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Results for “FOLIC ACID DEFICIENCY”

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At least 433 records · Page 24Linked to original sources
PubMed1991

Effect of folic acid deficiency upon lymphocyte subsets from lymphoid organs in mice.

1. Three groups of weanling C57BL/6 female mice were fed one of two folate-deficient diets (0 and 0.1 mg folic acid/kg diet) or a normal folate-containing diet (2 mg folic acid/kg diet) for 8 weeks. A control pair-fed group was introduced with the most severe folate-deficient diet. Seven mice were fed the 0 mg folic acid/kg diet for 8 weeks, then rehabilitated (R) on the 2 mg folic acid/kg diet for 10 days. 2. Mice fed 0 mg folic acid/kg diet were severely folate-deficient (SFD), whereas mice fed 0.1 mg folic acid/kg diet were moderately folate-deficient (MFD), as shown by their folate status parameters. 3. Thymus weight, thymocyte content and positive immature CD4+8+ cells were decreased in SFD mice compared to controls. These values were normalized after 10 days of rehabilitation. 4. Mesenteric lymph node cells were apparently not affected by folate deficiency. 5. The proportion of Thy-1+ splenocytes was mildly lower in SFD mice than in controls. In R mice, mean spleen weight and spleen cellularity were increased compared to the other groups, but the proportions of Thy-1+, CD4+8- and CD4-8+ cells were markedly lower than control values.

Animals↗
PubMed1981

Effect of folic acid deficiency on nonspecific immunity (phagocytic activity and nitroblue - tetrazolium reduction).

Fifty three critically ill patients (two of the following criteria : thyroxin - binding - prealbumin less than or = to 24 mg/dl, creatinin - height - index less than or = to 80 percent and transferrin less than or = to 225 mg/dl) were divided into two groups according to the level of folic acid (FA). Group A consisted of 29 with FA less than or = to 3 ng/ml and group B of 24 with FA greater than 3 ng/ml. The phagocytic activity (PA) was significantly lower in group A and significantly corrected by AB sera, whereas the NBT reduction capacities were within the normal range. A correlation is shown between PA and level of FA as well in autologous sera as in AB sera.

Adult↗