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[Ramsay Hunt syndrome--a case study].

In this work we present a patient, aged 40 with Ramsay Hunt syndrome, who was treated at the Department of Infectious Disease, Medical Academy in Lublin (Poland). The diagnosis of the disease was based on the anamnesis concerning epidemiology of the disease, the course and three major symptoms: facial paralysis, neuralgia, herpetic eruption in the mouth and on the ear. The combined treatment with antiviral drugs and corticosteroids was partially successful and did not resolve the seventh nerve palsy.

Adrenal Cortex Hormones↗

Bullet identification: a case of a fatal hunting accident resolved by comparison of lead shot using instrumental neutron activation analysis.

Bullet identification by chemical analysis often provides a powerful clue in forensic science. A case is reported in which a hunting accident was resolved by using instrumental neutron activation analysis (INAA) for direct comparison of the trace element content in lead shot. Different preparation batches of lead shot appear to have a high within-group composition homogeneity, and good differentiation is achieved between different batches. Determination of the nickel and antimony content on a bush branch demonstrated that the branch had been perforated by one of the shot pellets, and this helped the detectives in reconstruction of the crime scene.

Accidents↗

Brucellosis in two hunt club members in South Carolina.

We report two cases of brucellosis in members of a hunt club, both of whom had killed and dressed wild boars. Serologic studies usually suffice for screening patients with suspected or possible brucellosis; however, and as illustrated by our index case, one should ask the laboratory to dilute serum out beyond the customary 1:160 titer if results are negative yet the clinical suspicion high. Hunters should be advised to wear gloves prior to dressing wild mammals.

Adult↗

Coordination learning in stag hunt games with application to emergency management.

Response teams for natural disaster emergencies require coordinated and self-organized efforts for rescue, medical services, damage containment, and evacuation. The unfolding of events depends on initial conditions of specific time, location, and preparedness of the response teams. This study considered a new range of emergency response situations where the perpetrator is a sentient attacker that learns with repeated exchanges. The strategy is conceptualized as a stag hunt coordination game on the part of the defense agents and a strictly competitive game with respect to the attacking adversary. Participants were 28 university students who played an iterative board game (The Creature that Ate Sheboygan) wherein a team of three Humans represented military and civil resources, against one Godzilla-type monster. The Monster gained points by destroying buildings and human combat power. The Humans gained points by wearing down the Monster's defenses and containing damage caused by the Monster. Experimental manipulations and empirical analysis showed the following: Communication outages among the Humans assisted the Monster, but the ability to communicate only equalized the Humans' chances rather than providing them with an advantage. Coordination among Humans was instant, but it fluctuated greatly as a result of the Monster's progress. Nonlinear analysis showed an asymptotic decline in coordination to a non-zero level in response to outcome uncertainty. Learning effects were noted for Humans and Monsters, but there were significant interactions with communication blackout conditions

Adult↗

Postoperative Ramsay-Hunt syndrome after acoustic neuroma resection. Viral reactivation.

The aim of this paper is to present a patient suffering from acoustic neuroma and operated on with immediate postoperative hearing and facial function preservation who developed delayed Ramsay-Hunt syndrome. To our knowledge, this is the first case in whom a postoperative delayed facial palsy and hearing loss occurred. The patient gave an history of previously diagnosed herpes zoster reactivation limited to chest one-year before. This is undoubtdetly a predisposing factor for development of delayed facial palsy. It must not be underestimated and it obliges to consider a prophylaxis. Theoretically, the prophylactic antiviral therapy might prevent the evolution towards the herpes zoster oticus or reduce the severity of the symptoms allowing the preservation of the hearing function. It would be pointed out that the delayed facial plasy has favourable prognosis, while the hearing impairment may recover with a greater difficulty even after an antiviral treatment as in our case.

Acyclovir↗

[Tolosa-Hunt syndrome--case report].

This is a case of a 38-year-old male who developed painful ophthalmoplegia two years after head injury. Under the impression of Tolosa-Hunt syndrome, the patient received long term unsustained oral steroid therapy for two years. Persistent growth of the parasellar lesion was confirmed by computed tomography. Due to the aggravation of the symptoms, craniotomy and partial parasellar granulation tissue extirpation were performed. Symptoms were then gradually subsided. The pathological study confirmed the presence of granulation tissue with marked acute and chronic inflammatory cells. No evidence of malignancy was noted. No further steroid treatment was rendered to the patient and he was well in the following 18 months after the operation.

Adult↗

[Bogorad syndrome or crocodile tears after Ramsay-Hunt].

Crocodile tears or Bogorad Syndrome describes a complication or sequel after facial palsy with incomplete recovery characterized by an excessive hyperlacrimation during the food ingestion. We report the case of a 50 years old female with that pathology associated to facial syncinesias secondary to suffer a right Ramsay-Hunt syndrome. Its pathogenesis and different treatment modalities are analysed.

Female↗

[Ramsay-Hunt syndrome associated to unilateral recurrential paralysis].

Varicella herpes zoster (VZV) virus reactivaction can produce multiple neuropathies of the cranial and cervical region being the peripheral facial paralysys the most common one. We report one case of Ramsay-Hunt syndrome with eruption of vesicles on left auricular pinna and face besides facial palsy which associated to ipsilateral laryngeal or recurrential paralysis nonexisting previously. Our patient was treated by oral aciclovir (800 mg, 5 times daily) for 1 week. 3 months later she returned to Emergencies due to another cause and the ENT exploration showed a recovery in the mobility of the left cord but it persisted the affectation of VII pair, specially the inferior branch or cervicofacial. It is advised that the larynx should be examined in all cases of herpes zoster that involve the head and neck.

Acyclovir↗

Unilateral facial swelling caused by Ramsay Hunt syndrome resembles odontogenic infection.

Facial cellulitis and swellings of the head and neck are worrisome signs of odontogenic infection, which can be life threatening. Most head and neck infections are caused by bacterial pathogens. When treating such infections, dentists must also be aware of possible viral or fungal causes and their associated presentations. This report documents a case of viral infection that initially resembled a bacterial odontogenic infection. It is intended to familiarize dentists with the Ramsay Hunt syndrome and the need for prompt recognition and early definitive treatment.

Acyclovir↗

[Tolosa-Hunt syndrome. TC findings in a case].

The Tolosa Hunt Syndrome is a rare neurological disease. It can be the consequence of a number of processes localized in the cavernous sinus or near to it. The diagnosis has been until now a diagnosis of exclusion, even if the phlebography can give more informations. Recently the possibility of demonstrating the process has been obtained by the high resolution CT scan that can show peculiar findings as in the case that we are describing.

Cavernous Sinus↗

[Painful ophthalmoplegia of Tolosa-Hunt syndrome. 4 Nigerian cases].

The Tolosa-Hunt syndrome is a painful ophthalmoplegia in relation with a granulomatous lesion of the cavernous sinus of obscure etiology. The authors report 4 cases diagnosed at National Hospital of Niamey (Republic of Niger). They were 3 men and one woman. The unilateral retro-orbital cephalalgia was constant. Three patients had left oculomotor and abducens nerves' palsies and one only left trochlear nerve's palsy. In three cases the therapeutic efficacy of systemic corticosteroids was dramatic with complete remission of clinical signs. In a fourth case, chlorambucil was used with complete recovery.

Abducens Nerve↗

The hunt for the neurofibromatosis gene.

The neurofibromatosis type 1 (NF1) gene has been localized to the pericentromeric region of the long arm of chromosome 17. A chronology of events leading to the cloning of the NF1 gene is offered as a summary of modern gene hunting techniques. The gene was identified by its location rather than its function using positional cloning. Linkage analysis, based on DNA polymorphisms, is already available for prenatal and presymptomatic testing. This technique works only in cases when affected family members are available and is useless in spontaneous cases. The complete NF1 gene is huge, has a large number of exons, and is approximately 240,000 base pairs long. Its large size is consistent with the very high spontaneous mutation rate. The NF1 gene is evolutionarily conserved and expressed ubiquitously, not just in neural crest derivatives. Functional and structural homology with GAP (GTP [guanosine triphosphate]ase-activating protein) has been described. The GAP controls (or is controlled by) the ras oncogene. Aberration of ras function, which plays a fundamental role in growth, development, and differentiation, may play a role in the NF1 phenotype. Direct DNA diagnosis of mutations in the NF1 gene in clinical practice is premature. Current data suggest that the NF1 gene product may act as a tumor suppressor.

DNA↗

[The Tolosa-Hunt syndrome. Case report].

A case of headaches with recurrent paralysis of cranial nerves III, IV, V and VI is reported. A good therapeutic effect was obtained with corticoids. After ruling out other diseases and causes of ophthalmoplegia the Tolosa-Hunt syndrome was diagnosed.

Adult↗

[Aneurysms with severe clinical manifestations (Hunt and Hess grade IV and V). A series of 66 cases].

Among 250 patients consecutively admitted in our center with a ruptured intracranial aneurysm, 66 patients (24.4%) were initially classified in Hunt and Hess clinical grade IV (37 cases) or grade V (29 cases). All patients were studied as following: --The severity of subarachnoid haemorrhage was evaluated on the pre-operative C.T. scan using Fisher's criteria. Quantification of the intracerebral haematoma or the intraventricular associated haemorrhage or a subdural haematoma was estimated as well. --The arterial diameter, aneurysm size and location, and the eventual presence of intra-arterial embolus were noted on the pre-operative angiography. Aneurysm location was: anterior artery 27 cases, internal carotid artery 9 cases, middle cerebral artery 27 cases, posterior cerebral artery 2 cases, and 1 case on the basilar artery. In this series, a poor clinical condition on admission was related to the direct effect of the initial haemorrhage in 84.9% of the patients. Early seizures (7.6%) acute hydrocephalus (1.5%), multiple emboli (3%) and apparently early diffuse vasospasm (1.5%) were the other documented causes explaining the initial poor clinical condition. One case remained completely unexplained. Sixteen patients admitted with bilateral fixed dilated pupils or a major intracerebral haematoma from a ruptured anterior artery aneurysm were not operated on and subsequently died. Operative treatment (aneurysm clipping in all cases, and haematoma evacuation on demand) was performed in the remaining 50 cases within 12 hours after their admission. Thus, these patients underwent surgery on Day 0 in 31 cases, on Day 1 in 11 cases, and on Day 2 in 8 cases. A post-operative C.T. scan was performed in 46 cases. Post-operative angiographic control was only performed in 29 cases. Changes on the post-operative C.T. scan or the angiographic control were strictly compared to the neuroradiological information previously available. Final outcome was assessed at least two months after the onset. According to the Glasgow Outcome Score, the results were: good recovery 12 patients (18.2%); moderate disability 1 patient; severe disability 4 patients (6%); vegetative state 4 patients; death 45 patients (68.2%). Excluding the patients admitted in poor clinical grade but presenting with early seizures or minor initial haemorrhage, the mortality rate was 74.2%. According to the initial clinical grade, the initial C.T. scan findings, the eventual post-operative angiographic presence of an arterial thrombosis or vasospasm, it was obvious that the final bad outcome was mainly related to the severity of the initial haemorrhage. However, in 7 patients, post-operative disability or death can be explained by other complications, principally an arterial thrombosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

[The Tolosa-Hunt syndrome (author's transl)].

This paper reports 2 cases of the Tolosa-Hunt Syndrome and reviews 70 other cases reported in the literature. Common findings of this syndrome are the recurring painful ophthalmoplegia affecting the 3rd, 4th and 6th cranial nerve, as well as the first branch of the 5th and the optic nerve. No ethiologic factor has so far been found, but is regarded as a non specific inflammation in the area of the sinus cavernosus and adjacent orbital bone. Residual defects in about one third of affected persons is the normal course of the disease. Early diagnosis and initiation of steroid therapy results in quick relief of pain and may influence prognosis.

Adolescent↗

The Ramsay Hunt syndrome: a dynamic demonstration of applied anatomy.

The clinical features of herpes zoster of the geniculate ganglion were reviewed and related to the functional anatomy of the seventh cranial nerve. An illustrative case highlights many of the features of the syndrome that was first described by Ramsay Hunt. The significance of facial palsy is discussed in the light of its distribution.

Aged↗

[Tolosa-Hunt syndrome: current clinical and electrophysiologic evaluation].

Three patients with Tolosa-Hunt syndrome were reported. All clinical investigations were negative in two of them, apart from the orbital venography, which showed on the affected side, an obstruction of the superior ophthalmic vein in its third segment. In the third case, early subclinical optic nerve involvement were demonstrated and followed up by visual evoked responses to checker-board pattern stimuli.

Adolescent↗

Community scavenger hunts.

Interns in an urban family practice program are introduced to the communities of their patients through four half-day community visits which include a "community scavenger hunt." Interns are asked to record their observations of the physical, social, and economic environments of the neighborhoods as they walk through several blocks in groups of two or three. These community visits have heightened the residents' awareness of their patients and the neighborhoods they live in.

Community Health Centers↗