicine, contemporary nonmedical disciplines such as genetics, (neuro-)biology, and the information sciences influence modern research.

Aged↗
PubMed2005

Do users ignore spatial data quality? A decision-theoretic perspective.

Risk analysis (RA) has been proposed as a means of assessing fitness for use of spatial data but is only rarely adopted. The proposal is that better decisions can be made by accounting for risks due to errors in spatial data. Why is RA so rarely adopted? Most geographical information science (GISc) literature stresses educational and technical constraints. In this article we propose, based on decision theory, a number of hypotheses for why the user would be more or less willing to spend resources on RA. The hypotheses were tested with a questionnaire, which showed that the willingness to spend resources on RA depends on the presence of feedback mechanisms in the decision-making process, on how much is at stake, and to a minor extent on how well the decision-making process can be modeled.

Journal Article↗
PubMed2006

Risk analysis for biological hazards: what we need to know about invasive species.

Risk analysis for biological invasions is similar to other types of natural and human hazards. For example, risk analysis for chemical spills requires the evaluation of basic information on where a spill occurs; exposure level and toxicity of the chemical agent; knowledge of the physical processes involved in its rate and direction of spread; and potential impacts to the environment, economy, and human health relative to containment costs. Unlike typical chemical spills, biological invasions can have long lag times from introduction and establishment to successful invasion, they reproduce, and they can spread rapidly by physical and biological processes. We use a risk analysis framework to suggest a general strategy for risk analysis for invasive species and invaded habitats. It requires: (1) problem formation (scoping the problem, defining assessment endpoints); (2) analysis (information on species traits, matching species traits to suitable habitats, estimating exposure, surveys of current distribution and abundance); (3) risk characterization (understanding of data completeness, estimates of the "potential" distribution and abundance; estimates of the potential rate of spread; and probable risks, impacts, and costs); and (4) risk management (containment potential, costs, and opportunity costs; legal mandates and social considerations and information science and technology needs).

Animals↗