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Reinforcement of acrylic denture base resin by incorporation of various fibers.

This study was designed to evaluate improvements in the mechanical properties of acrylic resin following reinforcement with three types of fiber. Polyester fiber (PE), Kevlar fiber (KF), and glass fiber (GF) were cut into 2, 4, and 6 mm lengths and incorporated at concentrations of 1, 2, and 3% (w/w). The mixtures of resin and fiber were cured at 70 degrees C in a water bath for 13 h, then at 90 degrees C for 1 h, in 70 x 25 x 15 mm stone molds, which were enclosed by dental flasks. The cured resin blocks were cut to an appropriate size and tested for impact strength and bending strength following the methods of ASTM Specification No. 256 and ISO Specification No. 1567, respectively. Specimens used in the impact strength test were reused for the Knoop hardness test. The results showed that the impact strength tended to be enhanced with fiber length and concentration, particularly PE at 3% and 6 mm length, which was significantly stronger than other formulations. Bending strength did not change significantly with the various formulations when compared to a control without fiber. The assessment of Knoop hardness revealed a complex pattern for the various formulations. The Knoop hardness of 3%, 6 mm PE-reinforced resin was comparable to that of the other formulations except for the control without fiber, but for clinical usage this did not adversely affect the merit of acrylic denture base resin. It is concluded that, for improved strength the optimum formulation to reinforce acrylic resin is by incorporation of 3%, 6 mm length PE fibers.

Acrylic Resins↗

Inhibition of histidine ammonia lyase by heteroaryl-alanines and acrylates.

Histidine ammonia lyase (HAL) catalyzes the elimination of ammonia from the substrate to form (E)-urocanate. The interaction between HAL and acrylic acids or alanines substituted with heteroaryl groups in the beta-position was investigated. These proved to be strong competitive inhibitors when the heteroaryl groups were furanyl, thiophenyl, benzofuranyl, and benzothiophenyl, carrying the alanyl or acrylic side chains either in 2 or 3 positions, with K(i) values between 18 and 139 microM. The exception was (furan-3-yl)alanine which was found to be inert. Tryptophan and 1-methyltryptophan, as well as the corresponding acrylates (=prop-2-enoates), are strong mixed inhibitors of HAL. Theoretically, L-histidine can be dissected into 4-methyl-1H-imidazole and glycine. Whereas these two compounds separately are only very weak inhibitors of HAL, equimolar amounts of both show a K(i) value of 1.7+/-0.09 mM which is to be compared with the K(m) value of 15.6 mM for the normal reaction. We conclude that 5-methyl-1H-imidazole and glycine mimic the substrate and occupy the active site of HAL in a similar orientation.

Acrylates↗

Characterization of new acrylic bone cements prepared with oleic acid derivatives.

Acrylic bone-cement formulations were prepared with the use of a new tertiary aromatic amine derived from oleic acid, and also by incorporating an acrylic monomer derived from the same acid with the aim of reducing the leaching of toxic residuals and improving mechanical properties. 4-N,N dimethylaminobenzyl oleate (DMAO) was used as an activator in the benzoyl-peroxide radical cold curing of polymethyl methacrylate. Cements that contained DMAO exhibited much lower polymerization exotherm values, ranging between 55 and 62 C, with a setting time around 16--17 min, depending on the amine/BPO molar ratio of the formulation. On curing a commercial bone cement, Palacosreg R with DMAO, a decrease of 20 C in peak temperature and an increase in setting time of 7 min were obtained, the curing parameters remaining well within limits permitted by the standards. In a second stage, partial substitution of MMA by oleyloxyethyl methacrylate (OMA) in the acrylic formulations was performed, the polymerization being initiated with the DMAO/BPO redox system. These formulations exhibited longer setting times and lower peak temperatures with respect to those based on PMMA. The glass transition temperature of the experimental cements were lower than that of PMMA cement because of the presence of long aliphatic chains of both activator and monomer in the cement matrix. Number average molecular weights of the cured cements were in the range of 1.2x10(5). PMMA cements cured with DMAO/BPO revealed a significant (p<0.001) increase in the strain to failure and a significant (p<0.001) decrease in Young's modulus in comparison to Palacosreg R, whereas ultimate tensile strength remained unchanged. When the monomer OMA was incorporated, low concentrations of OMA provided a significant increase in tensile strength and elastic modulus without impairing the strain to failure. The results demonstrate that the experimental cements based on DMAO and OMA have excellent promise for use as orthopaedic and/or dental grouting materials.

Acrylates↗

Influence of application technique on microstructure and strength of acrylic restorations.

An investigation was made of the influence of application techniques on the microstructure and properties of an acrylic tooth restorative. Mixtures of acrylic powder and monomer ("Sevriton Simplified") were applied by the brush technique of Nealon (J. Prosth. Dent., 2, 513, 1952) and by two bulk flow techniques. While similar porosities (about 4%) were observed, the brush technique resulted in a greater quantity of grains from the acrylic powder. Despite this, there was little difference in values of compression modulus, compressive yield stress, and diametral compressive strength. The mechanical strength of the materials studied was less than one-half that of high molecular weight poly(methyl methacrylate) (PMMA). Crack propagation studies established that the interface between the grains and matrix was not a source of weakness. However, as the matrix was crosslinked this could not be checked by solution methods of polymer characterization.

Acrylic Resins↗

Fracture toughness of denture base acrylics.

Two types of fracture toughness specimen, the tapered cleavage (TC) and single edge notch (SEN), are compared. Their reproducibility, accuracy, and ease of preparation are investigated. The fracture toughness of four types of acrylic resin, heat cured, autopolymerized, injection molded, and high impact resistant, has been determined by one or both of the above methods. High impact acrylic proved too ductile for either of the specimens to be used to assesss K1c; however, these deviations from brittle behavior were revealed by the tests and some insight into impact resistance was gained. The SEN specimens proved capable of distinguishing between the fracture toughness characteristics of the four types of denture base acrylics and proved easy to fabricate. The TC specimens proved difficult to fabricate requiring specialized equipment; however, once made, the specimens revealed more of the fracture process than did the SEN specimens.

Acrylic Resins↗

Acrylated phosphonate esters containing 1,3-dioxane and 1,3-dioxolane moieties as adhesion-promoting agents for dentin and hard tissues, I.

Novel acrylated phosphonate esters containing 1,3-dioxane and 1,3-dioxolane moieties derived from polyols such as glycerol, D-mannitol, D-sorbitol, pentaerythritol, and dipentaerythritol have been evaluated in vitro for their role as adhesion-promoting agents in composites employed for restorative dentistry. Some of the acrylated phosphonate esters have been found to promote strong bonding to dentin; the dipentaerythritol derivative exhibits a bond strength of approximately 960 psi (7 MPa) which compares favorably to commercial dentin adhesive systems. The bonding agents appear to act in multifunctional ways: the phosphonate group of the monomer chelates the calcium ions of hydroxyapatite at the dentin surface, ethereal oxygen atoms of 1,3-dioxolane or 1,3-dioxane moieties interact with the proteinaceous content of collagen, and the methacrylic fragment copolymerizes concomitantly with the other comonomers of the restorative composite material. Methods of preparing radiopaque adhesion-promoting acrylated phosphonates are also discussed.

Acrylates↗

Thyroid carcinoma metastasized to the sternum: resection of the sternum and reconstruction with acrylic resin.

Recently we resected and reconstructed the sternum in two female patients with thyroid carcinoma metastatic to the sternum. Histological diagnosis of the metastatic lesion was follicular carcinoma in the first case and papillary carcinoma in the second case. Reconstruction of the sternum was accomplished by using an acrylic resin plate alone in the first case and an acrylic resin plate sandwiched between layers of Marlex mesh (Marlex sandwich procedure) in the second case. In the first case the acrylic resin plate was directly fixed to the ribs with metallic wires, most of which snapped off later, and a small amount of exudate accumulated around the plate for a short period of time. In contrast, the postoperative course in the second case was uneventful and the Marlex sandwich procedure seemed superior in the chest wall reconstruction following resection of the sternum.

Acrylic Resins↗

Biodegradation and sorption properties of polydisperse acrylate polymers.

Polyacrylate (PA), which is widely used in disposable diapers, is synthesized by polymerization and cross-linking of acrylate. During the synthesis, 3-6% of the polyacrylate polymers is not incorporated into the absorbent material, but remains soluble. If the soluble PA is mobilized from a landfill, it could enter the groundwater. Therefore, the biodegradation and adsorption properties of soluble polymers contained in PA are determined in this study. The soluble PA is highly polydisperse, and the fraction tested has a weight-average molecular-weight of 16,700 and a range extending from 10(3) to 10(5). Sand-column tracer tests show that about 1% of the polyacrylate is unadsorbed, but the remainder has a retardation factor that averages at least 58. Biodegradation kinetics are determined in completely mixed biofilm reactors having a methanogenic consortium grown on glucose. The polyacrylate fraction, as well as glucose and acrylate, are removed and mineralized to CO2. The Monod parameters for the polyacrylate are: maximum specific rate of substrate utilization = 0.0016 gC/g biomass-day, and half-maximum-rate concentration = 0.79 gC/m3. Although these kinetics are much slower than for glucose and acrylate, significant degradation and mineralization are observed.

Acrylic Resins↗

The disposition of [2,3-14C]-methyl and [2,3-14C]-2-ethylhexyl acrylate in male Wistar albino rats.

The disposition of methyl [2,3-14C]-acrylate (MA) and 2-ethylhexyl [2,3-14C]-acrylate (EHA) following intraperitoneal and oral administration to rats has been studied. The 14C found in the tissues was mainly associated with liver, kidneys and lungs. Loss of 14C from these tissues occurred fairly rapidly, excluding the rats given EHA intraperitoneally. Most of the administered acrylates underwent rapid metabolism and excretion with expired air (more than 50% of the dose and urine (10-50% of the dose). Significant differences in the rates of 14C loss from tissues and excretion occurred after intrapritoneal administration of MA and EHA. A possible cumulation of EHA in the organism was suggested.

Acrylates↗

Effects of acrylamide and acrylic acid on creatine kinase activity in the rat brain.

In vitro, both acrylamide and acrylic acid inhibited creatine kinase (CK) activity in rat brain homogenates, and acrylic acid was more potent than acrylamide. In vivo, however, when given i.p. 50 mg/kg per day for 8 days to rats, only acrylamide inhibited CK activity in the brain and caused apparent neurological signs. 14C in the brain 24h after the injection of 14C-labelled chemicals was more than 7 times greater with acrylamide than with acrylic acid. The inhibition of CK activity by acrylamide varied in eight regions of the brain; from 54% in hypothalamus to 27% in cerebellar vermis. The regional difference of CK inhibition, however, did not agree well with either 14C distribution or with the distribution in regions which appear clinically or pathologically vulnerable to acrylamide.

Acrylamide↗

[Intra-individual comparison of intraocular lenses of highly refractive silicone (Allergan SI40NB) and hydrophobic acrylate (Alcon Acrysof MA60BM). 1-year follow-up].

BACKGROUND: A prospective, randomized study was performed to evaluate intra-individually the biocompatibility of foldable, highly refractive silicone and hydrophobic acrylic intraocular lenses (IOL). MATERIALS AND METHODS: We studied 35 patients who underwent phacoemulsification using a self-sealing tunnel incision. In a randomized fashion one eye received a 6-mm optic IOL made of high-refractive index silicone (Allergan SI40NB) and the other eye a hydrophobic acrylic 6-mm optic IOL (Alcon AcrySof MA60BM). All patients were examined 7 days, 1-3 and 6 months, and 1 year postoperatively. RESULTS: The mean best-corrected visual acuity (BCVA) was 0.9 +/- 0.12 vs. 0.89 +/- 0.13 (SI40NB vs. MA60BM) after 1-3 months. One-year postoperatively BCVA was still 0.9 +/- 0.12 vs. 0.87 +/- 0.14. The flare values (photon counts/ms) increased slightly 7 days after surgery (14.2 +/- 8.68 vs. 15.49 +/- 7.2, n.s.). Three months after surgery these values were again in the normal range. The mean IOL decentration was 0.29 +/- 0.14 vs. 0.3 +/- 0.15 mm 1 year postoperatively. Scheimpflug slit photography showed 40% of MA60BM IOLs to have "glistenings." No significant difference regarding posterior capsular opacification was found. CONCLUSION: One year after implantation of foldable, highly refractive silicone and hydrophobic acrylic IOLs using a self-sealing tunnel incision and phacoemulsification, no significant functional or morphological differences between the two IOL types were observed.

Acrylates↗

Acrylic resin blockout for interim removable partial dentures.

A technique using autopolymerizing acrylic resin as a blockout material has been described. This technique greatly simplifies the laboratory construction and insertion phases of the complex interim removable partial denture. It is not suggested that the acrylic blockout replace the wax blockout if a heat-cured denture base is not indicated. Wax should be used if a "sprinkle-on" autopolymerizing acrylic resin is used for the denture base.

Acrylic Resins↗

Adhesion between copper-plated acrylic tray resin and a polysulfide rubber impression material.

The method of copper plating on acrylic resin was developed, and the bond strength to polysulfide rubber was measured in comparison with that of the adhesive coating. The bond strength with copper plating was greater than with adhesive coating. The specimens with adhesive coating failed due to a rupture occurring at the elastomer-adhesive interface, while those with copper plating had cohesive-adhesive failure. The method of copper plating on acrylic resin improved the adhesion between the polysulfide rubber and the custom-built acrylic resin tray.

Acrylic Resins↗

Reactions to acrylic resin dental prostheses.

A review of the pertinent literature concerning acrylic resin and its relation to allergic reactions and chemical injury has been presented. The relation of acrylic resin prostheses and materials to oral reactions and lesions is discussed and possible causes and means of evaluation are proposed. Examples of mucosal infection and mucosal disease are presented (which may mimic acrylic resin allergy) along with examples of direct chemical injury of the oral mucosa as a result of autopolymerizing prosthetic techniques.

Acrylic Resins↗

Porosity in boilable acrylic resin.

An acrylic resin developed to be processed by boiling for 20 minutes in water was compared to a conventional heat-processed acrylic resin for porosity when processed according to the manufacturer's directions. No porosity was found in the conventional resin in thicknesses up to 19.5 mm. The boilable resin developed porosity in thicknesses of 6 mm and greater. The porosity increased with increased thickness. The boilable resins should not be used for long-term prostheses or those requiring a thickness of acrylic resin that approaches 6 mm.

Acrylic Resins↗

Monopoly coating on acrylic resin surfaces: a bacteriologic study.

In an open bulb of a buccal flange obturator, it is almost impossible to polish the inner surface of the bulb. Because it cannot be cleaned easily, oral and nasal secretions lead to odors. To obtain a smoother surface, it is suggested that monopoly be painted on the unpolished surface of the open bulb. In this study, the effect of a monopoly coating on bacteria retention and washability of acrylic resin surfaces was investigated. Coated and uncoated acrylic resin samples were prepared and both were contaminated with Escherichia coli. After standard washing, the remaining viable E. coli colonies were counted. The statistical results showed that the difference in the number of E. coli colonies between coated and uncoated groups was highly significant (p less than 0.001). It was suggested that monopoly should be applied to the acrylic resin surfaces where mechanical polishing cannot be done.

Acrylic Resins↗

Adherence in vitro of various Candida species to acrylic surfaces.

Adherence of microorganisms to the surfaces of the host is believed to be an initial and essential step in the production of infection. The objective of the present study was to compare the adherence in vitro of 17 isolates of various Candida species to acrylic surfaces. The results showed that all 17 Candida strains adhered to acryl. Generally, all Candida albicans strains were more adherent than the other strains of Candida species that were tested. Marked differences in the adherence ability of strains belonging to the same species were noted. Future studies to search for possible association between adherence of Candida strains to acryl and pathogenesis of denture stomatitis are planned.

Acrylic Resins↗

Impact strength of acrylic resin denture base materials with surface defects.

The first part of this study involved the development of a method for evaluating the effect of small surface defects (3.0 microns-80.0 microns) on the impact strength of acrylic denture base materials. The method was used to compare the properties of 12 denture base materials, some of which are described as "high-impact strength" products. The defects were introduced by drawing the specimens over abrasive papers of varying grit sizes or by notching with a craft knife. Flexural toughness tests were also carried out in order to evaluate the materials under both rapid (impact) and slow (flexural) rate test conditions. The impact resistance of acrylic resins was significantly reduced by the presence of very small surface defects (e.g., < 16 microns), and this was particularly noticeable for so-called high-impact resins. The latter have values of impact strength only slightly higher than standard acrylic products when defects are present. Testing "notched" specimens with small surface defects was a simple method of obtaining reproducible results. This test was sensitive enough to differentiate among several types of currently available denture base resins.

Acrylic Resins↗