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Results for “Conjunctival Neoplasms”

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At least 433 records · Page 24Linked to original sources
PubMed1994

Cryotherapy for conjunctival lymphoid tumors.

Lymphoid tumors of the conjunctiva traditionally are treated with radiation therapy. Twelve patients with 42 lymphoid tumors were treated with liquid nitrogen spray and were followed up for 26 to 139 months (mean, 75 months). Twenty-eight (67%) tumors resolved with a single treatment, 39 (93%) with a second treatment, and 41 (98%) with a third treatment. Systemic lymphoma developed in two (17%) of 12 patients. These results are comparable to those with radiation therapy. The results of this case series indicate that cryotherapy for certain conjunctival lymphomatous tumors may be a viable option, because of fewer ocular and systemic complications and lower cost.

Adult↗
PubMed1991

Isolated neurofibromas of the conjunctiva.

We studied four histologically verified cases of isolated neurofibromas of the conjunctiva. The histologic pattern was diffuse in two patients, plexiform in one patient, and solitary in one patient. Simple excision was curative in all cases. We emphasize the importance of distinguishing neuromas (which may be associated with multiple endocrine neoplasia) from neurofibromas.

Adolescent↗
PubMed1990

Recurrent conjunctival papilloma causing nasolacrimal duct obstruction.

We treated two patients who had recurrent conjunctival papillomas that invaded the nasolacrimal sac and caused complete canalicular and nasolacrimal duct obstruction. The ophthalmologist should be aware of the possibility of a conjunctival papilloma invading the lacrimal sac when treating patients with conjunctival papillomas. Excision should be complete, and adjunctive therapy such as cryotherapy should be considered to reduce the chance of tumor recurrence.

Adult↗
PubMed1990

Human papillomavirus type 18 in conjunctival intraepithelial neoplasia.

Human papillomaviruses are oncogenic viruses that have been found in a variety of epithelial neoplasias. We sought to confirm their presence in conjunctival intraepithelial neoplasia. Five tumors were studied with a polymerase chain-reaction assay designed to detect the E6 region of human papillomavirus types 16 and 18. Human papillomavirus type-16 DNA was found in four of the five tumors, including two tumors that contained both type-16 and type-18 DNA. Viral DNA was not present in the fifth tumor.

Autoradiography↗
PubMed1990

Limbal autograft reconstruction after conjunctival squamous cell carcinoma.

Two patients who had squamous cell carcinoma with extensive limbal and corneal involvement were treated with surgery and cryotherapy. Rarely large areas of the cornea are involved by this tumor. Visual prognosis in such patients is poor. In these two patients, autologous limbal transplants were effective in restoring an excellent corneal surface and good visual function. This technique may be useful in the reconstruction of eyes with extensive neoplastic involvement of the corneoscleral limbus and cornea.

Aged↗
PubMed1990

Ocular adnexal Kaposi's sarcoma in acquired immunodeficiency syndrome.

We examined histopathologically 18 ocular adnexal Kaposi's sarcoma lesions related to acquired immunodeficiency syndrome. These lesions were classified into three types. Type I consisted of thin, dilated vascular channels lined by flat endothelial cells with lumen-containing erythrocytes. Type II featured plump, fusiform, endothelial cells, often with a hyperchromatic nucleus and foci of immature spindle cells and occasional slit vessels. Type III was characterized by large aggregates of densely packed spindle cells with hyperchromatic nuclei, occasional mitotic figures, and abundant slit spaces often containing erythrocytes in between. Clinically, type I and type II tumors were patchy and flat (less than 3 mm in height) and of less than four months' duration. Type III tumors were nodular and elevated (greater than 3 mm in height). We describe the clinical and histopathologic types of Kaposi's sarcoma that may help in diagnosis.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Management of intraepithelial conjunctival tumors and squamous cell carcinomas.

We compared the effects of excision, extensive freezing with a liquid nitrogen spray, and combined therapy with excision and superficial freezing with a liquid nitrogen probe on intraepithelial conjunctival tumors. After follow-up periods of at least 36 months, excision and extensive freezing produced recurrence rates similar to those previously reported (two of six lesions treated with excision alone recurred and three of nine treated with extensive freezing recurred), but excision combined with superficial freezing produced a recurrence rate of only 8% (two of 23 lesions recurred), almost three times better than any previously reported. Both lesions recurred in patients who had undergone previous therapy.

Adolescent↗
PubMed1983

Papillomavirus in human conjunctival papillomas.

Forty-one human conjunctival papillomas were histopathologically examined for koilocytosis and papillomavirus common antigen with a peroxidase-antiperoxidase technique immunospecific for genus-specific papillomavirus antigen. Koilocytotic cells, typically found in other papillomavirus-induced tumors, were present in 24 of the 41 specimens. Two of the 41 specimens were positive for viral antigen. The positive reactions were intranuclear within the superficial layers of the epithelium.

Antigens, Viral↗
PubMed1998

T-cell malignant lymphoma with conjunctival involvement.

PURPOSE: To report a rare case of T-cell malignant lymphoma involving the conjunctiva. METHODS: A 63-year-old woman had rapid onset of bilateral perilimbal congestion and chemosis. Perilimbal thickening with corneal infiltration developed 20 days later. Computed tomography incidentally disclosed a right maxillary sinus mass. Biopsy specimens from the maxillary sinus mass and the left limbus were subjected to histopathologic examination and immunohistochemical study. RESULTS: T-cell malignant lymphoma of diffuse large cell type, stage IV, was diagnosed. The patient was treated with combination chemotherapy plus 13-cis-retinoic acid and remained in remission 1 1/2 years after diagnosis. CONCLUSION: Conjunctival involvement with T-cell lymphoma may present as episcleritis and chemosis.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1998

Histopathology of the eye in diffuse neonatal hemangiomatosis.

PURPOSE: To report the ocular presentation and histopathology of a patient with diffuse neonatal hemangiomatosis. METHODS: Case report. A 3.7-kg female was born at term. Multiple hemangiomas were present, and the patient died 39 days after birth. RESULTS: Widespread cutaneous and visceral hemangiomas were present. Ophthalmic examination disclosed bilateral eyelid and conjunctival hemangiomas. The right eye had multiple iris hemangiomas, hyphema, vitreous hemorrhage, and discrete subretinal lesions. Histopathology of the right eye demonstrated hemangiomas involving the iris, ciliary body, and ciliary processes. CONCLUSION: Diffuse neonatal hemangiomatosis was associated with ophthalmic findings of multiple hemangiomas involving eyelid, conjunctiva, iris, ciliary body, and ciliary processes.

Conjunctival Neoplasms↗
PubMed1999

Renal cell carcinoma with involvement of iris and conjunctiva.

PURPOSE: To report a case of metastatic renal cell carcinoma with involvement of the iris and bulbar conjunctiva. METHODS: Case report. A 70-year-old man without known systemic disease developed an iris mass in his left eye. Iridocyclectomy was performed to remove the iris mass. RESULTS: Histopathologically, the iris mass was consistent with metastatic renal cell carcinoma. Further evaluation disclosed a mass of the left kidney. The patient underwent a left nephrectomy and was found to have renal cell carcinoma, with focal penetration into the renal capsule. One month after the nephrectomy, he developed a highly vascular nodule of the left bulbar conjunctiva. An excisional biopsy was performed, and histopathology disclosed an additional focus of renal cell carcinoma. CONCLUSIONS: Iris and conjunctival involvement may be a clinical manifestation of renal cell carcinoma. Renal cell carcinoma should be considered in the differential diagnosis of a fleshy, vascular iris and a conjunctival nodule.

Aged↗