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Tropical Medicine and Animal Diseases: Onderstepoort and the Development of Veterinary Science in South Africa 1908-1950.

This article traces the development of agricultural science at the Onderstepoort Veterinary Institute, near Pretoria, from its founding in 1908 until the 1950s, by which time many enzootic and epizootic diseases had either been eradicated, or were largely controllable through various forms of prophylaxis. The Institute demonstrated the political and economic significance attributed to the pastoral industry in South Africa and the conviction that scientific discoveries could increase output. During this period, researchers explicated the aetiology and provenance of hitherto mysterious diseases such as lamsiekte, geeldikkop and African horsesickness. They developed vaccines, some of which were adopted internationally. The nature of their investigations showed that veterinary science increasingly entailed more than just progress in biomedical procedures. Ecological factors, in particular the nutritional state of the veld, became a priority from the 1920s onwards as veterinarians saw their function as promoting animal health as well as eliminating disease. Dealing with contagious infections also incorporated less welcome, and at times controversial, approaches to disease control. The imposition of pastoral regulations illustrated the expanding powers of the South African state, founded on presumptions of scientific legitimacy. The article also explores the contribution made by African communities and settler farmers to the institutionalisation of veterinary knowledge, as well as the role South African researchers played in the evolution of a colonial, as well as an increasingly international, scientific culture.

Journal Article↗

The acquisition and application of absorption, distribution, metabolism, and excretion (ADME) data in agricultural chemical safety assessments.

A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk assessment. Incorporation of pharmacokinetic studies describing absorption, distribution, metabolism, and excretion is an essential tool for improving the design and interpretation of toxicity studies and their application for safety assessment. A tiered approach is described in which basic pharmacokinetic studies, similar to those for pharmaceuticals, are conducted for regulatory submission. Subsequent tiers provide additional information in an iterative manner, depending on pharmacokinetic properties, toxicity study results, and the intended uses of the compound.

Agrochemicals↗

A tiered approach to systemic toxicity testing for agricultural chemical safety assessment.

A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The goal is to ensure that studies are scientifically appropriate and necessary without being redundant, and that tests emphasize toxicological endpoints and exposure durations that are relevant for risk assessment. The ACSA Systemic Toxicity Task Force proposes an approach to systemic toxicity testing as one part of the overall assessment of a compound's potential to cause adverse effects on health. The approach is designed to provide more relevant data for deriving reference doses for shorter time periods of human exposure, and includes fewer studies for deriving longer term reference doses-that is, neither a 12-month dog study nor a mouse carcinogenicity study is recommended. All available data, including toxicokinetics and metabolism data and life stages information, are taken into account. The proposed tiered testing approach has the potential to provide new risk assessment information for shorter human exposure durations while reducing the number of animals used and without compromising the sensitivity of the determination of longer term reference doses.

Agrochemicals↗

Community-based HIV/AIDS research--whither community participation? Unsolved problems in a research programme in rural Uganda.

Involvement of the study community in research on HIV/AIDS has presented the MRC/UVRI programme in rural Uganda with a multi-layered challenge. A typology developed in agricultural research which defines different levels of community participation in research is described where participation may be at 'contract', 'consultative', 'collaborative' and 'collegiate' level (each level indicating an increasing degree of community participation). Community involvement in the MRC/UVRI Programme is then outlined and the typology applied. It is shown that the majority of community participation in the Programme is at the contract level since the nature of the research programme as a 'foreign imposition' with 'foreign goals' has precluded the involvement of the community in much of the policy development and research planning. However, it is noted that as the Programme becomes more established in the area community influence grows and signs of community impact on policy and increased research inputs are beginning to be seen. The question is raised as to whether it is realistic to expect that externally imposed health research, particularly on sensitive topics, can ever be truly community participatory research.

Acquired Immunodeficiency Syndrome↗

Impacts of population growth and economic development on the nitrogen cycle in Asia.

Asia is the major consumer of fertilizer nitrogen and energy in the world, and consequently shares a considerable proportion of the world creation of reactive nitrogen (Nr). However, if estimated on per capita basis, Asia is characterized by a lower arable land area, fertilizer nitrogen consumption, energy consumption, and gross domestic product, as well as lower daily protein intake. To meet the increasing needs for food and energy for the growing population combined with the improvement of living standards, Nr will inevitably increase. The present study estimates the creation of Nr and the emissions of various N compounds into environment in Asia currently and in 2030. In comparison with the world averages, the lower fertilizer nitrogen and energy use efficiencies, and the lower use of animal wastes for agriculture imply that there is potential for moderating the increase in Nr and its impacts on the environment. Strategies for moderating the increase are discussed.

Animals↗

The economic law of population distribution and migration.

"The economic law of population distribution and migration has been studied chiefly based on the Chinese situation. The distribution and development of productive forces decide the distribution and migration of population, and in turn, the latter influences the former. The population distributions in three different stages of social development, namely agricultural, industrial and information society, are described. A new concept in population economics is introduced, i.e. population economic density, which is different from the concept of population density. The formula of population economic density is P(population)/R(resources). Many kinds of migration are analysed, and it is believed that the main efficient cause of migration is economy."

Asia↗

Comparing the soil quality changes of different land uses determined by two quantitative methods.

Soil quality is one of the most important environmental factors in sustaining the global biosphere and developing sustainable agricultural practices. A study was initiated in Wolong Nature Reserve, Sichuan Province, China to elucidate the soil quality changes of natural secondary succession, forest planting and agricultural practices after deforestation in the humid mountainous region. The soil qualities of six land use types (natural forestland, grassland, shrub land, secondary forestland, cultivated land and reforested land) were compared using two quantitative methods: the integrated soil quality index (QI) and soil deterioration index (DI). The QI values of natural forestland, grassland, shrub land, secondary forestland, cultivated land, reforested land were 0.8039, 0.3277, 0.9127, 0.6881, 0.0285 and 0.3183, respectively. The DI values were 0%, -14%, 12%, 1%, -26% and -18% respectively. Both indexes suggested that shrub land can restore soil properties. To compare the two methods more directly, a deduced index QI' based on QI value was developed. The results showed that DI and QI' had a very high linear correlation coefficient (r = 0.9775) despite the values were different. Both methods were efficient in evaluating the soil quality levels and DI was a more simple way in soil quality assessment, while QI could show more ecological meanings.

China↗

[Sewage sludge].

Current knowledge of sewage sludge is reviewed, particular reference being made to the possible effect on the health of herds of cattle. The following measures should be urgently and seriously considered: more effective watching of sewage disposal; assessments on sewage disposals, related to the costs of alternatives; stricter checks on diffuse sources of pollution (refuse dumps, agriculture, etc.); development of long-term views to prevent the appearance of waste matter injurious to health and putting a stop to methods of production in which these wastes are released. The disposal of toxic substances in the environment was reduced by fifty per cent in particular sections during the past five years. When this is chosen as an objective, the Netherlands will be clean in approximately fifty years. In the opinion of experts, this would appear to be a practical approach which can be accomplished by considerable economic efforts. When the thoughtless disposal of toxic substances comes to an end, it will be possible to use sewage sludge in agriculture without this becoming a hazard to the health of animals and man.

Animals↗

The historiography of hunger: changing views on the world food problem, 1945-1980.

The author discusses changing views on the world food problem since 1945. "The extent of the problem has been a matter of debate as hunger cannot be directly measured; estimated minimum requirements for energy have been reduced since 1945 and the causes of malnutrition reappraised. World food production has kept up with population growth since 1945, as it has in all major regions except Africa. But when individual countries are considered, food output per head has been declining since 1961-5 in many countries in Africa and Asia. Food output has been increased in the developing countries by expanding the area under cultivation and by increasing yields." In addition the author concludes that "the Green Revolution has however not achieved early expectations and has had some adverse economic and social consequences. Because world food output per caput has risen considerably since 1945, some have argued that the world food problem is one of distribution, not production. Data on food output per caput suggest this is not always so."

Agriculture↗

Perspectives on genetics in china.

The long civilization of China traces its origin to the development of agriculture. Early records and archaeological findings demonstrate the success of plant and animal breeding in contributing to human livelihood and the national economy. Teaching and research in modern genetics began in China in the 1920s with individuals who received advanced training in the West. Over the following 30 years, notable contributions to genetics, both basic and applied, were made by Chinese scientists in universities and research institutions. Unfortunately, these activities were brought to a virtual standstill first by the official advocacy of Lysenkoism, followed by ten years of Cultural Revolution. Schools were closed and scientific research was interrupted. Not until 1978 did the universities begin to enroll new students and scientific research, including genetics, again receive endorsement. Since then, Chinese scientists have resumed contacts with colleagues in other countries and publication of their research findings in national and international journals. The material summarized in this article covers a long time span and a broad spectrum of scientific subjects and events. Representative examples of Chinese contributions to various areas of genetics are cited to depict the history, current status, and prospects for the development of genetics in China. After many ups and downs and despite limitations in material resources, the study of genetics in China seems to be on a sound footing, with a relatively complete system in place for training workers in this discipline.

Agriculture↗

Sustainable sludge management in developing countries.

Worldwide, unsanitary conditions are responsible for more than three million deaths annually. One of the reasons is the low level of sanitation in developing countries. Particularly, sludge from these regions has a high parasite concentration and low heavy metal content even though the available information is limited. Different issues needed to achieve a sustainable sludge management in developing nations are analysed. Based on this analysis some conclusions arise: sludge management plays an important role in sanitation programs by helping reduce health problems and associated risks; investments in sanitation should consider sludge management within the overall projects; the main restriction for reusing sludge is the high microbial concentration, which requires a science-based decision on the treatment process, while heavy metals are generally low; adequate sludge management needs the commitment of those sectors involved in the development and enforcement of the regulations as well as those that are directly related to its generation, treatment, reuse or disposal; current regulations have followed different approaches, based mainly on local conditions, but they favour sludge reuse to fight problems like soil degradation, reduced crop production, and the increased use of inorganic fertilizers. This paper summarises an overview of these issues.

Biodegradation, Environmental↗

Genetics: the not-so-new new thing.

Practical knowledge of heredity predates history. Indigenous peoples laid the foundations of modern agriculture by developing plants such as corn. However, the language and metaphors of the Human Genome Project treat modern genetics as if it had no historical antecedents and fail to acknowledge these early contributions to the science of heredity. The results of this blindness are twofold: it exacerbates reluctance of native peoples to take part in genetic research and to garner the benefits of genetic medicine, and it encourages "biopiracy," as modern scientists "discover" and patent native plants.

Agriculture↗

[Land-use and urinary schistosomiasis in Daloa (Côte d'Ivoire)].

The relation between agricultural land development of inland-valleys and health population has been studied in a town of the Ivorian forest area using urinary schistosomiasis as an indicator. Snails were collected during 4 months in rice fields and water holes used for market gardening of two urban inland-valleys (Batagnihi and Gakognihi). Prevalence of schistosomiasis was evaluated in two districts, Kennedy II and Fadiga, located close to the investigated inland-valleys. Schistosomiasis risk was higher in the Batagnihi where rice cultivation was more developed and prevalence of urinary schistosomiasis was higher in the Kennedy II district which is close to this inland-valley particularly among the Northern migrant people. The Kennedy II population has much more contacts with the inland-valley because of rice cultivation and social status. The higher socio-economic level of the Fadiga population limiting its contacts with the inland-valley can explain this result.

Adolescent↗

[Soil quality and its evaluation].

Preservation and improvement of soil quality is the basic task for agricultural sustainable development. For this reason, the concept and the evaluation method of soil quality should be clearly understood. In this paper, the concept of soil quality and its advanced researches were reviewed. Soil quality evaluation should be based on soil function, different types of soils should be evaluated by different criterions, and soil quality evaluation should be relational rather than absolute as well. Some methods of soil quality evaluation were introduced, and the selection of evaluation indicators was discussed.

Crops, Agricultural↗

Socio-economic aspects of animal diseases in southern Africa: research priorities in veterinary science.

During May 1995, members of organisations with a vested interest in the socio-economic aspects of animal diseases in southern Africa met for a one-day workshop. This was the first activity of a proposed three-year Forum and programme in this area under discussion. The workshop was sponsored by the Foundation for Research Development, the Agricultural Research Council and the University of Pretoria. The individuals who attended were representatives of academic and government institutions and included veterinarians, veterinary scientists, animal health officers, administrators from the region and abroad, economists, sociologists and animal welfare experts. The aims of the workshop were fourfold: 1. to define what is meant by socio-economic aspects of animal diseases in southern Africa; 2. to identify the socio-economic factors which influence occurrence and consequences of animal diseases; 3. to learn of methods which are used to assess socio-economic needs, and 4. to initiate an ongoing network and research programme in this area. Two key questions were considered and discussed by the participants, and a consensus reached for each. The first question considered the link between community development and socio-economic aspects of animal diseases. This included the role of production animals, companion animals and game in developing communities and factors influencing these roles, as well as constraints to this development. The second question concerned the gaps in our understanding of the socio-economic aspects of animal diseases in southern Africa which would lead to research opportunities. Six areas identified were were the collection of disease information, education and communication, policy, economics, community needs and technology.(ABSTRACT TRUNCATED AT 250 WORDS)

Africa, Southern↗

Enhancing the crops to feed the poor.

Solutions to the problem of how the developing world will meet its future food needs are broader than producing more food, although the successes of the 'Green Revolution' demonstrate the importance of technology in generating the growth in food output in the past. Despite these successes, the world still faces continuing vulnerability to food shortages. Given the necessary funding, it seems likely that conventional crop breeding, as well as emerging technologies based on molecular biology, genetic engineering and natural resource management, will continue to improve productivity in the coming decades.

Agriculture↗

Integrated functional genomics and safety assessment of plant-growth-promoting Caryophanales from post-maize-cultivation soils.

This study aimed to evaluate six environmental bacterial strains isolated from post-maize cultivation soils as candidates for agricultural biopreparation development, using an integrated functional genomic and safety assessment framework. Building on experimental validation of plant-growth-promoting activities, the analysis included: plant-growth-promoting traits (PGPT-Pred) using PLABase; carbohydrate-active enzymes (CAZymes) relevant for lignocellulosic crop residue degradation (dbCAN3); secondary metabolite profiles (antiSMASH); and screening for virulence factors and antibiotic resistance genes (ABRicate, BTyper3).All analyzed strains possess 1,449-1,617 predicted PGPT-encoding genes (24.1-35.9% of total genes), which are strongly shaped by taxonomic relatedness, as confirmed by congruence testing against ANI-based genomic divergence. Paenibacillus amylolyticus 5mez and Priestia megaterium 7psych showed distinct functional profiles compared to Bacillus spp., while Bacillus subtilis sensu lato strains were most similar to each other. Genomic predictions suggest involvement in nutrient acquisition (N, P, K, Fe) and stress mitigation. Secondary metabolite analysis revealed high biosynthetic potential, with non-Bacillus species harbouring a large proportion of unknown gene clusters, indicating underexplored metabolite diversity. CAZyme profiling identified P. amylolyticus 5mez as the most enzyme-rich strain, while B. cereus s.s. zielonkawy showed ligninolytic potential despite low overall CAZyme abundance. The safety assessment identified B. cereus s.s. zielonkawy as toxigenic and unsuitable for use. Of the remaining strains, P. amylolyticus 5mez and Pr. megaterium 7psych demonstrated the most favourable safety profiles, exhibiting no detectable virulence factors or antibiotic resistance genes, justifying their priority use in agricultural biopreparations, pending phenotypic validation. Given the high-dimensional, low-sample-size nature of multi-trait datasets in applied microbial genomics, tailored statistical approaches, including noise-reduction-validated PCA and distance-based congruence testing, were applied; their rationale and limitations are discussed.

Soil Microbiology↗

[Sensitization to pollens in a changing environment: Israel].

Israel was originally a country with desert climate and extensive agriculture. During the last 40 years, due to artificial irrigation, a rich vegetation and intensive agriculture have developed. Hayfever prevalence has risen between 1952 and 1986 from an average of 0.3% to 6.3% (with a range from 4% in the urban to 15% in the rural communities). Considering that significant (P less than 0.001) impact of pollen quantity upon hayfever incidence, an elementary pollen information system was organized (as described in the article) to help both allergists and allergic patients in their joint effort to avoid the harmful effect of a changing environment.

Agriculture↗