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Results for “Eye Neoplasms”

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At least 433 records · Page 24Linked to original sources
PubMed2004

An evaluation of Ki-67 and PCNA expression in conjunctival and eyelid tumours.

The aim of our study was an evaluation of the expression of cell proliferation markers (PCNA and Ki-67) in conjunctival and eyelid papillomas and squamous and basal cell cancers. A series of 9 cases of squamous cell cancer (SCC), 15 cases of basal cell cancer (BCC) and 43 cases of squamous cell papilloma (SCP) were assessed using the immunohistochemical method with monoclonal antibodies. PCNA overexpression was observed in 100% of SCP, in 88.8% of SCC and in 100% of BCC cases. Ki-67 overexpression was seen in 32.5% of cases of SCP, in 22.2% of SCC and in 66.6% of BCC. The results showed that an evaluation of Ki-67 expression is the most valuable cell proliferation marker.

Basal Cell Carcinoma↗
PubMed2004

[Ocular metastases of solid extraocular tumors. Frequency of ocular metastases and localization of the primary tumors].

The aim of this paper is, to characterize ocular metastases of solid extraocular tumors and analyze the frequency and localization of their primary sites, according to literature data of 1967-2002 years. The most common source of this metastases are breast, lung and prostate cancers in adults and neuroblastoma in children. Practically used diagnostic ways of ocular metastases in many cases omit histopathology investigation and for this reason in some cases, particularly with coexistence of hereditary cancer predisposition, second primary tumors may be misdiagnosed, as the distant--time ocular metastases.

Breast Neoplasms↗
PubMed2005

[Non-typical leukemic metastases localization in bulbus oculi and vertebral column and in thyroid gland and trachea in the course of chronic lymphocytic leukemia--two case reports].

Chronic lymphocytic leukemia (CLL) is characterized by the clonal proliferation of small mature lymphocytes with their accumulation in blood, bone marrow, lymph nodes, spleen and lien. In advanced stages of CLL, the leukemic metastases can occur in skin, pleura and lungs. They are often strictly connected with disease progression and are present with advanced lymphadenopathy and hepatosplenomegaly, high leukocytosis 100G/1 with 80-90% lymphocytes in blood smear, anemia Hb <10 g% and thrombocytopenia PLT < 100 G/L. In this article we present two CLL patients with non typical leukemic metastases localization in bulbus oculi, vertebral column (case 1) and in thyroid gland and trachea (case 2), that occurred in hematological stabilization phase of disease during normal lymphocytes number or a little lymphocytosis in peripheral blood and a lack of progression in lymphoid organs.

Aged↗
PubMedDate not supplied

[Radiowave surgery for epibulbar tumor and nontumor masses].

The paper analyzes the results of removal of epibulbar tumor and nontumor masses, by using the radiowave surgical technique. The authors used two basic modes: fulguration and completely rectified and/ or completely filtered wave. Postoperative healing was aseptic and areactive. The duration of reparation depended on the working conditions, the volume of excised tissues, and the individual pattern of reparative processes. No intraoperative and postoperative complications were found. There were no cases of relapses and on-going growth during 9-12-month follow-ups. The authors have concluded that a radiowave knife may be used in surgery for epibulbar tumor and nontumor masses.

Adolescent↗
PubMedDate not supplied

[Russian photosensitizer radachlorine in photodynamic therapy for epibulbar and choroid tumors: experimental studies].

The authors used the Russian agent Radachlorine as a photosensitizer (PS) in photodynamic therapy (PDT) for epibulbar and chorioid tumors. Analyzing the results suggests that the efficacy of Radachlorine used as PS in a correctly adjusted dose in PDT may be high. The optimization of effects in the experiment was observed when Radachlorine was used in a dose of 3 mg/kg with a light radiation dose of 500 mW/cm2 upon 5-min exposure. However, a rapid relapse in some cases indicates the instability of the effect and makes it necessary to make repeated PS injections and PDT sessions.

Animals↗
PubMed1992

[Vitreous body proteins. IV. Proteolytic activity of the vitreous body in pathological conditions of the eye].

Two groups of proteins are present in the vitreous: collagen and non-collagen, deriving probably from the blood serum. The authors examined the proteolytic activity against haemoglobin in the course of some ocular pathological conditions. It was demonstrated that the vitreous digests haemoglobin in the acid division of pH (optimum--3.0-4.5) with various activity dependent on the pathological condition of the eye.

Cataract↗
PubMed1990

Immunohistochemical studies of retinoblastoma.

Various immunohistochemical markers were detected in 27 cases of human retinoblastoma by immunohistochemical avidin-biotin-peroxidase complex and peroxidase-antiperoxidase techniques using mono- and polyclonal antibodies. The glial markers, glial fibrillary acidic protein and Leu-7, were detected in the natural retinal component and perivascular glial cells within the tumor mass. In 4 among 27 cases Leu-7 was positive in the glial cells which were interspersed randomly among tumor cells and not associated with blood vessels. The neural marker, neuron-specific enolase, stained strongly positive in undifferentiated tumor cells and weakly positive in rosettes and fleurettes in most of the cases (21/27). Opsin, the photoreceptor marker, which is present only in the outer segment of photoreceptor cells, was detected in tumor cells of fleurettes in one case and also in rosettes in 6 cases. These results support the view that retinoblastoma has a predominantly neuronal nature with significant photoreceptor-like differentiation and rarely glial differentiation.

Adult↗
PubMed2006

[Evaluation of the cosmetic effect of orbital endoimplantation after removal the eyeball].

The purpose of our study was to evaluate the cosmetic effect of endoimplantation after removal the eyeball. The removal of the globe creates anatomic and physiological alteration of the orbital tissue and orbital bones. A volume deficit occurs when an eye is enucleated. Deep upper lid sulcus, ptosis, lower lid laxity, and enophthalmus of the artificial eye together constitute the postenucleation socket syndrome, which creates an asymmetry of the face. The orbital prosthesis by placing it in the orbital cavity allows correcting volume deficit, so the implant with attached extraocular muscles, together with an artificial eye, creates an illusion of real eye. Forty patients were operated on in Clinic of Eye Diseases of Kaunas University of Medicine Hospital. Twenty patients underwent removal of the eye and procedure of orbital implant insertion (main group). Twenty patients had just an eyeball removal without insertion of an orbital implant (control group). There was a statistically significant difference in exophthalmometry data between main and control groups (14.20+/-2.73 vs. 10.35+/-1.23 mm, respectively; p<0.05). The motility of artificial eye laterally (4.30+/-1.66 mm), medially (3.65+/-1.23 mm), up (3.70+/-1.13 mm), and down (3.40+/-1.19 mm) in the main group was significantly better as compared to the control group (p<0.05), where motility of the artificial eye was 0.60+/-0.68 mm laterally, 0.70+/-0.92 mm medially, 0.30+/-0.66 mm up, and 0.30+/-0.47 mm down. Therefore, a much better symmetry, better movement of the artificial eye, and less severe form of postenucleation syndrome were observed in patients who underwent orbital endoimplantation after eyeball removal.

Adolescent↗
PubMed2006

Clinicopathological study of dermolipoma--a report of four cases.

Dermolipomas are congenital solid choristomas usually located in the superotemporal fornix, near the lacrimal gland and lateral rectus muscle. Retrospective analysis of four consecutive cases of dermolipoma reported between Jan 1994 and July 2005 was done. Three cases were males and one was female and in all the cases swelling was first noted in the early childhood. Histologically they show squamous epithelium lined tissue containing mature adipose tissue in addition to bundles of dense collagen and adnexal structures which were present in all our cases. Surgical excision of dermolipoma is conservative and confined to the irritating dermal surface or the visible portion of the lesion.

Adolescent↗
PubMed1991

[Mucoepidermoid carcinoma of the conjunctiva with intraocular invasion. Apropos of a case].

One case of mucoepidermoid carcinoma of the conjunctiva with intraocular invasion is described. Review of literature retrieve 15 cases of conjunctival localisation of mucoepidermoid carcinoma. These tumors appear to be locally aggressive, they all invade the intraocular or intraorbital structures. They require always a radical surgery with wide excision. Histopathologically, histochemical stains for glycoproteins confirm the diagnosis with admixture of squamous and mucus secreting cells.

Aged↗
PubMedDate not supplied

[Neuron-specific enolase in ophthalmology].

Tissue location and biochemical aspects of the enolase, enzyme belonging to the glycolytic pathway, are presented. Embryological applications of the dimer gamma-gamma (Neuronal Specific Enolase) as a biological marker of the neuroectodermal derivatives is discussed. The authors stress the clinical importance of the NSE in the early detection of tumors.

Biomarkers↗
PubMed1991

Orbital exenteration with eyelid sparing: indications, technique, and results.

Of 22 orbital exenterations performed from January 1980 to December 1989, 16 were performed by an eyelid-sparing technique, and six were allowed to heal by spontaneous granulation. Reviewing these procedures, we conclude that the eyelid-sparing method is indicated mainly for advanced primary orbital malignancies and for certain secondary orbital malignancies such as orbital extension of uveal melanoma, conjunctival melanoma, and conjunctival squamous cell carcinoma. It is not usually applicable to orbital invasion of malignant eyelid tumors such as basal cell carcinoma and sebaceous gland carcinoma. Advantages of the eyelid-sparing method are more rapid healing and earlier fitting of a prosthesis.

Aged↗