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At least 433 records · Page 24Linked to original sources

Patch testing with European and American standard allergens in Japanese patients.

256 patients with a clinical diagnosis of contact dermatitis were patch tested with European standard series allergens in a period from 1976 to 1979. Significant positive reactions were observed with all allergens, among which were paraphenylenediamine (7.8%), wood tars (7.8%), formaldehyde (7.0%), balsam of Peru (6.6%), neomycin (5.1%), ethylenediamine (0.8%), naphthyl-mix (0.8%), mercapto-mix and PPD-mix (1.2%). North American Standard Series allergens were also patch tested in another 178 patients in the years 1976, 1977, 1979, 1980. Similar results were obtained with allergens common to both series and, of the others, ammoniated mercury (12.9%), thimerosal (9.5%), captan (5.6%), and hydroxycitronellal and Caine mix (4.5% each) were positive.

Allergens↗

Chronic urticaria Investigations with patch and challenge tests.

56 patients with chronic urticaria were patch tested with particular reference to the immediate weal response to a range of materials and this was followed by challenge tests to most of the same substances. Positive immediate patch tests were commonly seen with balsam of Peru and cinnamon and this appears to be a reaction in many normal subjects. Positive challenge tests in patients who also had positive immediate patch tests to the same substance occurred in two patients with cinnamon and two patients with cloves. Other substances with a similar action may come to light, in which case the use of immediate patch tests in investigating chronic urticaria is more likely to be of value. 4 patients showed positive immediate patch tests to nickel, one of whom also had a positive 48 hr patch test to nickel. 2 other patients had only positive 48 h patch tests to nickel. However, none of these patients gave a positive challenge test to nickel.

Adolescent↗

The Scandinavian multicenter photopatch study. Preliminary results.

The Scandinavian photopatch test procedure has been applied to 745 patients with suspected photodermatoses during the years 1980-1981. Our experience has been encouraging with the recording of several relevant reactions. A total of 132 positive photocontact reactions and 120 ordinary contact reactions were seen. Photocontact reactions to musk ambrette (19 cases) and PABA (19 cases) were surprisingly frequent. The next most common photocontact reactions were to promethazine (24), chlorpromazine (22 cases) and fentichlor (12). Ordinary contact reactions were observed to balsam of Peru (30), PABA (23), lichen mix (21), wood mix (14) and to perfume mix (10).

4-Aminobenzoic Acid↗

Patch and photopatch testing in chronic actinic dermatitis.

Photopatch tests in 47 patients with chronic actinic dermatitis (CAD) showed musk ambrette to be the only significant allergen in our standard photopatch test series. The incidence of positive patch tests to a standard series of contact allergens in this group was compared with 213 men over the age of 50 years with eczema investigated in the contact clinic. Among the photosensitive patients, there was an increased incidence of reaction to thiuram-mix (CAD 10%; controls 3%), carba mix (CAD 6%; controls 1%), nickel sulphate (CAD 6%; controls 2%) and vioform (CAD 10%; controls 0.5%). A decreased incidence of reaction to potassium dichromate (CAD 0%; controls 8%) and balsam of Peru (CAD 4%; controls 10%) was recorded.

Adult↗

Contact sensitivity in adults with atopic dermatitis in childhood.

2 groups of patients were patch tested with a standard series of allergens. 1 group of 159 individuals aged 24-44 years had a history of severe atopic dermatitis, and the other group of 130 individuals in the same age range, had had moderate atopic dermatitis in childhood. In group 1, positive reactions were recorded in 17% and in group 2 in 23%. A significant difference in the % of individuals with positive reactions was found between those who had healed (9%) and those who had not healed (22%) before 15 years of age (P less than 0.05). The frequency of individuals with hand eczema in adult life was higher, but not significantly, among sensitized than non-sensitized individuals. Altogether 100 positive reactions were found in groups 1 and 2. The average number of positive reactions per person was significantly higher in individuals with than without hand eczema in adult life (P less than 0.05). The most frequent contact allergens were fragrance-mix, balsam of Peru and nickel, which had sensitized 8.0%, 4.5% and 4.1% of the individuals, respectively.

Adolescent↗

Sites of contact dermatitis in relationship to particular allergens.

A study of 1016 patients over a period of 2 years has been performed by using the DALUK computer system in order to find correlations between eczema sites and particular allergens. The study includes a control material of patients with other contact allergies or with negative patch tests. The investigation confirms some well-known correlations, e.g., between lanolin allergy and dermatitis of the lower leg, and between nickel allergy and dermatitis of the palm. Several new correlations are also described, e.g., chromium allergy and dermatitis of the back of the trunk, allergy to balsam of Peru and dermatitis of the forehead and cheek.

Adolescent↗

Contact sensitivity and urticaria in "wet" work.

A selected group of 142 hospital "wet" workers with hand eczema was studied. 91% were female. Atopy (58%), metal dermatitis (41%), and hand eczema prior to the current wet work (67%) were more common than in the total cohort to which these patients belonged. Patch tests were carried out on 120 patients and prick tests on 41 with a history of contact urticaria. Water, cleaning agents, hand disinfectants, the wearing of gloves and other trivial irritant factors were claimed to have elicited the current episodes of hand eczema in 92.3% of cases. In 35%, a considerable part of the exposure to irritant factors took place at home or during leisure time. Delayed contact sensitivity was found in 45 patients, nickel, cobalt, balsam of Peru and rubber chemicals being the most common allergens. Nickel and/or cobalt allergy was found in approximately half of the patients with contact allergy. Positive prick tests relevant for contact urticaria were found in 22 patients, and were most often obtained with various foods or rubber gloves. Although contact sensitivity and contact urticaria were common, they seemed to play a minor rôle in the etiology of the current hand eczema compared to endogenous factors and trivial irritants.

Adult↗

Dermatitis from phenyl salicylate in safety spectacle frames.

We report 3 cases of allergic contact dermatitis behind the ears from wearing the same brand of industrial safety spectacles. In each case, a positive patch test was obtained with scrapings of the plastic frame. In 2 cases further patch tests with constituents of the plastic were carried out; positive patch tests were obtained with phenyl salicylate. Phenyl salicylate is used as an ultraviolet inhibitor in some cellulose acetate butyrate and cellulose acetate propionate formulae. It has previously been reported as a contact sensitizer from its use as a sun screen in a lip salve. Positive patch test reactions were also obtained variously in these patients with balsam of Peru, resorcinol monobenzoate, and epoxy resin.

Adult↗

Do positive nickel reactions increase nonspecific patch test reactivity?

The patch test reaction pattern in nickel-positive and -negative female patients was compared. Cobalt allergy was found in 24.8% of the positive patients. However, the occurrence of allergy to other common agents, i.e., neomycin, perfume mix, balsam of Peru and bacitracin, did not differ significantly between the 2 groups. Even in patients allergic to nickel and cobalt simultaneously, the frequencies were comparable. Chromate and PPDA allergy was significantly commoner in nickel sensitive patients (p less than 0.05 and p less than 0.01). Erythematous or follicular reactions were seen most often to wood tars, propylene glycol, formaldehyde, cobalt, chromate and perfume mix. Reactions to propylene glycol and perfume mix were as frequent in both groups, whereas formaldehyde, cobalt and chromate caused reactions more often in nickel-positive patients (p less than 0.05) and wood tars in negatives (p less than 0.05). Follicular reactions developed especially in patients who were positive to nickel and cobalt. The total number of non-specific reactions was not overpresented in nickel sensitive patients, despite their multiple patch test reactivity.

Allergens↗

Scratch-chamber tests in food handler dermatitis.

Foods were tested by the scratch-chamber and open application techniques in 80 hand dermatitis patients, 55 of whom were food handlers. Both immediate and delayed reactions were seen. Most immediate scratch-chamber test reactions were provoked by vegetables and spices in patients with birch pollen allergy, and most delayed reactions from spices in patients with allergy to balsam of Peru, and from onion and leek. The evaluation of allergic and irritant reactions was difficult. Positive open application tests were seen in about 75% of patients with immediate or delayed scratch-chamber reactions. Immediate reactions from vegetables, fish and meat, and delayed reactions from orange and lemon peel and onion showed the best clinical relevance. Wet work, surface active agents and other irritant factors were considered the main causes, and food allergies as contributory factors only in food handler hand dermatitis.

Adolescent↗

Contact dermatitis in Nigeria (i). Hand dermatitis in women.

Of 545 consecutive contact dermatitis clinic patients, 271 (49.7%) were women, 29 (10.7%) of whom had hand dermatitis alone. 17 (58.6%) of these hand cases were allergic, the main sensitizers being nickel and essential oils in oranges. Dress makers were mostly affected by nickel, while orange sellers and peelers were positive to orange peel, fragrance mix, balsam of Peru and formaldehyde in varying combinations. 8 (27.6%) of the hand cases were due to irritants and wet jobs, and possibly to allergens not tested. 24 (83%) of the hand cases were occupational. Only 1 Nigerian woman had true housewife's hand dermatitis. It was not possible to define the rôle of atopy because of unreliable histories. 2 cases of pompholyx and a negative patch test occurred in the first trimester of pregnancy.

Adolescent↗

The role of contact allergy in the spectrum of adverse effects caused by cosmetics and toiletries.

Of 982 female clients of beauticians interviewed, 254 (25.9%) claimed to have experienced adverse reactions to cosmetics and toiletries in the preceding 5 years. Most reactions were caused by skin-care products (36.6%), followed by personal cleanliness products (29.5%), eye cosmetics (24.0%), deodorants and antiperspirants (12.6%), and facial make-up products (8.3%). 150 women were patch tested. In the European standard series, only a few positive reactions were seen to possible cosmetic allergens: fragrance mix (n = 3), wool alcohols (n = 3), formaldehyde (n = 2), balsam of Peru (n = 1), and colophony (n = 1). In the cosmetic series, only Kathon CG elicited positive patch test reactions (n = 3). Cosmetic allergy was considered to be "proven" in 3 patients (2.0%), and "possible" in 7 (4.7%). It is concluded that contact allergy is responsible for a minority (less than 10%) of all reactions to cosmetics and toiletries. The majority of reactions are due to irritation from personal cleanliness products such as soaps, shampoos, bath foams and from deodorants, or worsening of pre-existing dermatoses such as seborrhoeic dermatitis and acne.

Adolescent↗

Contact sensitivity to oak moss.

Oak moss allergy was the principle allergen in contact sensitivity to perfumes (45%); 31 patients reacting to oak moss were studied. The sensitivity was attributed to contact with perfumes in 20, lichens in 7 and unknown in 4. Atranorin was the most frequent allergen, followed by usnic, evernic and fumarprotocetraric acids. Concomitant allergy occurred to several lichen acids and also to balsam of Peru, colophony and other fragrance components.

Adolescent↗

Trends in allergic contact sensitization.

A standard patch test series was tested for 7 years (1977-1983) in a total of 11,962 patients. The annual frequency of positive reactions to the compounds tested was assessed for the total and for males and females separately. During the observation period, there were significant increases in positive reactions in the total group from 6.2% to 12.7% for nickel sulphate, from 5.3% to 7.0% for balsam of Peru and from 3.8% to 6.5% for potassium dichromate, reflecting significant changes in both sexes. The frequency of positive reactions to wool alcohols, formaldehyde, neomycin sulphate, paraben mix and gentamycin sulphate significantly increased, while that of positive reactions to clioquinol, mercuric chloride and turpentine peroxide significantly decreased in either males or females, sometimes leading to significant changes in the total group.

Allergens↗

Patch tests with occupational contactants in nurses, doctors and dentists.

In this study, 333 nurses, 92 dentists and 167 doctors were investigated. Most positive patch tests obtained were unrelated to occupation. Nurses were most often sensitized to penicillins and, of the disinfectants, formaldehyde was the commonest cause of occupational dermatitis. Among dentists, the most common occupational allergens were eugenol and mercuric chloride. Among surgeons, as compared with physicians, there were frequent reactions to mercuric chloride and balsam of Peru, and a higher number of positive patch tests with other contactants. Among those sensitized to chromium, 4 doctors found that contact with chromic catgut was harmful. 6 other doctors were intolerant to surgical gloves. A number of nurses and doctors had an irritant contact dermatitis from chlorhexidine.

Dentists↗

Clinical patch test data evaluated by multivariate analysis. Danish Contact Dermatitis Group.

The aim of the present study was to evaluate the influence of individual explanatory factors, such as sex, age, atopy, test time and presence of diseased skin, on clinical patch test results, by application of multivariate statistical analysis. The study population was 2166 consecutive patients patch tested with the standard series of the International Contact Dermatitis Research Group (ICDRG) by members of the Danish Contact Dermatitis Group (DCDG) over a period of 6 months. For the 8 test allergens most often found positive (nickel, fragrance-mix, cobalt, chromate, balsam of Peru, carba-mix, colophony, and formaldehyde), one or more individual factors were of significance for the risk of being sensitized, except for chromate and formaldehyde. It is concluded that patch test results can be compared only after stratification of the material or by multivariate analysis.

Adolescent↗

Occupational hand eczema in an industrial city.

Hand eczema in relation to occupation was studied in an industrial city. Questionnaires were sent to 20,000 individuals aged 20-65 years, randomly selected from the population register of the city. Those subjects (1385) considering themselves to have had hand eczema within the previous 12 months were invited to a dermatological examination including patch testing. It was found that the reported 1-year period prevalence of hand eczema in the total sample was 11.8%. The only occupational group reporting a statistically significant higher 1-year period prevalence was service work, 15.4%. Among all occupations, cleaners turned out to have the highest period prevalence, 21.3%. Hand eczema was more common among people reporting some kind of occupational exposure. The most harmful exposure turned out to be to unspecified chemicals, water and detergents and dust and dry dirt. The use of protective gloves is reported and analysed. The most common contact allergy was nickel, followed by cobalt, fragrance-mix, balsam of Peru and colophony. A statistically significant increase in contact allergy to colophony for women in administrative work was found. It is concluded that the type of hand eczema that is mostly dependent on occupation is irritant contact dermatitis.

Adult↗

Wood tars allergy, cross-sensitization and coal tar.

In a population of 1883 patients tested for allergic contact dermatitis (1985-1988), a prevalence of 5.4% (103 cases) was seen for wood tars (ICDRG allergen, 12% pet.) sensitization. In this group (n = 103), retrospectively, a combined allergy was seen to wood tars and fragrance mix in 43% and to wood tars and balsam of Peru in 31%. A combined allergy to wood tars and coal tar was seen in 19 patients (18.5%): 14 to liquor carbonis detergens (LCD), 8 to lianthral and 3 to both LCD and lianthral. Within the group with wood tars allergy (n = 103), a minority (n = 37) had a history of atopic dermatitis. Comparison of the test results in atopic and non-atopic subgroups (within the group of 103) revealed a higher incidence of combined wood tars-fragrance mix allergy in the atopic group (n = 37). In this group, a lower incidence of combined wood tars-coal tar sensitization was seen in comparison with the non-atopic group (n = 66). The authors believe that combined "wood tars-coal tar" allergy could be the consequence of cross-sensitization rather than due to long-term previous topical treatment with tar derivatives. The high % of cross-allergy between wood tars and fragrance mix emphasizes the role of wood tars as an important indicator allergen in perfume allergy.

Coal Tar↗