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At least 433 records · Page 24Linked to original sources

Citalopram, depression and pseudo dementia: a neuropsychological case study.

The author presents a case of (depressive) pseudo dementia, commenting on the clinical and neuropsychological findings before and after the use of citalopram, a serotoninergic anti depressive drug. The case portrays the current criticism about the old dichotomy between non-reversible ("functional") and reversible ("organic") dementia. The 73 year old woman initially diagnosed as pseudo demented showed some mild cognitive deterioration in neuropsychological evaluation after the improvement of her depressive symptoms. Some reasons for the divergent findings on pseudo dementia prognosis in the literature are proposed.

Aged↗

Choice reaction time modifiability in dementia and depression.

The effects of cognitive impairment resulting from either dementia of the Alzheimer type (DAT) or major depression (pseudodementia) on choice reaction time were examined in two conditions hypothesized to influence group performance selectively. Elderly controls had shorter reaction times than depressed patients who, in turn, were faster than dementia patients in the standard choice reaction time test. Elderly control and depressed subjects responded more quickly under conditions designed to reduce task demands. However, no effect was detected for DAT patients, presumably due to the neural constraints imposed on cognitive functioning in dementia. These results highlight the different etiologies for the intellectual decline in dementia and pseudodementia.

Aged↗

Pathological lying revisited.

Although pathological lying was first described in the medical literature over 100 years ago, it remains a poorly understood concept. Psychiatrists continue to grapple with the full ramifications of the condition, even though interest specifically in pathological lying seems to have waned in recent times. The impact of pathological lying deserves critical attention from forensic psychiatrists because of the implications that untruths have in a legal context. In this article, the authors review the considerable vagueness and confusion that has surrounded this concept and examine the extent to which a person can control lying behavior and the related question of whether pathological liars have responsibility for their actions. While providing a structured framework for considering pathological lying in the forensic context, the authors conclude that further systematic research is needed to resolve the questions raised in this article.

Adult↗

[Pseudodementia. A critical review of the literature].

A review is made of the concept of "pseudodementia" through the main studies of the literature on clinical series. These can be divided in homogeneous and heterogeneous diagnostic series. Some of the main methodological flows of the research on the subject are pointed out and the difficult problem of differential diagnosis between depressive pseudodementia and recent onset organic dementia is discussed.

Depressive Disorder↗

Neuropsychology of dementia.

In this article, the neuropsychology of dementia is discussed with special attention given to Alzheimer's disease. The clinical use of neuropsychological testing in neurologic practice is presented along with relevant recent research in the area.

Activities of Daily Living↗

[Hysteria and psychosis].

The relationship between endogenous-psychotic and hysterical behavior is presented in this paper on the basis of typical patients' accounts. Various patterns of behavior are revealed: chronic hysterical psychotic syndromes, acute hysterical psychotic syndromes, hysterical exalted psychotic episodes, simulated hysterical psychotic syndromes, hysterical behavior in the attempt to cope with psychosis, and pseudohysterical behavior in endogenous psychoses. The specific aspects of the doctor-patient relationship in the case of these patients are described.

Adaptation, Psychological↗

Concurrent depression and dementia: implications for diagnosis and treatment.

The need to distinguish between depression and dementia is well recognized and has been much discussed, but the coexistence of the two illnesses has received less attention. Three cases are presented which corroborate previous reports of the coexistence of dementia and depression but also raise other issues. It is suggested that this diagnosis should not be viewed as an "either/or" decision, but that each diagnosis should be considered independently. The cases illustrate that the type of depression present may vary and that an accurate assessment of dementia may be possible only after depressive symptoms have abated. Other issues encountered in this clinical situation are discussed.

Aged↗

Tricyclic use in the cognitively impaired elderly.

The complex interrelationships among tricyclic antidepressant (TCA) effects, depression, and dementia in elderly patients are reviewed. Although results are mixed, some studies have shown TCA efficacy in elderly patients with organic disorders and associated depressive symptoms, such as forced weeping in pseudobulbar states. Available data, although not clear-cut, indicate that memory deficits or overt confusional states directly attributable to TCAs are relatively rare in patients without preexisting organicity. Studies in normal nonelderly subjects suggest an interaction wherein cognitive improvement due to relief of depression competes at higher doses with drug-induced memory impairment. In older depressed patients, significant relationships have not been found between degree of response to TCA and either baseline cognitive impairment or cognitive impairment during drug trials. Results from an ongoing study comparing imipramine and trimipramine in older depressives suggest that clinical improvement outweighs the anticholinergic effect, resulting in improved memory function.

Age Factors↗

Chronic disease and depression in the geriatric population.

A brief review is given of the incidence and nature of psychiatric symptoms, particularly depression, that are associated with chronic physical diseases common in the elderly. A discussion of medical illnesses that mimic depression, and depression presenting as somatic disease, illustrates the challenge of differential diagnosis. Guidelines are presented for the treatment of depression in patients with central nervous system, cardiovascular, hepatic and renal, and gastrointestinal disorders. Pharmacokinetic factors relevant to the use of cyclic and monoamine oxidase inhibitor antidepressants in the elderly are reviewed.

Adjustment Disorders↗

Manic pseudodementia: case report.

The case of a 48-year-old woman hospitalized with a diagnosis of organic brain syndrome and later diagnosed as manic-depressive is presented to illustrate the occurrence of pseudodementia in bipolar illness. The patient's cognitive impairments and their response to lithium carbonate treatment were documented by clinical observation and neuropsychologic testing. This case raises the possibility that a preexisting subclinical neurologic disorder may contribute to the presentation of functional psychiatric illness as pseudodementia.

Bipolar Disorder↗